{"id":37116,"date":"2024-06-15T04:02:11","date_gmt":"2024-06-15T04:02:11","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=37116"},"modified":"2024-06-15T04:02:11","modified_gmt":"2024-06-15T04:02:11","slug":"%e6%8c%87%e5%8d%97-nccn%e8%83%b0%e8%85%ba%e7%99%8c%e6%8c%87%e5%8d%972023%e5%b9%b4%e6%9c%80%e6%96%b0%e7%89%88","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=37116","title":{"rendered":"\u6307\u5357 | NCCN\u80f0\u817a\u764c\u6307\u53572023\u5e74\u6700\u65b0\u7248"},"content":{"rendered":"<p>                                        \uff08\uff09\u201c\u5609\u8bae\u80bf\u7624\u201d\u516c\u4f17\u53f7\u201c\u6307\u5357\u201d\u4e13\u680f\u6bcf\u5468\u4e3a\u5927\u5bb6\u5206\u4eab\u6700\u65b0\u3001\u6700\u6743\u5a01\u7684\u56fd\u5185\u5916\u80bf\u7624\u4e34\u5e8a\u6307\u5357\u4fe1\u606f\u3002\u5728\u56fd\u9645\u6743\u5a01\u6307\u5357\u4e2d\uff0c\u7f8e\u56fd\u56fd\u5bb6\u7efc\u5408\u764c\u75c7\u7f51\u7edc\uff08NCCN\uff09\u6307\u5357\u4ee5\u8fed\u4ee3\u901f\u5ea6\u6781\u5feb\u800c\u95fb\u540d\u3002\u76ee\u524d\u300aNCCN\u80f0\u817a\u764c\u7ba1\u7406\u6307\u5357\u300b\u5df2\u66f4\u65b0\u81f32023.V2\uff0c\u4eca\u5929\u6211\u4eec\u5c06\u5206\u4eab\u66f4\u65b0\u8981\u70b9\u3002\u6587\u672b\u53ef\u514d\u8d39\u83b7\u53d6\u5b8c\u6574\u7684\u4e2d\u6587\u6307\u5357\u6587\u4ef6\u3002<\/p>\n<p>\u300aNCCN\u80f0\u817a\u764c\u6307\u5357\u300b2023.&nbsp;V2\u8f832023.&nbsp;V1\u66f4\u65b0\u8981\u70b9<\/p>\n<p>PANC-F 3\/12<\/p>\n<ul>\n<li>\n<p>\u5c40\u90e8\u665a\u671f\u75be\u75c5\uff08\u4e00\u7ebf\u6cbb\u7597\uff09\uff0c\u826f\u597d PS 0-1\uff0c\u5176\u4ed6\u63a8\u8350\u6cbb\u7597\u65b9\u6848\uff0c\u65b0\u589e\u9009\u9879\uff1a\u8102\u8d28\u4f53\u76d0\u9178\u4f0a\u7acb\u66ff\u5eb7 + 5-FU + leucovorin + \u5965\u6c99\u5229\u94c2\uff08NALIRIFOX\uff09\u3002\u3001<\/p>\n<\/li>\n<li>\n<p>\u65b0\u589e\u811a\u6ce8 i\uff1a\u867d\u7136 NCCN \u627f\u8ba4\u6709\u9ad8\u6c34\u5e73\u8bc1\u636e\u652f\u6301 NALIRIFOX \u7684\u4f7f\u7528\u4f18\u4e8e\u5409\u897f\u4ed6\u6ee8\u548c\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\uff0c\u4f46\u5e94\u8ba4\u8bc6\u5230\u8be5\u65b9\u6848\u4e0e FOLFIRINOX \u76f8\u6bd4\u4f3c\u4e4e\u5e76\u65e0\u4f18\u52bf\uff0c\u800c\u4e14\u4e0e FOLFIRINOX \u76f8\u6bd4\u589e\u52a0\u4e86\u76f8\u5f53\u591a\u7684\u8d39\u7528\u3002(\u53e6\u89c1PANC-F 4 of 12\u3001PANC-F 5 of 12&nbsp;\u548c&nbsp;PANC-F 6 of 12&nbsp;\uff09\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-F 4\/12<\/p>\n<ul>\n<li>\n<p>\u5c40\u90e8\u665a\u671f\u75be\u75c5\uff08\u4e00\u7ebf\u6cbb\u7597\uff09\uff0cPS 2 \u4e2d\u7ea7\uff0c\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u6709\u7528\uff0c\u65b0\u589e\u9009\u9879\uff1aNALIRIFOX\uff082B \u7c7b\uff09\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-F 5\/12<\/p>\n<ul>\n<li>\n<p>\u8f6c\u79fb\u6027\u75be\u75c5\uff0c\uff08\u4e00\u7ebf\u6cbb\u7597\uff09\uff0c\u826f\u597d PS 