\u592a\u957f\u4e0d\u770b\u7248<\/p>\n
\u76f4\u63a5\u62c9\u5230\u6587\u672b\u770b\u603b\u7ed3<\/p>\n
\u2193 \u2193 \u2193<\/p>\n
PDRN\uff0c\u5373\u201c\u591a\u805a\u8131\u6c27\u6838\u7cd6\u6838\u82f7\u9178\u201d\uff0c\u662f\u5176\u82f1\u6587\u5168\u79f0\u7684\u9996\u5b57\u6bcd\u7f29\u5199\uff1aPoly Deoxy Ribo Nucleotide<\/p>\n
PDRN\u662f\u4ece\u4e09\u6587\u9c7c\uff08\u53c8\u540d\u9c91\u9c7c\uff09\u7684\u751f\u6b96\u7ec6\u80de\u4e2d\u63d0\u53d6\u7684DNA\u7247\u6bb5\uff0c\u53c8\u540d\u201c\u5a74\u513f\u9488\u201d\u3002<\/p>\n
\u8be5\u6210\u5206\u4e0e\u4eba\u4f53\u7684DNA\u78b1\u57fa\u7ec4\u6210\u51e0\u4e4e\u662f\u4e00\u81f4\u7684\u3002<\/p>\n
\u7531\u4e8e\u6ca1\u6709\u514d\u75ab\u539f\u6027\uff0c\u7528\u4e8e\u4eba\u4f53\u65e0\u6bd2\u65e0\u526f\u4f5c\u7528\u3002<\/p>\n<\/p>\n
PDRN\u7684\u5546\u4e1a\u5316<\/p>\n
\u00b7 1952\u5e74 \u7531\u610f\u5927\u5229Mastelli \u516c\u53f8\u53d1\u73b0\u5e76\u8fdb\u884c\u7814\u7a76<\/p>\n
\u00b7 2008\u5e74\uff0c\u610f\u5927\u5229Mastelli \u516c\u53f8\u65d7\u4e0b\u54c1\u724cPlacentex \uff08\u5a74\u513f\u9488\uff09\u4e0a\u5e02<\/p>\n
\u00b7 2008\u5e74\uff0c\u97e9\u56fd\u6279\u51c6PDRN \u7528\u4e8e\u7ec4\u7ec7\u4fee\u590d\u548c\u76ae\u80a4\u79fb\u690d\u521b\u4f24\u7684\u6cbb\u7597<\/p>\n
\u00b7 \u65e9\u671f\u7528\u4e8e\u75be\u75c5\u9886\u57df\uff1a\u521b\u9762\u6108\u5408\u3001\u9aa8\u9abc\u8f6f\u7ec4\u7ec7\u518d\u751f<\/p>\n
\u00b7 \u8fd1\u5e74\u6765\uff0c PDRN\u7684\u5e94\u7528\u9886\u57df\u6269\u5c55\u81f3\u533b\u7f8e\u3001\u62a4\u80a4\u9886\u57df<\/p>\n<\/p>\n
PDRN\u7684\u4f5c\u7528\u673a\u5236<\/p>\n
1. \u6fc0\u6d3b\u817a\u82f7A2\u53d7\u4f53<\/p>\n
\u817a\u82f7\u6fc0\u6d3b\u56db\u79cd\u4e0d\u540c\u7684\u817a\u82f7\u53d7\u4f53\uff0c\u5206\u522b\u4e3aA1\u3001A2A\u3001A2B\u548cA3\u3002<\/p>\n
\u5176\u4e2d\uff0cA2A\u53d7\u4f53\u6fc0\u6d3b\u53ef\u4ee5\u8c03\u8282\u708e\u75c7\u53cd\u5e94\u548c\u7ec6\u80de\u51cb\u4ea1\u8fc7\u7a0b\uff0c\u5e76\u6539\u5584\u7ec4\u7ec7\u4fee\u590d\u548c\u6108\u5408\u3002<\/p>\n
A2A\u53d7\u4f53\u7684\u6fc0\u6d3b\u4f1a\u6291\u5236\u7531ROS\u6fc0\u6d3b\u7684NF-\u03baB\u548cMAPK\u4fe1\u53f7\u901a\u8def\uff0c\u8fdb\u800c\u6291\u5236\u591a\u79cd\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u91ca\u653e[1]\u3002<\/p>\n<\/p>\n
\u591a\u9879\u7814\u7a76\u8bc1\u5b9e\uff0c\u817a\u82f7A2A\u53d7\u4f53\u662fPDRN\u7684\u7279\u5f02\u6027\u9776\u6807\u3002<\/p>\n
