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\n

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\u8bba\u6587ID<\/p>\n

\u539f\u540d\uff1aGut microbiota-metabolic axis insight into the
\nhyperlipidemic effect of lotus seed resistant starch in hyperlipidemic mice\u8bd1\u540d\uff1a\u80a0\u9053\u5fae\u751f\u7269\u4ee3\u8c22\u8f74\u89e3\u6790\u83b2\u5b50\u6297\u6027\u6dc0\u7c89\u5bf9\u9ad8\u8102\u8840\u75c7\u5c0f\u9f20\u7684\u6297\u9ad8\u8102\u8840\u4f5c\u7528\u671f\u520a\uff1aCarbohydrate PolymersIF\uff1a10.723\u53d1\u8868\u65f6\u95f4\uff1a2023.04\u901a\u8baf\u4f5c\u8005\uff1a\u5f20\u6021\uff0c\u66fe\u7ea2\u4eae\u901a\u8baf\u4f5c\u8005\u5355\u4f4d\uff1a\u798f\u5efa\u519c\u6797\u5927\u5b66<\/p>\n

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\n0.73\uff0cMLRS 0.57\uff0cHLRS 0.95\uff09\u3002\u76f8\u5173\u7814\u7a76\u8868\u660e\uff0c\u539a\u58c1\u83cc\u95e8\u548c\u62df\u6746\u83cc\u95e8\u4e0e\u7cd6\u8102\u4ee3\u8c22\u548c\u80c6\u6c41\u9178\u4ee3\u8c22\u5bc6\u5207\u76f8\u5173\uff0c\u5b83\u4eec\u7684\u6bd4\u4f8b\uff08\u539a\u58c1\u83cc\/\u62df\u6746\u83cc\uff0cF\/B\uff09\u5df2\u6210\u4e3a\u51b3\u5b9a\u80a5\u80d6\u7684\u6307\u6807\u4e4b\u4e00\u3002F\/B\u6bd4\u7387\u8d8a\u9ad8\uff0c\u80a0\u9053\u8d8a\u5bb9\u6613\u5438\u6536\u80fd\u91cf\uff0c\u800cF\/B\u6bd4\u7387\u6108\u4f4e\uff0c\u80a0\u9053\u5438\u6536\u80fd\u91cf\u8d8a\u6162\uff0c\u4ece\u800c\u6709\u52a9\u4e8e\u964d\u4f4e\u8102\u8d28\u3002\u6839\u636e\u6211\u4eec\u7684\u53d1\u73b0\uff0c\u4e0eLLRS\u548cHLRS\u7ec4\u76f8\u6bd4\uff0cMLRS\u7ec4\u539a\u58c1\u83cc\u95e8\u7684\u4e30\u5ea6\u6700\u4f4e\uff0c\u62df\u6746\u83cc\u95e8\u7684\u4e30\u5ea6\u6700\u9ad8\uff0cF\/B\u6bd4\u7387\u4e5f\u6700\u4f4e\uff0c\u8868\u660e\u5728\u4e0d\u540c\u5242\u91cf\u7ec4\u4e2d\uff0c\u4e2d\u5242\u91cfLRS\u5728\u964d\u4f4eF\/B\u6bd4\u7387\u65b9\u9762\u6548\u679c\u6700\u597d\uff0c\u5bf9\u80a0\u9053\u80fd\u91cf\u7684\u5f71\u54cd\u6700\u4e3a\u663e\u8457\u3002\u56e0\u6b64\uff0cMLRS\u53ef\u80fd\u5177\u6709\u66f4\u597d\u7684\u964d\u8840\u8102\u6548\u679c\u3002<\/p>\n<\/p>\n

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\u7ec6\u83cc\u7c7b\u578b\u7684\u5c5e\u6c34\u5e73\u7ec4\u6210\u5982\u56fe3C\u6240\u793a\uff0c\u5747\u4e3a\u603b\u4e30\u5ea6\u6bd4>0.01\u7684\u7ec6\u83cc\u7c7b\u578b\u3002norank_f_Muribaculaceae\u3001Allobaculum\u3001Faecalibaculum\u3001norank_f_Desulfovibrionaceae\u548cnorank_f_Eubacterium_coprostanoligenes_group\u5728\u5c5e\u6c34\u5e73\u4e0a\u5360\u603b\u7269\u79cd\u7684\u5927\u591a\u6570\uff0c\u7ea6\u5360\u5404\u7ec4\u5fae\u751f\u7269\u768430%-80%\uff0c\u5c5e\u4e8e\u5c5e\u6c34\u5e73\u4e0a\u7684\u4f18\u52bf\u83cc\u7fa4\u3002\u4e0eNC\u7ec4\u76f8\u6bd4\uff0cMC\u7ec4\u5177\u6709\u66f4\u9ad8\u7684Allobaculum\u4e30\u5ea6\u548c\u66f4\u4f4e\u7684norank_f_Muribaculaceae\u4e30\u5ea6\uff08\u56fe3C\uff0cD\uff09\u3002\u7136\u800c\uff0c\u4e0eMC\u7ec4\u76f8\u6bd4\uff0cLRS\u663e\u8457\u6062\u590d\u4e86\u8fd9\u4e9b\u83cc\u7684\u4e30\u5ea6\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e0eLLRS\u548cHLRS\u7ec4\u76f8\u6bd4\uff0cMLRS\u7ec4\u7684Allobaculum\u4e30\u5ea6\u6700\u4f4e\uff0cnorank_f_Muribaculaceae\u4e30\u5ea6\u6700\u9ad8\uff08\u56fe3D\uff09\u3002Cao\u7b49\u4eba\u53d1\u73b0\uff0c\u5bf9HFD\u8bf1\u5bfc\u7684\u80a5\u80d6\u5177\u6709\u6297\u6027\u7684\u5c0f\u9f20\u80a0\u9053\u83cc\u7fa4\u4e2dMuribaculaceae\u7684\u6bd4\u4f8b\u9ad8\u4e8e\u5176\u4ed6\u5c0f\u9f20\u3002\u6b64\u5916\uff0c\u5728\u95e8\u548c\u5c5e\u6c34\u5e73\u4e0a\uff0cLRS\u5bf9\u9ad8\u8102\u8840\u75c7\u5c0f\u9f20\u5fae\u751f\u7269\u7fa4\u7ec4\u6210\u7684\u5f71\u54cd\u4e0ePC\u7ec4\u4e0d\u540c\uff0c\u8fd9\u53ef\u80fd\u4e0eLRS\u6539\u5584\u9ad8\u8102\u8840\u75c7\u7684\u673a\u5236\u6709\u5173\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cLRS\u53ef\u4ee5\u663e\u8457\u6539\u53d8HFD\u5f15\u8d77\u7684\u80a0\u9053\u5fae\u751f\u7269\u7ed3\u6784\uff0c\u4e2d\u7b49\u5242\u91cf\u7684LRS\u8865\u5145\u53ef\u80fd\u6709\u52a9\u4e8e\u63d0\u9ad8\u5c0f\u9f20\u7684\u80a5\u80d6\u62b5\u6297\u529b\u3002<\/p>\n<\/p>\n

