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\u3010\u524d\u8a00\u3011\u7425\u73c0\u9178\u8131\u6c22\u9176\u7f3a\u9677\u578b\u80be\u7ec6\u80de\u764c\uff08SDH-RCC\uff09\u662f\u4e16\u754c\u536b\u751f\u7ec4\u7ec72016\u5e74\u80be\u7ec6\u80de\u764c\u5206\u7c7b\u4e2d\u4e00\u79cd\u72ec\u7279\u4e9a\u578b[1]<\/sup>\u3002\u5b83\u975e\u5e38\u7f55\u89c1\uff08\u5360\u6240\u6709\u80be\u764c\u76840.05%\uff5e0.2%\uff09\uff0c\u6700\u5e38\u89c1\u4e8e\u9752\u5e74\u671f\u60a3\u8005[2]<\/sup>\u30022004\u5e74\uff0cVanharanta\u7b49\u4eba\u9996\u6b21\u63cf\u8ff0\u4e863\u4f8b\u80be\u764c\u60a3\u8005\u7684\u53d1\u75c5\u5e74\u9f84\u8f83\u5e74\u8f7b\uff0824,26\u548c28\u5c81\uff09\uff0c\u4ed6\u4eec\u7684\u5bb6\u65cf\u60a3\u6709\u9057\u4f20\u6027\u526f\u795e\u7ecf\u8282\u7624\/\u55dc\u94ec\u7ec6\u80de\u7624\u5e76\u4f34\u6709SDHB\u80da\u7cfb\u7a81\u53d8[3]<\/sup>\u3002\u4ed6\u4eec\u63d0\u51fa\uff0cSDHB\u80da\u7cfb\u7a81\u53d8\u53ef\u5bfc\u81f4\u65e9\u53d1\u6027\u80be\u764c\u3002\u4ece\u90a3\u4ee5\u540e\uff0c\u5173\u4e8eSDH\u57fa\u56e0\u7a81\u53d8\u60a3\u8005\u7684\u80be\u810f\u80bf\u7624\u9646\u7eed\u62a5\u9053[4-13]<\/sup>\u3002\u8fd9\u4e9b\u80be\u810f\u80bf\u7624\u88ab\u8bca\u65ad\u4e3a\u900f\u660e\u7ec6\u80de\u6027\u80be\u7ec6\u80de\u764c\u30012\u578b\u4e73\u5934\u72b6\u80be\u7ec6\u80de\u764c\u3001\u5acc\u8272\u6027\u80be\u7ec6\u80de\u764c\u3001\u55dc\u9178\u7ec6\u80de\u7624\u6216\u672a\u5206\u7c7b\u7684\u80be\u7ec6\u80de\u764c\u3002\u8fd9\u4e9b\u65e9\u671f\u7684\u62a5\u9053\u5f88\u5c11\u63cf\u8ff0\u80bf\u7624\u7684\u5f62\u6001\u5b66\u548c\u514d\u75ab\u67d3\u8272\u7ed3\u679c\uff0c\u56e0\u6b64\u4e0d\u786e\u5b9a\u5b83\u4eec\u662f\u5426SDH-RCC\u30022011\u5e74\uff0cGill\u7b49\u89e3\u91ca\u4e86\u8fd9\u79cd\u80be\u80bf\u7624\u5177\u6709\u72ec\u7279\u7684\u7ec4\u7ec7\u5f62\u6001\u5b66[14]<\/sup>\u30022013\u5e74\uff0c\u7531\u4e8e\u53d1\u8868\u7684\u75c5\u4f8b\u5f88\u5c11\uff0c\u5b83\u4f5c\u4e3a\u6682\u5b9a\u5b9e\u4f53\u88ab\u7eb3\u5165\u56fd\u9645\u6ccc\u5c3f\u5916\u79d1\u75c5\u7406\u5b66\u4f1a\u6e29\u54e5\u534e\u5206\u7c7b[15]<\/sup>\u30022014\u5e74\u548c2015\u5e74\uff0cGill\u7b49[2]<\/sup>\u548cWilliamson\u7b49[16]<\/sup>\u5206\u522b\u53d1\u8868\u4e8627\u4f8b\u548c10\u4f8b\u60a3\u8005\u7684\u4e24\u9879\u5927\u578b\u7814\u7a76\u30022016\u5e74\uff0cSDH-RCC\u88ab\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u8ba4\u53ef\u4e3aRCC\u7684\u4e00\u79cd\u5f62\u6001\u72ec\u7279\u4e9a\u578b\u3002<\/p>\n \u3010\u4e34\u5e8a\u7279\u5f81\u3011SDH-RCC\u51e0\u4e4e\u603b\u662f\u53d1\u751f\u5728SDH\u80da\u7cfb\u7a81\u53d8\u7684\u60a3\u8005\u4e2d\uff0c\u6700\u5e38\u89c1\u7684\u662fSDHB\uff0c\u4e0d\u5e38\u89c1\u7684SDHC\uff0c\u5f88\u5c11\u53d1\u751fSDHA\u6216SDHD[2,16,17]<\/sup>\u3002\u7f16\u7801SDH\u4e9a\u5355\u4f4d\u7684\u80da\u7cfb\u57fa\u56e0\u7a81\u53d8\u5bb9\u6613\u53d1\u751f\u526f\u795e\u7ecf\u8282\u7624\/\u55dc\u94ec\u7ec6\u80de\u7624\u30012\u578b\u80c3\u80a0\u9053\u95f4\u8d28\u7624\uff0c\u5f88\u5c11\u53d1\u751fRCC\u548c\u5782\u4f53\u817a\u7624[18-20]<\/sup>\u3002\u526f\u795e\u7ecf\u8282\u7624\/\u55dc\u94ec\u7ec6\u80de\u7624\u957f\u671f\u4ee5\u6765\u88ab\u79f0\u4e3a\u201c10%\u80bf\u7624\u201d\u3002\u7136\u800c\uff0c\u636e\u4f30\u8ba1\uff0c\u9ad8\u8fbe30%\u7684\u526f\u795e\u7ecf\u8282\u7624\/\u55dc\u94ec\u7ec6\u80de\u7624\u662f\u9057\u4f20\u6027\u7684\u3002\u5927\u7ea6\u4e00\u534a\u7684\u5bb6\u65cf\u6027\u75c5\u4f8b\u662f\u7531SDH\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\u3002\u5927\u7ea640%\u7684\u526f\u795e\u7ecf\u8282\u7624\u548c3%\u7684\u55dc\u94ec\u7ec6\u80de\u7624\u662fSDH\u7f3a\u4e4f\u7684[18]<\/sup>\u3002SDH\u7f3a\u9677\u578b\u80c3\u80a0\u9053\u95f4\u8d28\u7624\u5360\u6563\u53d1\u6027\u80c3\u80a0\u95f4\u8d28\u7624\u76845%\uff5e7.5% [19]<\/sup>\u3002\u5b83\u4eec\u5177\u6709\u660e\u663e\u7684\u4e34\u5e8a\u548c\u5f62\u6001\u5b66\u7279\u5f81\u3002\u4ed6\u4eec\u5e38\u53d1\u751f\u4e8e\u513f\u7ae5\u548c\u9752\u5e74\u671f\uff0c\u8868\u73b0\u4e3a\u80c3\u591a\u7076\u6027\u75c5\u53d8\uff0c\u4e0a\u76ae\u6837\u5f62\u6001\uff0c\u7f3a\u4e4fKIT\u548cPDGFRA\u7a81\u53d8\uff1b\u800c\u4e14\u7ecf\u5e38\u8f6c\u79fb\u5230\u6dcb\u5df4\u7ed3\u4f46\u503e\u5411\u4e8e\u60f0\u6027\u7684\u751f\u7269\u5b66\u884c\u4e3a\u3002\u9884\u540e\u4e0d\u80fd\u901a\u8fc7\u80bf\u7624\u5927\u5c0f\u6216\u6838\u5206\u88c2\u8c61\u6765\u9884\u6d4b\u3002\u5b83\u4eec\u5bf9\u4f0a\u9a6c\u66ff\u5c3c\u65e0\u53cd\u5e94\uff0c\u4f46\u5bf9\u7b2c\u4e8c\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u53ef\u80fd\u6709\u66f4\u597d\u7684\u53cd\u5e94[19]<\/sup>\u3002SDH\u7f3a\u9677\u578b\u5782\u4f53\u817a\u7624\u4ec5\u5360\u672a\u9009\u62e9\u6027\u5782\u4f53\u817a\u7624\u76840.3%\u3002\u53d1\u75c5\u5e74\u9f84\u5c0f\uff0c\u591a\u4e3a\u5927\u817a\u7624\uff0c\u5e38\u5206\u6ccc\u50ac\u4e73\u7d20\uff0c\u7537\u6027\u7565\u591a\u89