\u817a\u82f7A2A\u53d7\u4f53\u6fc0\u6d3b\u540e\uff0c\u53ef\u901a\u8fc7\u51cf\u5c11\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u751f\u6210\uff08IL-6\u3001IL-1\u03b2\u3001TNF-\u03b1\u7b49\uff09\u548c\u4fc3\u8fdb\u6297\u708e\u7ec6\u80de\u56e0\u5b50\uff08IL-10\uff09\u7684\u8868\u8fbe\u53d1\u6325\u5f3a\u5927\u7684\u6297\u708e\u4f5c\u7528[2-4]\u3002<\/p>\n
\u5927\u91cf\u7814\u7a76\u8bc1\u5b9e\uff0cPDRN\u5177\u6709\u4f18\u5f02\u7684\u4fc3\u8fdb\u521b\u9762\u6108\u5408\u4f5c\u7528\u3002<\/p>\n
\u5176\u673a\u5236\u4e5f\u662f\u901a\u8fc7\u6fc0\u6d3b\u817a\u82f7A2A\u53d7\u4f53\uff0c\u5e76\u8fdb\u4e00\u6b65\u5206\u6cccEGF\uff08\u8868\u76ae\u751f\u957f\u56e0\u5b50\uff09\u3001FGF\uff08\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff09\u53caVEGF\uff08\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff09\u548c\u8840\u7ba1\u751f\u6210\u7d20[2-6]\u3002<\/p>\n
EGF\u3001FGF\u7b49\u751f\u957f\u56e0\u5b50\u4fc3\u8fdb\u76ae\u80a4\u7684\u518d\u4e0a\u76ae\u5316\u53ca\u8089\u82bd\u7ec4\u7ec7\u7684\u5f62\u6210\u3002<\/p>\n
VEGF\u548c\u8840\u7ba1\u751f\u6210\u7d20\u901a\u8fc7\u4fc3\u8fdb\u8840\u7ba1\u65b0\u751f\u800c\u6539\u5584\u5c40\u90e8\u7ec4\u7ec7\u8840\u6db2\u5faa\u73af\uff0c\u4ece\u800c\u52a0\u901f\u7ec4\u7ec7\u518d\u751f\u548c\u521b\u9762\u6108\u5408\u3002<\/p>\n<\/p>\n
PDRN\u7684\u4f5c\u7528\u673a\u5236<\/p>\n
\u56fe\u6e90\uff1a\u53c2\u8003\u6587\u732e2<\/p>\n
2\u3001\u8865\u6551\u9014\u5f84<\/p>\n
\u53d7\u635f\u6216\u7f3a\u6c27\u7ec4\u7ec7\u901a\u5e38\u65e0\u6cd5\u8fdb\u884c DNA\u201c\u4ece\u5934\u201d\u5408\u6210\u3002<\/p>\n
\u6b64\u65f6\uff0c\u201c\u8865\u6551\u9014\u5f84\u201d\u5f00\u59cb\u8fd0\u4f5c\u4ee5\u56de\u6536\u7531 DNA \u548c RNA \u5206\u89e3\u4ea7\u751f\u7684\u78b1\u57fa\u548c\u6838\u82f7\u3002\u7136\u540e\u53ef\u4ee5\u5c06\u56de\u6536\u7684\u78b1\u57fa\u8f6c\u5316\u4e3a\u6838\u82f7\u9178\u5e76\u91cd\u65b0\u6574\u5408\u5230 DNA \u4e2d\u3002<\/p>\n
PDRN\u901a\u8fc7\u8fd9\u6837\u7684\u8865\u6551\u9014\u5f84\uff0c\u52a0\u5feb\u53d7\u635f\u7ec6\u80de\u7684\u4fee\u590d[2]\u3002<\/p>\n
\u7814\u7a76\u663e\u793a\uff0cPDRN\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u7684DNA \u635f\u4f24\uff0c\u53ef\u80fd\u4e0e\u201c\u8865\u6551\u9014\u5f84\u201d\u7684\u542f\u52a8\u6709\u5173[2,7]\u3002<\/p>\n<\/p>\n
PDRN\u7684\u6297\u708e\u4f5c\u7528<\/p>\n
\u5982\u4e0a\u6240\u8ff0\uff0cPDRN\u5177\u6709\u5f3a\u5927\u7684\u6297\u708e\u4f5c\u7528\u3002<\/p>\n
