{"id":35544,"date":"2024-05-31T00:01:33","date_gmt":"2024-05-31T00:01:33","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=35544"},"modified":"2024-05-31T00:01:33","modified_gmt":"2024-05-31T00:01:33","slug":"%e6%94%b9%e5%86%99%e7%bb%86%e8%83%9e%e6%ad%bb%e4%ba%a1%e6%b3%95%e5%88%99%ef%bc%9fscience%ef%bc%9a%e5%8f%91%e7%8e%b0%e7%99%8c%e7%bb%86%e8%83%9e%e6%ad%bb%e4%ba%a1%e7%9a%84%e6%96%b0%e9%80%94%e5%be%84","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=35544","title":{"rendered":"\u6539\u5199\u7ec6\u80de\u6b7b\u4ea1\u6cd5\u5219\uff1fScience\uff1a\u53d1\u73b0\u764c\u7ec6\u80de\u6b7b\u4ea1\u7684\u65b0\u9014\u5f84\u2014\u2014SLafen1\u57fa\u56e0"},"content":{"rendered":"

<\/h2>\n
  • p53<\/li>\n
  • \u5316\u7597<\/li>\n
  • Schlafen11<\/li>\n

    \u6765\u6e90\uff1a\u751f\u7269\u8c37\u539f\u521b 2024-05-29 09:48<\/p>\n

    SLafen1\u7684\u5d2d\u9732\u9762\u7eb1\uff0c\u4e3a\u6297\u764c\u6218\u5f79\u63d0\u51fa\u4e86\u65b0\u7684\u7b56\u7565\u3002Brummelkamp\u56e2\u961f\u7684\u53d1\u73b0\uff0c\u4e0d\u4ec5\u662f\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u7bc7\u7ae0\uff0c\u66f4\u662f\u57fa\u56e0\u63a2\u7d22\u7684\u91cc\u7a0b\u7891\uff0c\u4e3a\u540e\u7eed\u7814\u7a76\u6307\u660e\u4e86\u65b9\u5411\u3002<\/p>\n

    \u5728\u6297\u764c\u6218\u5f79\u7684\u6f2b\u957f\u5f81\u9014\u4e2d\uff0c\u5316\u7597\u4f5c\u4e3a\u4f20\u7edf\u6b66\u5668\uff0c\u5176\u65a9\u6740\u764c\u7ec6\u80de\u7684\u673a\u5236\u4f3c\u4e4e\u85cf\u533f\u7740\u672a\u89e3\u4e4b\u8c1c\u3002\u8377\u5170\u764c\u75c7\u7814\u7a76\u6240\u7684Thijn Brummelkamp\u53ca\u5176\u540c\u4e8b\u4eec\u53d1\u73b0\u4e86\u4e00\u79cd\u5168\u65b0\u7684\u764c\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\uff1a\u7531 Schlafen11 \u57fa\u56e0\u5bfc\u81f4\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u57282024\u5e745\u670817\u65e5\u7684Science\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cDNA damage induces p53-independent apoptosis through ribosome stalling\u201d\u3002<\/p>\n<\/p>\n

    \u201c\u8fd9\u662f\u4e00\u4e2a\u975e\u5e38\u51fa\u4eba\u610f\u6599\u7684\u53d1\u73b0\u3002\u764c\u75c7\u60a3\u8005\u63a5\u53d7\u5316\u7597\u5df2\u6709\u8fd1\u4e00\u4e2a\u4e16\u7eaa\u7684\u5386\u53f2\uff0c\u4f46\u8fd9\u79cd\u7ec6\u80de\u6b7b\u4ea1\u9014\u5f84\u4ee5\u524d\u4ece\u672a\u88ab\u89c2\u5bdf\u5230\u3002\u60a3\u8005\u5728\u4f55\u65f6\u4f55\u5730\u51fa\u73b0\u8fd9\u79cd\u60c5\u51b5\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u3002\u8fd9\u4e00\u53d1\u73b0\u6700\u7ec8\u53ef\u80fd\u4f1a\u5bf9\u764c\u75c7\u60a3\u8005\u7684\u6cbb\u7597\u4ea7\u751f\u5f71\u54cd\u3002\u201d<\/p>\n