0-1\uff0c\u5176\u4ed6\u63a8\u8350\u7597\u6cd5\uff0c\u65b0\u589e\u9009\u9879\uff1aNALIRIFOX\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-F 6\/12<\/p>\n<ul>\n<li>\n<p>\u8f6c\u79fb\u6027\u75be\u75c5\uff08\u4e00\u7ebf\u6cbb\u7597\uff09\uff0cPS 2 \u4e2d\u7ea7\uff0c\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u6709\u7528\uff0c\u65b0\u589e\u9009\u9879\uff1aNALIRIFOX\uff082B \u7c7b\uff09\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-F 11 of 12<\/p>\n<ul>\n<li>\n<p>\u65b0\u589e\u53c2\u8003\u6587\u732e 16\uff1aWainberg Z, Bekai-Saab T, Boland P, et al. First-line liposomal irinotecan with oxaliplatin, 5-fluorouracil and leucovorin (NALIRIFOX) in pancreatic ductal adenocarcinoma: A phase I\/II study. Eur J Cancer. 2021 Jul;151:14-24.<\/p>\n<\/li>\n<\/ul>\n<p>\u300aNCCN\u80f0\u817a\u764c\u6307\u5357\u300b2023.&nbsp;V1\u8f832022.&nbsp;V2\u66f4\u65b0\u8981\u70b9PANC-1<\/p>\n<ul>\n<li>\n<p>\u4e34\u5e8a\u8868\u73b0\u548c\u68c0\u67e5\uff0c\u7b2c2\u680f\u4fee\u8ba2\uff1a\u8f74\u5411\u6210\u50cf\uff1a\u80f0\u817a CT \u6216 MRI\uff08\u8179\u90e8\uff09\uff08PANC-A\uff09\u3002<\/p>\n<\/li>\n<li>\n<p>\u65e0\u8f6c\u79fb\u6027\u75be\u75c5\u540e\uff0c\u4fee\u6539\u7b2c4\u70b9\uff1a\u9ad8\u5371\u60a3\u8005\u8003\u8651 PET\/CT\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-1A<\/p>\n<ul>\n<li>\n<p>\u4fee\u8ba2\u811a\u6ce8\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u811a\u6ce8 d\uff1a\u5bf9\u4e8e\u9ad8\u98ce\u9669\u60a3\u8005\uff0c\u53ef\u5728\u6b63\u5f0f\u80f0\u817a CT \u65b9\u6848\u540e\u8003\u8651 PET\/CT \u626b\u63cf\uff0c\u4ee5\u68c0\u6d4b\u80f0\u817a\u5916\u8f6c\u79fb\u7076\u3002\u5b83\u4e0d\u80fd\u66ff\u4ee3\u9ad8\u8d28\u91cf\u3001\u5bf9\u6bd4\u5ea6\u589e\u5f3a CT\u3002\u5bf9\u4e8e\u65b0\u8f85\u52a9\u6cbb\u7597\uff0c\u53ef\u8003\u8651\u5728\u5f00\u59cb\u6cbb\u7597\u524d\u540e\u8fdb\u884c PET \u626b\u63cf\uff0c\u4ee5\u8bc4\u4f30\u5bf9\u5168\u8eab\u6cbb\u7597\u7684\u53cd\u5e94\u5e76\u8fdb\u884c\u91cd\u65b0\u5206\u671f&#8230;<\/p>\n<\/li>\n<li>\n<p>\u811a\u6ce8 f\uff1aCA 19-9 \u5347\u9ad8\u5e76\u4e0d\u4e00\u5b9a\u8868\u793a\u764c\u75c7\u6216\u665a\u671f\u75be\u75c5\u3002\u80c6\u9053\u611f\u67d3\uff08\u80c6\u7ba1\u708e\uff09\u3001\u708e\u75c7\u6216\u6897\u963b\uff08\u826f\u6027\u6216\u6076\u6027\uff09\u90fd\u53ef\u80fd\u5bfc\u81f4 CA 19-9 \u5347\u9ad8\u3002\u6b64\u5916\uff0c\u8def\u6613\u65af\u6297\u539f\u9634\u6027\uff08\u764c\u80da\u6297\u539f [CEA] \u548c CA-125 \u5728\u65e0\u5206\u6ccc\u6216 CA 19-9 \u6c34\u5e73\u6b63\u5e38\u7684\u60a3\u8005\u4e2d\uff09\u7684\u60a3\u8005\u4e5f\u68c0\u6d4b\u4e0d\u5230 CA 19-9\uff08\u89c1\u8ba8\u8bba\uff09\u3002(\u53e6\u89c1 PANC-2\u3001PANC-3A \u548c PANC-7 \uff09<\/p>\n<\/li>\n<li>\n<p>\u811a\u6ce8 