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\u5176\u6b21\uff0c\u5728\u03b1\u7ec6\u80de\u65b9\u9762\uff0cGIP\u5728\u03b1\u7ec6\u80de\u4e2d\u4e3b\u8981\u901a\u8fc7\u80f0\u9ad8\u8840\u7cd6\u7d20\u7684\u5206\u6ccc\u548c\u7ec6\u80de\u95f4\u901a\u8baf\u53d1\u6325\u751f\u7269\u5b66\u6548\u5e94[9]<\/sup>\u3002\u5065\u5eb7\u4eba\u4e2d\uff0c\u6b63\u5e38\u8840\u7cd6\u548c\u4f4e\u8840\u7cd6\u671f\u95f4\uff0cGIP\u53ef\u4fc3\u8fdb\u80f0\u9ad8\u8840\u7cd6\u7d20\u7684\u5206\u6ccc\u3002\u4e00\u9879\u5728\u5065\u5eb7\u53d7\u8bd5\u8005\u4e2d\u8fdb\u884c\u7684\u8461\u8404\u7cd6\u94b3\u5939\u8bd5\u9a8c\u663e\u793a\uff0c\u9ad8\u8840\u7cd6\u671f\u95f4\uff0c\u751f\u7406\u6d53\u5ea6\u7684GIP\u5bf9\u80f0\u9ad8\u8840\u7cd6\u7d20\u5206\u6ccc\u65e0\u5f71\u54cd\uff1b\u6b63\u5e38\u8840\u7cd6\u548c\u4f4e\u8840\u7cd6\u671f\u95f4\uff0c\u751f\u7406\u6d53\u5ea6\u7684GIP\u53ef\u4fc3\u8fdb\u80f0\u9ad8\u8840\u7cd6\u7d20\u7684\u5206\u6ccc[11]<\/sup>\uff08\u56fe6\uff09\u3002<\/p>\n

\u56fe6. \u751f\u7406\u5242\u91cfGIP\uff08\u5b9e\u5fc3\uff09\u548c\u751f\u7406\u76d0\u6c34\uff08\u7a7a\u5fc3\uff09\u8f93\u6ce8\u540e\u7684\u80f0\u9ad8\u8840\u7cd6\u7d20\u5206\u6ccc[11]<\/sup><\/p>\n

\u5728\u5065\u5eb7\u4eba\u7684\u03b1\u7ec6\u80de\u4e2d\uff0cGIP\u4fc3\u8fdb\u80f0\u9ad8\u8840\u7cd6\u7d20\u7684\u5206\u6ccc\u4e0e\u8840\u7cd6\u6c34\u5e73\u76f8\u5173\u3002\u6b64\u5916\uff0cGIP\u4f5c\u7528\u4e8e\u03b1\u7ec6\u80de\u540e\u523a\u6fc0\u80f0\u9ad8\u8840\u7cd6\u7d20\u5206\u6ccc\uff0c\u95f4\u63a5\u523a\u6fc0\u80f0\u5c9b\u7d20\u7684\u5206\u6ccc[9]<\/sup>\uff08\u56fe7\uff09\u3002\u56fe7. GIP\u5728\u80f0\u817a\u4e2d\u76f4\u63a5\u548c\u95f4\u63a5\u523a\u6fc0\u80f0\u5c9b\u7d20\u5206\u6ccc\u7684\u673a\u5236[9]<\/sup><\/p>\n

\u56fd\u9645\u7cd6\u5c3f\u75c5<\/p>\n

\u90a3\u4e48\uff0c\u5728\u75c5\u7406\u6761\u4ef6\u4e0b\uff0cGIP\u7684\u751f\u7269\u6d3b\u6027\u6709\u54ea\u4e9b\u53d8\u5316\uff1f\u53ef\u80fd\u539f\u56e0\u662f\u4ec0\u4e48\uff1f<\/p>\n

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\u56fe8. T2DM\u60a3\u8005\u4e2dGIP\u523a\u6fc0\u03b2\u7ec6\u80de\u5206\u6ccc\u80f0\u5c9b\u7d20\u7684\u4f5c\u7528\u660e\u663e\u51cf\u5f31[16]<\/sup><\/p>\n