    \u8bb8\u591a\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\u90fd\u4f1a\u635f\u4f24\u7ec6\u80de DNA\u3002\u5728\u53d7\u5230\u8fc7\u591a\u65e0\u6cd5\u5f25\u8865\u7684\u635f\u4f24\u540e\uff0c\u7ec6\u80de\u4f1a\u81ea\u884c\u6b7b\u4ea1\u3002\u9ad8\u4e2d\u751f\u7269\u5b66\u544a\u8bc9\u6211\u4eec\uff0cp53 \u86cb\u767d\u8d1f\u8d23\u8fd9\u4e00\u8fc7\u7a0b\u3002p53 \u786e\u4fdd\u4fee\u590d\u53d7\u635f\u7684 DNA\uff0c\u4f46\u5f53\u635f\u4f24\u53d8\u5f97\u8fc7\u4e8e\u4e25\u91cd\u65f6\uff0c\u5c31\u4f1a\u542f\u52a8\u7ec6\u80de\u81ea\u6740\u3002\u8fd9\u53ef\u4ee5\u9632\u6b62\u7ec6\u80de\u5206\u88c2\u5931\u63a7\u548c\u764c\u75c7\u5f62\u6210\u3002<\/p>\n

    \u9707\u60ca\uff01\u60ac\u800c\u672a\u51b3\u7684\u95ee\u9898<\/p>\n

    \u8fd9\u542c\u8d77\u6765\u50cf\u662f\u4e00\u4e2a\u4e07\u65e0\u4e00\u5931\u7684\u7cfb\u7edf\uff0c\u4f46\u5b9e\u9645\u60c5\u51b5\u5374\u66f4\u4e3a\u590d\u6742\u3002Brummelkamp \u8bf4\uff0c\u201c\u5728\u4e00\u534a\u4ee5\u4e0a\u7684\u80bf\u7624\u4e2d\uff0cp53 \u4e0d\u518d\u8d77\u4f5c\u7528\u3002\u5173\u952e\u57fa\u56e0 p53 \u5728\u5176\u4e2d\u4e0d\u8d77\u4efb\u4f55\u4f5c\u7528\u3002\u90a3\u4e48\uff0c\u4e3a\u4ec0\u4e48\u6ca1\u6709 p53 \u7684\u764c\u7ec6\u80de\u5728\u5316\u7597\u6216\u653e\u7597\u7834\u574f\u5176 DNA \u65f6\u4ecd\u7136\u4f1a\u6b7b\u4ea1\u5462\uff1f\u4ee4\u6211\u60ca\u8bb6\u7684\u662f\uff0c\u8fd9\u7adf\u7136\u662f\u4e00\u4e2a\u6ca1\u6709\u7b54\u6848\u7684\u95ee\u9898\u3002\u201d<\/p>\n

    \u968f\u540e\uff0c\u4ed6\u7684\u7814\u7a76\u56e2\u961f\u4e0e\u4ed6\u7684\u540c\u4e8bReuven Agami\u7684\u7814\u7a76\u56e2\u961f\u4e00\u8d77\uff0c\u53d1\u73b0\u4e86\u4e00\u79cd\u4ee5\u524d\u672a\u77e5\u7684\u7ec6\u80de\u5728 DNA \u53d7\u635f\u540e\u6b7b\u4ea1\u7684\u65b9\u5f0f\u3002\u5728\u5b9e\u9a8c\u5ba4\u91cc\uff0c\u4ed6\u4eec\u5bf9\u7ec6\u80de\u8fdb\u884c\u4e86\u5316\u7597\uff0c\u5e76\u5bf9\u5176\u4e2d\u7684DNA\u8fdb\u884c\u4e86\u4ed4\u7ec6\u6bd4\u5bf9\u3002Brummelkamp\u8bf4\uff0c\u201c\u6211\u4eec\u4e00\u76f4\u5728\u5bfb\u627e\u4e00\u79cd\u80fd\u8ba9\u7ec6\u80de\u5728\u5316\u7597\u4e2d\u5b58\u6d3b\u4e0b\u6765\u7684\u9057\u4f20\u6539\u53d8\u3002\u6211\u4eec\u7684\u56e2\u961f\u5728\u9009\u62e9\u6027\u8ba9\u57fa\u56e0\u5931\u6d3b\u65b9\u9762\u6709\u5f88\u591a\u7ecf\u9a8c\uff0c\u6211\u4eec\u5b8c\u5168\u53ef\u4ee5\u5c06\u5176\u5e94\u7528\u4e8e\u6b64\u3002\u201d<\/p>\n