i\uff1a\u5efa\u8bae\u5bf9\u63a5\u53d7\u6297\u764c\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\/\u8f6c\u79fb\u6027\u75be\u75c5\u60a3\u8005\u8fdb\u884c\u80bf\u7624\/\u75c7\u72b6\u5206\u5b50\u8c31\u5206\u6790\uff0c\u4ee5\u786e\u5b9a\u4e0d\u5e38\u89c1\u7684\u7a81\u53d8\u3002\u8003\u8651\u4e13\u95e8\u68c0\u6d4b\u53ef\u80fd\u5177\u6709\u53ef\u64cd\u4f5c\u6027\u7684\u4f53\u7ec6\u80de\u53d1\u73b0\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u878d\u5408\uff08ALK\u3001NRG1\u3001NTRK\u3001ROS1\u3001FGFR2 \u548c RET\uff09\u3001\u7a81\u53d8\uff08BRAF\u3001BRCA1\/2\u3001KRAS \u548c PALB2\uff09\u3001\u6269\u589e\uff08HER2\uff09\u3001\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027 (MSI)\u3001\u548c\/\u6216\u9519\u914d\u4fee\u590d (MMR) \u7f3a\u4e4f (dMMR) \u6216\u80bf\u7624\u7a81\u53d8\u8d1f\u8377 (TMB)\u3002&#8230;\uff08\u53e6\u89c1 PANC-4\u3001PANC-5A\u3001PANC-8\u3001PANC-9 \u548c PANC-10 \uff09<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<ul>\n<li>\n<p>\u65b0\u589e\u811a\u6ce8 k\uff1a\u53ef\u7528\u9ad8\u8d28\u91cf MRI \u66ff\u4ee3\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-2<\/p>\n<ul>\n<li>\n<p>\u672c\u9875\u9762\u6709\u5927\u5e45\u53d8\u66f4\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-3<\/p>\n<ul>\n<li>\n<p>\u6d3b\u7ec4\u7ec7\u68c0\u67e5\u5448\u9633\u6027\u540e\u7684\u6cbb\u7597\uff0c\u65b0\u589e\u9009\u9879\uff1a\u75be\u75c5\u8fdb\u5c55\u4e0d\u6392\u9664\u624b\u672f\u3002<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u65b0\u589e\u9009\u9879\uff1a\u8003\u8651\u5176\u4ed6\u65b0\u8f85\u52a9\u7cfb\u7edf\u7597\u6cd5\u3002<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<p>PANC-3A<\/p>\n<ul>\n<li>\n<p>\u65b0\u589e\u811a\u6ce8\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u5728\u672f\u524d\u6216\u56f4\u672f\u671f\u8fdb\u884c\u957f\u8fbe 6 \u4e2a\u6708\u7684\u4e00\u7ebf\u65b0\u8f85\u52a9\u7cfb\u7edf\u6cbb\u7597\u3002<\/p>\n<\/li>\n<li>\n<p>\u75be\u75c5\u8fdb\u5c55\u4ee5 CA 19-9 \u5347\u9ad8\u6216\u80bf\u5757\u589e\u5927\u4e3a\u6807\u5fd7\u3002<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<p>PANC-5<\/p>\n<ul>\n<li>\n<p>\u5c40\u90e8\u665a\u671f\u75be\u75c5\uff0c\u4fee\u8ba2\u9009\u9879\uff1a\u826f\u597d\u6216\u4e2d\u7b49\u8868\u73b0\u72b6\u6001\uff08PS\uff09\u3002<\/p>\n<\/li>\n<li>\n<p>\u5728\u201c\u4e00\u7ebf\u6cbb\u7597\u201d\u680f\u4e4b\u540e\uff0c\u4fee\u6539\u4e86\u6700\u9ad8\u9009\u9879\uff1a\u826f\u597d\u6216\u4e2d\u7b49 PS\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-5A<\/p>\n<ul>\n<li>\n<p>\u826f\u597d PS \u5b9a\u4e49\u4e3a ECOG 0-1\uff0c\u6709\u826f\u597d\u7684\u80c6\u9053\u5f15\u6d41\u548c\u5145\u8db3\u7684\u8425\u517b\u6444\u5165\uff1b\u5982\u679c\u8003\u8651\u76d0\u9178\u5409\u897f\u4ed6\u6ee8 + \u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\uff0c\u5219\u4e2d\u7b49 PS \u5b9a\u4e49\u4e3a ECOG 0-2\u3002(\u53e6\u89c1 PANC-8 \u548c PANC-9 \uff09<\/p>\n<\/li>\n<\/ul>\n<p>PANC-6<\/p>\n<ul>\n<li>\n<p>\u5728\u624b\u672f\u4e2d\u53d1\u73b0\u65e0\u6cd5\u5207\u9664\u7684\u75be\u75c5\u540e\uff0c\u4fee\u6539\u4e13\u680f\uff1a\u6d3b\u68c0\u786e\u8bca\u548c\u9057\u4f20\u7a81\u53d8\u57fa\u56e0\u68c0\u6d4b\uff08\u5982\u4e4b\u524d\u672a\u8fdb\u884c\uff09\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-7<\/p>\n<ul>\n<li>\n<p>\u9875\u9996\u7b2c\u56db\u680f\u4fee\u6539\uff1a\u4e34\u5e8a\u8bd5\u9a8c\uff08\u9996\u9009\uff09\u6216\u5355\u72ec\u5316\u7597\u6216\u8bf1\u5bfc\u5316\u7597\u540e&#8230;<\/p>\n<\/li>\n<\/ul>\n<p>PANC-8<\/p>\n<ul>\n<li>\n<p>\u4e00\u7ebf\u6cbb\u7597\uff0c\u4fee\u8ba2\u540e\u7684\u9876\u7ea7\u65b9\u6848\uff1a\u826f\u597d\u6216\u4e2d\u7b49 PS\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-9<\/p>\n<ul>\n<li>\n<p>\u75be\u75c5\u8fdb\u5c55\u540e\uff0c\u65b0\u589e\u680f\uff1a\u5982\u679c\u65e0\u6cd5\u83b7\u5f97\u8db3\u591f\u7684\u7ec4\u7ec7\u8fdb\u884c\u5206\u5b50\u5206\u6790\uff0c\u5219\u8003\u8651\u91cd\u65b0\u6d3b\u68c0\u3002<\/p>\n<\/li>\n<li>\n<p>\u540e\u7eed\u6cbb\u7597\uff0c\u4fee\u8ba2\u6700\u9ad8\u9009\u9879\uff1a\u826f\u597d\u6216\u4e2d\u7b49 PS\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-10<\/p>\n<ul>\n<li>\n<p>\u5207\u9664\u672f\u540e\u590d\u53d1\uff0c\u4fee\u6539\u7b2c3\u9879\uff1a\u80bf\u7624\u7ec4\u7ec7\u7684\u5206\u5b50\u56fe\u8c31\u5206\u6790\uff0c\u5982\u679c\u4ee5\u524d\u672a\u8fdb\u884c\u8fc7\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-A 2 of 8<\/p>\n<ul>\n<li>\n<p>\u4fee\u6539\u7b2c1\u9879\uff1aPET\/CT \uff08\u4e0d\u542b\u7898\u9759\u8109\u6ce8\u5c04\u9020\u5f71\u5242\uff09\u7684\u4f5c\u7528\u4ecd\u4e0d\u660e\u786e\u3002\u8bca\u65ad CT \u6216 MRI\uff08\u5982\u4e0a\u6240\u8ff0\uff0c\u9759\u8109\u6ce8\u5c04\u9020\u5f71\u5242\uff09\u4e0e\u529f\u80fd PET \u6210\u50cf\u53ef\u6839\u636e\u673a\u6784\u504f\u597d\u7ed3\u5408\u4f7f\u7528\u3002\u5bf9\u4e8e\u9ad8\u98ce\u9669\u60a3\u8005\uff0c\u53ef\u8003\u8651\u5728\u6b63\u5f0f\u7684\u80f0\u817a CT \u65b9\u6848\u540e\u8fdb\u884c PET\/CT \u626b\u63cf\uff0c\u4ee5\u68c0\u6d4b\u80f0\u817a\u5916\u8f6c\u79fb\u2026\u2026<\/p>\n<\/li>\n<\/ul>\n<p>PANC-B<\/p>\n<ul>\n<li>\n<p>\u5bf9\u672c\u8282\u8fdb\u884c\u4e86\u5927\u5e45\u4fee\u8ba2\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-F 2\/12<\/p>\n<ul>\n<li>\n<p>\u4fee\u8ba2\u4e86\u5176\u4ed6\u63a8\u8350\u7597\u6cd5\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u7b2c2\u680f\uff1a\u9759\u8109\u6ce8\u5c04 5-FU + leucovorin\uff08 1 \u7c7b\uff09<\/p>\n<\/li>\n<li>\n<p>\u7b2c5\u9879\uff1a\u8bf1\u5bfc\u5316\u7597\uff08\u76d0\u9178\u5409\u897f\u4ed6\u6ee8\u30015-FU + leucovorin \u6216\u6301\u7eed\u8f93\u6ce8 5-FU\uff09\u540e\u8fdb\u884c\u5316\u7597\u653e\u7597\uff1a\u76d0\u9178\u5409\u897f\u4ed6\u6ee8\uff08Gemcitabine\uff09\u30015-FU\uff0bleucovorin\uff08Bolus 5-FU\uff0bleucovorin\uff09\u30015-FU\u6301\u7eed\u8f93\u6ce8\uff08Continuous infusion 5-FU\uff09\u3002<\/p>\n<\/li>\n<li>\n<p>\u7b2c6\u9879\uff1a\u8bf1\u5bfc\u5316\u7597\uff08\u76d0\u9178\u5409\u897f\u4ed6\u6ee8\u30015-FU + leucovorin\u6216\u6301\u7eed\u8f93\u6ce8 5-FU\uff09\u540e\u8fdb\u884c\u5316\u653e\u7597\uff0c\u7136\u540e\u8fdb\u884c\u540e\u7eed\u5316\u7597\uff1a\u76d0\u9178\u5409\u897f\u4ed6\u6ee8\u5316\u7597\u540e\uff0c\u518d\u8fdb\u884c\u76d0\u9178\u5409\u897f\u4ed6\u6ee8\uff1b5-FU+ leucovorin\u6ce8\u5c04\u6db2\u5316\u7597\u540e\uff0c\u518d\u8fdb\u884c5-FU+ leucovorin\u6ce8\u5c04\u6db2\u5316\u7597\uff1b5-FU\u6301\u7eed\u8f93\u6ce8\u5316\u7597\u540e\uff0c\u518d\u8fdb\u884c5-FU\u6301\u7eed\u8f93\u6ce8\u5316\u7597\u3002<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<p>PANC-F 3\/12<\/p>\n<ul>\n<li>\n<p>\u7b2c1\u680f\uff0c\u6807\u9898\u4fee\u6539\uff1a\u826f\u597d PS 0-1\u3002<\/p>\n<\/li>\n<li>\n<p>\u5220\u9664\u811a\u6ce8 a\uff1aFOLFIRINOX \u6216\u6539\u826f FOLFIRINOX \u5e94\u4ec5\u9650\u4e8e ECOG \u4e3a 0-1 \u7684\u60a3\u8005\u3002(\u53e6\u89c1 PANC-F 5\/12 \u9875\u548c PANC-F 8\/12 \u9875\uff09\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-F 4\/12<\/p>\n<ul>\n<li>\n<p>\u65b0\u589e\u5c40\u90e8\u665a\u671f\u75be\u75c5\uff08\u4e00\u7ebf\u6cbb\u7597\uff09\u9875\u9762\uff0c\u9002\u7528\u4e8e PS 2 \u4e2d\u7ea7\u548c PS 3-4 \u5dee\u7ea7\u3002<\/p>\n<\/li>\n<li>\n<p>\u6dfb\u52a0\u4e2d\u7ea7 PS 2 \u7684\u6cbb\u7597\u65b9\u6848\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u9996\u9009\u7597\u6cd5\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u5361\u57f9\u4ed6\u6ee8<\/p>\n<\/li>\n<li>\n<p>\u76d0\u9178\u5409\u897f\u4ed6\u6ee8<\/p>\n<\/li>\n<li>\n<p>\u76d0\u9178\u5409\u897f\u4ed6\u6ee8+\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187<\/p>\n<\/li>\n<\/ul>\n<li>\n<p>\u5176\u4ed6\u63a8\u8350\u7597\u6cd5\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u65e0<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<\/ul>\n<ul>\n<ul>\n<li>\n<p>\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u6709\u7528\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u7279\u9009\u60a3\u8005\uff08\u5c40\u90e8\u665a\u671f\u75be\u75c5\uff0c\u65e0\u5168\u8eab\u8f6c\u79fb\uff09\u63a5\u53d7\u4efb\u4f55\u9996\u9009\u65b9\u6848\u7684\u8bf1\u5bfc\u5316\u7597\uff08\u22654-6 \u4e2a\u5468\u671f\uff09\uff0c\u7136\u540e\u8fdb\u884c\u5316\u653e\u7597\u6216 SBRT\u3002<\/p>\n<\/li>\n<li>\n<p>\u5316\u7597\u6216 SBRT\uff08\u9002\u7528\u4e8e\u4e0d\u9002\u5408\u63a5\u53d7\u8bf1\u5bfc\u5316\u7597\u7684\u60a3\u8005\uff09\u3002<\/p>\n<\/li>\n<li>\n<p>NALIRIFOX\uff082B \u7c7b\uff09<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<\/ul>\n<p>PANC-F 5\/12<\/p>\n<ul>\n<li>\n<p>&nbsp;\u7b2c1\u680f\uff0c\u6807\u9898\u4fee\u6539\uff1a\u826f\u597d PS 0-1\u3002<\/p>\n<\/li>\n<li>\n<p>\u5176\u4ed6\u63a8\u8350\u7597\u6cd5\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u4fee\u8ba2\u7b2c6\u9879\uff1aFluoropyrimidine +\u5965\u6c99\u5229\u94c2\uff0c\uff08\u59825-FU+ leucovorin +\u5965\u6c99\u5229\u94c2[OFF]\uff0c\u6216CapeOx\uff09\uff082B\u7c7b\uff09\u3002<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u589e\u52a0\u5b50\u9879\uff1a<\/p>\n<p>&#8211; \u6c27\u5316\u89d2\uff082B \u7c7b\uff09<\/p>\n<p>&#8211; \u5173\uff082B \u7c7b\uff09<\/p>\n<\/li>\n<li>\n<p>\u4fee\u8ba2\u7b2c 7 \u9879\uff1a\u56fa\u5b9a\u5242\u91cf\u76d0\u9178\u5409\u897f\u4ed6\u6ee8\u3001\u591a\u897f\u4ed6\u8d5b\u3001\u5361\u57f9\u4ed6\u6ee8\uff08GTX \u65b9\u6848\uff09\uff082B \u7c7b\uff09\u3002<\/p>\n<\/li>\n<\/ul>\n<li>\n<p>\u811a\u6ce8 f \u5220\u9664\uff1a\u5bf9\u4e8e ECOG \u4e3a 0-2 \u7684\u60a3\u8005\uff0c\u76d0\u9178\u5409\u897f\u4ed6\u6ee8+\u767d\u86cb\u767d\u7ed3\u5408\u7d2b\u6749\u9187\u662f\u5408\u7406\u7684\u3002(\u53e6\u89c1 PANC-F 8\/12 \u9875)\u8154\u6dcb\u5df4\u817a\u5207\u9664\u672f\u5217\u4e3a\u9996\u9009\u3002<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<p>PANC-F 6\/12<\/p>\n<ul>\n<li>\n<p>\u4e3a PS2 \u4e2d\u7ea7\u548c PS3-4 \u5dee\u7684\u8f6c\u79fb\u6027\u75be\u75c5\uff08\u4e00\u7ebf\u6cbb\u7597\uff09\u65b0\u589e\u9875\u9762\u3002<\/p>\n<\/li>\n<li>\n<p>\u6dfb\u52a0\u5230\u4e2d\u7ea7 PS 2 \u7684\u6cbb\u7597\u65b9\u6848\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u9996\u9009\u7597\u6cd5\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u76d0\u9178\u5409\u897f\u4ed6\u6ee8+\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\uff08\u7b2c1\u7c7b\uff09<\/p>\n<\/li>\n<li>\n<p>\u5361\u57f9\u4ed6\u6ee8<\/p>\n<\/li>\n<li>\n<p>\u76d0\u9178\u5409\u897f\u4ed6\u6ee8<\/p>\n<\/li>\n<\/ul>\n<li>\n<p>\u5176\u4ed6\u63a8\u8350\u7597\u6cd5\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u65e0<\/p>\n<\/li>\n<\/ul>\n<li>\n<p>\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u6709\u7528\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>NALIRIFOX\uff082B \u7c7b\uff09<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<\/ul>\n<p>PANC-F 7 of 12<\/p>\n<ul>\n<li>\n<p>\u8f6c\u79fb\u6027\u75be\u75c5\uff08\u7ef4\u6301\u6cbb\u7597\uff09\uff0c\u4fee\u8ba2\u516c\u544a\uff1a\u5316\u7597 4-6 \u4e2a\u6708\u540e\u6709\u53cd\u5e94\u6216\u75c5\u60c5\u7a33\u5b9a\u7684\u60a3\u8005\u53ef\u63a5\u53d7\u5316\u7597\u5047\u671f\u6216\u7ef4\u6301\u6cbb\u7597\u3002<\/p>\n<\/li>\n<li>\n<p>\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u6709\u7528\uff0c\u7b2c1\u9879\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u65b0\u589e\u5b50\u9879\uff1a5-FU + leucovorin + \u76d0\u9178\u4f0a\u7acb\u66ff\u5eb7\uff08FOLFIRI\uff09<\/p>\n<\/li>\n<li>\n<p>\u7b2c1\u5b50\u9879\u4fee\u8ba2\uff1a5-FU \u00b1 \u76d0\u9178\u4f0a\u7acb\u66ff\u5eb7 + leucovorin<\/p>\n<\/li>\n<li>\n<p>\u7b2c3\u5b50\u9879\u6539\u826f\uff1a5-FU+ leucovorin +\u5965\u6c99\u5229\u94c2\uff08FOLFOX\uff09\uff082B\u7c7b\uff09<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<p>PANC-F 8\/12<\/p>\n<ul>\n<li>\n<p>&nbsp;\u7b2c1\u680f\uff0c\u6807\u9898\u4fee\u6539\uff1a\u826f\u597d