\u7b2c\u4e09\u8282\u3000\u753e\u4f53\u6fc0\u7d20<\/p>\n
\u753e\u4f53\u6fc0\u7d20\u7684\u5b9a\u4e49\uff1a\u753e\u4f53\u6fc0\u7d20\u662f\u4e00\u7c7b\u56db\u73af\u8102\u70c3\u5316\u5408\u7269\uff0c\u5177\u6709\u73af\u620a\u70f7\u591a\u6c22\u83f2\u6bcd\u6838\u3002 \u753e\u4f53\u6fc0\u7d20\u7684\u5206\u7c7b\uff1a\u6309\u5176\u836f\u7406\u4f5c\u7528\uff0c\u53ef\u5206\u4e3a\u6027\u6fc0\u7d20\u53ca\u76ae\u8d28\u6fc0\u7d20\uff1b \u6839\u636e\u5176\u5316\u5b66\u7ed3\u6784\uff0c\u5219\u53ef\u5206\u4e3a\u96cc\u753e\u70f7\u3001\u96c4\u753e\u70f7\u53ca\u5b55\u753e\u70f7\u4e09\u5927\u7c7b\uff0c\u5176\u5316\u5b66\u7ed3\u6784\u5982\u4e0b\uff1a<\/p>\n<\/p>\n
\u7ed3\u6784\u7279\u70b9\uff1a\u5b83\u4eec\u5747\u5177\u6709\u73af\u620a\u70f7\u591a\u6c22\u83f2\u6bcd\u6838\u3002\u5176\u4e2d\u96cc\u753e\u70f7\u5728C-13\u4e0a\u6709\u7532\u57fa\u53d6\u4ee3\uff0c\u6b64\u7532\u57fa\u7f16\u53f7\u4e3aC-18\uff1b\u96c4\u753e\u70f7\u53ca\u5b55\u753e\u70f7\u5728C-10\u53caC-13\u4e0a\u6709\u7532\u57fa\u53d6\u4ee3\uff0c\u5206\u522b\u4e3aC-18\u3001C-19\uff1b\u5b55\u753e\u70f7\u5728C-17\u4e0a\u6709\u4e24\u4e2a\u78b3\u53d6\u4ee3\uff0c\u5206\u522b\u4e3aC-20\u3001C-21\u3002\u56db\u5143\u73af\u7684A\u3001B\u3001C\u3001D\u8fd8\u53ef\u6309\u4ee5\u4e0b\u6784\u578b\u5206\u5e03\uff1a<\/p>\n<\/p>\n
\u5373\u53cd-\u53cd-\u53cd\u3001\u987a-\u53cd-\u53cd\u53ca\u987a-\u53cd-\u987a\u5f0f\uff0c\u6b64\u65f6\u5728\u73af\u5e73\u9762\u4ee5\u4e0a\u7684\u53d6\u4ee3\u57fa\uff08\u5e73\u9762\u5f0f\u4e2d\u7684\u5b9e\u7ebf\uff09\u79f0\u03b2\u4f4d\u53d6\u4ee3\uff0c\u5728\u73af\u5e73\u9762\u4ee5\u4e0b\u7684\u53d6\u4ee3\u57fa\uff08\u5e73\u9762\u5f0f\u4e2d\u7684\u865a\u7ebf\uff09\u79f0\u03b1\u4f4d\u53d6\u4ee3\u3002\u672c\u8282\u4e2d\u4ecb\u7ecd\u7684\u753e\u4f53\u6fc0\u7d20\u836f\u7269\u90fd\u662f\u53cd-\u53cd-\u53cd\u5f0f\u6784\u578b\u7684\u5316\u5408\u7269\u3002 \u53d1\u5c55\u8fc7\u7a0b\uff1a1932~1939\u5e74\u95f4\uff0c\u4ece\u817a\u4f53\u4e2d\u83b7\u5f97\u96c4\u916e\uff08estrone 1932\u5e74\uff09\u3001\u96cc\u4e8c\u9187\uff08estradiol 1932\u5e74\uff09\u3001\u777e\u916e\uff08testosterone 1935\u5e74\uff09\u53ca\u76ae\u8d28\u916e\uff08corticosterone 1939\u5e74\uff09\u7b49\u7684\u7eaf\u54c1\u7ed3\u6676\uff0c\u4e4b\u540e\u9610\u660e\u4e86\u5176\u5316\u5b66\u7ed3\u6784\uff0c\u4ece\u6b64\u5f00\u521b\u4e86\u753e\u4f53\u5316\u5b66\u548c\u753e\u4f53\u836f\u7269\u5316\u5b66\u7684\u65b0\u9886\u57df\u3002\u968f\u540e\uff0c\u53c8\u6709\u8bb8\u591a\u91cd\u5927\u7684\u6210\u5c31\uff0c\u53d1\u660e\u7528\u85af\u828b\u7682\u7519(diosgenin)\u4e3a\u539f\u6599\u8fdb\u884c\u534a\u5408\u6210\u751f\u4ea7\u753e\u4f53\u836f\u7269\uff0c\u4f7f\u751f\u4ea7\u89c4\u6a21\u6269\u5927\uff0c\u6210\u672c\u964d\u4f4e\u3002\u53d1\u73b0\u80be\u4e0a\u817a\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u98ce\u6e7f\u6027\u5173\u8282\u708e\u53ca\u5176\u5728\u514d\u75ab\u8c03\u8282\u4e0a\u7684\u91cd\u8981\u4ef7\u503c\uff0c\u4f7f\u753e\u4f53\u836f\u7269\u6210\u4e3a\u533b\u9662\u4e2d\u4e0d\u53ef\u7f3a\u5c11\u7684\u836f\u7269\u3002\u753e\u4f53\u53e3\u670d\u907f\u5b55\u836f\u7684\u7814\u7a76\u6210\u529f\uff0c\u4f7f\u4eba\u7c7b\u751f\u80b2\u63a7\u5236\u8fbe\u5230\u4e86\u65b0\u6c34\u5e73\u3002\u5176\u4e2d18-\u7532\u57fa\u7094\u8bfa\u5b55\u916e\u7528\u5168\u5408\u6210\u65b9\u6cd5\u5236\u5f97\uff0c\u4ece\u800c\u6446\u8131\u4e86\u5b8c\u5168\u4f9d\u9760\u5929\u7136\u6765\u6e90\u7684\u72b6\u51b5\uff0c\u5f00\u521b\u4e86\u753e\u4f53\u5168\u5408\u6210\u7684\u65b0\u5c40\u9762\u3002\u7528\u751f\u7269\u5408\u6210\u6cd5\u5728\u753e\u4f53\u4e2d\u5f15\u516511-\u6c27\uff0c\u4ee5\u53ca\u76ae\u8d28\u6fc0\u7d20\u6784\u6548\u5173\u7cfb\u7684\u7814\u7a76\uff0c\u90fd\u5145\u5b9e\u4e86\u836f\u7269\u5316\u5b66\u7684\u57fa\u7840\u53ca\u5e94\u7528\u5185\u5bb9\u3002<\/p>\n
\u4e00\u3001\u753e\u4f53\u96cc\u6fc0\u7d20<\/p>\n
\u5929\u7136\u96cc\u6fc0\u7d20\u6709\u96cc\u4e8c\u9187\uff08estradiol\uff09\u3001\u96cc\u916e\uff08estrone\uff09\u53ca\u96cc\u4e09\u9187\uff08estriol\uff09\u3002\u5176\u7ed3\u6784\u7279\u5f81\u90fd\u662fA\u73af\u82b3\u9999\u7c7b\u753e\u4f53\u5316\u5408\u7269\uff0c\u5176\u751f\u7406\u4f5c\u7528\u4e3a\u4fc3\u8fdb\u96cc\u6027\u52a8\u7269\u7b2c\u4e8c\u6027\u5f81\u7684\u53d1\u80b2\u548c\u6027\u5668\u5b98\u7684\u6210\u719f\uff0c\u8fd8\u4e0e\u5b55\u6fc0\u7d20\u4e00\u8d77\u5b8c\u6210\u6027\u5468\u671f\u3001\u598a\u5a20\u3001\u54fa\u4e73\u7b49\u3002\u4e34\u5e8a\u4e0a\u7528\u4e8e\u6cbb\u7597\u5973\u6027\u6027\u529f\u80fd\u75be\u75c5\u3001\u66f4\u5e74\u671f\u7efc\u5408\u5f81\u3001\u9aa8\u8d28\u758f\u677e\u75c7\uff0c\u4f5c\u4e3a\u53e3\u670d\u907f\u5b55\u836f\u53ca\u5bf9\u9884\u9632\u653e\u5c04\u7ebf\u3001\u8102\u8d28\u7684\u4ee3\u8c22\u90fd\u6709\u5341\u5206\u91cd\u8981\u7684\u4f5c\u7528\u3002 \u96cc\u6fc0\u7d20\u53ef\u5206\u7c7b\u4e3a\u753e\u4f53\u96cc\u6fc0\u7d20\u53ca\u975e\u753e\u4f53\u96cc\u6fc0\u7d20\u4e24\u5927\u7c7b\u3002<\/p>\n