\u56fe4 \u7269\u79cd\u5dee\u5f02\u5206\u6790\u3002\uff08A\uff09NC\u4e0eMC\uff0c\uff08B\uff09MC\u4e0eLLRS\uff0c\uff08C\uff09MC\u4e0eMLRS\uff0c\uff08D\uff09MC\u4e0eHLRS\uff0c\uff08E\uff09MC\u4e0ePC\u30024. \u5404\u7ec4\u95f4\u80a0\u9053\u83cc\u7fa4\u5dee\u5f02\u5206\u6790<\/p>\n

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\u56fe5 \u4ee3\u8c22\u56fe\u8c31\uff1a\uff08A\uff09\u6b63\u79bb\u5b50\u6a21\u5f0f\u7535\u6d41\u56fe\uff0c\uff08B\uff09\u8d1f\u79bb\u5b50\u6a21\u5f0f\u7535\u6d41\u66f2\u7ebf\u56fe\u3002PLS-DA\u8bc4\u5206\u56fe\uff1a\uff08C\uff09\u6b63\u79bb\u5b50\uff0c\uff08D\uff09\u8d1f\u79bb\u5b50\u3002\uff08E\uff09\u603b\u5dee\u5f02\u4ee3\u8c22\u7269\u7684\u7ef4\u6069\u56fe\uff0c\uff08F\uff09\u5b9e\u9a8c\u7ec4\u4e2d\u5dee\u5f02\u4ee3\u8c22\u7269\u7684\u7ef4\u6069\u56fe\u3002<\/p>\n

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\u6b63\uff08\u56fe5A\uff09\u548c\u8d1f\uff08\u56fe5B\uff09\u79bb\u5b50\u7535\u6d41\u56fe\u663e\u793a\uff0c\u5728\u672c\u5b9e\u9a8c\u7684\u68c0\u6d4b\u6761\u4ef6\u4e0b\uff0c\u5cf0\u503c\u5f62\u72b6\u662f\u53ef\u63a5\u53d7\u7684\uff0c\u5206\u5e03\u76f8\u5bf9\u5747\u5300\u3002\u6211\u4eec\u5bf9\u6240\u6709\u7ec4\u7684\u7ed3\u80a0\u5185\u5bb9\u7269\u6837\u672c\u8fdb\u884cPLS-DA\u5206\u6790\uff0c\u9009\u62e995%\u7f6e\u4fe1\u533a\u95f4\uff0c\u5e76\u901a\u8fc7Pareto\u8f6c\u6362\u8fdb\u884c\u6570\u636e\u8f6c\u6362\u3002\u5982\u56fe5C\uff0cD\u6240\u793a\uff0cNC\u7ec4\u7684\u6837\u54c1\u4e0e\u5176\u4ed6\u7ec4\u5206\u79bb\uff0c\u5176\u4f59\u7ec4\u7684\u6837\u54c1\u7d27\u5bc6\u805a\u96c6\uff0c\u8868\u660eNC\u7ec4\u7684\u80a0\u9053\u4ee3\u8c22\u4ea7\u7269\u7ec4\u6210\u4e0e\u5176\u4ed6\u7ec4\u6709\u663e\u8457\u5dee\u5f02\uff0c\u800c\u5176\u4ed6\u7ec4\u7684\u6837\u54c1\u5219\u7d27\u5bc6\u805a\u96c6\uff0c\u5177\u6709\u826f\u597d\u7684\u7ec4\u5185\u91cd\u590d\u6027\u3002\u56e0\u6b64\uff0c\u8be5\u65b9\u6cd5\u662f\u53ef\u9760\u7684\uff0c\u7ed3\u679c\u662f\u53ef\u9760\u7684\u3002<\/p>\n

\u88681 \u4e0d\u540c\u7ec4\u5c0f\u9f20\u7ed3\u80a0\u4ee3\u8c22\u7269\u7684\u5dee\u5f02<\/p>\n

\u5404\u7ec4\u548cMC\u7ec4\u4e4b\u95f4\u5177\u6709\u663e\u8457\u5dee\u5f02\u7684\u4ee3\u8c22\u7269\u6570\u91cf\u4e4b\u95f4\u7684\u5173\u7cfb\u5982\u56fe5E\u6240\u793a\u3002\u5dee\u5f02\u4ee3\u8c22\u7269\u7684\u603b\u6570\u53ea\u6709\u4e00\u4e2a\uff0c\u800cNC\u4e0eMC\u3001LLRS\u4e0eMC\u3001MLRS\u4e0eMC\uff0cHLRS\u4e0eMC\u548cPC\u4e0eMC\u4e4b\u95f4\u7684\u72ec\u7279\u5dee\u5f02\u4ee3\u8c22\u7269\u7684\u6570\u91cf\u5206\u522b\u4e3a350\u300178\u300176\u300115\u548c129\u4e2a\u3002\u5b9e\u9a8c\u7ec4\u548c\u6a21\u578b\u7ec4\u4e4b\u95f4\u5171\u4eab\u7684\u5dee\u5f02\u4ee3\u8c22\u4ea7\u7269\u7684\u6570\u91cf\u4e3a12\uff08\u56fe5F\uff09\uff0c\u800cLLRS vs MC\u7279\u6709135\u4e2a\uff0cMLRS vs MC\u7279\u6709127\u4e2a\uff0cHLRS vs MC\u7279\u670966\u4e2a\u3002<\/p>\n

