{"id":36178,"date":"2024-06-06T04:01:09","date_gmt":"2024-06-06T04:01:09","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=36178"},"modified":"2024-06-06T04:01:09","modified_gmt":"2024-06-06T04:01:09","slug":"cell-%e8%af%84%e8%ae%ba%ef%bc%9a%e8%ae%a4%e8%af%86%e7%99%8c%e7%97%87%e7%9a%84%e5%a4%8d%e6%9d%82%e6%80%a7%e4%b8%8a%ef%bc%89","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=36178","title":{"rendered":"Cell \u8bc4\u8bba\uff1a\u8ba4\u8bc6\u764c\u75c7\u7684\u590d\u6742\u6027(\u4e0a\uff09"},"content":{"rendered":"<\/p>\n

     \u56de\u987e50\u5e74\u524d\u81f3\u4eca\uff0c\u764c\u75c7\u7814\u7a76\u7684\u683c\u5c40\u5df2\u7ecf\u53d1\u751f\u4e86\u5de8\u5927\u53d8\u5316\u3002\u671f\u95f4\u5bf9\u7ec6\u80de\u5468\u671f\u7684\u8c03\u8282\u3001\u7ec6\u80de\u51cb\u4ea1\u3001\u7ec6\u80de\u8fd0\u52a8\u3001\u4fb5\u88ad\u548c\u514d\u75ab\u5931\u8c03\u4ea7\u751f\u4e86\u975e\u51e1\u7684\u89c1\u89e3\uff0c\u4ece\u800c\u5728\u764c\u75c7\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u65b9\u9762\u53d6\u5f97\u4e86\u91cd\u5927\u8fdb\u5c55\u30025 \u5e74\u751f\u5b58\u7387\u4ece 1950 \u5e74\u4ee3\u7684 35% \u589e\u52a0\u5230 2017 \u5e74\u7684 69.7%\u3002\u5c3d\u7ba1\u53d6\u5f97\u4e86\u8fd9\u4e9b\u8fdb\u5c55\uff0c\u4f46\u764c\u75c7\u4ecd\u7136\u662f\u5168\u7403\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002     \u764c\u75c7\u751f\u7269\u5b66\u548c\u9057\u4f20\u5b66\u7684\u77e5\u8bc6\u6b63\u5728\u7206\u70b8\u5f0f\u589e\u957f\uff0c\u5df2\u9274\u5b9a\u51fa>1,000\u4e2a\u57fa\u56e0\uff0c\u8fd9\u4e9b\u57fa\u56e0\u5728\u80bf\u7624\u4e2d\u901a\u8fc7\u53cd\u590d\u7a81\u53d8\u6216\u8868\u89c2\u9057\u4f20\u53d1\u751f\u6539\u53d8\uff0c\u5bfc\u81f4\u5176\u8c03\u8282\u548c\u8868\u8fbe\u53d1\u751f\u53d8\u5316\u3002\u80bf\u7624\u8fdb\u5c55\u548c\u8f6c\u79fb\u6269\u6563\u7684\u673a\u5236\uff0c\u4ee5\u53ca\u8868\u9762\u4e0a\u6b63\u5e38\u4f46\u529f\u80fd\u53d7\u635f\u7684\u72ec\u7279\u8d77\u6e90\u7684\u7ec6\u80de\u3002\u8fd9\u4e9b\u77e5\u8bc6\u5f80\u5f80\u96c6\u4e2d\u5728\u764c\u7ec6\u80de\u672c\u8eab\u53ca\u5176\u5c40\u90e8\u5fae\u73af\u5883\u4e0a\uff0c\u4f7f\u65b0\u4e00\u4ee3\u673a\u5236\u6307\u5bfc\u7684\u6cbb\u7597\u836f\u7269\u548c\u6cbb\u7597\u65b9\u6848\u6210\u4e3a\u53ef\u80fd\uff0c\u4f7f\u4e00\u4e9b\u60a3\u6709\u67d0\u4e9b\u5f62\u5f0f\u7684\u764c\u75c7\u7684\u60a3\u8005\u53d7\u76ca\u3002\u4ee4\u4eba\u6cae\u4e27\u7684\u662f\uff0c\u8fd9\u4e9b\u521b\u65b0\u7684\u65b0\u6cbb\u7597\u7b56\u7565\u4e2d\u5f88\u5c11\u6709\u5bf9\u4eba\u7c7b\u764c\u75c7\u5e7f\u6cdb\u6709\u76ca\u7684\uff0c\u800c\u4e14\uff0c\u7531\u4e8e\u80bf\u7624\u8fdb\u5316\u51fa\u8010\u836f\u6027\u7684\u9014\u5f84\u5f88\u591a\uff0c\u4f46\u80fd\u663e\u7740\u5ef6\u957f\u603b\u751f\u5b58\u671f\u7684\u5c31\u66f4\u5c11\u4e86\u3002     \u8870\u8001\u662f\u5927\u591a\u6570\u80bf\u7624\u7684\u5934\u53f7\u9884\u540e\u56e0\u7d20\uff0c\u56e0\u4e3a\u8d85\u8fc7 90% \u7684\u88ab\u8bca\u65ad\u60a3\u6709\u764c\u75c7\u7684\u60a3\u8005\u5e74\u9f84\u8d85\u8fc7 50 \u5c81\u3002\u9664\u4e86\u764c\u75c7\u590d\u6742\u6027\u7684\u8fd9\u4e00\u4e3b\u8981\u56e0\u7d20\uff0c\u4ee5\u53ca\u53ef\u884c\u7684\u9884\u9632\u7b56\u7565\u7684\u9014\u5f84\u4e4b\u5916\uff0c\u6211\u4eec\u751f\u6d3b\u7684\u73af\u5883\uff0c\u5f71\u54cd\u591a\u8fbe80%\u7684\u4eba\u7c7b\u764c\u75c7\u7684\u53d1\u5c55\u3002\u201c\u73af\u5883\u201d\u4e00\u8bcd\u5305\u62ec\u5e7f\u6cdb\u7684\u5916\u6e90\u6027\u56e0\u7d20\uff0c\u5305\u62ec\u7a7a\u6c14\u6216\u996e\u98df\u4e2d\u7684\u5de5\u4e1a\u6c61\u67d3\u7269\uff0c \u4ee5\u53ca\u804c\u4e1a\u6216\u533b\u7597\u66b4\u9732\u4e8e\u6709\u6bd2\u7269\u8d28\u6216\u67d0\u4e9b\u7c7b\u578b\u7684\u8f90\u5c04\u548c\u81f4\u75c5\u6027\u75c5\u6bd2\u548c\u7ec6\u83cc\u611f\u67d3\u3002\u5b83\u8fd8\u5305\u62ec\u6240\u8c13\u7684\u201c\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u201d\uff1a\u996e\u98df\u3001\u996e\u9152\u3001\u5438\u70df\u3001\u9633\u5149\u7167\u5c04\u548c\u4e45\u5750\u4e0d\u52a8\u7684\u884c\u4e3a\uff0c\u6240\u6709\u8fd9\u4e9b\u90fd\u4f1a\u5f71\u54cd\u764c\u75c7\u98ce\u9669\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u4e9b\u4e0d\u540c\u7684\u73af\u5883\u56e0\u7d20\u901a\u8fc7\u5f71\u54cd\u4e0a\u8ff0\u76f8\u540c\u7684\u764c\u75c7\u6807\u5fd7\u6027\u7279\u5f81\uff08\u57fa\u56e0\u7ec4\u7a81\u53d8\u3001\u4ee3\u8c22\u6539\u53d8\u3001\u67d3\u8272\u4f53\u4e0d\u7a33\u5b9a\u548c\u708e\u75c7\uff09\u6765\u589e\u52a0\u764c\u75c7\u98ce\u9669\u3002     \u672a\u676550\u5e74\u764c\u75c7\u7814\u7a76\u7684\u672a\u6765\u65b9\u5411\uff0c\u53ef\u80fd\u4f1a\u8003\u8651\u56fe1\u4e2d\u672a\u7a81\u51fa\u663e\u793a\u7684\u5176\u4ed6\u4e3b\u9898\u3002\u6700\u7a81\u51fa\u7684\u662f\u751f\u7406\u6027\u522b\u5728\u764c\u75c7\u6613\u611f\u6027\u3001\u53d1\u5c55\u548c\u6cbb\u7597\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528\u3002\u9664\u4e86\u6027\u6fc0\u7d20\u5728\u4e73\u817a\u764c\u3001\u5375\u5de2\u764c\u548c\u524d\u5217\u817a\u764c\u53d1\u5c55\u4e2d\u7684\u91cd\u8981\u6027\u5916\uff0c\u751f\u7406\u6027\u522b\u8fd8\u4e0e\u4e00\u7cfb\u5217\u5176\u4ed6\u764c\u75c7\u7c7b\u578b\u7684\u4e0d\u540c\u53d1\u75c5\u7387\u6709\u5173\uff0c\u5305\u62ec\u8180\u80f1\u764c\u3001\u80be\u764c\u548c\u98df\u9053\u764c\uff0c\u6240\u6709\u8fd9\u4e9b\u764c\u75c7\u5728\u7537\u6027\u4e2d\u90fd\u66f4\u9ad8\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