\u4ee3\u8868\u836f\u7269 \u96cc\u4e8c\u9187 estradiol<\/p>\n<\/p>\n
\u5316\u5b66\u540d\uff1a\u96c4\u753e-1,3,5(10)-\u4e09\u70ef-3,17\u03b2-\u4e8c\u9187((17\u03b2)-estra-1,3,5(10)-triene-3,17-diol)\u3002 \u4f53\u5185\u4ee3\u8c22\uff1a\u5728\u4f53\u5185\uff0cestradiol\u7ecf\u4ee3\u8c22\u7f9f\u5316\u6216\u6c27\u5316\u540e\uff0c\u4e0e\u8461\u8404\u7cd6\u919b\u9178\u6216\u786b\u9178\u916f\u7ed3\u5408\u6210\u4e3a\u6c34\u6eb6\u6027\u5316\u5408\u7269\u4ece\u5c3f\u4e2d\u6392\u51fa\u3002 \u7ed3\u6784\u6539\u9020\uff1aestradiol\u6709\u6781\u5f3a\u7684\u751f\u7269\u6d3b\u6027\uff0c11-8~11-10mol\/L\u7684\u6d53\u5ea6\u5bf9\u9776\u5668\u5b98\u5373\u80fd\u8868\u73b0\u51fa\u6d3b\u6027\u3002\u56e0\u800c\uff0c\u4ee5estradiol\u4e3a\u5148\u5bfc\u7269\u7684\u7ed3\u6784\u6539\u9020\u7684\u4e3b\u8981\u76ee\u7684\u5f80\u5f80\u4e0d\u662f\u4e3a\u4e86\u63d0\u9ad8\u6d3b\u6027\uff0c\u800c\u662f\u4e3a\u4e86\u4f7f\u7528\u65b9\u4fbf\uff0c\u5982\u80fd\u591f\u53e3\u670d\uff0c\u6216\u957f\u6548\uff0c\u6216\u5176\u4ed6\u7684\u4e13\u4e00\u7528\u9014\u3002 \u7094\u96cc\u9187\uff08ethinylestradiol\uff09\u662f\u4e00\u79cd\u53e3\u670d\u6709\u6548\u7684\u5316\u5408\u7269\uff0c\u5176\u53e3\u670d\u6d3b\u6027\u662festradiol\u768410~20\u500d\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e17\u03b1\u4f4d\u5f15\u5165\u4e59\u7094\u57fa\u4e4b\u540e\uff0c\u5728\u809d\u4e2d17\u03b2\u7f9f\u57fa\u7684\u786b\u9178\u916f\u5316\u4ee3\u8c22\u53d7\u963b\uff0c\u5728\u80c3\u80a0\u9053\u4e2d\u4e5f\u53ef\u62b5\u5fa1\u5fae\u751f\u7269\u7684\u964d\u89e3\u4f5c\u7528\u6240\u81f4\u3002\u73b0\u5df2\u6210\u4e3a\u53e3\u670d\u753e\u4f53\u907f\u5b55\u836f\u4e2d\u6700\u5e38\u7528\u7684\u96cc\u6fc0\u7d20\u7ec4\u5206\u3002<\/p>\n<\/p>\n
\u8fdb\u4e00\u6b65\u5c06\u5b83\u76843-\u7f9f\u57fa\u919a\u5316\u5982\u7532\u919a\u5316\uff0c\u7279\u522b\u662f\u73af\u620a\u919a\u5316\u540e\u7684\u4ea7\u7269\u7094\u96cc\u9187-3-\u73af\u620a\u919a\uff08\u7094\u96cc\u919a\uff0cquinestrol\uff09\uff0c\u4e0d\u4f46\u4fdd\u6301\u4e86\u53e3\u670d\u6d3b\u6027\uff0c\u919a\u5316\u4ea7\u7269\u7684\u8102\u6eb6\u6027\u589e\u5927\uff0c\u80fd\u5728\u4f53\u5185\u8102\u80aa\u5c0f\u7403\u4e2d\u8d2e\u5b58\uff0c\u6162\u6162\u964d\u89e3\u540e\u79bb\u89e3\u51fa3-\u7f9f\u57fa\u5316\u5408\u7269\u800c\u8d77\u4f5c\u7528\uff0c\u7531\u4e8e\u919a\u952e\u5728\u4f53\u5185\u7684\u4ee3\u8c22\u66f4\u52a0\u590d\u6742\u53ca\u7f13\u6162\uff0c\u56e0\u800c\u5b83\u662f\u4e00\u79cd\u53e3\u670d\u53ca\u6ce8\u5c04\u957f\u6548\u96cc\u6fc0\u7d20\u3002\u6211\u56fd\u5f00\u53d1\u7684\u4e00\u79cd\u957f\u6548\u53e3\u670d\u96cc\u6fc0\u7d20\u5c3c\u5c14\u96cc\u9187\uff08nilestriol\uff09\uff0c\u5b83\u662f\u4e59\u7094\u96cc\u4e09\u9187\u7684\u73af\u620a\u919a\uff0c\u96cc\u6fc0\u7d20\u6d3b\u6027\u5c0f\u4e8e\u7094\u96cc\u9187\u3002\u53e3\u670d\u4e00\u72475mg\u53ef\u5ef6\u6548\u4e00\u4e2a\u6708\u3002\u836f\u7269\u8fdb\u5165\u4f53\u5185\u540e\u7f13\u6162\u5730\u8fdb\u884c\u8131\u70f7\u57fa\u5316\uff0c\u751f\u62103-\u7f9f\u57fa\u5316\u5408\u7269\u540e\u53d1\u6325\u4f5c\u7528\u3002 estradiol\u76843\u621617\u03b2\u4f4d\u7f9f\u57fa\u7684\u5404\u79cd\u5404\u6837\u7684\u916f\u5316\u4ea7\u7269\u662f\u6700\u5e38\u89c1\u7684\u884d\u751f\u7269\uff0c\u5b83\u4eec\u80fd\u5728\u690d\u7269\u6cb9\u4e2d\u6eb6\u89e3\u5236\u6210\u957f\u6548\u9488\u5242\u3002\u82ef\u7532\u9178\u96cc\u4e8c\u9187\uff08estradiol benzoate\uff09\u662f3-\u4f4d\u916f\uff0c\u620a\u9178\u96cc\u4e8c\u9187\uff08estradiol valerate\uff09\u662f17\u03b2-\u4f4d\u916f\u5316\u884d\u751f\u7269\uff0c\u5728\u5408\u6210\u65f6\u5148\u751f\u6210\u53cc\u916f\uff0c\u7531\u4e8e3-\u4f4d\u916f\u76f8\u5bf9\u6613\u6c34\u89e3\uff0c\u53ef\u90e8\u5206\u53ea\u4fdd\u755917\u03b2-\u916f\u3002<\/p>\n<\/p>\n
\u4ece\u836f\u6548\u7684\u89c2\u70b9\uff0c3\u4f4d\u621617\u03b2\u916f\u5316\u4ea7\u7269\u90fd\u9700\u8981\u5728\u4f53\u5185\u8f6c\u5316\u6210estradiol\u540e\u624d\u80fd\u53d1\u751f\u4f5c\u7528\uff0c\u56e0\u800c\u9009\u62e93\u4f4d\u621617\u03b2\u4f4d\u916f\u7684\u4f9d\u636e\u53ef\u80fd\u4e3b\u8981\u662f\u8003\u8651\u5408\u6210\u4e0a\u7684\u65b9\u4fbf\u3002 \u5408\u6210\u8def\u7ebf\uff1aestradiol\u53ef\u7528\u5168\u5408\u6210\u6cd5\u5236\u5907\uff1a\u75316-\u7532\u6c27\u8418\u6ee1\u916e\u4e0e2-\u7532\u57fa\u620a\u4e8c\u916e-1\uff0c3\u52a0\u6210\uff0c\u73af\u5408\u53ca\u6c22\u5316\u540e\u5f97\u5230estrone\uff0c\u518d\u7528\u787c\u6c22\u5316\u94be\u8fd8\u539f\u540e\u5f97\u672c\u54c1\u3002<\/p>\n<\/p>\n