6. \u9274\u522b\u5dee\u5f02\u4ee3\u8c22\u7269<\/p>\n

\u53cc\u79bb\u5b50\u6a21\u5f0f\u4e0b\u5dee\u5f02\u4ee3\u8c22\u7269\u7684\u706b\u5c71\u56fe\u5982\u56fe6A\u2013E\u6240\u793a\u3002\u6211\u4eec\u5bf9\u6c34\u5e73\u548c\u5782\u76f4\u5750\u6807\u503c\u8fdb\u884c\u4e86\u6570\u503c\u5904\u7406\u3002\u6c34\u5e73\u5750\u6807\u8868\u793a\u4e24\u7ec4\u4ee3\u8c22\u4ea7\u7269\u8868\u8fbe\u5dee\u5f02\u7684\u500d\u6570\u53d8\u5316\u503c\uff0c\u5373log2FC\uff08FC:\u500d\u6570\u53d8\u5316\uff09\uff0c\u5782\u76f4\u5750\u6807\u8868\u793a\u4ee3\u8c22\u4ea7\u7269\u8868\u8fbe\u5dee\u503c\u7684\u7edf\u8ba1\u68c0\u9a8c\u503c\uff0c\u5373-log10\uff08P\u503c\uff09\u3002\u5728p\uff1c0.05\u3001VIP\uff08\u53d8\u91cf\u6295\u5f71\u91cd\u8981\u6027\uff09\uff1e1\u548cFC\uff1e1\u6216\uff1c1\u7684\u6761\u4ef6\u4e0b\uff0c\u6211\u4eec\u68c0\u9a8c\u4e86\u6240\u6709\u4ee3\u8c22\u4ea7\u7269\u5e76\u4e0eKEGG\u6570\u636e\u5e93\u8fdb\u884c\u6bd4\u8f83\uff0c\u603b\u5171\u786e\u5b9a\u4e8612\u79cd\u6709\u673a\u9178\u53ca\u5176\u884d\u751f\u7269\u300133\u79cd\u80c6\u6c41\u9178\u53ca\u5176\u884d\u751f\u7269\u548c71\u79cd\u8102\u80aa\u9178\u53ca\u5176\u5076\u8054\u7269\u3002\u6211\u4eec\u6839\u636e\u4e0a\u8ff0\u4e09\u79cd\u6807\u5fd7\u6027\u4ee3\u8c22\u4ea7\u7269\uff08\u6709\u673a\u9178\u53ca\u5176\u884d\u751f\u7269\u3001\u80c6\u6c41\u9178\u53ca\u5176\u884d\u751f\u7269\u548c\u8102\u80aa\u9178\u53ca\u5176\u5076\u8054\u7269\uff09\u5206\u522b\u6784\u5efa\u5404\u7ec4\u7684\u4ee3\u8c22\u8c31\uff0c\u5e76\u6bd4\u8f83\u4e24\u7ec4\u4e4b\u95f4\u4ee3\u8c22\u7269\u7684\u5dee\u5f02\uff0c\u5bf952\u79cd\u5dee\u5f02\u4ee3\u8c22\u4ea7\u7269\u8fdb\u884c\u8bc4\u5206\u3002\u9009\u62e9\u768452\u79cd\u5dee\u5f02\u4ee3\u8c22\u7269\u5982\u88681\u6240\u793a\u3002\u80c6\u6c41\u9178\u3001\u9187\u7c7b\u548c\u884d\u751f\u7269\u4ee5\u53ca\u7fa7\u9178\u548c\u884d\u751f\u7269\u4e3b\u8981\u5c5e\u4e8eKEGG\u5206\u7c7b\uff08\u88681\uff09\u3002\u7814\u7a76\u8868\u660e\uff0c\u80c6\u6c41\u9178\u884d\u751f\u7269\u3001\u8102\u80aa\u9178\u5076\u8054\u7269\u548c\u7fa7\u9178\u5316\u5408\u7269\uff08\u4e59\u9178\u548c\u7532\u9178\uff09\u53ef\u80fd\u6709\u52a9\u4e8e\u6539\u5584\u9ad8\u8102\u8840\u75c7\u3002<\/p>\n<\/p>\n

\u56fe7 \u5dee\u5f02\u4ee3\u8c22\u7269KEGG\u5bcc\u96c6\u5206\u6790\u6c14\u6ce1\u56fe\uff1a\uff08A\uff09NC\u4e0eMC\uff0c\uff08B\uff09MC\u4e0eLLRS\uff0c\uff08C\uff09MC\u4e0eMLRS\uff0c\uff08D\uff09MC\u4e0eHLRS\u3002<\/p>\n