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\u56fe9. 2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u80f0\u5c9b\u4e2dGIPR mRNA\u7684\u8868\u8fbe\u964d\u4f4e[19]<\/sup><\/p>\n

T2DM\u60a3\u8005\u4e2d\uff0cGIP\u7684\u80a0\u4fc3\u80f0\u7d20\u4f5c\u7528\u51cf\u5f31\uff0c\u53ef\u80fd\u4f1a\u5bfc\u81f4\u7cd6\u4ee3\u8c22\u6076\u5316\uff0c\u5f62\u6210\u6076\u6027\u5faa\u73af[20]<\/sup>\u3002\u4f46\u662f\uff0c\u4e00\u9879\u5728T2DM\u60a3\u8005\uff08n=8\uff09\u4e2d\u8fdb\u884c\u7684\u7814\u7a76\u89c2\u5bdf\u5230\uff0c\u5f53T2DM\u60a3\u8005\u6539\u5584\u8840\u7cd6\u63a7\u5236\u540e\uff0c\u89c2\u5bdf\u5230GIP\u7684\u4fc3\u80f0\u5c9b\u7d20\u5206\u6ccc\u90e8\u5206\u6062\u590d\uff0cGIP\u7684\u80a0\u4fc3\u80f0\u7d20\u4f5c\u7528\u6709\u6240\u6539\u5584[21]<\/sup>\uff08\u56fe10\uff09\u3002\u56fe10. T2DM\u60a3\u8005\u80f0\u5c9b\u7d20\u6cbb\u7597\u524d\u540e\u9ad8\u7cd6\u94b3\u5939\u8bd5\u9a8c\u671f\u95f4GIP\u8f93\u6ce8\u540e\u7684\u7b2c\u4e8c\u65f6\u76f8\uff0810-120min\uff09\u7684\u80f0\u5c9b\u7d20\u5206\u6ccc[21]<\/sup><\/p>\n

\u5c0f \u7ed3<\/p>\n

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\u53c2\u8003\u6587\u732e\uff1a\uff08\u4e0a\u4e0b\u6ed1\u52a8\u67e5\u770b\u66f4\u591a\uff09<\/p>\n

1. Aronoff SL, et al. Diabetes Spectr. 2004;17(3):183-190.<\/p>\n

2. Mayo Clin Proc. 2018 Feb;93(2):217-239. doi: 10.1016\/j.mayocp.2017.12.003. Epub 2018 Jan 5.The Role of Glucagon in the Pathophysiology and Treatment of Type 2 Diabetes<\/p>\n

3. \u6d2a\u5929\u914d, \u7530\u52cd, \u6768\u8fdb. \u80a0\u4fc3\u80f0\u7d20\u6548\u5e94\u7684\u53d1\u73b0\u53ca\u5176\u4e34\u5e8a\u5e94\u7528\u5c55\u671b[J]. \u4e2d\u534e\u5185\u5206\u6ccc\u4ee3\u8c22\u6742\u5fd7, 2018, 34(8):5.<\/p>\n

4. Rehfeld JF, et al. Front Endocrinol (Lausanne) 2018,9:387<\/p>\n

5. Dominijanni S, Cipriani S, Malaguti M, Triolo L, Ansali F, Floccari F. Antidiabetic Medication in Patients with Chronic Kidney Disease: What\u2019s New? Nephrology @ Point of Care. 2017;3(1). doi:10.5301\/napoc.5000210<\/p>\n

6. Nauck MA, et al. Diabetes 2019,68(5):897-900<\/p>\n

7.  M A Nauck J Clin Endocrinol Metab. 1986 Aug;63(2):492-8. doi: 10.1210\/jcem-63-2-492.<\/p>\n

8. McIntosh CHS, et al. Vitam Horm 2009,80:409-71.<\/p>\n

9. El K, Gray SM, et al. Sci Adv. 2021 Mar 12;7(11):eabf1948. doi: 10.1126\/sciadv.abf1948. Print 2021 Mar<\/p>\n

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