\u7ed3\u5408\u96cc\u6fc0\u7d20\uff1a\u7ed3\u5408\u96cc\u6fc0\u7d20\uff08conjugated estrogens\uff0c\u5546\u54c1\u540dpremarin\uff09\u662f\u76ee\u524d\u4f7f\u7528\u8f83\u591a\u5f97\u96cc\u6fc0\u7d20\uff0c\u5b83\u662f\u4ee5\u96cc\u916e\u786b\u9178\u5355\u94a0\u76d0\u3001\u9a6c\u70ef\u96cc\u916e\u786b\u9178\u5355\u94a0\u76d0\u4e3a\u4e3b\u8981\u6210\u5206\uff08\u5206\u522b\u536050%~63%\u53ca22.5%~32.5%\uff09\uff0c\u5c1a\u5b58\u5728\u5c11\u91cf17\u03b1-\u96cc\u4e8c\u9187\u3001\u9a6c\u8418\u96cc\u916e\u3001\u9a6c\u8418\u96cc\u915a\u53ca\u5b83\u4eec\u7684\u786b\u9178\u916f\u5355\u94a0\u76d0\uff0c\u5176\u4ed6\u6240\u542b\u5c11\u91cf\u6210\u5206\u662f\u56e0\u4e3a\u5929\u7136\u6765\u6e90\u96be\u4ee5\u5206\u79bb\u800c\u5939\u6742\uff0c\u6216\u5728\u836f\u6548\u5b66\u4e0a\u8d77\u534f\u540c\u4f5c\u7528\u6216\u751a\u81f3\u662f\u56e0\u5546\u54c1\u5316\u7684\u9700\u8981\u800c\u6709\u610f\u4fdd\u7559\uff0c\u539f\u56e0\u4e0d\u5f97\u800c\u77e5\u3002\u5b83\u662f\u4e00\u79cd\u53e3\u670d\u96cc\u6fc0\u7d20\u836f\u7269\u3002\u8be5\u4ea7\u54c1\u662f\u4ece\u5b55\u6bcd\u9a6c\u5c3f\u4e2d\u63d0\u53d6\u5236\u5f97\uff0c\u300a\u7f8e\u56fd\u836f\u5178\u300b\u4e2d\u6536\u8f7d\u8be5\u4ea7\u54c1\u9664\u5929\u7136\u7269\u5916\u5c1a\u6709\u5176\u5408\u6210\u4ee3\u7528\u54c1\u3002 estradiol\u53ca\u9a6c\u70ef\u96cc\u916e\u5747\u662f\u5f31\u96cc\u6fc0\u7d20\u7269\u8d28\uff0c\u4f5c\u4e3a\u6fc0\u7d20\u66ff\u8865\u6cbb\u7597\u7528\u836f\u662f\u6bd4\u8f83\u7406\u60f3\u7684\u3002\u5b83\u4eec\u8fdb\u5165\u4f53\u5185\u7ecf\u786b\u9178\u916f\u5316\u6210\u94a0\u76d0\u540e\u6210\u4e3a\u6c34\u6eb6\u6027\u7269\u8d28\u800c\u4ece\u5c3f\u4e2d\u6392\u6cc4\u3002\u56e0\u800c\uff0c\u672c\u4ea7\u54c1\u5b9e\u9645\u4e0a\u662f\u4e00\u7c7b\u4ee3\u8c22\u4ea7\u7269\uff0c\u662f\u7528\u4ee3\u8c22\u4ea7\u7269\u4f5c\u4e3a\u836f\u7269\u4f7f\u7528\u7684\u4e00\u79cd\u5178\u578b\u5b9e\u4f8b\u3002 \u7ed3\u5408\u96cc\u6fc0\u7d20\u5728\u80c3\u80a0\u9053\u5438\u6536\u8fdb\u5165\u4f53\u5185\u540e\u518d\u91ca\u653e\u51faestrone\u53ca\u9a6c\u70ef\u96cc\u916e\u800c\u53d1\u6325\u4f5c\u7528\uff0c\u56e0\u800c\u5728\u4f53\u5185\u662f\u4e00\u5e73\u8861\u53cd\u5e94\u3002<\/p>\n
\u4e8c\u3001\u975e\u753e\u4f53\u96cc\u6fc0\u7d20\u53ca\u9009\u62e9\u6027\u96cc\u6fc0\u7d20\u53d7\u4f53\u8c03\u8282\u5242 \u975e\u753e\u4f53\u96cc\u6fc0\u7d20\u4e3b\u8981\u662f\u4e8c\u82ef\u4e59\u70ef\u7c7b\u5316\u5408\u7269\uff0c\u9009\u62e9\u6027\u96cc\u6fc0\u7d20\u53d7\u4f53\u8c03\u8282\u5242\u4e3b\u8981\u662f\u4e09\u82ef\u4e59\u70ef\u7c7b\u5316\u5408\u7269\u3002 \u5df1\u70ef\u96cc\u915a\u3000diethylstilbestrol<\/p>\n<\/p>\n
\u5316\u5b66\u540d\uff1a(E)-4,4\u2032-(1,2-\u4e8c\u4e59\u57fa-1,2-\u4e9a\u4e59\u70ef\u57fa)\u53cc\u82ef\u915a(4,4\u2032[(1E)-1,2-diethyl-1,2-ethenediyl]bisphenol)\u3002 diethylstilbestrol\u53ef\u4ee5\u5f88\u5feb\u4ece\u80c3\u80a0\u9053\u5438\u6536\uff0c\u5728\u809d\u4e2d\u5931\u6d3b\u5f88\u6162\uff0c\u53e3\u670d\u6709\u6548\uff0c\u591a\u5236\u6210\u53e3\u670d\u7247\u5242\u5e94\u7528\uff0c\u4e5f\u6709\u5c06\u5b83\u6eb6\u5728\u690d\u7269\u6cb9\u4e2d\u5236\u6210\u6cb9\u9488\u5242\u3002 \u53cd\u5f0f\u5df1\u70ef\u96cc\u915a\u6709\u6548\uff0c\u987a\u5f0f\u65e0\u6548\uff0c\u5206\u5b50\u4e2d\u4e24\u4e2a\u82ef\u73af\u53d6\u4ee3\u76f8\u5bf9\u5bf9\u79f0\uff0c\u542b\u6709\u4e24\u4e2a\u915a\u7f9f\u57fa\uff0c\u56e0\u800c\u4e0eFeCl3\u80fd\u5448\u8272\u53cd\u5e94\u3002 diethylstilbestrol\u7684\u4e24\u4e2a\u915a\u7f9f\u57fa\u662f\u6d3b\u6027\u5b98\u80fd\u57fa\uff0c\u7528\u4e8e\u5236\u5907\u5404\u79cd\u884d\u751f\u7269\u3002\u76ee\u524d\u4f5c\u4e3a\u5546\u54c1\u7684\u6700\u5e38\u7528\u7684\u884d\u751f\u7269\u662f\u5df1\u70ef\u96cc\u915a\u4e19\u9178\u916f\uff08diethylstilbestrol dipropionate\uff09\u53ca\u5df1\u70ef\u96cc\u915a\u78f7\u9178\u916f\uff08diethylstilbestrol diphosphate\uff09\u548c\u5b83\u7684\u94a0\u76d0\u3002\u524d\u8005\u4f5c\u4e3a\u957f\u6548\u6cb9\u5242\u4f7f\u7528\u3002\u540e\u8005\u4e3b\u8981\u7528\u4e8e\u524d\u5217\u817a\u764c\uff0c\u8003\u8651\u5230\u764c\u7ec6\u80de\u6709\u8f83\u9ad8\u7684\u78f7\u9178\u916f\u9176\u7684\u6d3b\u6027\uff0c\u836f\u7269\u8fdb\u5165\u4f53\u5185\u540e\u5728\u764c\u7ec6\u80de\u4e2d\u66f4\u6613\u88ab\u6c34\u89e3\u91ca\u653e\u51fa\u66f4\u591a\u7684diethylstilbestrol\uff0c\u63d0\u9ad8\u836f\u7269\u7684\u9009\u62e9\u6027\u3002\u94a0\u76d0\u53ef\u5236\u6210\u9759\u8109\u6ce8\u5c04\u5242\u3002<\/p>\n
\u67b8\u6a7c\u9178\u4ed6\u83ab\u6614\u82ac tamoxifen Citrate<\/p>\n<\/p>\n