c1[20]<\/sup>\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u81f3\u5c11\u670970\u4f8b\u660e\u786e\u7684SDH-RCC\uff08\u7531\u5178\u578b\u7684\u5f62\u6001\u5b66\u3001\u514d\u75ab\u67d3\u8272\u7ed3\u679c\u548c\u5206\u5b50\u7814\u7a76\u786e\u5b9a\uff09\u5df2\u7ecf\u53d1\u8868\u30024\u4f8b\u7ecf\u75c5\u7406\u8bc1\u5b9e\u5177\u6709\u5bf9\u4fa7SDH-RCC\uff0c1\u4f8b\u80be\u810f\u4e0a\u4e0b\u6781\u5747\u6709\u80bf\u5757\u3002\u7537\u6027\u7a0d\u5fae\u591a\u89c1\uff08\u7537\u5973\u6bd4\u4f8b\u4e3a1.75:1\uff09\u3002\u9996\u6b21\u53d1\u75c5\u7684\u5e73\u5747\u5e74\u9f84\u4e3a36\uff5e40\u5c81\uff0814\uff5e76\u5c81\uff09\u3002\u60a3\u8005\u53ef\u56e0\u4f53\u68c0\u800c\u5076\u7136\u53d1\u73b0\uff0c\u65e0\u5c3f\u9891\u3001\u5c3f\u6025\u3001\u5c3f\u75db\u53ca\u8089\u773c\u8840\u5c3f\uff0c\u65e0\u8170\u8179\u90e8\u75bc\u75db\u53ca\u5bd2\u6218\u53d1\u70ed\u7b49\u75c7\u72b6\u3002\u4f53\u683c\u68c0\u67e5\u672a\u89c1\u5f02\u5e38[26,28,29]<\/sup>\u3002\u5177\u6709\u5178\u578b\u4f4e\u7ea7\u522b\u6838\u7684SDH-RCC\u8f6c\u79fb\u7684\u98ce\u9669\u8f83\u4f4e\uff0812%\uff09\uff0c\u901a\u5e38\u4ec5\u901a\u8fc7\u5b8c\u5168\u5207\u9664\u5373\u53ef\u6cbb\u6108\u3002\u7136\u800c\uff0c\u9ad8\u7ea7\u522b\u7ec6\u80de\u6838\u3001\u8089\u7624\u6837\u6539\u53d8\u6216\u51dd\u56fa\u6027\u574f\u6b7b\u7684\u80bf\u7624\u8f6c\u79fb\u98ce\u9669\u9ad8\uff0870%\uff09\uff0c\u9700\u8981\u79ef\u6781\u7684\u6839\u6cbb\u6027\u6cbb\u7597[2]<\/sup>\u3002\u7531\u4e8e\u67d0\u4e9bSDH-RCC\u53ef\u80fd\u662f\u4e00\u79cd\u7cfb\u7edf\u6027\u75be\u75c5\uff0c\u56e0\u6b64\u4e5f\u5efa\u8bae\u5bf9\u5176\u4ed6\u7efc\u5408\u75c7\u5019\u8868\u73b0\uff08\u526f\u795e\u7ecf\u8282\u7624\/\u55dc\u94ec\u7ec6\u80de\u7624\u3001\u80c3\u80a0\u9053\u95f4\u8d28\u7624\u3001\u5782\u4f53\u817a\u7624\uff09\u7684\u60a3\u8005\u8fdb\u884c\u5b9a\u671f\u968f\u8bbf\u3002<\/p>\n \u3010\u5927\u4f53\u75c5\u7406\u5b66\u3011\u5927\u4f53\u53ef\u89c1\u80bf\u7624\u8fb9\u754c\u6e05\u695a\uff0c\u88ab\u8910\u8272\u6216\u7ea2\u68d5\u8272\u5047\u5305\u819c\u5305\u56f4\uff0c\u5207\u9762\u6709\u65f6\u53ef\u89c1\u51fa\u8840\u3002\u591a\u6570\u80bf\u7624\u4e3a\u5b9e\u6027\uff0c\u6709\u65f6\u53ef\u89c1\u56ca\u6027\u53d8\uff08\u56fe1\uff09\u3002<\/p>\n \u3010\u7ec4\u7ec7\u75c5\u7406\u5b66\u3011\u663e\u5fae\u955c\u4e0b\uff0c\u80bf\u7624\u8fb9\u754c\u6e05\u695a\u6216\u5448\u5206\u53f6\u3002\u80bf\u7624\u5448\u5b9e\u6027\u5de2\u72b6\u6216\u5c0f\u7ba1\u72b6\u6392\u5217\uff0c\u5e38\u4f34\u6709\u56ca\u6027\u53d8\uff0c\u56ca\u6027\u533a\u57df\u901a\u5e38\u542b\u6709\u6de1\u55dc\u9178\u6027\u6db2\u4f53\uff08\u56fe2\uff09\u3002\u4e5f\u53ef\u5448\u5de2\u56e2\u72b6\u3001\u6881\u7d22\u72b6\u7ed3\u6784\u5206\u5e03\u4e8e\u758f\u677e\u6c34\u80bf\u7684\u95f4\u8d28\u6216\u7622\u75d5\u5468\u56f4\uff0c\u7c7b\u4f3c\u4e8e\u55dc\u9178\u7ec6\u80de\u817a\u7624\u3002\u826f\u6027\u80be\u5c0f\u7ba1\u6216\u80be\u5c0f\u7403\u5e38\u88ab\u5305\u56f4\u5728\u80bf\u7624\u5468\u56f4\u3002\u7624\u5185\u5e38\u89c1\u80a5\u5927\u7ec6\u80de\uff08\u56fe3\uff09\u3002\u5c11\u6570\u80bf\u7624\u53ef\u89c1\u660e\u663e\u7684\u9ecf\u6db2\u6837\u6216\u73bb\u7483\u6837\u57fa\u8d28\u3002\u80bf\u7624\u7531\u7acb\u65b9\u5230\u5375\u5706\u5f62\u7ec6\u80de\u7ec4\u6210\uff0c\u6838\u5706\u5f62\uff0c\u5177\u6709\u795e\u7ecf\u5185\u5206\u6ccc\u6837\u7684\u7ec6\u817b\u67d3\u8272\u8d28\uff0c\u6838\u4ec1\u4e0d\u660e\u663e\uff08ISUP\u6838\u7ea7\u4e00\u822c\u4e3a1\u7ea7\u62162\u7ea7\uff09\u3002\u80de\u8d28\u5448\u55dc\u9178\u6027\u6216\u7d6e\u72b6\uff0c\u4f46\u4e0d\u662f\u771f\u6b63\u7684\u55dc\u9178\u6027\u7ec6\u80de\uff0c\u90e8\u5206\u80bf\u7624\u7ec6\u80de\u4e5f\u53ef\u80de\u8d28\u900f\u4eae\u3002\u6700\u5178\u578b\u7684\u7ec4\u7ec7\u5b66\u7279\u5f81\u662f\u80de\u8d28\u7a7a\u6ce1\u6216\u5305\u6db5\u4f53\u7684\u5b58\u5728\uff0c\u5373\u4e3a\u7535\u955c\u4e0b\u89c1\u5230\u7684\u80de\u8d28\u6db2\u6ce1\u6216\u5305\u6db5\u4f53\uff0c\u5b83\u4eec\u4ee3\u8868\u589e\u5927\u7684\u7ebf\u7c92\u4f53\uff08\u56fe4\uff09[21]<\/sup>\u3002\u4e00\u4e9b\u80bf\u7624\u8868\u73b0\u51fa\u660e\u663e\u7684\u6838\u4ec1\u3001\u8089\u7624\u6837\u6539\u53d8\u6216\u51dd\u56fa\u6027\u574f\u6b7b\u7279\u5f81\u3002\u5728\u8fd9\u7c7b\u80bf\u7624\u4e2d\uff0c\u5728\u6574\u4e2a\u5207\u7247\u4e2d\u5bfb\u627e\u5178\u578b\u7684\u4f4e\u7ea7\u522b\u5f62\u6001\u6216\u80de\u8d28\u5185\u5305\u6db5\u4f53\u6709\u52a9\u4e8e\u8bca\u65ad[2,14,16,27,29]<\/sup>\u3002<\/p>\n<\/p>\n \u3010\u514d\u75ab\u8868\u578b\u3011\u514d\u75ab\u7ec4\u5316\u4e0a\uff0c\u80bf\u7624\u901a\u5e38\u8868\u8fbePAX8\u548cEMA\uff08\u53ef\u80fd\u662f\u5c40\u7076\u9633\u6027\uff09[2]<\/sup>\u3002\u8bb8\u591a\u75c5\u4f8b\uff0868%\uff09\u663e\u793a\u6240\u6709\u7ec6\u80de\u89d2\u86cb\u767d\uff08CK\uff09\u5448\u9634\u6027\u8868\u8fbe[2]<\/sup>\u3002CD10\u7684\u8868\u8fbe\u4ece\u9634\u6027\u5230\u5f25\u6f2b\u9633\u6027\u4e0d\u7b49[16]<\/sup>\u3002vimentin\u3001CD117\u3001RCC\u6297\u539f\u3001\u78b3\u9178\u9150\u9176IX\uff08CAIX\uff09\u3001\u55dc\u94ec\u7c92\u86cb\u767d\uff08CgA\uff09\u3001syn\u3001cathepsin