PS 0-1\u3002<\/p>\n<\/li>\n<li>\n<p>\u5176\u4ed6\u5efa\u8bae\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u589e\u52a0\u4e86\u65b0\u7684\u6cbb\u7597\u65b9\u6848\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>Dostarlimab-gxly\uff08\u5982\u679c\u662f MSI-H \u6216 dMMR\uff09<\/p>\n<\/li>\n<li>\n<p>\u7eb3\u6b66\u5229\u5c24\u5355\u6297+\u4f0a\u5339\u68ee\u6797\u5355\u6297\uff08\u5982\u679c TMB-H [\u226510 mut\/Mb]\uff09\uff082B \u7c7b\uff09<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<li>\n<p>&nbsp;\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u6709\u7528\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u589e\u52a0\u4e86\u65b0\u7684\u6cbb\u7597\u65b9\u6848\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>Adagrasib\uff08\u5982\u679c KRAS G12C \u7a81\u53d8\u9633\u6027\uff09<\/p>\n<\/li>\n<li>\n<p>Sotorasib\uff08\u5982\u679c KRAS G12C \u7a81\u53d8\u9633\u6027\uff09<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<li>\n<p>&nbsp;\u811a\u6ce8 m \u5220\u9664\uff1a5-FU+ leucovorin +\u8102\u8d28\u4f53\u76d0\u9178\u4f0a\u7acb\u66ff\u5eb7\u662f ECOG \u4e3a 0-2 \u7684\u60a3\u8005\u7684\u5408\u7406\u540e\u7eed\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n<\/li>\n<\/ul>\n<p>PANC-F 9 of 12<\/p>\n<ul>\n<li>\n<p>&nbsp;\u65b0\u589e \u201c\u5c40\u90e8\u665a\u671f\/\u8f6c\u79fb\u6027\u75be\u75c5\u7684\u540e\u7eed\u6cbb\u7597\u201d\u548c\u201c\u4e2d\u5ea6 PS 2 \u548c\u4e0d\u826f PS 3-4 \u590d\u53d1\u6027\u75be\u75c5\u7684\u6cbb\u7597\u201d\u9875\u9762\u3002<\/p>\n<\/li>\n<li>\n<p>\u4e3a PS 2 \u4e2d\u7ea7\u9636\u6bb5\u589e\u52a0\u7684\u6cbb\u7597\u65b9\u6848\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u5176\u4ed6\u63a8\u8350\u7597\u6cd5\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u5982\u679c\u4e4b\u524d\u63a5\u53d7\u8fc7\u6c1f\u5627\u5576\u7c7b\u836f\u7269\u6cbb\u7597\uff1a<\/p>\n<p>&#8211; 5-FU + leucovorin + \u8102\u8d28\u4f53\u76d0\u9178\u4f0a\u7acb\u66ff\u5eb7\uff08\u5982\u679c\u4e4b\u524d\u672a\u4f7f\u7528\u76d0\u9178\u4f0a\u7acb\u66ff\u5eb7\uff09<\/p>\n<p>&#8211; \u76d0\u9178\u5409\u897f\u4ed6\u6ee8+\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187<\/p>\n<\/li>\n<li>\n<p>\u5982\u679c\u4e4b\u524d\u63a5\u53d7\u8fc7\u4ee5\u76d0\u9178\u5409\u897f\u4ed6\u6ee8\u4e3a\u57fa\u7840\u7684\u6cbb\u7597\uff1a<\/p>\n<p>&#8211; 5-FU+ leucovorin +\u8102\u8d28\u4f53\u76d0\u9178\u4f0a\u7acb\u66ff\u5eb7\uff08\u8f6c\u79fb\u6027\u75be\u75c5\u4e3a 1 \u7c7b\uff09<\/p>\n<\/li>\n<\/ul>\n<li>\n<p>\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u6709\u7528<\/p>\n<\/li>\n<ul>\n<li>\n<p>Adagrasib\uff08\u5982\u679c KRAS G12C \u7a81\u53d8\u9633\u6027\uff09<\/p>\n<\/li>\n<li>\n<p>Sotorasib\uff08\u5982\u679c KRAS G12C \u7a81\u53d8\u9633\u6027\uff09<\/p>\n<\/li>\n<li>\n<p>Dostarlimab-gxly\uff08\u5982\u679c\u662f MSI-H \u6216 