\u76ee\u524d\uff0c\u533b\u5b66\u5404\u5b66\u79d1\uff0c\u5c06PDRN\u7528\u4e8e\u8f85\u52a9\u6cbb\u7597\u5404\u79cd\u708e\u75c7\u6027\u75be\u75c5\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\uff1a\u9aa8\u9abc\u3001\u808c\u8089\u708e\u75c7\u6027\u75be\u75c5\uff1b\u7259\u5468\u708e\uff1b\u53e3\u8154\u9ecf\u819c\u708e\uff1b\u80c3\u80a0\u708e\uff1b\u8180\u80f1\u708e\uff1b\u795e\u7ecf\u708e\u3002\u4ee5\u53ca\u201c\u708e\u75c7\u6027\u76ae\u80a4\u75c5\u201d\u3002<\/p>\n
\u76ee\u524d\u7814\u7a76\u5df2\u8bc1\u5b9e\uff0cPDRN\u53ef\u6cbb\u7597\u94f6\u5c51\u75c5\u3001\u786c\u5316\u840e\u7f29\u6027\u82d4\u85d3\u7684\u708e\u75c7\u6027\u76ae\u80a4\u75c5\u3002<\/p>\n
PDRN\u53ef\u4ee5\u89e3\u51b3\u54ea\u4e9b\u76ae\u80a4\u95ee\u9898\uff1f<\/p>\n
1.\u4fc3\u8fdb\u80f6\u539f\u5408\u6210\uff0c\u5bf9\u6297\u76ae\u80a4\u8001\u5316<\/p>\n
\u7814\u7a76\u663e\u793a\uff0cPDRN\u53ef\u4fc3\u8fdb\u80f6\u539f\u86cb\u767d\u5408\u6210\uff0c\u6291\u5236\u91d1\u5c5e\u86cb\u767d\u9176\u548c\u5f39\u6027\u86cb\u767d\u9176\uff0c\u53d1\u6325\u91cd\u5851\u7ec6\u80de\u5916\u57fa\u8d28\uff0c\u5bf9\u6297\u76ae\u80a4\u8001\u5316\u7684\u4f5c\u7528[8,9]\u3002<\/p>\n
\u6b64\u5916\uff0cPDRN\u8fd8\u6709\u6297\u6c27\u5316\u548c\u5149\u4fdd\u62a4\u4f5c\u7528 [7,8]\u3002<\/p>\n
\u7814\u7a76\u8868\u660e\uff0c\u76ae\u80a4\u8001\u5316\u7684\u53d1\u751f\u4e8e\u6c27\u5316\u5e94\u6fc0\u548c\u7d2b\u5916\u7ebf\u6162\u6027\u7167\u5c04\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n
PDRN\u53ef\u901a\u8fc7\u6297\u6c27\u5316\u548c\u5149\u4fdd\u62a4\u4f5c\u7528\u9884\u9632\u5149\u8001\u5316\u7684\u53d1\u751f\u3002<\/p>\n
\u4e34\u5e8a\u7814\u7a76\u8bc1\u5b9e\uff0cPDRN\u53ef\u6539\u5584\u76ae\u80a4\u5f39\u6027\u548c\u7c97\u7cd9\u5ea6\uff0c\u6709\u4fc3\u8fdb\u900f\u660e\u8d28\u9178\u5408\u6210\u7684\u4f5c\u7528[10]\u3002<\/p>\n
\u56fd\u5185\u7684\u7814\u7a76\u663e\u793a\uff0cPDRN\u53ef\u6709\u6548\u6539\u5584\u6bdb\u5b54\u7c97\u5927[11]\u3002<\/p>\n<\/p>\n
PDRN\u5bf9\u6297\u76ae\u80a4\u8001\u5316\u7684\u673a\u5236<\/p>\n<\/p>\n
PDRN\u4fc3\u8fdb\u80f6\u539f\u86cb\u767d\u5408\u6210\uff0c\u5448\u5242\u91cf\u4f9d\u8d56\u6027<\/p>\n
2.\u7f8e\u767d\u6de1\u6591<\/p>\n
\u591a\u9879\u7814\u7a76\u663e\u793a\uff0cPDRN \u53ef\u4f7f\u9ed1\u7d20\u7ec6\u80de\u9ed1\u8272\u7d20\u4ea7\u91cf\u51cf\u5c11\u3001\u6291\u5236\u916a\u6c28\u9178\u9176\u6d3b\u6027\u4ee5\u53ca MITF\uff08\u5c0f\u773c\u7578\u5f62\u76f8\u5173\u8f6c\u5f55\u56e0\u5b50\uff09 \u548c TRP-1 \uff08\u916a\u6c28\u9178\u9176\u76f8\u5173\u86cb\u767d-1\uff09\u8868\u8fbe[8,12]\u3002<\/p>\n