u652f\u6301\u6027\u67d3\u8272\u4f53\u57fa\u56e0\u6548\u5e94\u7684\u4f5c\u7528\u4ee5\u53ca\u6027\u6fc0\u7d20\u4e0e\u5176\u4ed6\u53c2\u4e0e\u708e\u75c7\u548c\u514d\u75ab\u7684\u7cfb\u7edf\u4e4b\u95f4\u7684\u4e32\u6270\uff0c\u6548\u5e94\u5bf9\u764c\u75c7\u6cbb\u7597\u548c\u6cbb\u7597\u53cd\u5e94\u6709\u660e\u786e\u7684\u5f71\u54cd\u3002\u4f8b\u5982\uff0c\u8981\u4e86\u89e3\u4e3a\u4ec0\u4e48\u4ece\u4e0d\u5438\u70df\u8005\u7684\u80ba\u764c\u5728\u5973\u6027\u4e2d\u66f4\u5e38\u89c1\uff0c\u5c31\u9700\u8981\u5f04\u6e05\u695a\u73af\u5883\u3001\u9057\u4f20\u548c\u4eba\u7c7b\u884c\u4e3a\u7684\u4f5c\u7528\u3002<\/p>\n

\u56fe1 \u201c\u590d\u6742\u6027\u7684\u4e4c\u4e91\u201d\u51b2\u51fb\u7740\u764c\u75c7\u751f\u7269\u5b66\u548c\u764c\u75c7\u533b\u5b66\u7684\u524d\u6cbf<\/p>\n

\u4e86\u89e3\u80bf\u7624\u7684\u53d1\u751f\u548c\u8fdb\u5c55\uff1a\u591a\u6b65\u9aa4\u53d1\u751f     \u957f\u671f\u4ee5\u6765\uff0c\u4eba\u4eec\u4e00\u76f4\u8ba4\u8bc6\u5230\u764c\u75c7\u662f\u901a\u8fc7\u9010\u6b65\u53d1\u751f\u548c\u6076\u6027\u8fdb\u5c55\u7684\uff0c\u7279\u522b\u662f\u901a\u8fc7\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u6027\u548c\u57fa\u56e0\u7a81\u53d8\u4ee5\u53ca\u7ec4\u7ec7\u708e\u75c7\u7684\u7a81\u51fa\u8868\u578b\u7279\u5f81\u6765\u5b9e\u73b0\u3002\u764c\u75c7\u9057\u4f20\u5b66\u544a\u8bc9\u6211\u4eec\uff0c\u7279\u5b9a\u8c03\u8282\u57fa\u56e0\uff08\u79f0\u4e3a\u764c\u57fa\u56e0\uff0c\u5176\u4e2d RAS \u57fa\u56e0\u662f\u539f\u578b\uff09\u7684\u7a81\u53d8\u662f\u8fd9\u79cd\u75be\u75c5\u7684\u91cd\u8981\u9a71\u52a8\u56e0\u7d20\u3002\u4e0e\u80bf\u7624\u6291\u5236\u57fa\u56e0\u7684\u529f\u80fd\u4e27\u5931\u7a81\u53d8\u4e00\u8d77\uff0c\u8fd9\u4e9b\u4e92\u8865\u7684\u9057\u4f20\u4e8b\u4ef6\u53ef\u4ee5\u5bfc\u81f4\u83b7\u5f97\u5728\u5927\u591a\u6570\u4eba\u7c7b\u764c\u75c7\u4e2d\u53d1\u73b0\u7684\u591a\u79cd\u764c\u75c7\u6807\u5fd7\u6027\u80fd\u529b\u3002\u65b0\u7684\u8bc1\u636e\u8868\u660e\uff0c\u6574\u4e2a\u8eab\u4f53\u8868\u9762\u4e0a\u7684\u201c\u6b63\u5e38\u201d\u7ec4\u7ec7\u5305\u542b\u5927\u91cf\u81f4\u764c\u9a71\u52a8\u4e8b\u4ef6\uff0c\u5305\u62ec\u7a81\u53d8\u7ec6\u80de\u5728\u8870\u8001\u8fc7\u7a0b\u4e2d\u6301\u7eed\u5b58\u5728\u5e76\u53ef\u4ee5\u4f5c\u4e3a\u65e0\u75c7\u72b6\u514b\u9686\u6269\u589e\u3002\u8fd9\u7ed3\u679c\u63d0\u793a\u201c\u9a71\u52a8\u201d\u81f4\u764c\u57fa\u56e0\u7684\u7a81\u53d8\u53ef\u80fd\u662f\u5fc5\u8981\u7684\uff0c\u4f46\u5e76\u4e0d\u603b\u662f\u8db3\u4ee5\u53d1\u751f\u80bf\u7624\uff08\u56fe2\uff09\u3002<\/p>\n

\u56fe2 \u764c\u75c7\u9a71\u52a8\u7a81\u53d8\u4e0e\u73af\u5883\u6216\u5185\u6e90\u6027\u80bf\u7624\u542f\u52a8\u5b50\u5728\u764c\u75c7\u98ce\u9669\u4e2d\u7684\u76f8\u4e92\u4f5c\u7528<\/p>\n