\u6b64\u5916\uff0c\u4e0eNC\u7ec4\u76f8\u6bd4\uff0cMC\u7ec4\u5c0f\u9f20\u7ed3\u80a0\u4e2d\u7684\u7518\u6c28\u718a\u53bb\u6c27\u80c6\u9178\uff08GUDCA\uff09\u3001\u03b1-MCA\u548c\u725b\u78fa\u9178\u8131\u6c27\u80c6\u9178\uff08TUDCA\uff09\u7684\u542b\u91cf\u5747\u4e0a\u8c03\uff08P<0.05\uff09\u3002\u6211\u4eec\u7684\u53d1\u73b0\u8868\u660e\uff0cHFD\u5f71\u54cd\u5c0f\u9f20\u7ed3\u80a0\u4e2d\u80c6\u6c41\u9178\u548c\u8102\u80aa\u9178\u7684\u4ee3\u8c22\u3002UDCA\u548c\u03b1-MCA\u662f\u75316\u03b2-\u7f9f\u5316\u9176\u8f6c\u5316\u5c0f\u9f20\u809d\u810f\u4e2d\u7684\u80c6\u56fa\u9187\u5f62\u6210\u7684\u521d\u7ea7\u80c6\u6c41\u9178\u3002\u56e0\u6b64\uff0cG\/T-UDCA\u548c\u03b1-MCA\u542b\u91cf\u7684\u589e\u52a0\u4e5f\u8868\u660eMC\u7ec4\u7684\u80c6\u56fa\u9187\u542b\u91cf\u8f83\u9ad8\u3002<\/p>\n

\u4e0eMC\u7ec4\u76f8\u6bd4\uff0cLLRS\u7ec4\u5c0f\u9f20\u7ed3\u80a0\u4e2d\u80c6\u9178\uff08CA\uff09\u548c\u7532\u9178\u7684\u542b\u91cf\u4e0a\u8c03\uff0c\u800c\u03b1-MCA\u3001\u718a\u53bb\u6c27\u80c6\u9178\uff08UDCA\uff09\u548c\u8131\u6c27\u80c6\u9178\uff08DCA\uff09\u7684\u542b\u91cf\u4e0b\u8c03\uff08P<0.05\uff09\u3002CA\u5728\u809d\u810f\u4e2d\u7531\u80c6\u56fa\u9187\u8f6c\u5316\u800c\u6765\uff0c\u8fdb\u5165\u80a0\u9053\u540e\u53ef\u88ab\u80a0\u9053\u5fae\u751f\u7269\u4ee3\u8c22\u4e3aDCA\u3002UDCA\u6765\u6e90\u4e8e\u809d\u810f\u4e2d\u76846-\u7f9f\u5316\u9176\u8f6c\u5316\u7684\u9e45\u53bb\u6c27\u80c6\u9178\uff08CDCA\uff09\u6216\u80a0\u9053\u4e2d\u7684\u5fae\u751f\u7269\u4ee3\u8c22\u7684CDCA\u3002\u76f8\u5173\u7814\u7a76\u8868\u660e\uff0c\u81b3\u98df\u7ea4\u7ef4\u53ef\u4ee5\u901a\u8fc7\u5305\u88f9\u6b21\u7ea7\u80c6\u6c41\u9178\uff08DCA\u6216\u77f3\u80c6\u9178\uff08LCA\uff09\uff09\u8fdb\u884c\u6392\u6cc4\uff0c\u4ece\u800c\u4fc3\u8fdb\u80c6\u56fa\u9187\u5206\u89e3\u4ee3\u8c22\u4e3a\u521d\u7ea7\u80c6\u6c41\u9178\uff0c\u5e76\u8d77\u5230\u964d\u4f4e\u8840\u8102\u7684\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u7532\u9178\u4f5c\u4e3a\u4e00\u79cd\u77ed\u94fe\u8102\u80aa\u9178\uff0c\u5df2\u88ab\u5e7f\u6cdb\u8bc1\u5b9e\u4e0e\u6297\u80a5\u80d6\u3001\u7f13\u89e3\u4ee3\u8c22\u7efc\u5408\u5f81\u548c\u80a0\u9053\u5c4f\u969c\u6709\u5173\u3002\u56e0\u6b64\uff0cLLRS\u7684\u6444\u5165\u53ef\u4ee5\u4fc3\u8fdb\u9ad8\u8102\u8840\u75c7\u5c0f\u9f20\u80c6\u56fa\u9187\u7684\u5206\u89e3\u4ee3\u8c22\u548c\u6b21\u751f\u80c6\u6c41\u9178\u7684\u6392\u6cc4\uff0c\u4ece\u800c\u5f71\u54cd\u8102\u8d28\u6c34\u5e73\u3002<\/p>\n<\/p>\n

\u56fe8 \u76f8\u5173\u6027\u5206\u6790\uff1a\u8102\u8d28\u6c34\u5e73\u3001\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u548c\u4ee3\u8c22\u4ea7\u7269\u4e4b\u95f4\u7684Pearson\u76f8\u5173\u6027\u3002\u7ea2\u7ebf\u8868\u793a\u6b63\u76f8\u5173\uff0c\u800c\u84dd\u7ebf\u8868\u793a\u8d1f\u76f8\u5173\u3002<\/p>\n

\u5728MLRS\u7ec4\u4e2d\uff0cCA\u548cCerbronic
\nacid\u5747\u663e\u8457\u589e\u52a0\uff0c\u800cGUDCA\u3001\u03b1-MCA\u548c20-\u7fa7\u57fa\u767d\u4e09\u70efB4\u663e\u8457\u51cf\u5c11\uff08P<0.05\uff09\u3002CA\u542b\u91cf\u7684\u589e\u52a0\u53ef\u80fd\u4e0e\u80c6\u56fa\u9187\u5206\u89e3\u4ee3\u8c22\u4e3aCA\u6709\u5173\u300220-\u7fa7\u57fa\u767d\u4e09\u70efB4\uff08C20\uff09\u662f\u4e00\u79cd\u957f\u94fe\u8102\u80aa\u9178\uff0c\u88ab\u8ba4\u4e3a\u53ef\u4ee5\u4fc3\u8fdb\u8102\u80aa\u751f\u6210\u548c\u8102\u6ef4\u5f62\u6210\u3002\u56e0\u6b64\uff0c\u8865\u5145MLRS\u4e0d\u4ec5\u53ef\u4ee5\u4fc3\u8fdb\u80c6\u56fa\u9187\u5206\u89e3\u548c\u80c6\u6c41\u9178\u4ee3\u8c22\uff0c\u8fd8\u53ef\u4ee5\u6291\u5236\u957f\u94fe\u8102\u80aa\u9178\u7684\u4ea7\u751f\uff0c\u4ece\u800c\u4fc3\u8fdb\u8840\u8102\u7684\u964d\u4f4e\u3002<\/p>\n