K\u3001TFE3\u548cHMB45\u67d3\u8272\u901a\u5e38\u5448\u9634\u6027\uff0c\u4f46\u80bf\u7624\u4e2d\u7684\u80a5\u5927\u7ec6\u80de\u6ce2\u5f62\u86cb\u767d\uff08\u56fe5\uff09\u548cCD117\uff08\u56fe6\uff09\u9633\u6027[2,16]<\/sup>\u3002\u6240\u6709\u75c5\u4f8bSDHB\u514d\u75ab\u67d3\u8272\u5747\u4e3a\u9634\u6027\uff08\u56fe7\uff09\uff0c\u53ea\u6709\u4e0eSDHA\u80da\u7cfb\u7a81\u53d8\u76f8\u5173\u7684\u80bf\u7624SDHA\u514d\u75ab\u67d3\u8272\u4e3a\u9634\u6027\u3002<\/p>\n<\/p>\n \u3010\u5206\u5b50\u9057\u4f20\u5b66\u53ca\u53d1\u75c5\u673a\u5236\u3011SDH\u4e5f\u88ab\u79f0\u4e3a\u7ebf\u7c92\u4f53\u590d\u5408\u4f532\uff0c\u7531\u51e0\u4e2a\u4e9a\u57fa\uff08SDHA\u3001SDHB\u3001SDHC\u3001SDHD\u548cSDHAF2\uff09\u7ec4\u6210[18]<\/sup>\u3002\u5b83\u662f\u8fde\u63a5\u4e09\u7fa7\u9178\u5faa\u73af\u548c\u7535\u5b50\u4f20\u9012\u94fe\u7684\u5173\u952e\u547c\u5438\u9176\uff0c\u5176\u4f5c\u7528\u662f\u50ac\u5316\u7425\u73c0\u9178\u5411\u5bcc\u9a6c\u9178\u7684\u80fd\u91cf\u4f9d\u8d56\u6027\u8f6c\u5316\u3002\u9664\u4e86\u5176\u4ee3\u8c22\u4f5c\u7528\uff0cSDH\u662f\u516c\u8ba4\u7684\u80bf\u7624\u6291\u5236\u57fa\u56e0\u53c2\u4e0e\u80bf\u7624\u5f62\u6210\u3002\u5f53\u7ebf\u7c92\u4f53\u590d\u5408\u4f532\u7684\u4efb\u4f55\u7ec4\u6210\u90e8\u5206\u7ecf\u5386\u53cc\u91cd\u5931\u6d3b\uff08\u51e0\u4e4e1\u4e2a\u80da\u7cfb\u548c1\u4e2a\u4f53\u7ec6\u80de\u7a81\u53d8\uff09\u65f6\uff0c\u6574\u4e2a\u590d\u5408\u4f53\u53d8\u5f97\u4e0d\u7a33\u5b9a\uff0c\u5e76\u5bfc\u81f4SDHB\u4e9a\u57fa\u964d\u89e3\u3002SDH\u7f3a\u9677\u578b\u80bf\u7624\u7684\u53d1\u751f\u673a\u5236\u5c1a\u4e0d\u5b8c\u5168\u6e05\u695a\uff0c\u4f46\u4f3c\u4e4e\u4e0e\u8f6c\u5f55\u56e0\u5b50\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50\uff08hypoxia-inducible 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Cali\u00f3\u7b49\u6700\u8fd1\u62a5\u9053\u4e864\u4f8bTFE3\u67d3\u8272\u9633\u6027\u548cSDHB\u67d3\u8272\u9634\u6027\u7684RCCs[23]<\/sup>\u3002\u80bf\u7624\u8868\u73b0\u51faXp11\u6613\u4f4d\u6027RCCs\u548csdh\u7f3a\u5931\u6027RCCs\u7684\u591a\u79cd\u5f62\u6001\u3002\u5206\u5b50\u7814\u7a76\u663e\u793a\uff0c\u6240\u6709\u80bf\u7624\u5747\u5b58\u5728TFE3\u57fa\u56e0\u91cd\u6392\uff0c3\u4f8b\