\u5316\u5b66\u540d\uff1a(Z)-N,N-\u4e8c\u7532\u57fa-2-[4-(1,2-\u4e8c\u82ef\u57fa-1-\u4e01\u70ef\u57fa)\u82ef\u6c27\u57fa]-\u4e59\u80fa\u7684\u67b8\u6a7c\u9178\u76d0((Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxyl]-N,N-dimethyl ethanamine citrate)\u3002 tamoxifen\u4e3a\u4e09\u82ef\u4e59\u70ef\u7c7b\u5316\u5408\u7269\uff0c\u4ee5\u5df1\u70ef\u96cc\u915a\u7c7b\u96cc\u6fc0\u7d20\u4e3a\u5148\u5bfc\u7269\u53d1\u5c55\u51fa\u6765\u7684\u6297\u96cc\u6fc0\u7d20\u836f\u7269\u3002\u5206\u5b50\u4e2d\u5177\u6709\u4e8c\u82ef\u4e59\u70ef\u7684\u57fa\u672c\u7ed3\u6784\uff0c\u5176\u4e2d\u53cc\u952e\u4e00\u7aef\u78b3\u4e0a\u589e\u52a0\u4e8c\u7532\u6c28\u57fa\u4e59\u6c27\u82ef\u57fa\uff0c\u6b64\u53d6\u4ee3\u57fa\u662f\u5f88\u591a\u836f\u7269\u4e2d\u7684\u7ed3\u6784\u5355\u5143\u3002\u6309\u51e0\u4f55\u5f02\u6784\u5316\u5b66\u547d\u540d\u539f\u5219\uff0c\u7531\u4e8eC-1\u4e0a\u53d6\u4ee3\u82ef\u57fa\u7acb\u4f53\u6392\u5217\u987a\u5e8f\u5927\u4e8e\u82ef\uff0c\u800c\u5728C-2\u4e2d\u82ef\u57fa\u7684\u5e8f\u6570\u53c8\u5927\u4e8e\u4e59\u57fa\uff0c\u6545\u836f\u7528\u54c1\u4e3a\u987a\u5f0f\u51e0\u4f55\u5f02\u6784\u4f53\uff0c\u53cd\u5f0f\u5f02\u6784\u4f53\u7684\u6d3b\u6027\u5c0f\u4e8e\u987a\u5f0f\u3002 tamoxifen\u7531\u4e8e\u809d\u80a0\u5faa\u73af\u4ee5\u53ca\u548c\u6e05\u86cb\u767d\u9ad8\u5ea6\u7684\u7ed3\u5408\u529b\uff0c\u4f7f\u5f97\u534a\u8870\u671f\u957f\u8fbe7d\u5de6\u53f3\u3002 \u53e3\u670dtamoxifen\u540e\uff0c\u80fd\u5f88\u597d\u7684\u5438\u6536\uff0c\u5728\u4f53\u5185\u88ab\u5e7f\u6cdb\u4ee3\u8c22\u3002\u4ee3\u8c22\u7269\u4e3b\u8981\u5728\u80c6\u6c41\u4e2d\u4ee5\u7ed3\u5408\u7269\u5f62\u5f0f\u6392\u6cc4\uff0c\u53ea\u6709\u6781\u5c11\u91cf\u6216\u6ca1\u6709\u672a\u88ab\u4ee3\u8c22\u7684tamoxifen\u88ab\u6392\u51fa\u4f53\u5916\u3002<\/p>\n
\u4e09\u3001\u96c4\u6027\u6fc0\u7d20\u548c\u86cb\u767d\u540c\u5316\u6fc0\u7d20 \u96c4\u6027\u6fc0\u7d20\u80fd\u4fc3\u8fdb\u7537\u6027\u6027\u5668\u5b98\u53ca\u526f\u6027\u5f81\u7684\u53d1\u80b2\u3001\u6210\u719f\uff0c\u5bf9\u6297\u96cc\u6fc0\u7d20\u6291\u5236\uff0c\u6291\u5236\u5b50\u5bab\u5185\u819c\u751f\u957f\u53ca\u5375\u5de2\u3001\u5782\u4f53\u529f\u80fd\u3002\u540c\u65f6\uff0c\u8fd8\u5177\u6709\u86cb\u767d\u540c\u5316\u4f5c\u7528\uff0c\u5373\u4fc3\u8fdb\u86cb\u767d\u8d28\u5408\u6210\u548c\u9aa8\u8d28\u5f62\u6210\uff0c\u523a\u6fc0\u9aa8\u9ad3\u9020\u8840\u529f\u80fd\uff0c\u4ee5\u53ca\u86cb\u767d\u8d28\u4ee3\u8c22\uff0c\u4ece\u800c\u4f7f\u808c\u8089\u589e\u957f\uff0c\u4f53\u91cd\u589e\u52a0\u3002\u5bf9\u96c4\u6027\u6fc0\u7d20\u7684\u5316\u5b66\u7ed3\u6784\u4fee\u9970\u7684\u7ed3\u679c\u5bfc\u81f4\u5f97\u5230\u4e00\u4e9b\u96c4\u6027\u6d3b\u6027\u5f88\u5fae\u5f31\uff0c\u800c\u86cb\u767d\u540c\u5316\u6d3b\u6027\u589e\u5f3a\u7684\u65b0\u5316\u5408\u7269\u3002\u5b83\u4eec\u5e38\u88ab\u79f0\u4f5c\u86cb\u767d\u540c\u5316\u6fc0\u7d20\uff0c\u5bf9\u96c4\u6027\u6fc0\u7d20\u7684\u5316\u5b66\u7ed3\u6784\u4fee\u9970\u7684\u4e3b\u8981\u76ee\u7684\u5c31\u662f\u4e3a\u4e86\u83b7\u5f97\u86cb\u767d\u540c\u5316\u6fc0\u7d20\u3002\u96c4\u6027\u6d3b\u6027\u7684\u7ed3\u6784\u4e13\u4e00\u6027\u5f88\u5f3a\uff0c\u5bf9testosterone\u7684\u7ed3\u6784\u7a0d\u52a0\u53d8\u52a8\uff08\u598219\u53bb\u7532\u57fa\u3001A\u73af\u53d6\u4ee3\u3001A\u73af\u9a88\u73af\u7b49\u4fee\u9970\uff09\u5c31\u53ef\u4f7f\u96c4\u6027\u6d3b\u6027\u964d\u4f4e\u53ca\u86cb\u767d\u540c\u5316\u6d3b\u6027\u589e\u52a0\u3002\u4f46\u8981\u505a\u5230\u5b8c\u5168\u6ca1\u6709\u96c4\u6027\u6d3b\u6027\u662f\u5341\u5206\u56f0\u96be\u7684\uff0c\u56e0\u6b64\uff0c\u96c4\u6027\u6d3b\u6027\u4ecd\u662f\u86cb\u767d\u540c\u5316\u6fc0\u7d20\u7684\u4e3b\u8981\u526f\u4f5c\u7528\u3002 \u4ee3\u8868\u836f\u7269 \u4e19\u9178\u777e\u916e testosterone propionate<\/p>\n<\/p>\n
\u5316\u5b66\u540d\uff1a17\u03b2-\u7f9f\u57fa\u96c4\u753e-4-\u70ef-3-\u916e\u4e19\u9178\u916f((17\u03b2)-17-hydroxyandrost-4-en-3-one propionate)\u3002\u53c8\u540d\u4e19\u9178\u777e\u4e38\u7d20\u3002 \u53d1\u73b0\u8fc7\u7a0b\uff1atestosterone\u662f\u5929\u7136\u96c4\u6027\u6fc0\u7d20\uff0c1935\u5e74\u4ece\u96c4\u4ed4\u725b\u777e\u4e38\u4e2d\u63d0\u53d6\u5236\u5f97\u7eaf\u54c1\u3002\u540e\u7ecf\u7ed3\u6784\u9610\u660e\u4e3a\u96c4\u753e\u70f7\u884d\u751f\u7269\u3002\u5728\u6bcd\u6838\u4e0a\u53d6\u4ee3\u6709-3-\u916e\u53ca17\u03b2-\u7f9f\u57fa\uff0c\u672c\u54c1\u662f\u5176\u4e19\u9178\u916f\u5316\u5408\u7269\u3002 \u7ed3\u6784\u6539\u9020\uff1a\u4f5c\u4e3a\u96c4\u6027\u6fc0\u7d20\u66ff\u8865\u6cbb\u7597\u836f\u7269\u7684\u5929\u7136testosterone\uff0c\u8fdb\u884c\u7ed3\u6784\u4fee\u9970\u7684\u76ee\u7684\u4e3b\u8981\u4e3a\u4e86\u4f7f\u7528\u65b9\u4fbf\u548c\u8fbe\u5230\u957f\u6548\u3002\u5982testosterone\u9664\u4e19\u9178\u916f\u4e4b\u5916\uff0c\u5c1a\u6709\u620a\u9178\u916f\u548c\u5341\u4e00\u70ef\u9178\u916f\u4f5c\u4e3a\u957f\u6548\u836f\u7269\uff0c\u53ef\u6bcf\u5468\u6216\u6bcf\u6708\u4f7f\u7528\u4e00\u6b21\u3002testosterone\u768417\u03b1-\u7532\u57fa\u884d\u751f\u7269\u53e3\u670d\u5438\u6536\u5f88\u5feb\uff0c\u751f\u7269\u5229\u7528\u5ea6\u597d\uff0c\u53c8\u4e0d\u6613\u5728\u809d\u5185\u88ab\u7834\u574f\u3002\u7532\u777e\u916e\uff08methyltestosterone\uff09\u73b0\u5df2\u4f5c\u4e3a\u5e38\u7528\u7684\u53e3\u670d\u96c4\u6fc0\u7d20\u7684\u4e3b\u8981\u836f\u7269\u3002\u5bf9\u809d\u7684\u6bd2\u6027\u662f\u5176\u4e3b\u8981\u7684\u526f\u4f5c\u7528\u3002<\/p>\n<\/p>\n