\u5728HLRS\u7ec4\u4e2d\uff0c\u8865\u5145HLRS\u4e5f\u4fc3\u8fdb\u4e86CA\u7684\u589e\u52a0\u4ee5\u53caUDCA\u548cDCA\u7684\u51cf\u5c11\u3002\u6b64\u5916\uff0c\u4e0eMC\u7ec4\u76f8\u6bd4\uff0cHLRS\u7ec4\u548cPC\u7ec4\u4e2d3\uff0c4-Mmethyleneazelaic acid\uff08C11\uff09\u7684\u76f8\u5bf9\u91cf\u5747\u663e\u8457\u589e\u52a0\uff0cMC\u7ec4\u5df1\u9178\uff08C6\uff09\u3001\u58ec\u4e8c\u9178\uff08C9\uff09\u30013,4-Methyleneazelaic acid\uff08C11\uff09\u548c\uff08E\uff09-10-Oxo-8-decenoic acid\uff08C10\uff09\u7684\u76f8\u5bf9\u542b\u91cf\u4e0eNC\u7ec4\u76f8\u6bd4\u663e\u8457\u964d\u4f4e\u3002Liu\u7b49\u4eba\u53d1\u73b0\uff0c\u4e2d\u94fe\u8102\u80aa\u9178\u53ef\u4ee5\u901a\u8fc7\u8c03\u8282\u80c6\u6c41\u9178\u4ee3\u8c22\u6765\u964d\u4f4e\u8840\u6e05\u80c6\u56fa\u9187\uff0c\u4ece\u800c\u5728\u6539\u5584\u9ad8\u8102\u8840\u75c7\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u5148\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u5355\u4e0d\u9971\u548c\u8102\u80aa\u9178\u5728\u80a5\u80d6\u548c\u708e\u75c7\u4e2d\u8d77\u7740\u79ef\u6781\u4f5c\u7528\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0cHLRS\u548cPC\u7ec4\u4e2d\u5355\u4e0d\u9971\u548c\u8102\u80aa\u9178\uff08\u6cb9\u9178\u3001\u68d5\u6988\u9178\u548c\u786c\u8102\u9178\uff09\u7684\u76f8\u5bf9\u542b\u91cf\u663e\u8457\u964d\u4f4e\u3002\u56e0\u6b64\uff0cHLRS\u8fd8\u53ef\u4ee5\u4fc3\u8fdb\u80c6\u56fa\u9187\u5206\u89e3\u4ee3\u8c22\u4e3aCA\uff0cHLRS\u4e5f\u53ef\u4ee5\u901a\u8fc7\u4fc3\u8fdb\u4e2d\u94fe\u8102\u80aa\u9178\u7684\u4ea7\u751f\u548c\u6291\u5236\u5355\u4e0d\u9971\u548c\u8102\u80aa\u9178\u7684\u589e\u52a0\u6765\u53d1\u6325\u964d\u8840\u8102\u7684\u4f5c\u7528\u3002PC\u7ec4\u7684\u964d\u4f4e\u6548\u679c\u4e0eHLRS\u7ec4\u76f8\u4f3c\u3002<\/p>\n

\u76f8\u5173\u7814\u7a76\u8868\u660e\uff0cRS\u7684\u6444\u5165\u53ef\u4ee5\u6539\u5584\u80a5\u80d6\uff0c\u5e76\u5728\u964d\u8102\u4e2d\u53d1\u6325\u4f5c\u7528\uff0c\u8fd9\u53ef\u80fd\u4e0e\u83cc\u7fa4\u8c03\u8282\u7684\u80c6\u6c41\u9178\u6210\u5206\u53d8\u5316\u6709\u5173\u3002Chen\u7b49\u4eba\u53d1\u73b0BA\u53ef\u4ee5\u901a\u8fc7\u6fc0\u6d3bFXR\u548cSREBP1c\u9014\u5f84\u6765\u8c03\u8282\u8102\u80aa\u751f\u6210\u5e76\u6291\u5236\u8d85\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff08VLDL\uff09\u7684\u4ea7\u751f\u3002\u603b\u4e4b\uff0c\u5728\u6211\u4eec\u7684\u7814\u7a76\u4e2d\uff0cLLRS\u3001MLRS\u548cHLRS\u90fd\u53ef\u4ee5\u901a\u8fc7\u4fc3\u8fdb\u80c6\u56fa\u9187\u5206\u89e3\u4ee3\u8c22\u4e3aCA\u6765\u5f71\u54cd\u8102\u8d28\u6c34\u5e73\uff0c\u4f46MLRS\u4e5f\u53ef\u4ee5\u6291\u5236\u957f\u94fe\u8102\u80aa\u9178\u7684\u4ea7\u751f\uff0c\u8fd9\u53ef\u80fd\u4e0eMLRS\u5728\u6539\u5584\u9ad8\u8102\u8840\u75c7\u548c\u964d\u4f4e\u8102\u8d28\u6c34\u5e73\u65b9\u9762\u7684\u6700\u4f73\u6548\u679c\u6709\u5173\u3002<\/p>\n

