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Muvalaplin\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\uff0c\u4ee5\u53ca\u5bf9\u8102\u86cb\u767d\uff08a\uff09\u6c34\u5e73\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u7ed3\u5c40\u7684\u5f71\u54cd\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u53c2\u8003\u6587\u732e\uff1a<\/p>\n<p>[1]Bittner VA, Szarek M, Aylward PE, et al; ODYSSEY OUTCOMES Committees and Investigators. Effect of alirocumab on lipoprotein(a) and cardiovascular risk after acute coronary syndrome. J Am Coll Cardiol. 2020;75(2):133-144. doi:10.1016\/j.jacc.2019.10.057<\/p>\n<p>[2]O\u2019Donoghue ML, Rosenson RS, Gencer B, et al; OCEAN(a)-DOSE Trial Investigators. Small interfering RNA to reduce lipoprotein(a) in cardiovascular disease. N Engl J Med. 2022;387(20):1855-1864. doi:10.1056\/NEJMoa2211023<\/p>\n<p>[3]https:\/\/\/journals\/jama\/fullarticle\/2808864<\/p>\n<p>[4]Tsimikas S, Karwatowska-Prokopczuk E, Gouni-Berthold I, et al; AKCEA-APO(a)-LRx Study Investigators. Lipoprotein(a) reduction in persons with cardiovascular disease. N Engl J Med. 2020;382(3):244-255. doi:10.1056\/NEJMoa1905239PubMedGoogle ScholarCrossref<\/p>\n<p>[5]Nissen SE, Wolski K, Balog C, et al. Single ascending dose study of a short interfering RNA targeting lipoprotein(a) production in individuals with elevated plasma lipoprotein(a) levels. 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