\u5408\u6210\u8def\u7ebf\uff1atestosterone propionate\u53camethyltestosterone\u90fd\u53ef\u4ee5\u7528\u53bb\u6c22\u8868\u96c4\u916e\u4e3a\u539f\u6599\u7ecfOppenauer\u6c27\u5316\u53caKBH4\u8fd8\u539f\uff0c\u5f97\u5230testosterone\u53ca\u53cc\u6c22\u777e\u916e\u7684\u6df7\u5408\u7269\uff0c\u5176\u4e2d\u53cc\u6c22\u777e\u916e\u7528MnO2\u6c27\u5316\u53ef\u8f6c\u5316\u6210testosterone\u3002\u518d\u7528\u76f8\u5e94\u7684\u9170\u9150\u6216\u9170\u6c2f\u916f\u5316\u5373\u53ef\u5f97\u5230\u777e\u916e\u916f\u3002\u82e5\u5c06\u918b\u9178\u53bb\u6c22\u8868\u96c4\u916e\u5148\u7528\u7898\u5316\u7532\u57fa\u9541Grigner\u53cd\u5e94\uff0c\u6c34\u89e3\u540e\u7ecfOppenauer\u6c27\u5316\u5219\u5f97methyltesterone\u3002<\/p>\n<\/p>\n
\u56db\u3001\u5b55\u6fc0\u7d20 \u9ec4\u4f53\u916e\uff08progesterone\uff09\u53ca17\u03b1-\u7f9f\u57fa\u9ec4\u4f53\u916e\uff0817\u03b1-hydroxyprogesterone\uff09\u662f\u5929\u7136\u6765\u6e90\u7684\u5b55\u6fc0\u7d20\u3002\u5b83\u4eec\u4e0e\u96cc\u6fc0\u7d20\u5171\u540c\u7ef4\u6301\u5973\u6027\u751f\u6b96\u5468\u671f\u53ca\u5973\u6027\u751f\u7406\u7279\u5f81\u3002\u76ee\u524d\u5b55\u6fc0\u7d20\u4e3b\u8981\u7528\u4e8e\u4fdd\u62a4\u598a\u5a20\uff0c\u5b83\u4e0e\u96cc\u6fc0\u7d20\u914d\u4f0d\u7528\u505a\u53e3\u670d\u907f\u5b55\u836f\uff0c\u4e5f\u7528\u5728\u96cc\u6fc0\u7d20\u66ff\u8865\u6cbb\u7597\u4e2d\uff0c\u4f5c\u4e3a\u62b5\u6d88\u526f\u4f5c\u7528\u7684\u7528\u836f\u3002 \u53d1\u73b0\u8fc7\u7a0b\uff1aprogesterone\u662f\u6700\u65e9\u53d1\u73b0\u7684\u5929\u7136\u5b55\u6fc0\u7d20\uff0c1934\u5e74\u9996\u5148\u4ece\u5b55\u5987\u5c3f\u4e2d\u5206\u79bb\u51fa\u6765\uff0c\u4e00\u5e74\u540e\u786e\u5b9a\u5176\u5316\u5b66\u7ed3\u6784\u662f-3-\u916e\u7684C-21-\u753e\u4f53\u3002\u4ece\u5316\u5b66\u7ed3\u6784\u6765\u770bprogesterone\u4e0etestosterone\u753e\u6838\u7684-3-\u916e\u662f\u5b8c\u5168\u4e00\u6837\uff0c\u4ec517\u03b2\u4f4d\u524d\u8005\u662f\u4e59\u9170\u57fa\u540e\u8005\u662f\u7f9f\u57fa\u3002 progesterone\u53e3\u670d\u65e0\u6548\uff0c\u5728\u5bfb\u627e\u53e3\u670d\u5b55\u6fc0\u7d20\u7684\u7814\u7a76\u4e2d\uff0c\u7b2c\u4e00\u4e2a\u6210\u4e3a\u53e3\u670d\u6709\u6548\u836f\u7269\u7684\u4e0d\u662fprogesterone\u884d\u751f\u7269\uff0c\u800c\u662ftestostrone\u884d\u751f\u7269\u2015\u7094\u5b55\u916e\uff08ethisterone\uff09\uff0c17\u03b1\u4f4d\u5f15\u5165\u4e59\u7094\u57fa\u540e\uff0c\u96c4\u6fc0\u7d20\u6d3b\u6027\u51cf\u5f31\u800c\u663e\u793a\u51fa\u5b55\u6fc0\u7d20\u6d3b\u6027\uff0c\u4e14\u53e3\u670d\u6709\u6548\u3002\u4e0d\u4e45\u4ee5\u540e\uff0c\u5728\u7814\u7a76\u76ae\u8d28\u6fc0\u7d20\u751f\u7269\u5408\u6210\u8fc7\u7a0b\u4e2d\uff0c\u53d1\u73b017\u03b1-hydroxyprogesterone\uff0c\u5b83\u65e0\u53e3\u670d\u6d3b\u6027\uff0c\u7ecf\u4e59\u9170\u5316\u540e\u53e3\u670d\u6d3b\u6027\u589e\u52a0\uff0c\u867d\u5176\u53e3\u670d\u6d3b\u6027\u4ec5\u6709\u7094\u8bfa\u916e\uff08norethisterone\uff09\u76841\/100\uff0c\u4f46\u4ece\u6b64\u5f00\u8f9f\u51fa\u4e00\u7c7b\u9ec4\u4f53\u916e\u7c7b\u53e3\u670d\u5b55\u6fc0\u7d20\u3002\u82e5\u7528\u5df1\u9178\u9150\u8fdb\u884c\u9170\u5316\u5f97\u5df1\u9178\u7f9f\u5b55\u916e\uff0817\u03b1-hydroxyprogesterone caproate\uff09\uff0c\u4e3a\u957f\u6548\u5b55\u6fc0\u7d20\uff0c\u5176\u6cb9\u5242\u6ce8\u5c04\u4e00\u6b21\u5ef6\u65481\u4e2a\u6708\u3002<\/p>\n<\/p>\n
\u4ee3\u8868\u836f\u7269 \u918b\u9178\u7532\u7f9f\u5b55\u916e\u3000medroxyprogesterone acetate<\/p>\n<\/p>\n
\u5316\u5b66\u540d\uff1a6\u03b1-\u7532\u57fa-17\u03b1-\u7f9f\u57fa\u5b55\u753e-4-\u70ef-3,20-\u4e8c\u916e\u918b\u9178\u916f\uff08(6\u03b1)-17-hydroxy-6-methylpregn-4-ene-3,20-dione acetate\uff09\u3002 \u53d1\u73b0\u8fc7\u7a0b\uff1a\u918b\u9178\u7532\u7f9f\u5b55\u916e\uff08medroxyprogesterone acetate\uff09\u662f17\u03b1\u4e59\u9170\u6c27\u57fa\u9ec4\u4f53\u916e\u76846\u03b1-\u7532\u57fa\u53d6\u4ee3\u7269\u3002\u5bf9\u9ec4\u4f53\u916e\u7684\u836f\u7269\u4ee3\u8c22\u7814\u7a76\u53d1\u73b0\uff0c\u5b55\u916e\u7c7b\u5316\u5408\u7269\u5931\u6d3b\u7684\u4e3b\u8981\u9014\u5f84\u662f6\u4f4d\u7f9f\u57fa\u5316\uff0c16\u4f4d\u548c17\u4f4d\u6c27\u5316\uff0c\u62163,20\u4e8c\u916e\u88ab\u8fd8\u539f\u6210\u4e8c\u9187\u3002 \u56e0\u800c\u7ed3\u6784\u4fee\u9970\u4e3b\u8981\u662f\u5728C6\u53caC16\u4f4d\u4e0a\u8fdb\u884c\uff0c\u5982\u7528\u70f7\u57fa\u3001\u5364\u7d20\u3001\u53cc\u952e\u7b49\u8fdb\u884c\u53d6\u4ee3\uff0c\u7ed3\u679c\u662f\u6ee1\u610f\u7684\u300217\u03b1-\u4e59\u9170\u6c27\u57fa\u9ec4\u4f53\u916e\u76846\u03b1-\u7532\u57fa\u884d\u751f\u7269\uff0c\u5373\u918b\u9178\u7532\u7f9f\u5b55\u916e\uff08medroxyprogesterone acetate\uff09\u53ca\u25b36-6-\u6c2f\u884d\u751f\u7269\uff0c\u5373\u918b\u9178\u7532\u5730\u5b55\u916e\uff08megestrol acetate\uff09\uff0c\u53ca\u25b36-6-\u6c2f\u884d\u751f\u7269\uff0c\u5373\u918b\u9178\u6c2f\u5730\u5b55\u916e\uff08chlormadinone acetate\uff09\u90fd\u662f\u5f3a\u6548\u53e3\u670d\u5b55\u6fc0\u7d20\uff0c\u5176\u6d3b\u6027\u5206\u522b\u662fnorethisterone\u768420\u300112\u53ca50\u500d\uff0c\u4e5f\u662f\u76ee\u524d\u5e38\u7528\u7684\u5b55\u6fc0\u7d20\u836f\u7269\u3002<\/p>\n<\/p>\n