    \u7ec6\u80de\u6b7b\u4ea1\u4e2d\u7684\u65b0\u5173\u952e\u89d2\u8272<\/p>\n

    \u901a\u8fc7\u9009\u62e9\u6027\u4f7f\u7279\u5b9a\u57fa\u56e0\u5931\u6548\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u4ee5 Schlafen11\uff08SLFN11\uff09\u57fa\u56e0\u4e3a\u9996\u7684\u7ec6\u80de\u6b7b\u4ea1\u65b0\u9014\u5f84\u3002\u8bba\u6587\u7b2c\u4e00\u4f5c\u8005Nicolaas Boon\u8bf4\uff0c\u201c\u5728DNA\u53d7\u635f\u7684\u60c5\u51b5\u4e0b\uff0cSLFN11\u4f1a\u5173\u95ed\u7ec6\u80de\u7684\u86cb\u767d\u5236\u9020\u5de5\u5382\uff1a\u6838\u7cd6\u4f53\u3002\u8fd9\u4f1a\u7ed9\u8fd9\u4e9b\u7ec6\u80de\u9020\u6210\u5de8\u5927\u538b\u529b\uff0c\u5bfc\u81f4\u5b83\u4eec\u6b7b\u4ea1\u3002\u6211\u4eec\u53d1\u73b0\u7684\u8fd9\u4e2a\u65b0\u9014\u5f84\u5b8c\u5168\u7ed5\u8fc7\u4e86 p53\u3002\u201d<\/p>\n

    SLFN11 \u57fa\u56e0\u5728\u764c\u75c7\u7814\u7a76\u4e2d\u5e76\u4e0d\u964c\u751f\u3002Brummelkamp\u8bf4\uff0c\u5728\u5bf9\u5316\u7597\u6ca1\u6709\u53cd\u5e94\u7684\u60a3\u8005\u7684\u80bf\u7624\u4e2d\uff0cSLFN11 \u57fa\u56e0\u7ecf\u5e38\u5904\u4e8e\u975e\u6d3b\u6027\u72b6\u6001\u3002\u201c\u6211\u4eec\u5982\u4eca\u53ef\u4ee5\u89e3\u91ca\u8fd9\u79cd\u8054\u7cfb\u4e86\u3002\u5f53\u7ec6\u80de\u7f3a\u4e4f SLFN11 \u65f6\uff0c\u5b83\u4eec\u4e0d\u4f1a\u4ee5\u8fd9\u79cd\u65b9\u5f0f\u5bf9 DNA \u635f\u4f24\u505a\u51fa\u53cd\u5e94\u800c\u6b7b\u4ea1\u3002\u7ec6\u80de\u4f1a\u5b58\u6d3b\u4e0b\u6765\uff0c\u764c\u75c7\u4e5f\u4f1a\u6301\u7eed\u5b58\u5728\u3002\u201d<\/p>\n