7. \u4ee3\u8c22\u9014\u5f84\u5206\u6790<\/p>\n

\u4e0d\u540c\u4ee3\u8c22\u4ea7\u7269\u7684\u53d8\u5316\u901a\u8fc7\u76f8\u5e94\u4ee3\u8c22\u9014\u5f84\u7684\u6ce2\u52a8\u8fdb\u4e00\u6b65\u53cd\u6620\u51fa\u6765\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u63a5\u4e0b\u6765\u5bf9NC\u3001LRS\u548cMC\u7ec4\u4e4b\u95f4\u7684\u5dee\u5f02\u4ee3\u8c22\u7269\u8fdb\u884c\u4e86KEGG\u5bcc\u96c6\u5206\u6790\uff0c\u4ee5\u786e\u5b9a\u54ea\u4e9b\u9014\u5f84\u4e0e\u5dee\u5f02\u4ee3\u8c22\u7269\u6709\u5173\uff08\u56fe7A\u2013D\uff09\u3002NC\u7ec4\u548cMC\u7ec4\u4e4b\u95f4\u53d7\u4e0d\u540c\u4ee3\u8c22\u4ea7\u7269\u5f71\u54cd\u7684\u9014\u5f84\uff08\u524d5\u4e2a\uff09\u662f\u03b1-\u4e9a\u9ebb\u9178\u4ee3\u8c22\u3001\u6b21\u7ea7\u80c6\u6c41\u9178\u751f\u7269\u5408\u6210\u3001\u86cb\u767d\u8d28\u6d88\u5316\u548c\u5438\u6536\u3001\u4e19\u9178\u4ee3\u8c22\u548c\u521d\u7ea7\u80c6\u6c41\u9178\u751f\u7269\u5408\u6210\uff08\u56fe7A\uff09\u3002\u7814\u7a76\u8868\u660e\uff0c\u8102\u80aa\u9178\u4ee3\u8c22\u4e0e\u03b1-\u4e9a\u9ebb\u9178\u4ee3\u8c22\u9014\u5f84\u5bc6\u5207\u76f8\u5173\u3002Oliva\u7b49\u4eba\u8fd8\u53d1\u73b0\uff0c\u03b1-\u4e9a\u9ebb\u9178\u4e0e\u8102\u8d28\u4ee3\u8c22\u7684\u6539\u5584\u6709\u5173\uff0c\u5728\u672c\u7814\u7a76\u4e2d\uff0cNC\u7ec4\u548cMC\u7ec4\u4e4b\u95f4\u7684\u5dee\u5f02\u4ee3\u8c22\u4ea7\u7269\u4e5f\u5c06\u5176\u786e\u5b9a\u4e3a\u4e00\u79cd\u5bcc\u96c6\u9014\u5f84\u3002\u6b64\u5916\uff0cHFD\u5f15\u8d77\u7684\u8102\u80aa\u5806\u79ef\u548c\u809d\u810f\u8102\u80aa\u53d8\u6027\u4e0e\u80c6\u6c41\u9178\u5408\u6210\u6709\u5173\u3002\u8865\u5145NC\u548cMC\u7ec4\u7684\u9ad8\u8102\u8840\u75c7\u5c0f\u9f20\u7684\u5dee\u5f02\u4ee3\u8c22\u4ea7\u7269\u4e5f\u663e\u793a\u51fa\u521d\u7ea7\u80c6\u6c41\u9178\u5408\u6210\u9014\u5f84\u548c\u6b21\u7ea7\u80c6\u6c41\u9178\u5408\u6210\u901a\u8def\u7684\u663e\u8457\u5bcc\u96c6\u3002<\/p>\n

LLRS\u548cMC\u7ec4\u4e4b\u95f4\u53d7\u5dee\u5f02\u4ee3\u8c22\u4ea7\u7269\u5f71\u54cd\u7684\u9014\u5f84\uff08\u524d5\u4e2a\uff09\u662f\u6b21\u7ea7\u80c6\u6c41\u9178\u751f\u7269\u5408\u6210\u3001\u4e19\u916e\u9178\u4ee3\u8c22\u3001\u521d\u7ea7\u80c6\u6c41\u9178\u751f\u7269\u5408\u6210\u3001\u81a6\u9178\u76d0\u548c\u4e9a\u81a6\u9178\u76d0\u4ee3\u8c22\u4ee5\u53ca\u6c2e\u4ee3\u8c22\uff08\u56fe7B\uff09\u3002\u5728MLRS\u548cMC\u7ec4\u4e4b\u95f4\uff0c\u53d7\u5f71\u54cd\u7684\u4ee3\u8c22\u9014\u5f84\uff08\u524d5\u4e2a\uff09\u5305\u62ec\u6b21\u7ea7\u80c6\u6c41\u9178\u751f\u7269\u5408\u6210\u3001\u4e19\u916e\u9178\u4ee3\u8c22\u3001\u521d\u7ea7\u80c6\u6c41\u9178\u751f\u7269\u5408\u6210\uff0c\u81a6\u9178\u76d0\u548c\u4e9a\u81a6\u9178\u76d0\u4ee3\u8c22\u4ee5\u53ca\u6c2e\u4ee3\u8c22\uff08\u56fe7C\uff09\u3002\u6b64\u5916\uff0c\u76f8\u5173\u7814\u7a76\u8868\u660e\uff0c\u4e19\u916e\u9178\u8131\u6c22\u9176\u590d\u5408\u7269\u7684\u4e0a\u8c03\u53ef\u4ee5\u7f13\u89e3HFD\u5f15\u8d77\u7684\u80a5\u80d6\u3002McCommis\u548cFinck\u8fd8\u53d1\u73b0\uff0c\u809d\u810f\u8102\u80aa\u53d8\u6027\u548c\u7ea4\u7ef4\u5316\u53ef\u4ee5\u901a\u8fc7\u8c03\u8282\u4e19\u916e\u9178\u4ee3\u8c22\u6765\u6cbb\u7597\u3002LLRS\u3001MLRS\u548cMC\u7ec4\u4e4b\u95f4\u7684\u5dee\u5f02\u4ee3\u8c22\u4ea7\u7269\u4e5f\u663e\u793a\u51fa\u4e19\u916e\u9178\u4ee3\u8c22\u9014\u5f84\u7684\u663e\u8457\u5bcc\u96c6\u3002<\/p>\n