u80bf\u7624\u5b58\u5728SDHB\u7a81\u53d8\uff081\u4f8b\u80da\u7cfb\u7a81\u53d8\uff09\u3002\u4f5c\u8005\u63a8\u6d4b\uff0c\u5728\u8fd9\u7c7b\u80bf\u7624\u4e2d\uff0cSDH\u7a81\u53d8\u662f\u80bf\u7624\u53d1\u751f\u7684\u9a71\u52a8\u56e0\u7d20\uff0cTFE3\u968f\u540e\u53d1\u751f\u6613\u4f4d\u3002\u7136\u800c\uff0cChou\u7b49\u4eba\u62a5\u9053\u572830\u4e2aSDH\u7f3a\u9677\u578bRCCs\u4e2d\u6ca1\u6709TFE3\u57fa\u56e0\u91cd\u6392[24]<\/sup>\u3002\u4ed6\u4eec\u6307\u51fa\uff0cCali\u00f3\u7b49\u7814\u7a76\u4e2dTFE3\u5206\u88c2\u4fe1\u53f7\u6a21\u5f0f\u7684\u767e\u5206\u6bd4\u76f8\u5f53\u4f4e\uff08\u5e73\u574716%\uff1b\u8303\u56f4\u4e3a12%\uff5e19%)\uff0c\u5e76\u5efa\u8bae\u8367\u5149\u539f\u4f4d\u6742\u4ea4\u4e34\u754c\u7ed3\u679c\u5e94\u8c28\u614e\u89e3\u91ca\u3002\u53ef\u80fd\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u6765\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\u3002<\/p>\n 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\u53c2\u8003\u6587\u732e<\/p>\n [1] Gill AJ, Amin MB, Smith SC, Trpkov K. Succinate dehydrogenase-deficient renal cell carcinoma. In: Holger M, Humphrey PA, Ulbright TM, Reuter VE, eds. WHO Classification of Tumors of the Urinary System and Male Genital Organs. 4th ed. Lyon, France: International Agency for Research on Cancer; 2016:35-36.<\/p>\n [2]Gill AJ, Hes O, Papathomas T, et al. Succinate dehydrogenase(SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients. Am J Surg Pathol,2014;38(12):1588-1602.<\/p>\n [3]Vanharanta S, Buchta M, McWhinney SR, et al. Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma. Am J Hum Genet. 2004;74(1):153-159.<\/p>\n [4]Ricketts CJ, Shuch B, Vocke CD, et al. Succinate dehydrogenase kidney<\/p>\n cancer: an aggressive example of the Warburg effect in cancer. J Urol. 2012, 188(6): 2063-2071.<\/p>\n [5]Solis DC, Burnichon N, Timmers HJ, et al. Penetrance and clinical consequences of a gross SDHB deletion in a large family. Clin Genet. 2009,75(4):354-363.<\/p>\n [6]Henderson A, Douglas F, Perros P, Morgan C, Maher ER. SDHB-associated renal oncocytoma suggests a broadening of the renal phenotype in hereditary paragangliomatosis. Fam Cancer. 2009,8(3):257-260.<\/p>\n [7]Schimke RN, Collins DL, Stolle CA. Paraganglioma, neuroblastoma, and a SDHB mutation: resolution of a 30-year-old mystery. Am J Med Genet A. 2010,152A(6): 1531 -1535.