     Riva\u53ca\u5176\u540c\u4e8b\u6700\u8fd1\u8bc1\u660e\uff0c\u8bb8\u591a\u5df2\u77e5\u6216\u7591\u4f3c\u7684\u81f4\u764c\u7269\u672c\u8eab\u4f3c\u4e4e\u5e76\u4e0d\u4f1a\u5f15\u8d77\u7a81\u53d8\uff0c\u800c\u662f\u53ef\u80fd\u901a\u8fc7\u523a\u6fc0\u5176\u4ed6\u6807\u5fd7\u7269\uff08\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u6162\u6027\u708e\u75c7\uff09\u8d77\u4f5c\u7528\uff0c\u8fd9\u4e9b\u6807\u5fd7\u7269\u5524\u9192\u5e76\u89e6\u53d1\u643a\u5e26\u6f5c\u5728\u81f4\u764c\u7a81\u53d8\u7684\u7ec6\u80de\u7684\u514b\u9686\u6269\u589e\u3002\u66b4\u9732\u4e8e\u73af\u5883\u4e2d\u7684\u5316\u5b66\u7269\u8d28\u2014\u2014\u53ef\u4ee5\u523a\u6fc0\u542b\u6709\u6b64\u7c7b\u764c\u57fa\u56e0\u6fc0\u6d3b\u7a81\u53d8\u6216\u80bf\u7624\u6291\u5236\u57fa\u56e0\u5931\u6d3b\u7a81\u53d8\u7684\u7ec6\u80de\u7684\u751f\u957f\u3002\u76ee\u524d\u7f3a\u4e4f\u751f\u7269\u6d4b\u5b9a\u6765\u8bc4\u4f30\u5f15\u5165\u73af\u5883\u4e2d\u7684\u73b0\u6709\u6216\u65b0\u5316\u5b66\u7269\u8d28\u7684\u6f5c\u5728\u201c\u80bf\u7624\u4fc3\u8fdb\u6d3b\u6027\u201d\u3002\u9884\u8ba1\u9700\u8981\u7ed8\u5236\u8de8\u7ec4\u7ec7\u80bf\u7624\u53d1\u751f\u7684\u6574\u4e2a\u591a\u9636\u6bb5\u9014\u5f84\uff0c\u4ee5\u9610\u660e\u73af\u5883\u6216\u5185\u6e90\u6027\u751f\u7406\u542f\u52a8\u5b50\u5728\u643a\u5e26\u81f4\u764c\u7a81\u53d8\u7684\u9884\u542f\u52a8\u7ec6\u80de\u4e2d\u89e6\u53d1\u5e72\u7ec6\u80de\/\u7956\u7ec6\u80de\u6837\u7279\u6027\u7684\u673a\u5236\uff0c\u901a\u8fc7\u4e0d\u540c\u7ec4\u7ec7\u548c\u7ec6\u80de\u7c7b\u578b\u7684\u4e0d\u540c\u708e\u75c7\/\u635f\u4f24\u9014\u5f84\u8d77\u4f5c\u7528\u4ee5\u6539\u53d8\u514b\u9686\u9009\u62e9\u3002\u53ef\u80fd\u4f5c\u4e3a\u73af\u5883\u80bf\u7624\u4fc3\u8fdb\u5242\u7684\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u5fae\u5851\u6599\u3001\u8349\u7518\u81a6\u3001\u5168\/\u591a\u6c1f\u70f7\u57fa\u7269\u8d28 \uff08PFAS\uff09\u3001\u70ed\u6db2\u4f53\u548c\u5e7d\u95e8\u87ba\u6746\u83cc\u7b49\u4f20\u67d3\u6027\u75c5\u539f\u4f53\uff08\u56fe 2\uff09\u3002\u6b64\u5916\uff0c\u5185\u6e90\u6027\u6216\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\uff0c\u5305\u62ec\u996e\u98df\u3001\u538b\u529b\u3001\u7761\u7720\u5265\u593a\u3001\u4e45\u5750\u884c\u4e3a\u548c\u663c\u591c\u8282\u5f8b\u7d0a\u4e71\uff0c\u5176\u4e2d\u8bb8\u591a\u56e0\u7d20\u4f1a\u5f71\u54cd\u5fae\u751f\u7269\u7ec4\uff0c\u4e5f\u53ef\u80fd\u8d77\u5f62\u6210\u4f5c\u7528\u3002\u867d\u7136\u764c\u75c7\u7684\u57fa\u7840\u53ef\u80fd\u5728\u4e8e\u7a81\u53d8\u7684\u81f4\u764c\u57fa\u56e0\u548c\u6291\u764c\u57fa\u56e0\uff0c\u4f46\u8d8a\u6765\u8d8a\u660e\u663e\u7684\u662f\uff0c\u80bf\u7624\u8fdb\u5c55\u6d89\u53ca\u975e\u7a81\u53d8\u8868\u89c2\u9057\u4f20\u7f16\u7a0b\uff0c\u8fd9\u53cd\u6620\u5728\u8bb8\u591a\u80bf\u7624\u4e2d\u660e\u663e\u7684\u52a8\u6001\u5f02\u8d28\u6027\u4e2d\uff0c\u56e0\u6b64\uff0c\u764c\u7ec6\u80de\u548c\u80bf\u7624\u5fae\u73af\u5883 \uff08TME\uff09 \u7684\u4e0d\u540c\u7ec6\u80de\u7684\u8868\u89c2\u57fa\u56e0\u7ec4\u5fc5\u7136\u9700\u8981\u5728\u6240\u6709\u9636\u6bb5\u9610\u660e\u3002\u80bf\u7624\u53d1\u751f\u548c\u4f24\u53e3\u6108\u5408\uff1a\u4e00\u679a\u786c\u5e01\u7684\u4e24\u9762     \u4e0d\u53ef\u5426\u8ba4\u6bcf\u79cd\u4eba\u7c7b\u764c\u75c7\u7684\u590d\u6742\u6027\u548c\u72ec\u7279\u6027\uff0c\u4f46\u764c\u75c7\u4e4b\u95f4\u4e5f\u6709\u663e\u7740\u7684\u5171\u6027\u3002\u5176\u4e2d\u4e00\u4e9b\u5171\u6027\u662f\u666e\u904d\u7684\u2014\u2014\u6240\u6709\u764c\u75c7\u90fd\u53c2\u4e0e\u76f8\u540c\u7684\u7ec6\u80de\u5468\u671f\u673a\u5236\uff0c\u5e76\u4e14\u51e0\u4e4e\u6240\u6709\u764c\u75c7\u90fd\u8868\u73b0\u51fa p53 \u901a\u8def\u5931\u6d3b\uff0c\u4ee5\u53ca Myc \u548c Ras\/\u78f7\u8102\u9170\u808c\u9187 3-\u6fc0\u9176 \uff08PI3K\uff09 \u901a\u8def\u7684\u6df7\u6742\u6fc0\u6d3b\u3002\u6b64\u5916\uff0c\u7279\u5b9a\u7c7b\u578b\u6216\u7ec4\u7ec7\u8d77\u6e90\u7684\u764c\u75c7\u5177\u6709\u6807\u5fd7\u6027\u7684\u80bf\u7624\/\u57fa\u8d28\u8868\u578b\uff0c\u5373\u4f7f\u7531\u4e0d\u540c\u7684\u81f4\u764c\u7a81\u53d8\u9a71\u52a8\uff0c\u8fd9\u4e9b\u8868\u578b\u4e0e\u5176\u4ed6\u5668\u5b98\u4e2d\u51fa\u73b0\u7684\u817a\u764c\u6709\u5f88\u5927\u4e0d\u540c\uff0c\u5373\u4f7f\u7531\u76f8\u540c\u7684\u81f4\u764c\u7a81\u53d8\u9a71\u52a8\u3002\u5fb7\u6c83\u590f\u514b\uff08Dvorak\uff09\u63d0\u4f9b\u4e86\u5173\u4e8e\u8fd9\u4e9b\u5668\u5b98\u7279\u5f02\u6027\u80bf\u7624\u9650\u5236\u6765\u6e90\u7684\u7b2c\u4e00\u4e2a\u7ebf\u7d22\uff0c\u4ed6\u63d0\u51fa\u80bf\u7624\u662f\u672a\u89e3\u51b3\u7684\u4f24\u53e3\uff0c\u4e14\u764c\u75c7\u7684\u6807\u5fd7\u4e0e\u4f24\u53e3\u6108\u5408\u7684\u6807\u5fd7\u4e4b\u95f4\u5b58\u5728\u660e\u663e\u7684\u76f8\u4f3c\u4e4b\u5904\u3002\u764c\u75c7\u8868\u578b\u7684\u4e3b\u8981\u51b3\u5b9a\u56e0\u7d20\u4e0d\u662f\u5b83\u4eec\u72ec\u7279\u7684\u81f4\u764c\u7a81\u53d8\uff0c\u800c\u662f\u5b83\u4eec\u7684\u8d77\u6e90\u5668\u5b98\/\u7ec4\u7ec7\u3002\u76f8\u540c\u7684\u81f4\u764c\u9014\u5f84\u6b63\u5728\u4fb5\u5165\u6bcf\u79cd\u9776\u7ec4\u7ec7\/\u7ec6\u80de\u7c7b\u578b\u7684\u72ec\u7279\u5185\u6e90\u6027\u4f24\u53e3\u4fee\u590d\u7a0b\u5e8f\u3002     \u8fd9\u662f\u4e00\u4e2a\u5f3a\u6709\u529b\u7684\u6982\u5ff5\u8fdb\u6b65\u3002\u9996\u5148\uff0c\u5b83\u8c08\u5230\u4e86\u4eba\u4eec\u666e\u904d\u6301\u6709\u7684\u5047\u8bbe\uff0c\u5373\u764c\u75c7\u7684\u6807\u5fd7\uff08\u708e\u75c7\u3001\u514d\u75ab\u6291\u5236\u3001\u6df7\u6742\u589e\u6b96\u3001\u6291\u5236\u7ec6\u80de\u51cb\u4ea1\u7b49\uff09\u662f\u901a\u8fc7\u80bf\u7624\u8fdb\u5316\u9009\u62e9\u7684\u65b0\u751f\u6027\u72b6\uff0c\u56e0\u4e3a\u5b83\u4eec\u6709\u5229\u4e8e\u80bf\u7624\u8fdb\u5c55\u3002\u5176\u6b21\uff0c\u4f24\u53e3\u4fee\u590d\u7684\u4e3b\u8981\u7ec4\u6210\u90e8\u5206\u662f\u521d\u59cb\u518d\u751f\u9636\u6bb5\uff0c\u7136\u540e\u662f\u6d88\u9000\u9636\u6bb5\uff0c\u8fd9\u662f\u4e00\u4e2a\u79bb\u6563\u7684\u5f62\u6001\u53d1\u751f\u7a0b\u5e8f\uff0c\u53ef\u91cd\u7ec4\u5185\u5207\u7ec4\u7ec7\u5e76\u91cd\u65b0\u786e\u8ba4\u7a33\u6001\u7ed3\u6784\u3001\u7ec6\u80de\u6027\u548c\u529f\u80fd\u3002\u80bf\u7624\u5fae\u89c2\u73af\u5883\uff08TME)\uff1a\u89e3\u5f00\u548c\u7784\u51c6\u7ec6\u80de\u751f\u6001\u4f4d     \u764c\u75c7\u542f\u52a8\u5b50\u8bf1\u5bfc\u7684\u708e\u75c7\u548c\u7531\u6b64\u4ea7\u751f\u7684\u591a\u6b65\u80bf\u7624\u53d1\u751f\u4e0e\u590d\u6742\u7684\u591a\u7ec6\u80de TME \u53ca\u5176\u76f8\u5173\u7ec6\u80de\u5916\u73af\u5883\u7684\u9636\u6bb5\u7279\u5f02\u6027\u6539\u53d8\u4ea4\u7ec7\u5728\u4e00\u8d77\uff0c\u540e\u8005\u9010\u6e10\u4e0e\u764c\u7ec6\u80de\u5171\u540c\u8fdb\u5316\u3002\u65b0\u51fa\u73b0\u7684\u8bc1\u636e\u8868\u660e\uff0c\u4e0e\u5e74\u9f84\u3001\u70df\u8349\u66b4\u9732\u6216\u73af\u5883\u6c61\u67d3\u7269\u7b49\u76f8\u5173\u7684\u7ec4\u7ec7\u5b8c\u6574\u6027\u6539\u53d8\uff08 \u8870\u8001\u4e0e\u764c\u75c7\uff1a\u7ec6\u80de\u9002\u5e94\u6027\u3001\u5fae\u73af\u5883\u52a8\u529b\u5b66\u548c\u968f\u65f6\u95f4\u63a8\u79fb\u7684\u8fdb\u5316\u90e8\u5206\uff09\u53ef\u4ee5\u5141\u8bb8\u643a\u5e26\u81f4\u764c\u7a81\u53d8\u7684\u6b63\u5e38\u4f53\u7ec6\u80de\u7684\u514b\u9686\u6269\u589e\u3002TME\u663e\u7136\u53c2\u4e0e\u8c03\u8282\u75be\u75c5\u8fdb\u5c55\u548c\u8c03\u8282\u5bf9\u5404\u79cd\u764c\u75c7\u7597\u6cd5\u7684\u53cd\u5e94\u3002     TME \u4e2d\u7684\u7ec6\u80de\u751f\u6001\u4f4d\u7531\u4e0d\u540c\u7684\u7ec6\u80de\u7fa4\u7ec4\u6210\uff0c\u5305\u62ec\u764c\u7ec6\u80de\u3001\u514d\u75ab\u7ec6\u80de\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u3001\u8109\u7ba1\u7cfb\u7edf\u3001\u8102\u80aa\u3001\u795e\u7ecf\u7ec6\u80de\u548c\u7ec6\u80de\u5916\u57fa\u8d28 \uff08ECM\uff09 \u6210\u5206\u3002\u6bcf\u4e2a\u751f\u6001\u4f4d\u53ef\u80fd\u901a\u8fc7\u652f\u6301\u5c45\u4f4f\u5728\u5176\u4e2d\u7684\u764c\u7ec6\u80de\u7684\u7279\u5b9a\u7279\u5f81\uff0c\u4ee5\u4e0d\u540c\u7684\u65b9\u5f0f\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u3001\u4fb5\u88ad\u548c\u8f6c\u79fb\uff08\u56fe3\uff09\u3002\u4f8b\u5982\uff0c\u5177\u6709\u9ad8\u5e72\u6027\u6f5c\u529b\u7684\u764c\u7ec6\u80de\u4f4d\u4e8e\u5e72\u7ec6\u80de\u6837\u751f\u6001\u4f4d\u4e2d\uff0c\u652f\u6301\u5176\u81ea\u6211\u66f4\u65b0\u548c\u5bf9\u5e38\u89c4\u7597\u6cd5\u7684\u62b5\u6297\u529b\uff0c\u5bfc\u81f4\u75be\u75c5\u590d\u53d1\u3002\u514d\u75ab\u7ec6\u80de\u751f\u6001\u4f4d\u53ef\u4ee5\u4fc3\u8fdb\u6216\u6291\u5236\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u4ece\u800c\u6df1\u523b\u5f71\u54cd\u6cbb\u7597\u7ed3\u679c\u3002\u5176\u4ed6TME\u6210\u5206\u7684\u7a7a\u95f4\u5f02\u8d28\u6027\uff0c\u5982\u80bf\u7624\u57fa\u8d28\u4e2d\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c \u53ef\u4fc3\u8fdb\u7ea4\u7ef4\u589e\u751f\u3001\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u8c03\u8282\u3002<\/p>\n

\u56fe3 \u80bf\u7624\u5fae\u89c2\u548c\u5b8f\u89c2\u73af\u5883<\/p>\n

     \u5728\u8f6c\u79fb\u6027\u5b9a\u690d\u7684\u80cc\u666f\u4e0b\uff0c\u764c\u75c7\u751f\u6001\u4f4d\u7684\u91cd\u8981\u6027\u5c24\u5176\u91cd\u8981\uff0c\u8f6c\u79fb\u7ec6\u80de\u5728\u64ad\u79cd\u65b0\u5668\u5b98\u65f6\u5fc5\u987b\u91cd\u65b0\u521b\u9020\u4e00\u4e2a\u652f\u6301\u6027\u73af\u5883\u3002\u8f6c\u79fb\u7624\u53ef\u80fd\u5728\u539f\u53d1\u6027\u80bf\u7624\u5207\u9664\u540e\u6570\u5e74\u7206\u53d1\uff0c\u8fd9\u8868\u660e\uff0c\u5177\u6709\u8f6c\u79fb\u80fd\u529b\u7684\u7ec6\u80de\u53ef\u4ee5\u4ee5\u975e\u589e\u6b96\u3001\u4f11\u7720\u72b6\u6001\u5b58\u5728\u4e8e\u8fdc\u5904\u5668\u5b98\u4e2d\u3002     \u5728\u8868\u5f81TME\u4e2d\u7684\u7ec6\u80de\u751f\u6001\u4f4d\u65b9\u9762\u53d6\u5f97\u4e86\u91cd\u5927\u6280\u672f\u8fdb\u6b65\uff0c\u63ed\u793a\u4e86\u5176\u52a8\u6001\u548c\u590d\u6742\u6027\u8d28\u3002\u5148\u8fdb\u7684\u6210\u50cf\u6280\u672f\u3001\u5355\u7ec6\u80de\u6d4b\u5e8f\u3001\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u3001\u591a\u91cd\u9ad8\u5206\u8fa8\u7387\u6210\u50cf\u6280\u672f\u548c\u751f\u6001\u4f4d\u6807\u8bb0\u7b56\u7565\u4f7f\u7814\u7a76\u4eba\u5458\u80fd\u591f\u8bc6\u522b\u4e0d\u540c\u7684\u7ec6\u80de\u7fa4\u5e76\u7ed8\u5236\u5b83\u4eec\u5728\u80bf\u7624\u5185\u7684\u7a7a\u95f4\u7ec4\u7ec7\u3002 \u4f8b\u5982\uff0c\u8fd9\u80fd\u591f\u8bc6\u522b\u5728\u8f6c\u79fb\u6027\u751f\u6001\u4f4d\u542f\u52a8\u7684\u65e9\u671f\u9636\u6bb5\u6fc0\u6d3b\u7684\u7ec4\u7ec7\u5185\u5728\u518d\u751f\u7a0b\u5e8f\uff0c \u7279\u5b9a\u80bf\u7624\u751f\u6001\u4f4d\u56fa\u6709\u7684\u8868\u578b\u72b6\u6001\u4e0e\u67d0\u4e9b\u9057\u4f20\u5f02\u5e38\u6216\u539f\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u764c\u75c7\u60a3\u8005\u4e4b\u95f4\u7684\u9057\u4f20\u5f02\u5e38\uff0c\u4e0e\u764c\u75c7\u8fdb\u5c55\u76f8\u5173\u7684\u80bf\u7624-\u57fa\u8d28\u7ec4\u6210\u53d8\u5316\uff0c\u4ee5\u53ca