    \u5bf9\u764c\u75c7\u6cbb\u7597\u7684\u5f71\u54cd<\/p>\n

    Brummelkamp\u8bf4\uff0c\u201c\u8fd9\u4e00\u53d1\u73b0\u63ed\u793a\u4e86\u8bb8\u591a\u65b0\u7684\u7814\u7a76\u95ee\u9898\u3002\u6211\u4eec\u5728\u5b9e\u9a8c\u5ba4\u57f9\u517b\u7684\u764c\u7ec6\u80de\u4e2d\u8bc1\u5b9e\u4e86\u6211\u4eec\u7684\u53d1\u73b0\uff0c\u4f46\u4ecd\u5b58\u5728\u8bb8\u591a\u91cd\u8981\u95ee\u9898\uff1a\u8fd9\u6761\u9014\u5f84\u5728\u60a3\u8005\u4f53\u5185\u4f55\u65f6\u4f55\u5730\u51fa\u73b0\uff1f\u5b83\u5bf9\u514d\u75ab\u7597\u6cd5\u6216\u5316\u7597\u6709\u4f55\u5f71\u54cd\uff1f\u5b83\u662f\u5426\u4f1a\u5f71\u54cd\u764c\u75c7\u6cbb\u7597\u7684\u526f\u4f5c\u7528\uff1f\u5982\u679c\u4e8b\u5b9e\u8bc1\u5b9e\u8fd9\u79cd\u7ec6\u80de\u6b7b\u4ea1\u5f62\u5f0f\u5728\u60a3\u8005\u4f53\u5185\u4e5f\u8d77\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u90a3\u4e48\u8fd9\u4e00\u53d1\u73b0\u5c06\u4f1a\u5bf9\u764c\u75c7\u6cbb\u7597\u4ea7\u751f\u5173\u952e\u7684\u5f71\u54cd\uff0c\u800c\u8fd9\u4e9b\u90fd\u662f\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u7684\u91cd\u8981\u95ee\u9898\u3002\u201d<\/p>\n

    \u9010\u4e2a\u5173\u95ed\u57fa\u56e0<\/p>\n

    \u4eba\u7c7b\u6709\u6210\u5343\u4e0a\u4e07\u4e2a\u57fa\u56e0\uff0c\u5176\u4e2d\u8bb8\u591a\u57fa\u56e0\u7684\u529f\u80fd\u6211\u4eec\u5e76\u4e0d\u6e05\u695a\u3002\u4e3a\u4e86\u786e\u5b9a\u4eba\u7c7b\u57fa\u56e0\u7684\u4f5c\u7528\uff0cBrummelkamp\u5f00\u53d1\u4e86\u4e00\u79cd\u4f7f\u7528\u5355\u500d\u4f53\u7ec6\u80de\u7684\u65b9\u6cd5\u3002\u8fd9\u4e9b\u7ec6\u80de\u53ea\u5305\u542b\u6bcf\u4e2a\u57fa\u56e0\u7684\u4e00\u4e2a\u62f7\u8d1d\uff0c\u4e0e\u6211\u4eec\u4f53\u5185\u5305\u542b\u6bcf\u4e2a\u57fa\u56e0\u4e24\u4e2a\u62f7\u8d1d\u7684\u666e\u901a\u7ec6\u80de\u4e0d\u540c\u3002\u5728\u9057\u4f20\u5b9e\u9a8c\u4e2d\uff0c\u5904\u7406\u4e24\u4e2a\u62f7\u8d1d\u662f\u4e00\u9879\u6311\u6218\uff0c\u56e0\u4e3a\u53d8\u5316\uff08\u7a81\u53d8\uff09\u5f80\u5f80\u53ea\u53d1\u751f\u5728\u5176\u4e2d\u7684\u4e00\u4e2a\u62f7\u8d1d\u4e2d\u3002\u8fd9\u6837\u5c31\u5f88\u96be\u89c2\u5bdf\u5230\u8fd9\u4e9b\u7a81\u53d8\u7684\u5f71\u54cd\u3002<\/p>\n<\/p>\n

    \u56fe\u7247\u6765\u81eaScience, 2024, doi:10.1126\/science.adh7950<\/p>\n

    \u591a\u5e74\u6765\uff0cBrummelkamp\u4e0e\u5176\u4ed6\u4eba\u4e00\u8d77\uff0c\u5229\u7528\u8fd9\u79cd\u591a\u7528\u9014\u65b9\u6cd5\u63ed\u793a\u4e86\u5bf9\u75be\u75c5\u81f3\u5173\u91cd\u8981\u7684\u8fc7\u7a0b\u3002\u4f8b\u5982\uff0c\u4ed6\u7684\u56e2\u961f\u8fd1\u671f\u5df2\u53d1\u73b0\uff0c\u7ec6\u80de\u5236\u9020\u8102\u8d28\u7684\u65b9\u5f0f\u4e0e\u4e4b\u524d\u5df2\u77e5\u7684\u4e0d\u540c\u3002<\/p>\n