<\/p>\n [8]Srirangalingam U, Walker L, Khoo B, et al. Clinical manifestations of familial paraganglioma and phaeochromocytomas in succinate dehydrogenase B(SDH-B) gene mutation carriers. Clin Endocrinol (Oxf). 2008,69(4):587-596.<\/p>\n [9]Ricketts C, Woodward ER, Killick P, et al. Germline SDHB mutations and familial renal cell carcinoma. J Natl Cancer Inst. 2008,100(17):1260-1262.<\/p>\n [10]Casc\u00b4on A, Landa I, L\u00b4opez-Jim\u00b4enez E, et al. Molecular characterisation of a common SDHB deletion in paraganglioma patients. J Med Genet. 2008,45(4):233-238.<\/p>\n [11]Ni Y, Zbuk KM, Sadler T, et al. Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes. Am J Hum Genet. 2008,83(2):261-268.<\/p>\n [12]Jasperson KW, Kohlmann W, Gammon A, et al. Role of rapid sequence whole-body MRI screening in SDH-associated hereditary paraganglioma<\/p>\n families. Fam Cancer. 2014;13(2):257\u2013265.<\/p>\n [13]Malinoc A, Sullivan M, Wiech T, et al. Biallelic inactivation of the SDHC gene in renal carcinoma associated with paraganglioma syndrome type 3. Endocr Relat Cancer. 2012,19(3):283-290.<\/p>\n [14]Gill AJ, Pachter NS, Chou A, et al. Renal tumors associated with germline SDHB mutation show distinctive morphology. Am J Surg Pathol.2011,35(10):1578-1585.<\/p>\n [15]Srigley JR, Delahunt B, Eble JN, et al. The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. Am J Surg Pathol. 2013,37(10):1469-1489.<\/p>\n [16]Williamson SR, Eble JN, Amin MB, et al. Succinate dehydrogenase deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma. Mod Pathol. 2015,28(1):80-94.<\/p>\n [17]Yakirevich E, Ali SM, Mega A, et al. A novel SDHA-deficient renal cell carcinoma revealed by comprehensive genomic profiling. Am J Surg Pathol. 2015,39(6):858-863.<\/p>\n [18]Gill AJ. Succinate dehydrogenase (SDH) and mitochondrial driven neoplasia. Pathology. 2012,44(4):285-292.<\/p>\n [19]Gill AJ, Chou A, Vilain R, et al. Immunohistochemistry for SDHB divides<\/p>\n gastrointestinal stromal tumors (GISTs) into 2 distinct types. Am J Surg Pathol.<\/p>\n 2010,34(5):636-644.<\/p>\n [20]Gill AJ, Toon CW, Clarkson A, et al. Succinate dehydrogenase deficiency is rare in pituitary adenomas. Am J Surg Pathol. 2014,38(4):560-566.<\/p>\n [21] Housley SL, Lindsay RS, Young B, et al. Renal carcinoma with giant mitochondria associated with germ-line mutation and somatic loss of the succinate dehydrogenase B gene. Histopathology. 