TME \u4e2d\u53ef\u80fd\u4e0e\u4e34\u5e8a\u7ed3\u679c\u76f8\u5173\u6216\u9884\u6d4b\u6cbb\u7597\u53cd\u5e94\u7684\u7279\u5f81\u3002\u5c3d\u7ba1\u6211\u4eec\u9884\u8ba1\u8bb8\u591a\u80bf\u7624\u6700\u7ec8\u5c06\u9002\u5408 TME \u8c03\u8282\uff0c\u4f46\u53ef\u4ee5\u60f3\u8c61\u67d0\u4e9b\u764c\u75c7\u5c06\u88ab\u8bc1\u660e\u7279\u522b\u5177\u6709\u6311\u6218\u6027\uff0c\u4f8b\u5982\u5fae\u536b\u661f\u7a33\u5b9a\u7ed3\u76f4\u80a0\u764c\u6216\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624 \uff08GBM\uff09 \u60a3\u8005\u7684\u809d\u8f6c\u79fb\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u4e9b\u5668\u5b98\u4e5f\u662f\u5728\u7a33\u6001\u6761\u4ef6\u4e0b\u53d7\u5230\u514d\u75ab\u6291\u5236\u7684\u5668\u5b98\uff0c\u8fd9\u53ef\u80fd\u4e3a\u5efa\u7acb\u6709\u6548\u7684\u514d\u75ab\u53cd\u5e94\u63d0\u4f9b\u4e86\u989d\u5916\u7684\u969c\u788d\u3002     \u5c55\u671b\u672a\u6765\uff0c\u786e\u5b9aTME\u7a7a\u95f4\u591a\u6837\u6027\u7684\u751f\u7269\u5b66\u57fa\u7840\u5c06\u975e\u5e38\u91cd\u8981\u3002\u7f3a\u6c27\u3001\u8425\u517b\u53ef\u7528\u6027\u3001\u4ee3\u8c22\u7269\u548c ECM \u7ec4\u6210\u5982\u4f55\u5f71\u54cd\u7ec6\u80de\u751f\u6001\u4f4d\u7684\u884c\u4e3a\u3002\u4f8b\u5982\uff0c\u4e86\u89e3\u80bf\u7624\u5185\u4e0d\u540c\u7ec6\u80de\u751f\u6001\u4f4d\u4e4b\u95f4\u9519\u7efc\u590d\u6742\u7684\u76f8\u4e92\u4f5c\u7528\u5bf9\u4e8e\u533a\u5206\u4fc3\u764c\u548c\u9650\u5236\u764c\u75c7\u7684\u751f\u6001\u4f4d\u81f3\u5173\u91cd\u8981\u3002\u7814\u7a76\u8fd9\u4e9b\u7ec6\u80de\u751f\u6001\u4f4d\u7684\u65f6\u95f4\u8fdb\u5316\u5c06\u6df1\u5165\u4e86\u89e3TME\u5728\u764c\u75c7\u8fdb\u5c55\u671f\u95f4\u548c\u6cbb\u7597\u5e72\u9884\u540e\u7684\u6f14\u53d8\u60c5\u51b5\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/p>\n

Embracing cancer complexity: Hallmarks of systemic disease: Cell<\/p>\n","protected":false},"excerpt":{"rendered":"

     \u56de\u987e50\u5e74\u524d\u81f3\u4eca\uff0c\u764c\u75c7\u7814\u7a76\u7684\u683c\u5c40\u5df2\u7ecf\u53d1\u751f … \u7ee7\u7eed\u9605\u8bfb →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-36178","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/36178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=36178"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/36178\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=36178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=36178"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=36178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}