\u4e34\u5e8a\u6848\u4f8b\u663e\u793a\uff0cPDRN\u5bf9\u4e8e\u9ec4\u8910\u6591\u3001\u5149\u8001\u5316\u6591\u6709\u4e00\u5b9a\u7597\u6548[12]\u3002<\/p>\n<\/p>\n
3\u6b21PDRN\u76ae\u5185\u6ce8\u5c04\u540e\u8272\u6591\u7684\u6539\u5584<\/p>\n
a.\u9ec4\u8910\u6591 b.\u5149\u8001\u5316\u6591 c.\u8272\u7d20\u6c89\u7740<\/p>\n
\u56fe\u6e90\uff1a\u53c2\u8003\u6587\u732e12<\/p>\n<\/p>\n
PDRN\u7f8e\u767d\u6de1\u6591\uff0c\u6539\u5584\u76ae\u80a4\u5f39\u6027\u7684\u673a\u5236<\/p>\n
3\u3001\u5149\u7535\u672f\u540e\u4fee\u590d<\/p>\n
\u533b\u7f8e\u9879\u76ee\uff0c\u901a\u5e38\u53ef\u5206\u4e3a\u65e0\u521b\u6216\u6709\u521b\u3002<\/p>\n
CO2\u5265\u8131\u6027\u70b9\u9635\u6fc0\u5149\u662f\u6700\u5e38\u7528\u7684\u6709\u521b\u6027\u533b\u7f8e\u9879\u76ee\uff0c\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u7622\u75d5\uff0c\u5e76\u6709\u660e\u786e\u7684\u5ae9\u80a4\u4f5c\u7528\u3002<\/p>\n
\u70b9\u9635\u6fc0\u5149\u672f\u540e\u4f1a\u5f62\u6210\u521b\u9762\uff0c\u9700\u8981\u79ef\u6781\u5e72\u9884\u3002<\/p>\n
\u5f71\u54cd\u521b\u9762\u6108\u5408\u7684\u4e3b\u8981\u56e0\u7d20\uff0c\u5305\u62ec\u521b\u9762\u7684\u6df1\u5ea6\uff0c\u708e\u75c7\u8f7b\u91cd\uff0c\u662f\u5426\u6709\u7cd6\u5c3f\u75c5\u3001\u5c40\u90e8\u7f3a\u8840\u7b49\u4e0d\u5229\u56e0\u7d20\u3002<\/p>\n<\/p>\n
\u6709\u5b66\u8005\u4f7f\u7528\u5927\u9f20\u52a8\u7269\u6a21\u578b\uff0c\u53d1\u73b0PDRN\u5bf9\u4e8c\u6c27\u5316\u78b3\u5265\u8131\u6027\u70b9\u9635\u6fc0\u5149\u672f\u540e\u521b\u9762\u4fee\u590d\u5177\u6709\u660e\u786e\u7684\u4fc3\u8fdb\u4f5c\u7528\u3002<\/p>\n
PDRN\u6cbb\u7597\u7ec4\u7684\u4f24\u53e3\u6108\u5408\u660e\u663e\u6bd4\u5bf9\u7167\u7ec4\u5feb\u3002<\/p>\n
\u5728\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\u4e2d\uff0cPDRN\u7ec4\u8089\u82bd\u7ec4\u7ec7\u539a\u5ea6\u8bc4\u5206\u660e\u663e\u9ad8\u4e8e\u5bf9\u7167\u7ec4\u3002<\/p>\n
\u514d\u75ab\u7ec4\u5316\u67d3\u8272\u7ed3\u679c\u663e\u793a\u6cbb\u7597\u7ec4VEGF\u9633\u6027\u7ec6\u80de\u548cPECAM-1\/CD31\u9633\u6027\u5fae\u8840\u7ba1\u663e\u8457\u589e\u52a0\u3002<\/p>\n<\/p>\n
4\u3001\u9884\u9632\u7622\u75d5\u5f62\u6210<\/p>\n
2\u9879\u7814\u7a76\u663e\u793a\uff0c\u624b\u672f\u540e\u65e9\u671f\u7ed9\u4e88PDRN\uff0c\u53ef\u6709\u6548\u9884\u9632\u624b\u672f\u7622\u75d5\u7684\u5f62\u6210\u3002<\/p>\n
\u5176\u673a\u7406\uff0c\u6b63\u662f\u6297\u708e\uff0c\u53ca\u4fc3\u8fdb\u521b\u9762\u6108\u5408\u3002<\/p>\n<\/p>\n
5\u3001\u6539\u5584\u96c4\u6fc0\u7d20\u6027\u8131\u53d1<\/p>\n