dMMR\uff09<\/p>\n<\/li>\n<li>\n<p>\u5316\u7597\uff0c\u5982\u679c\u4e4b\u524d\u672a\u8fdb\u884c\u8fc7\u5316\u7597\uff0c\u4ec5\u9002\u7528\u4e8e\u4ee5\u4e0b\u60c5\u51b5<\/p>\n<p>&#8211; \u5982\u679c\u539f\u53d1\u90e8\u4f4d\u662f\u552f\u4e00\u8fdb\u5c55\u90e8\u4f4d\uff0c\u5219\u4e3a\u5c40\u90e8\u665a\u671f\u75be\u75c5<\/p>\n<p>&#8211; \u9009\u62e9\u75be\u75c5\u590d\u53d1\u7684\u60a3\u8005\uff0c\u4e0e\u5168\u8eab\u6cbb\u7597\u76f8\u7ed3\u5408<\/p>\n<\/li>\n<li>\n<p>\u7eb3\u6b66\u5229\u5c24\u5355\u6297+\u4f0a\u5339\u68ee\u6797\u5355\u6297\uff08\u5982\u679c TMB-H [\u226510 mut\/Mb]\uff09\uff08 2B \u7c7b\uff09<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<li>\n<p>&nbsp;\u4e3a PS3-4 \u7ea7\u56f0\u96be\u8005\u589e\u52a0\u4e86\u65b0\u7684\u6cbb\u7597\u65b9\u6848\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u9996\u9009\u65b9\u6848\uff1aDostarlimab-gxly\uff08\u5982\u679cMSI-H\u6216dMMR\uff09\uff082B\u7c7b\uff09<\/p>\n<\/li>\n<li>\n<p>\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u6709\u7528\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>Adagrasib\uff08\u5982\u679c KRAS G12C \u7a81\u53d8\u9633\u6027\uff09\uff082B \u7c7b\uff09<\/p>\n<\/li>\n<li>\n<p>Sotorasib\uff08\u5982\u679cKRAS G12C\u7a81\u53d8\u9633\u6027\uff09\uff082B\u7c7b\uff09<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<\/ul>\n<p>PANC-H 1 of 2<\/p>\n<ul>\n<li>\n<p>&nbsp;\u6cbb\u7597\u680f\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u7ee7\u80c3\u51fa\u53e3\/\u5341\u4e8c\u6307\u80a0\u963b\u585e\u4e4b\u540e\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u9879\u5df2\u4fee\u8ba2\uff1a\u8003\u8651\u4f7f\u7528\u80a0\u5185\u652f\u67b6\u3002<\/p>\n<\/li>\n<li>\n<p>\u9879\u5df2\u79fb\u9664\uff1a<\/p>\n<p>&#8211; \u8868\u73b0\u826f\u597d\u3002<\/p>\n<p>&#8211; \u8868\u73b0\u4e0d\u4f73\u3002<\/p>\n<p>&#8211; \u80a0\u5185\u652f\u67b6<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<\/ul>\n<p>ABBR-1<\/p>\n<ul>\n<li>\n<p>\u65b0\u589e\u9875\u9762\uff1a\u7f29\u7565\u8bed\u3002<\/p>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\uff08\uff09\u201c\u5609\u8bae\u80bf\u7624\u201d\u516c\u4f17\u53f7\u201c\u6307\u5357\u201d\u4e13\u680f\u6bcf\u5468\u4e3a\u5927\u5bb6\u5206\u4eab\u6700\u65b0\u3001\u6700\u6743\u5a01\u7684\u56fd\u5185\u5916\u80bf\u7624\u4e34\u5e8a\u6307\u5357 &hellip; <a href=\"http:\/\/zydq.1006ss.com\/?p=37116\">\u7ee7\u7eed\u9605\u8bfb <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-37116","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/37116","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=37116"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/37116\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=37116"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=37116"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=37116"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}