    \u4ed6\u4eec\u63ed\u793a\u4e86\u67d0\u4e9b\u75c5\u6bd2\uff08\u5305\u62ec\u81f4\u547d\u7684\u57c3\u535a\u62c9\u75c5\u6bd2\uff09\u662f\u5982\u4f55\u8fdb\u5165\u4eba\u4f53\u7ec6\u80de\u7684\u3002\u4ed6\u4eec\u6df1\u5165\u7814\u7a76\u4e86\u764c\u7ec6\u80de\u5bf9\u7279\u5b9a\u7597\u6cd5\u7684\u62b5\u6297\u6027\uff0c\u5e76\u786e\u5b9a\u4e86\u5bf9\u514d\u75ab\u7cfb\u7edf\u8d77\u5236\u52a8\u4f5c\u7528\u7684\u86cb\u767d\uff0c\u8fd9\u4e0e\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u606f\u606f\u76f8\u5173\u3002<\/p>\n

    \u5728\u8fc7\u53bb\u51e0\u5e74\u4e2d\uff0c\u4ed6\u7684\u56e2\u961f\u53d1\u73b0\u4e86\u56db\u5341\u5e74\u6765\u4e00\u76f4\u96be\u4ee5\u6349\u6478\u7684\u4e24\u79cd\u9176\uff0c\u800c\u8fd9\u4e24\u79cd\u9176\u5bf9\u808c\u8089\u529f\u80fd\u548c\u5927\u8111\u53d1\u80b2\u81f3\u5173\u91cd\u8981\u3002<\/p>\n

    \u7efc\u4e0a\u6240\u8ff0\uff0cSLafen1\u7684\u5d2d\u9732\u9762\u7eb1\uff0c\u4e3a\u6297\u764c\u6218\u5f79\u63d0\u51fa\u4e86\u65b0\u7684\u7b56\u7565\u3002Brummelkamp\u56e2\u961f\u7684\u53d1\u73b0\uff0c\u4e0d\u4ec5\u662f\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u7bc7\u7ae0\uff0c\u66f4\u662f\u57fa\u56e0\u63a2\u7d22\u7684\u91cc\u7a0b\u7891\uff0c\u4e3a\u540e\u7eed\u7814\u7a76\u6307\u660e\u4e86\u65b9\u5411\u3002\uff08\u751f\u7269\u8c37Bioon.com\uff09<\/p>\n

    \u53c2\u8003\u8d44\u6599\uff1a<\/p>\n

    Nicolaas J. Boon et al. DNA damage induces p53-independent apoptosis through ribosome stalling. Science, 2024, doi:10.1126\/science.adh7950.<\/p>\n

    Researchers discover new pathway to cancer cell suicidehttps:\/\/www.\/en\/news\/2024\/researchers-discover-new-pathway-to-cancer-cell-suicide\/<\/p>\n<\/tbody>\n

    365\u7bc7” title=”\u5feb\u901f\u627e\u5230\u4eba\u4f53\u7684\u5404\u4e2a\u7a74\u4f4d 365\u7bc7” style=”border-width: initial; border-style: none; margin: 0pt auto; padding: 0px; max-width: 100%; vertical-align: top; display: block;”>365\u7bc7” title=”\u5feb\u901f\u627e\u5230\u4eba\u4f53\u7684\u5404\u4e2a\u7a74\u4f4d 365\u7bc7” style=”border-width: initial; border-style: none; margin: 0pt auto; padding: 0px; max-width: 100%; vertical-align: top; display: block;”><\/p>\n","protected":false},"excerpt":{"rendered":"

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