\u7531\u4e8ePDRN\u5177\u6709\u6297\u708e\u53ca\u6539\u5584\u7ec4\u7ec7\u5fae\u5faa\u73af\u7684\u4f5c\u7528\uff0c\u7406\u8bba\u4e0a\u6709\u52a9\u4e8e\u6bdb\u53d1\u7684\u751f\u957f\u3002<\/p>\n
\u6709\u4e24\u7bc7\u7814\u7a76\uff0c\u5206\u522b\u91c7\u7528\u81ea\u4f53\u5bcc\u8840\u5c0f\u677f\u8840\u6d46(PRP)\u6216\u8054\u54081927nm\u70b9\u9635\u6fc0\u5149\u8054\u5408PDRN\u6cbb\u7597\u96c4\u6fc0\u7d20\u6027\u8131\u53d1\uff0c\u53d6\u5f97\u4e86\u4e0d\u9519\u7684\u7597\u6548[14,15]<\/sup>\u3002<\/p>\n \u4ece\u76ae\u80a4\u955c\u89c2\u5bdf\uff0cPDRN\u4e0d\u4f46\u4fc3\u8fdb\u4e86\u5934\u53d1\u7684\u589e\u591a\uff0c\u5934\u76ae\u7ea2\u6591\u7b49\u708e\u75c7\u53cd\u5e94\u5f97\u5230\u660e\u663e\u7684\u6539\u5584\u3002<\/p>\n<\/p>\n \u76ae\u80a4\u955c\u4e0b\uff0cPRP\u8054\u5408PDRN\u6cbb\u7597\u540e\uff0c\u5934\u53d1\u660e\u663e\u589e\u591a<\/p>\n \u56fe\u6e90\uff1a\u53c2\u8003\u6587\u732e15<\/p>\n<\/p>\n 1927nm\u70b9\u9635\u6fc0\u5149\u8054\u5408PDRN\u5bf9\u5934\u53d1\u7684\u6539\u5584\u60c5\u51b5<\/p>\n C,D\u76ae\u80a4\u955c\u663e\u793a\uff0c\u5934\u76ae\u708e\u75c7\u6d88\u9000\uff0c\u6bdb\u53d1\u589e\u591a\u3002<\/p>\n \u56fe\u6e90\uff1a\u53c2\u8003\u6587\u732e14<\/p>\n 6\u3001\u8f85\u52a9\u6cbb\u7597\u654f\u611f\u6027\u76ae\u80a4\u3001\u73ab\u7470\u75e4\u75ae<\/p>\n \u654f\u611f\u6027\u76ae\u80a4\u4e0e\u73ab\u7470\u75e4\u75ae\u7684\u76f8\u540c\u53d1\u75c5\u673a\u5236\u5305\u62ec\u76ae\u80a4\u5c4f\u969c\u53d7\u635f\u3001\u53ca\u795e\u7ecf\u6e90\u6027\u708e\u75c7\u3002<\/p>\n \u800cPDRN\u5177\u6709\u660e\u786e\u7684\u6297\u708e\u3001\u4fee\u590d\u4f5c\u7528\u3002\u7406\u8bba\u4e0a\u5bf9\u654f\u611f\u6027\u76ae\u80a4\u3001\u73ab\u7470\u75e4\u75ae\u6709\u6548\u3002<\/p>\n \u6211\u672c\u4eba\u5e94\u7528PDRN\u7f8e\u5851\u7597\u6cd5\u6cbb\u7597\u654f\u611f\u6027\u76ae\u80a4\u3001\u73ab\u7470\u75e4\u75ae\uff0c\u603b\u4f53\u6548\u679c\u4e0d\u9519\u3002<\/p>\n PDRN\u53ef\u5728\u4e0d\u8bf1\u53d1\u6216\u52a0\u91cd\u73ab\u7470\u75e4\u75ae\u76ae\u80a4\u514d\u75ab\u53cd\u5e94\u7684\u540c\u65f6\u8d77\u5230\u826f\u597d\u7684\u6cbb\u7597\u6548\u679c\uff0c\u63d0\u9ad8\u76ae\u80a4\u542b\u6c34\u91cf\uff0c\u964d\u4f4e\u4e86TWEL\uff0c\u589e\u5f3a\u4e86\u76ae\u80a4\u539a\u5ea6\uff0c\u6539\u5584\u4e86\u76ae\u80a4\u654f\u611f\u3002<\/p>\n<\/p>\n \u603b \u7ed3<\/p>\n 