\u6784\u6548\u5173\u7cfb\uff1a<\/p>\n<\/p>\n
\u4e94\u3001\u753e\u4f53\u907f\u5b55\u836f \u4ee3\u8868\u836f\u7269 \u5de6\u7094\u8bfa\u5b55\u916e levonorgestrel<\/p>\n<\/p>\n
\u5316\u5b66\u540d\uff1aD-(\uff0d)-17\u03b1-\u4e59\u7094\u57fa-17\u03b2-\u7f9f\u57fa-18-\u7532\u57fa\u96cc\u753e-4-\u70ef-3-\u916e\uff08(17\u03b1)-ethynyl-17(\u03b2)-hydroxy-18-methyl-estro-4-en-3-on\uff09\u3002 \u53d1\u73b0\u8fc7\u7a0b\uff1a\u5de6\u7094\u8bfa\u5b55\u916e\uff08levonorgestrel\uff09\u662f\u5728\u7094\u8bfa\u916e\uff08norethisterone\uff09\u7684\u57fa\u7840\u4e0a\u53d1\u5c55\u8d77\u6765\u7684\uff0cnorethisterone\u662f\u7b2c\u4e00\u4e2a\u4e0a\u5e02\u768419\u53bb\u7532\uff0819nor-\uff09\u578b\u753e\u4f53\u5b55\u6fc0\u7d20\uff0c\u524d\u9762\u5df2\u6709\u4ecb\u7ecdethisterone\u662f\u777e\u916e\u7684\u4e59\u7094\u5316\u7269\uff0c\u5177\u6709\u53e3\u670d\u5b55\u6fc0\u7d20\u6d3b\u6027\uff0c\u4f46\u5b83\u4eec\u4ecd\u4fdd\u7559\u6709testosterone\u76841\/10\u96c4\u6027\u6d3b\u6027\uff0c\u96be\u4ee5\u88ab\u5987\u5973\u63a5\u53d7\u3002\u7ecf\u8fc7\u8fdb\u4e00\u6b65\u7ed3\u6784\u4fee\u9970\uff0c\u5c06ethisterone\u768419\u4f4d\u7532\u57fa\u9664\u53bb\u540e\u5373norethisterone\uff0c\u53d1\u73b0\u5176\u5b55\u6fc0\u7d20\u6d3b\u6027\u589e\u5927\u4e865\u500d\u800c\u96c4\u6027\u6d3b\u6027\u53c8\u5c0f\u4e861\u500d\uff0c\u53ef\u4e3a\u5987\u5973\u63a5\u53d7\u800c\u4e0a\u5e02\u3002 \u4e34\u5e8a\u7528\u9014\uff1alevonorgestrel\u7684\u4f5c\u7528\u53ca\u7528\u9014\u4e0enorethisterone\u4e00\u6837\uff0c\u80fd\u6291\u5236\u5782\u4f53\u91ca\u653eLH\u548cSH\uff0c\u6291\u5236\u6392\u5375\u4f5c\u7528\u5f3a\u4e8eprogesterone\uff0c\u4f46\u53e3\u670d\u540e\u5438\u6536\u5b8c\u5168\uff0c\u751f\u7269\u5229\u7528\u5ea6\u6781\u597d\uff0887%~99%\uff09\uff0c\u6bd4norethisterone\uff0870%\uff09\u5927\u3002\u5176\u5b55\u6fc0\u7d20\u6d3b\u6027\u4ea6\u6bd4norethisterone\u5f3a\uff0c\u800c\u6297\u96cc\u6fc0\u7d20\u6d3b\u6027\u4ea6\u589e\u52a0\uff0c\u4e5f\u6709\u4e00\u5b9a\u7684\u96c4\u6fc0\u7d20\u53ca\u540c\u5316\u6fc0\u7d20\u5316\u4f5c\u7528\u3002\u56e0\u800c\u672c\u54c1\u7684\u836f\u6548\u3001\u836f\u4ee3\u603b\u4f53\u8bc4\u4ef7\u6bd4norethisterone\u6709\u66f4\u591a\u4f18\u70b9\u53ca\u66f4\u5c0f\u7684\u526f\u4f5c\u7528\uff0c\u5728\u4e16\u754c\u4e0a\u8f83\u5e7f\u6cdb\u7684\u4f7f\u7528\u3002 \u516d\u3001\u5b55\u6fc0\u7d20\u62ee\u6297\u5242 \u5b55\u6fc0\u7d20\u62ee\u6297\u5242\u7684\u5b9a\u4e49\uff1a\u5b55\u6fc0\u7d20\u62ee\u6297\u5242\u6307\u4e0e\u5b55\u6fc0\u7d20\u7ade\u4e89\u53d7\u4f53\u5e76\u62ee\u6297\u5176\u6d3b\u6027\u7684\u5316\u5408\u7269\uff0c\u4e5f\u79f0\u6297\u5b55\u6fc0\u7d20\uff08antiprogestins\uff09\u3002 \u53d1\u73b0\u8fc7\u7a0b\uff1a\u572820\u4e16\u7eaa80\u5e74\u4ee3\u4e4b\u524d\u6297\u5b55\u6fc0\u7d20\u5c1a\u672a\u6210\u4e3a\u836f\u7269\uff0c\u5c3d\u7ba1\u5bf9\u6297\u5b55\u6fc0\u7d20\u7684\u6d3b\u6027\u53ca\u6784\u6548\u5173\u7cfb\u6709\u8bb8\u591a\u7814\u7a76\uff0c\u7ec8\u56e0\u6ca1\u6709\u627e\u5230\u6070\u5f53\u7684\u9002\u5e94\u8bc1\uff0c\u7814\u7a76\u5de5\u4f5c\u505c\u6ede\u4e0d\u524d\u30021982\u5e74\u6cd5\u56fdRoussel-Uclaf\u516c\u53f8\u63a8\u51fa\u7c73\u975e\u53f8\u916e\uff08mifepristone\uff09\u4f5c\u4e3a\u6297\u65e9\u5b55\u836f\u7269\uff0c\u4e0d\u4f46\u4fc3\u8fdb\u4e86\u6297\u5b55\u6fc0\u7d20\u53ca\u6297\u76ae\u8d28\u6fc0\u7d20\u836f\u7684\u53d1\u5c55\uff0c\u800c\u4e14\u5728\u753e\u4f53\u836f\u7269\u7814\u7a76\u5386\u53f2\u4e0a\u8d77\u7740\u91cc\u7a0b\u7891\u7684\u4f5c\u7528\u3002\u5b83\u4f7f\u5f97\u5df2\u7ecf\u53d8\u5f97\u4e0d\u751a\u6d3b\u8dc3\u7684\u753e\u4f53\u836f\u7269\u7814\u7a76\u9886\u57df\u91cd\u65b0\u71c3\u8d77\u4e86\u65b0\u7684\u671f\u671b\u3002 \u6297\u5b55\u6fc0\u7d20\u4f5c\u7528\u7684\u9776\u90e8\u4f4d\u662f\u5b55\u6fc0\u7d20\u53d7\u4f53\u3002\u76ee\u524d\u4e3b\u8981\u7528\u4e8e\u6297\u65e9\u5b55\uff0c\u4e5f\u6709\u4e9b\u6297\u5b55\u6fc0\u7d20\u836f\u7269\u7528\u4e8e\u4e73\u817a\u764c\u7684\u6cbb\u7597\u3002<\/p>\n
\u7c73\u975e\u53f8\u916e\u3000mifepristone<\/p>\n<\/p>\n