HLRS\u548cMC\u7ec4\u5728\u6b21\u7ea7\u80c6\u6c41\u9178\u751f\u7269\u5408\u6210\u3001\u521d\u7ea7\u80c6\u6c41\u9178\u751f\u7269\u5408\u6210\u3001\u5bff\u547d\u8c03\u8282\u9014\u5f84\u3001\u8102\u80aa\u9178\u751f\u7269\u5408\u6210\u4ee5\u53ca\u89d2\u8d28\u3001\u6728\u6813\u8d28\u548c\u8721\u7684\u751f\u7269\u5408\u6210\u4e2d\u5177\u6709\u663e\u8457\u5bcc\u96c6\u7684\u4e0d\u540c\u4ee3\u8c22\u4ea7\u7269\uff08\u56fe7D\uff09\u3002\u6cb9\u9178\u548c3,4-Mmethyleneazelaic acid\u7b49\u8102\u80aa\u9178\u88ab\u8ba4\u4e3a\u4e0e\u8102\u8d28\u4ee3\u8c22\u6709\u5173\uff0c\u8fd9\u4e0e\u672c\u7814\u7a76\u4e2dHLRS\u548cMC\u7ec4\u4e4b\u95f4\u7684\u5dee\u5f02\u4ee3\u8c22\u4ea7\u7269\u5728\u8102\u80aa\u9178\u5408\u6210\u9014\u5f84\u4e2d\u663e\u8457\u5bcc\u96c6\u7684\u4e8b\u5b9e\u4e00\u81f4\u3002<\/p>\n

\u6b64\u5916\uff0c\u6b21\u7ea7\u80c6\u6c41\u9178\u901a\u8fc7\u80a0\u9053\u91cd\u65b0\u5438\u6536\u6216\u901a\u8fc7\u7caa\u4fbf\u6392\u51fa\uff0c\u4ee5\u51cf\u5c11\u809d\u810f\u4e2d\u7684\u80c6\u56fa\u9187\u79ef\u805a\uff0c\u4ece\u800c\u6709\u52a9\u4e8e\u9884\u9632\u548c\u6539\u5584\u8102\u80aa\u809d\u75be\u75c5\u3002\u8865\u5145LLRS\u3001MLRS\u3001HLRS\u548cMC\u7ec4\u7684\u9ad8\u8102\u8840\u75c7\u5c0f\u9f20\u7684\u5dee\u5f02\u4ee3\u8c22\u4ea7\u7269\u5728\u521d\u7ea7\u80c6\u6c41\u9178\u5408\u6210\u9014\u5f84\u548c\u6b21\u7ea7\u80c6\u6c41\u9178\u5408\u6210\u901a\u8def\u4e2d\u4e5f\u8868\u73b0\u51fa\u663e\u8457\u5bcc\u96c6\u3002<\/p>\n

8. \u201c\u80a0\u9053\u5fae\u751f\u7269\u7fa4-\u4ee3\u8c22\u4ea7\u7269-\u8840\u8102\u6307\u6570\u201d\u8f74\u7684\u6784\u5efa<\/p>\n

\u63a5\u4e0b\u6765\u6211\u4eec\u5728\u5c5e\u6c34\u5e73\u4e0a\u5bf9\u7ed3\u80a0\u5dee\u5f02\u4ee3\u8c22\u4ea7\u7269\u3001\u5dee\u5f02\u83cc\u7fa4\u548c\u8840\u8102\u6c34\u5e73\u8fdb\u884cPearson\u76f8\u5173\u6027\u5206\u6790\uff08\u56fe8\uff09\u3002\u5728\u8f6c\u5f55\u7ec4\u5b66\u65b9\u9762\uff0c\u5148\u524d\u7684\u7814\u7a76\u8868\u660e\uff0cLRS\u5bf9\u9ad8\u8102\u8840\u75c7\u5c0f\u9f20\u5177\u6709\u4e00\u5b9a\u7a0b\u5ea6\u7684\u964d\u8102\u4f5c\u7528\u3002\u6211\u4eec\u4e4b\u524d\u7684\u7814\u7a76\u5df2\u7ecf\u8bc1\u5b9e\u8865\u5145LRS\u53ef\u4ee5\u964d\u4f4e\u7518\u6cb9\u4e09\u916f\uff08TG\uff09\u3001\u603b\u80c6\u56fa\u9187\uff08TC\uff09\u3001\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\uff08HDL-C\uff09\u548c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff08LDL-C\uff09\u3002\u6b64\u5916\uff0c\u672c\u7814\u7a76\u53d1\u73b0\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u4e0e\u9ad8\u8102\u8840\u75c7\u6709\u5173\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u4f7f\u7528Cytoscape
\nV3.7.1\u6784\u5efa\u4e86\u80a0\u9053\u5fae\u751f\u7269\u7fa4-\u4ee3\u8c22\u7269-\u8840\u8102\u6307\u6570\u7684\u76f8\u5173\u7f51\u7edc\u56fe\uff08\u56fe8\uff09\u3002<\/p>\n