1\u3001\u57fa\u4e8ePDRN\u7684\u591a\u91cd\u6d3b\u6027\uff0c\u5176\u5728\u76ae\u80a4\u6297\u8001\u3001\u7f8e\u767d\u6de1\u6591\u3001\u5149\u7535\u672f\u540e\u4fee\u590d\u3001\u654f\u611f\u808c\u6297\u708e\u4fee\u590d\uff0c\u751f\u53d1\u7b49\u7f8e\u5bb9\u76ae\u80a4\u79d1\u5177\u6709\u826f\u597d\u7684\u5e94\u7528\u524d\u666f\u3002<\/p>\n PDRN\uff0c\u4e00\u79cd\u6210\u5206\uff0c\u591a\u79cd\u7f8e\u5bb9\u529f\u6548\uff0c\u7279\u522b\u9002\u5408\u6539\u5584\u9762\u90e8\u635f\u5bb9\u6027\u76ae\u80a4\u95ee\u9898\uff01<\/p>\n 2\u3001\u5728\u56fd\u5185\uff0cPDRN\u4e3b\u8981\u4ee5\u7f8e\u5851\u7597\u6cd5\u4f7f\u7528\u3002\u5728\u56fd\u5916\uff0c\u4e5f\u914d\u5236\u6210\u5916\u7528\u836f\u818f\u6216\u4ee5PDRN\u4e3a\u4e3b\u8981\u6210\u5206\u7684\u529f\u6548\u6027\u62a4\u80a4\u54c1\u4f7f\u7528\u3002\u5916\u7528\u4ea7\u54c1\u66f4\u9002\u5408\u5bb6\u5c45\u4f7f\u7528\u3002<\/p>\n \u56fd\u5185\u5e94\u52a0\u5f3a\u7814\u53d1\uff0c\u63a8\u8fdbPDRN\u5916\u7528\u4ea7\u54c1\u7684\u4e0a\u5e02\u53ca\u5e94\u7528\u3002<\/p>\n \u53c2\u8003\u6587\u732e\uff1a<\/p>\n [1] Varano F, Catarzi D, Vigiani E, et al. Adenosine Receptor Ligands as Potential Therapeutic Agents for Impaired Wound Healing and Fibrosis[M]. 2022. In: Topics in Medicinal Chemistry. Springer, Berlin, Heidelberg. <\/p>\n [2] Squadrito F, Bitto A, Irrera N, et al. Pharmacological activity and clinical use of PDRN[J]. Frontiers in pharmacology, 2017, 8: 224.<\/p>\n [3] Kim TH, Heo SY, Oh GW, et al. Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering[J]. Marine Drugs, 2021, 19(6): 296.<\/p>\n [4] Colangelo M T, Galli C, Guizzardi S. Polydeoxyribonucleotide Regulation of Inflammation[J]. Advances in Wound Care, 2020, 9(10): 576-589.<\/p>\n [5] Shin D Y, Park J U, Choi M H, et al. Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing[J]. Scientific Reports, 2020, 10(1): 1-14.<\/p>\n [6] Koo Y, Yun Y. Effects of polydeoxyribonucleotides (PDRN) on wound healing: Electric cell-substrate impedance sensing (ECIS)[J]. Materials Science and Engineering: C, 2016, 69: 554-560.<\/p>\n [7] Belletti S, Uggeri J, Gatti R, et al. Polydeoxyribonucleotide promotes cyclobutane pyrimidine dimer repair in UVB\u2010exposed dermal fibroblasts[J]. Photodermatology, photoimmunology & photomedicine, 2007, 23(6): 242-249.<\/p>\n [8] Kim Y J, Kim M J, Kweon D K, et al. Polydeoxyribonucleotide activates mitochondrial biogenesis but reduces MMP-1 activity and melanin biosynthesis in cultured skin cells[J]. Applied Biochemistry and Biotechnology, 2020, 191: 540-554.