\u5316\u5b66\u540d\uff1a11\u03b2-(4-\u4e8c\u7532\u6c28\u57fa)-17\u03b2-\u7f9f\u57fa-17-(1-\u4e19\u7094\u57fa)-\u96cc\u753e-4,9-\u4e8c\u70ef-3-\u916e((11\u03b2,)-[4-(dimethylamino)phenyl]-17\u03b2-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one)\u3002 \u53d1\u73b0\u8fc7\u7a0b\uff1amifepristone\u7684\u53d1\u660e\u4e0e\u6297\u96cc\u6fc0\u7d20\u836f\u7269\u7684\u53d1\u73b0\u662f\u6709\u8054\u7cfb\u7684\uff0ctamoxifen\u53ca\u5176\u4ed6\u7684\u6297\u96cc\u6fc0\u7d20\u5316\u5408\u7269\u5177\u6709\u4e09\u82ef\u57fa\u4e59\u70ef\u57fa\u7684\u7ed3\u6784\uff0c\u5176\u7ed3\u6784\u4e2d\u7684\u53cc\u952e\u4e0d\u540c\u78b3\u4e0a\u8fde\u63a5\u7684\u4e24\u4e2a\u82ef\u73af\uff0c\u76f8\u5f53\u4e8e\u753e\u4f53\u6fc0\u7d20\u5206\u5b50\u4e2d\u7684A\u73af\u548cD\u73af\uff0c\u886811-7\u4e2d\u7684\u975e\u753e\u4f53\u96cc\u6fc0\u7d20diethylstibestrol\u6240\u793a\u3002tamoxifen\u5206\u5b50\u4e2d\u7684\u7b2c\u4e09\u4e2a\u82ef\u73af\u6240\u5904\u4f4d\u7f6e\uff0c\u76f8\u5f53\u4e8e\u753e\u4f53\u6bcd\u6838\u4e2d\u7684\u03b2\u4fa7\u7684C-11\u4f4d\uff0c\u8fd9\u79cd\u7ed3\u6784\u7279\u70b9\u5bf9\u6297\u6fc0\u7d20\u4f5c\u7528\u6781\u4e3a\u91cd\u8981\u3002<\/p>\n
\u4e03\u3001\u80be\u4e0a\u817a\u76ae\u8d28\u6fc0\u7d20 \u5206\u7c7b\uff1a\u80be\u4e0a\u817a\u76ae\u8d28\u6fc0\u7d20\u6309\u5176\u751f\u7406\u4f5c\u7528\u7279\u70b9\u53ef\u5206\u4e3a\u76d0\u76ae\u8d28\u6fc0\u7d20\uff08mineralcorticoids\uff09\u53ca\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff08glucocorticoids\uff09\u3002 \u4ee3\u8868\u836f\u7269 \u6c22\u5316\u53ef\u7684\u677e hydrocortisone<\/p>\n<\/p>\n
\u5316\u5b66\u540d\uff1a11\u03b2,17\u03b1,21-\u4e09\u7f9f\u57fa\u5b55\u753e-4-\u70ef-3,20-\u4e8c\u916e\uff0811\u03b2,17\u03b1,21-trihydroxy-pregn-4-ene-3,20-dione\uff09\u3002 \u6784\u6548\u5173\u7cfb\uff1a 1\uff0eC-21\u4f4d\u7684\u4fee\u9970\u3000hydrocortisone\u5206\u5b50\u4e2d\u7684\u4e09\u4e2a\u7f9f\u57fa\uff0c\u7528\u5e38\u89c4\u65b9\u6cd5\u8fdb\u884c\u916f\u5316\u65f6\uff0c\u5982\u4e0e\u9178\u9150\u6216\u9170\u6c2f\u53cd\u5e94\u65f6\uff0c\u53ea\u6709C-21\u7f9f\u57fa\u80fd\u88ab\u916f\u5316\uff0cC-11\u7f9f\u57fa\u56e2\uff0cC-13\u53caC-18\u89d2\u7532\u57fa\u7684\u4f4d\u963b\uff0cC-17\u7f9f\u57fa\u56e0\u4fa7\u94fe\u7684\u4f4d\u963b\u5747\u4e0d\u80fd\u5f62\u6210\u916f\u3002<\/p>\n<\/p>\n
hydrocortisone\u4e0e\u918b\u9150\u53cd\u5e94\uff0c\u53ef\u5f97C-21\u4f4d\u7f9f\u57fa\u88ab\u916f\u5316\u7684\u524d\u4f53\u836f\u7269\u2014\u2014\u918b\u9178\u6c22\u5316\u53ef\u7684\u677e\uff08hydrocortisone acetate\uff09\uff0c\u5176\u4f5c\u7528\u65f6\u95f4\u5ef6\u957f\uff0c\u7a33\u5b9a\u6027\u589e\u52a0\u3002\u4e4b\u540e\u6709\u4e00\u7cfb\u5217\u916f\u7c7b\u884d\u751f\u7269\u95ee\u4e16\u3002\u5176\u4e2d\uff0c\u957f\u78b3\u94fe\u8102\u80aa\u9178\u916f\u53ca\u4e8c\u5143\u6709\u673a\u9178\u7684\u5355\u916f\u94a0\u53ca\u78f7\u9178\u916f\u76d0\uff0c\u5b83\u4eec\u5747\u4e3a\u524d\u836f\uff0c\u524d\u8005\u6c34\u6eb6\u6027\u5c0f\uff0c\u5e38\u4ee5\u53e3\u670d\u6216\u5c40\u90e8\u7ed9\u836f\uff0c\u53ef\u5ef6\u957f\u4f5c\u7528\u65f6\u95f4\uff0c\u540e\u8005\u53ef\u5236\u6210\u6c34\u6eb6\u6db2\u4f9b\u6ce8\u5c04\u7528\uff0c\u5982\u6c22\u5316\u53ef\u7684\u677e\u7425\u73c0\u9178\u94a0\u3001\u6c22\u5316\u53ef\u7684\u677e\u78f7\u9178\u916f\u94a0\u76d0\uff0c\u6c34\u6eb6\u6027\u5927\u3002C-21\u4f4d\u7684\u4fee\u9970\u4e0d\u6539\u53d8\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684\u6d3b\u6027\u3002 2\uff0eC-1\u4f4d\u7684\u4fee\u9970 \u4ee5hydrocortisone acetate\u4e3a\u5148\u5bfc\u5316\u5408\u7269\uff0c\u7ecfC1-2\u4f4d\u8131\u6c22\u5728A\u73af\u5f15\u5165\u53cc\u952e\u540e\u5f97\u5230\u918b\u9178\u6cfc\u5c3c\u677e\u9f99\uff08hydroprednisone acetate\uff09\uff0c\u5176\u6297\u708e\u6d3b\u6027\u6bd4\u5176\u5148\u5bfc\u7269\u59274\u500d\uff0c\u800c\u94a0\u6f74\u7559\u4f5c\u7528\u4e0d\u53d8\u3002\u5bf9\u8fd9\u79cd\u6d3b\u6027\u6539\u53d8\u7684\u89e3\u91ca\u662f\u8ba4\u4e3aA\u73af\u6784\u578b\u4ece\u534a\u6905\u5f0f\u53d8\u6210\u8239\u5f0f\uff0c\u80fd\u63d0\u9ad8\u4e0e\u53d7\u4f53\u7684\u4eb2\u548c\u529b\u3002 C-1\u4f4d\u7684\u4fee\u9970\u662f\u5bf9\u76ae\u8d28\u6fc0\u7d20\u753e\u73af\u6bcd\u6838\u7ed3\u6784\u6539\u53d8\u7684\u8d77\u70b9\uff0c\u4e4b\u540e\uff0c\u4e00\u4e9b\u5f3a\u6548\u76ae\u8d28\u6fc0\u7d20\u90fd\u91c7\u7528\u4e86\u8fd9\u4e00\u7ed3\u6784\u4fee\u9970\u624b\u6bb5\u3002<\/p>\n
\u918b\u9178\u5730\u585e\u7c73\u677e dexamethasone acetate<\/p>\n<\/p>\n
\u5316\u5b66\u540d\uff1a16\u03b1-\u7532\u57fa-11\u03b2,17\u03b1,21-\u4e09\u7f9f\u57fa-9\u03b1-\u6c1f\u5b55\u753e-1,4-\u4e8c\u70ef-3-20\u4e8c\u916e-21-\u918b\u9178\u916f((11\u03b2,16\u03b1)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione-21-acetate)\u3002 \u7ed3\u6784\u7279\u70b9\uff1adexamethasone acetate\u6709\u660e\u663e\u7684\u5316\u5b66\u7ed3\u6784\u7279\u70b9\uff0c\u5728\u5b55\u753e\u70f7\u7684\u6bcd\u6838\u4e0a\uff0c\u51e0\u4e4e\u5728\u53ef\u80fd\u88ab\u53d6\u4ee3\u7684\u4f4d\u7f6e\u4e0a\u90fd\u5f15\u5165\u4e86\u53d6\u4ee3\u57fa\u3002\u5982C-1\uff0c2\u53caC-4\uff0c5\u7684\u53cc\u952e\uff0cC-3\u7684\u916e\u57fa\uff0cC-9\u7684\u6c1f\u3001C-11\u03b2\u3001C-17\u03b1\u53caC-21\u7f9f\u57fa\u53d6\u4ee3\uff0c\u800c\u4e14C-16\u6709C-16\u03b1-\u7532\u57fa\u53d6\u4ee3\u3002\uff08C-16\u03b2-\u7532\u57fa\u53d6\u4ee3\u4e5f\u662f\u76ae\u8d28\u6fc0\u7d20\u836f\u7269\u2014\u2014\u500d\u4ed6\u7c73\u677e\uff09\u3002<\/p>\n<\/p>\n