LLRS\u5c0f\u9f20\u7ed3\u80a0\u4e2dAlistipes\u4e30\u5ea6\u7684\u589e\u52a0\u4e0e\u7532\u9178\u5448\u6b63\u76f8\u5173\u3002\u7532\u9178\u4e0e\u8840\u6e05TC\u3001LDL-C\u548cHDL-C\u5448\u8d1f\u76f8\u5173\uff08P<0.05\uff09\u3002HLRS\u5c0f\u9f20\u7ed3\u80a0\u4e2dParasuttevella\u4e30\u5ea6\u7684\u964d\u4f4e\u4e0e3,4-Mmethyleneazelaic acid\u5448\u8d1f\u76f8\u5173\uff0c3,4-Mmethyleneazelaic
\nacid\u4e0e\u8840\u6e05TC\u3001LDL-C\u548cHDL-C\u5448\u8d1f\u76f8\u5173\uff08P<0.05\uff09\u3002HLRS\u5c0f\u9f20\u7ed3\u80a0\u4e2d\u80a0\u6746\u83cc\u4e30\u5ea6\u7684\u964d\u4f4e\u4e0e\u6cb9\u9178\u5448\u6b63\u76f8\u5173\uff0c\u800c\u6cb9\u9178\u4e0eTG\u548cHDL-C\u5448\u6b63\u76f8\u5173\uff08P<0.05\uff09\u3002\u4e2d\u94fe\u8102\u80aa\u9178(3,4 -Mmethyleneazelaic acid)\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u901a\u8fc7\u964d\u4f4e\u8840\u6e05\u80c6\u56fa\u9187\u6765\u6539\u5584\u9ad8\u8102\u8840\u75c7\uff0c\u800c\u6cb9\u9178\u88ab\u8ba4\u4e3a\u4e0e\u8102\u8d28\u6c89\u79ef\u548c\u8102\u8d28\u4ea7\u751f\u6709\u5173\u3002\u5728MLRS\u7ec4\u4e2d\uff0cnorank_f_Muribaculaceae\u4e30\u5ea6\u7684\u589e\u52a0\u4e0eCA\u5448\u6b63\u76f8\u5173\u3002CA\u4e0e\u8840\u6e05TG\u3001TC\u548cLDL-C\u5448\u8d1f\u76f8\u5173\uff08P<0.05\uff09\u3002\u76f8\u5173\u7814\u7a76\u8bc1\u5b9e\uff0cCA\u662f\u7531\u80c6\u56fa\u9187\u5206\u89e3\u4ee3\u8c22\u5f62\u6210\u7684\uff0c\u56e0\u6b64CA\u7684\u4ea7\u751f\u6709\u5229\u4e8e\u80c6\u56fa\u9187\u7684\u5206\u89e3\u4ee3\u8c22\uff0c\u4ece\u800c\u8d77\u5230\u964d\u4f4e\u8840\u8102\u7684\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u8865\u5145LLRS\u3001MLRS\u548cHLRS\u53ef\u964d\u4f4e\u5c0f\u9f20\u7ed3\u80a0\u4e2dAllobaculum\u7684\u6c34\u5e73\uff0cAllobaculum\u4e0e20-\u7fa7\u57fa\u767d\u4e09\u70efB4\uff08C20\uff09\u548c\u6cb9\u9178\uff08C18\uff09\u5448\u6b63\u76f8\u5173\u3002\u8fd9\u4e9b\u4ee3\u8c22\u4ea7\u7269\u4e0eTG\u3001TC\u3001LDL-C\u548cHDL-C\u5448\u6b63\u76f8\u5173\uff08P<0.05\uff09\u3002\u7814\u7a76\u8868\u660e\uff0c\u957f\u94fe\u8102\u80aa\u9178\u53ef\u4ee5\u5f71\u54cd\u8102\u80aa\u751f\u6210\u548c\u8102\u6ef4\u7684\u5f62\u6210\u3002\u6b64\u5916\uff0cAllobaculum\u5728HFD\u5c0f\u9f20\u80a0\u9053\u4e2d\u7684\u4e30\u5ea6\u5df2\u88ab\u8bc1\u660e\u663e\u8457\u589e\u52a0\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u4e0d\u540c\u5242\u91cf\u7684LRS\u53ef\u4ee5\u6291\u5236Allobaculum\u7684\u589e\u6b96\uff0c\u51cf\u5c11DCA\u300120-\u7fa7\u57fa\u767d\u4e09\u70efB4\u548c\u6cb9\u9178\u7684\u5206\u6ccc\uff0c\u4ece\u800c\u964d\u4f4eTG\u3001TC\u3001LDL-C\u548cHDL-C\u7684\u6c34\u5e73\u3002\u6b64\u5916\uff0cLLRS\u8fd8\u53ef\u4ee5\u901a\u8fc7\u4fc3\u8fdbAlistipes\u7684\u589e\u6b96\u3001\u5206\u6ccc\u7532\u9178\u548c\u964d\u4f4eTC\u3001LDL-C\u548cHDL-C\u6c34\u5e73\u6765\u6539\u5584\u5c0f\u9f20\u7684\u9ad8\u8102\u8840\u75c7\u3002MLRS\u8fd8\u53ef\u4ee5\u901a\u8fc7\u589e\u52a0norank_f_Muribaculaceae\u7684\u4e30\u5ea6\u3001\u5206\u6cccCA\u4ee5\u53ca\u964d\u4f4eTG\u3001TC\u3001LDL-C\u548cHDL-C\u7684\u6c34\u5e73\u6765\u6539\u5584\u5c0f\u9f20\u7684\u9ad8\u8102\u8840\u75c7\u3002\u800cHLRS\u8fd8\u53ef\u4ee5\u901a\u8fc7\u6291\u5236Parasuttevella\u548c\u80a0\u6746\u83cc\u7684\u589e\u6b96\uff0c\u4fc3\u8fdb3\uff0c4-Mmethyleneazelaic acid\u548c\u51cf\u5c11\u6cb9\u9178\u5206\u6ccc\uff0c\u4ee5\u53ca\u964d\u4f4eTC\u3001HDL-C\u3001TG\u548cLDL-C\u6c34\u5e73\u6765\u6539\u5584\u5c0f\u9f20\u7684\u9ad8\u8102\u8840\u75c7\u3002<\/p>\n<\/p>\n

\u56fe9 \u83b2\u5b50\u6297\u6027\u6dc0\u7c89\u901a\u8fc7\u80a0\u9053\u5fae\u751f\u7269\u4ee3\u8c22\u8f74\u6539\u5584\u9ad8\u8102\u8840\u75c7\u7684\u793a\u610f\u56fe<\/p>\n

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\u7ed3\u8bba<\/p>\n

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\u539f\u6587\u94fe\u63a5\uff1a  https:\/\/www.\/science\/article\/abs\/pii\/S0144861723004046<\/p>\n<\/p>\n

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