<\/p>\n [9] Hwang K H, Kim J H, Park E Y, et al. An effective range of polydeoxyribonucleotides is critical for wound healing quality[J]. Molecular Medicine Reports, 2018, 18(6): 5166-5172.<\/p>\n [10] Hsu T F, Wang M F, Sekido H, et al. Effect of DNA from salmon milt on human skin conditions[J]. International Journal of Cosmetic Science, 2010, 32(2): 165-165.<\/p>\n [11] \u59dc\u6d77\u71d5,\u738b\u9896,\u9648\u68a6\u5a07,\u7b49.\u591a\u805a\u8131\u6c27\u6838\u7cd6\u6838\u82f7\u9178\u5bf9\u9762\u90e8\u6bdb\u5b54\u7c97\u5927\u6539\u5584\u7684\u4e34\u5e8a\u89c2\u5bdf[J].\u4e2d\u56fd\u533b\u7597\u7f8e\u5bb9,2020,10(3):41-44. <\/p>\n [12] Noh, Tai Kyung, et al. ‘Novel anti-melanogenesis properties of polydeoxyribonucleotide, a popular wound healing booster.’ International Journal of Molecular Sciences 17.9 (2016): 1448.<\/p>\n [13] Yu, Mi, and Jun Young Lee. ‘Polydeoxyribonucleotide improves wound healing of fractional laser resurfacing in rat model.’ Journal of CosmetiC and laser therapy 19.1 (2017): 43-48.<\/p>\n [14] Cho, Sung Bin, et al. Therapeutic efficacy of 1,927-nm fractionated thulium laser energy and polydeoxyribonucleotide on pattern hair loss. Medical Lasers 5.1 (2016): 22-28.<\/p>\n [15] Lee, Si-Hyung, et al. Therapeutic efficacy of autologous platelet-rich plasma and polydeoxyribonucleotide on female pattern hair loss. Wound Repair and Regeneration 23.1 (2015): 30-36.<\/p>\n [16] Irrera N, Bitto A, Vaccaro M, et al. PDRN, a bioactive natural compound, ameliorates imiquimod-induced psoriasis through NF-\u03baB pathway inhibition and Wnt\/\u03b2-Catenin signaling modulation[J]. International Journal of Molecular Sciences, 2020, 21(4): 1215..<\/p>\n [17] Laino L, Suetti S, Sperduti I. Polydeoxyribonucleotide Dermal Infiltration in Male Genital Lichen Sclerosus: Adjuvant Effects during Topical Therapy. Dermatol Res Pract. 2013;2013:654079.<\/p>\n [18] \u6bb7\u73ca,\u80e1\u6657\u83f2,\u5218\u7fd4,\u7b49.\u591a\u805a\u8131\u6c27\u6838\u7cd6\u6838\u82f7\u9178\u5fae\u9488\u6ce8\u5c04\u914d\u5408\u653e\u8840\u7597\u6cd5\u6cbb\u7597\u7ea2\u6591\u6bdb\u7ec6\u8840\u7ba1\u6269\u5f20\u578b\u73ab\u7470\u75e4\u75ae\u7684\u4e34\u5e8a\u7814\u7a76[J].\u4e2d\u56fd\u533b\u7597\u7f8e\u5bb9,2021,11(9):44-48.<\/p>\n","protected":false},"excerpt":{"rendered":" \u592a\u957f\u4e0d\u770b\u7248 \u76f4\u63a5\u62c9\u5230\u6587\u672b\u770b\u603b\u7ed3 \u2193 \u2193 \u2193 PDRN\uff0c\u5373\u201c\u591a\u805a\u8131\u6c27\u6838\u7cd6\u6838\u82f7\u9178\u201d\uff0c … \u7ee7\u7eed\u9605\u8bfb