\u6784\u6548\u5173\u7cfb\uff1a\u7cd6\u76ae\u8d28\u6fc0\u7d20\u662f\u5177\u6709\u4e0b\u9762\u57fa\u672c\u7ed3\u6784\u768421\u4e2a\u78b3\u753e\u4f53\u6fc0\u7d20\u3002\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684C-17\u4f4d\u6709\u4e00\u7f9f\u57fa\u6210\u916f\uff0cC-11\u4f4d\u6709\u4e00\u6c27\u539f\u5b50\u4ee5\u7f9f\u57fa\u6216\u7fb0\u57fa\u6c27\u7684\u5f62\u5f0f\u5b58\u5728\uff0cC-6\u3001C-9\u3001C-16\u4f4d\u53ef\u53d1\u751f\u53d6\u4ee3\u3002\u4fee\u9970\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684\u6bcd\u6838\u5c06\u5f71\u54cd\u836f\u7406\u6d3b\u6027\uff0c\u800c\u4e14\u591a\u4e2a\u90e8\u4f4d\u7684\u4fee\u9970\u6bd4\u5355\u4e2a\u90e8\u4f4d\u7684\u4fee\u9970\u66f4\u5177\u4f5c\u7528\u3002<\/p>\n<\/p>\n
1. C-9\u4f4d\u7684\u4fee\u9970 \u5bf9\u76ae\u8d28\u6fc0\u7d20\u7c7b\u836f\u7269C-9\u4f4d\u7ed3\u6784\u7684\u4fee\u9970\u662f\u63d0\u9ad8\u4f5c\u7528\u5f3a\u5ea6\u7684\u4e0d\u53ef\u7f3a\u4e4f\u7684\u624b\u6bb5\uff0c\u73b0\u5728\u5f3a\u6548\u76ae\u8d28\u6fc0\u7d20\u51e0\u4e4e\u90fd\u6709C-9F\u53d6\u4ee3\u3002 9\u03b1-\u6c1f\u4ee3\u6c22\u5316\u53ef\u7684\u677e\u662f\u6700\u65e9\u5f15\u4eba\u6ce8\u610f\u7684\u5408\u6210\u76ae\u8d28\u6fc0\u7d20\uff0c\u5b83\u7684\u53d1\u73b0\u662f\u5076\u7136\u7684\u3002\u5728\u6c22\u5316\u53ef\u7684\u677e\u7684\u5408\u6210\u8fc7\u7a0b\u4e2d\uff0c\u5f15\u516511-\u7f9f\u57fa\u65f6\uff0c\u540c\u65f6\u4ea7\u751f\u03b1\u548c\u03b2\u5f02\u6784\u4f53\uff0c\uff08\u73b0\u5728C-11\u7f9f\u57fa\u5df2\u7528\u5177\u6709\u7acb\u4f53\u9009\u62e9\u6027\u7684\u5fae\u751f\u7269\u6cd5\uff0c\u5f15\u5165\u7684\u90fd\u662f\u03b2\u7f9f\u57fa\uff09\uff0c\u4e3a\u4e86\u4f7f\u65e0\u6548\u7684\u03b1\u4f53\u8f6c\u4e3a\u6709\u6548\u7684\u03b2\u4f53\uff0c\u5f53\u65f6\u8bbe\u8ba1\u4e86\u51e0\u6b65\u8def\u7ebf\u3002\u4e2d\u95f4\u4f539-\u5364\u5316\u7269\u7ecf\u836f\u7406\u7b5b\u9009\u53d1\u73b0\uff0c\u5b83\u4eec\u7684\u836f\u7406\u6d3b\u6027\u6bd4\u6bcd\u4f53\u5316\u5408\u7269\u5927\u6709\u589e\u52a0\uff0c\u5176\u4e2d\u4ee59\u03b1-\u6c1f\u5316\u7269\u4f5c\u7528\u6700\u5f3a\uff0c\u6297\u708e\u6d3b\u6027\u548c\u7cd6\u539f\u6c89\u79ef\u6d3b\u6027\u6bd4\u6c22\u5316\u53ef\u7684\u677e\u592710\u500d\u3002\u53ef\u60dc\uff0c\u7531\u4e8e\u94a0\u6f74\u7559\u4f5c\u7528\u589e\u52a0\u66f4\u591a\uff0850\u500d\uff09\uff0c\u6700\u7ec8\u5b83\u672a\u80fd\u6210\u4e3a\u5185\u7528\u836f\u7269\uff0c\u53ea\u80fd\u4f5c\u4e3a\u5916\u7528\u76ae\u80a4\u75c5\u6cbb\u7597\u836f\uff0c\u7136\u800c\u5374\u9f13\u52b1\u4eba\u4eec\u53bb\u5bfb\u627e\u53ea\u589e\u52a0\u6297\u708e\u6d3b\u6027\u800c\u4e0d\u589e\u52a0\u94a0\u6f74\u7559\u4f5c\u7528\u7684\u65b0\u836f\u3002 2. C-16\u4f4d\u7684\u4fee\u9970 \u540e\u6765\u53d1\u73b0\u5728C-9\u5f15\u5165\u6c1f\u7684\u540c\u65f6\u518d\u5728C-16\u4e0a\u5f15\u5165\u57fa\u56e2\u53ef\u6d88\u9664\u94a0\u6f74\u7559\u7684\u4f5c\u7528\u3002\u5728\u60a3\u80be\u4e0a\u817a\u764c\u75c5\u4eba\u7684\u5c3f\u4e2d\u53d1\u73b0hydrocortisone\u768416\u03b1\u7f9f\u57fa\u4ee3\u8c22\u4ea7\u7269\uff0c\u5b83\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6d3b\u6027\u4f9d\u65e7\u4fdd\u7559\uff0c\u800c\u94a0\u6f74\u7559\u7684\u526f\u4f5c\u7528\u660e\u663e\u964d\u4f4e\u3002\u4ece\u4ee3\u8c22\u4ea7\u7269\u4e2d\u5bfb\u627e\u65b0\u7684\u836f\u7269\u662f\u4eba\u4eec\u4e00\u8d2f\u5e38\u7528\u7684\u624b\u6bb5\uff0c\u8fd9\u91cc\u4e5f\u4e0d\u4f8b\u5916\u3002\u56e0\u800c\u5728C-9\u6c1f\u753e\u4f53\u4e2d\u5bf9\u5f15\u5165\u7532\u57fa\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u53d1\u73b0C-16\u7532\u57fa\u7684\u5f15\u5165\u4f7f17\u03b1\u7f9f\u57fa\u53caC-20\u7fb0\u57fa\u5728\u8840\u6d46\u4e2d\u7684\u7a33\u5b9a\u6027\u589e\u52a0\uff0c\u5176\u6297\u708e\u6d3b\u6027\u6bd4hydrocortisone\u592720\u500d\u3001\u6297\u98ce\u6e7f\u6027\u592730\u500d\u3002 3. C-6\u4f4d\u7684\u4fee\u9970 \u5728C-6\u4f4d\u5f15\u5165\u6c1f\u539f\u5b50\u540e\u53ef\u963b\u6edeC-6\u6c27\u5316\u5931\u6d3b\uff0c\u5982\u918b\u9178\u6c1f\u8f7b\u677e\uff08fluocinonide acetate\uff09\uff0c\u5176\u6297\u708e\u53ca\u94a0\u6f74\u7559\u6d3b\u6027\u5747\u5927\u5e45\u589e\u52a0\uff0c\u800c\u540e\u8005\u589e\u52a0\u5f97\u66f4\u591a\uff0c\u56e0\u800c\u53ea\u80fd\u5916\u7528\uff0c\u6cbb\u7597\u76ae\u80a4\u8fc7\u654f\u75c7\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
\u7b2c\u4e09\u8282\u3000\u753e\u4f53\u6fc0\u7d20 \u753e\u4f53\u6fc0\u7d20\u7684\u5b9a\u4e49\uff1a\u753e\u4f53\u6fc0\u7d20 … \u7ee7\u7eed\u9605\u8bfb