2010,56(3):405-408.<\/p>\n [22] Barletta JA, Hornick JL. Succinate dehydrogenase-deficient tumors: diagnostic advances and clinical implications. Adv Anat Pathol. 2012,19(4):193-203.<\/p>\n [23] Cali\u00b4o A, Grignon DJ, Stohr BA, Williamson SR, Eble JN, Cheng L. Renal cell<\/p>\n carcinoma with TFE3 translocation and succinate dehydrogenase B mutation. Mod Pathol. 2017,30(3):407-415.<\/p>\n [24] Chou A, Hes O, Turchini J, Trpkov K, Gill AJ. Do significant TFE3 gene<\/p>\n rearrangements occur in succinate dehydrogenase-deficient renal cell carcinoma?<\/p>\n Borderline FISH results should be interpreted with caution. Mod Pathol. 2017,30(10):1507-1508.<\/p>\n [25] \u5468\u6653\u519b,\u4f59\u82f1\u8c6a,\u4e3b\u7f16.\u4e34\u5e8a\u75c5\u7406\u8bca\u65ad\u4e0e\u9274\u522b\u8bca\u65ad—\u6ccc\u5c3f\u53ca\u7537\u6027\u751f\u6b96\u7cfb\u7edf\u75be\u75c5[M].\u4eba\u6c11\u536b\u751f\u51fa\u7248\u793e,2020\u5e74.<\/p>\n [26] \u8d75\u5a9b,\u9648\u7ea2,\u91d1\u6728\u5170. \u7425\u73c0\u9178\u8131\u6c22\u9176\u7f3a\u9677\u578b\u80be\u764c1\u4f8b\u5e76\u6587\u732e\u590d\u4e60[J]. \u4e34\u5e8a\u4e0e\u5b9e\u9a8c\u75c5\u7406\u5b66\u6742\u5fd7,2019,35(12):1472-1474. <\/p>\n [27] \u738b\u5c0f\u6850,\u738b\u7487,\u7ae0\u5982\u677e,\u7b49. \u7425\u73c0\u9178\u8131\u6c22\u9176\u7f3a\u9677\u578b\u80be\u7ec6\u80de\u764c\u7684\u4e34\u5e8a\u75c5\u7406\u5b66\u3001\u8d85\u5fae\u7ed3\u6784\u53ca\u5206\u5b50\u7279\u5f81[J]. \u4e2d\u534e\u75c5\u7406\u5b66\u6742\u5fd7,2022,51(1):12-16.<\/p>\n [28] \u6731\u6e05,\u674e\u6960,\u6b66\u4fa0,\u7b49. \u7425\u73c0\u9178\u8131\u6c22\u9176\u7f3a\u9677\u578b\u80be\u764c\u7684\u4e34\u5e8a\u75c5\u7406\u7279\u5f81[J]. \u4e2d\u56fd\u7ec4\u7ec7\u5316\u5b66\u4e0e\u7ec6\u80de\u5316\u5b66\u6742\u5fd7,2020,29(6):529-533. <\/p>\n [29] \u738b\u6843\u4e3d,\u66f9\u4e91,\u9648\u680b\u826f. \u7425\u73c0\u9178\u8131\u6c22\u9176\u7f3a\u9677\u578b\u80be\u7ec6\u80de\u764c\u7684\u4e34\u5e8a\u75c5\u7406\u7279\u5f81[J]. \u4e34\u5e8a\u4e0e\u75c5\u7406\u6742\u5fd7,2021,41(1):233-239.<\/p>\n<\/p>\n #artContent h1#artContent p img#artContent table<\/p>\n","protected":false},"excerpt":{"rendered":" \u3010\u6458\u8981\u3011\u7425\u73c0\u9178\u8131\u6c22\u9176\u7f3a\u9677\u578b\u80be\u7ec6\u80de\u764c\uff08SDH-RCC\uff09\u662f2016\u5e74\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u80be\u7ec6 … \u7ee7\u7eed\u9605\u8bfb