{"id":34720,"date":"2024-05-24T04:01:10","date_gmt":"2024-05-24T04:01:10","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=34720"},"modified":"2024-05-24T04:01:10","modified_gmt":"2024-05-24T04:01:10","slug":"who%e8%83%b8%e9%83%a8%e8%82%bf%e7%98%a4%e5%88%86%e7%b1%bb%ef%bc%88%e7%ac%ac5%e7%89%88%ef%bc%89%e4%b8%ad%e8%83%b8%e8%86%9c%e3%80%81%e5%bf%83%e5%8c%85%e5%8f%8a%e8%83%b8%e8%85%ba%e8%82%bf%e7%98%a4","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=34720","title":{"rendered":"WHO\u80f8\u90e8\u80bf\u7624\u5206\u7c7b\uff08\u7b2c5\u7248\uff09\u4e2d\u80f8\u819c\u3001\u5fc3\u5305\u53ca\u80f8\u817a\u80bf\u7624\u90e8\u5206\u89e3\u8bfb"},"content":{"rendered":"

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1<\/p>\n

\u80f8\u819c\u53ca\u5fc3\u5305\u80bf\u7624\u5206\u7c7b<\/p>\n

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1.1\u3000\u95f4\u76ae\u80bf\u7624<\/p>\n

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in situ hybridization\uff0cFISH\uff09\u68c0\u6d4bCDKN2A\u7eaf\u5408\u5b50\u7f3a\u5931\uff0c\u5219\u6709\u52a9\u4e8e\u539f\u4f4d\u95f4\u76ae\u7624\u7684\u8bca\u65ad\u3002\u5c0f\u6d3b\u68c0\u548c\u7ec6\u80de\u5b66\u6807\u672c\u4e0d\u9002\u5b9c\u7528\u6765\u8bca\u65ad\uff0c\u6700\u597d\u53d6\u591a\u4e2a\u90e8\u4f4d\u7684\u8f83\u5927\u6d3b\u68c0\u7ec4\u7ec7\uff08100~200 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death ligand-1\uff0cPD-L1\uff09\u6297\u4f53\u5728\u8089\u7624\u6837\u95f4\u76ae\u7624\u4e2d\u7684\u8868\u8fbe\u9ad8\u4e8e\u4e0a\u76ae\u6837\u95f4\u76ae\u7624\uff0c\u800c\u4e0a\u76ae\u6837\u95f4\u76ae\u7624\u5177\u6709\u66f4\u9ad8\u7684VSIR\uff08VISTA\uff09\u8868\u8fbe\uff0c\u53ef\u80fd\u662fPD-L1\/\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u6297\u539f4\uff08cytotoxic T lymphocyte associated 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mm2<\/sup>\u30012~4\u4e2a\/2 mm2<\/sup>\u3001\u22655\u4e2a\/2 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2<\/p>\n

\u80f8\u817a\u80bf\u7624\u5206\u7c7b<\/p>\n

\u65b0\u7248WHO\u80f8\u817a\u80bf\u7624\u76ee\u5f55\uff08\u88682\uff09\u7684\u8c03\u6574\u4e3b\u8981\u4f53\u73b0\u5728\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\uff1a\u2460\u7531\u4e8e\u65b0\u7248\u5206\u7c7b\u5bf9\u4e8e\u4e0d\u540c\u90e8\u4f4d\u53d1\u751f\u7684\u540c\u6e90\u6027\u80bf\u7624\u8fdb\u884c\u4e86\u5408\u5e76\uff0c\u65e7\u7248\u5206\u7c7b\u7684\u80f8\u817a\u80bf\u7624\u4e2d\u751f\u6b96\u7ec6\u80de\u76f8\u5173\u80bf\u7624\u3001\u8840\u6db2\u6dcb\u5df4\u80bf\u7624\u3001\u8f6f\u7ec4\u7ec7\u80bf\u7624\u3001\u80f8\u817a\u5f02\u4f4d\u80bf\u7624\u3001\u80f8\u817a\u6216\u7eb5\u9694\u8f6c\u79fb\u80bf\u7624\u88ab\u8c03\u6574\u81f3\u65b0\u7248\u5206\u7c7b\u4e2d\u7684\u7eb5\u9694\u751f\u6b96\u7ec6\u80de\u80bf\u7624\u3001\u7eb5\u9694\u8840\u6db2\u6dcb\u5df4\u80bf\u7624\u3001\u80f8\u90e8\u95f4\u53f6\u80bf\u7624\u3001\u7532\u72b6\u817a\u548c\u7532\u72b6\u65c1\u817a\u8d77\u6e90\u7684\u5f02\u4f4d\u80bf\u7624\u53ca\u8f6c\u79fb\u7624\u7ae0\u8282\u4e2d\u3002\u2461\u5220\u9664\u4e86\u65e7\u7248\u5206\u7c7b\u80f8\u817a\u7624\u4e2d\u7684\u5fae\u5c0f\u80f8\u817a\u7624\u53ca\u786c\u5316\u6027\u80f8\u817a\u7624\u3002\u2462\u65b0\u7248\u5206\u7c7b\u76ee\u5f55\u4e2d\u53d6\u6d88\u4e86\u6df7\u5408\u6027\u80f8\u817a\u764c\u3002<\/p>\n

2.1\u3000\u4e0a\u76ae\u6027\u80bf\u7624<\/p>\n

2.1.1\u3000\u80f8\u817a\u7624\u80f8\u817a\u7624\u5305\u542bA\u578b\uff08\u5305\u62ec\u4e0d\u5178\u578b\u4e9a\u578b\uff09\u3001AB\u578b\u3001B1\u578b\u3001B2\u578b\u3001B3\u578b\u80f8\u817a\u7624\u3001\u4f34\u6709\u6dcb\u5df4\u95f4\u8d28\u7684\u5fae\u7ed3\u8282\u578b\u80f8\u817a\u7624\u3001\u5316\u751f\u578b\u80f8\u817a\u7624\u53ca\u8102\u80aa\u7ea4\u7ef4\u817a\u7624\u3002\u80f8\u817a\u7624\u5728\u65b0\u7248\u5206\u7c7b\u4e2d\u66f4\u65b0\u5185\u5bb9\u5982\u4e0b\uff1a\u2460\u80f8\u817a\u7624\u5e38\u91c7\u7528Masaoka\u5206\u671f\u7cfb\u7edf\uff0c\u65b0\u7248\u5206\u7c7b\u4e2d\u5f15\u5165\u56fd\u9645\u6297\u764c\u8054\u76df\uff08Union for International Cancer Control\uff0cUICC\uff09\u63a8\u8350\u7684TNM\u5206\u671f\u7cfb\u7edf\u3002\u7531\u4e8eMasaoka\u5206\u671f\u4ecd\u662f\u76ee\u524d\u6700\u5e38\u7528\u7684\u80f8\u817a\u7624\u5206\u671f\u7cfb\u7edf\uff0c\u6545\u63a8\u8350\u5728\u65e5\u5e38\u8bca\u65ad\u4e2d\u5e73\u884c\u4f7f\u7528\u3002\u2461\u5220\u9664\u4e86\u65e7\u7248\u5206\u7c7b\u4e2d\u7684\u5fae\u5c0f\u80f8\u817a\u7624\uff08\u53c8\u8bd1\u4e3a\u663e\u5fae\u955c\u4e0b\u80f8\u817a\u7624\uff09\uff0c\u5fae\u5c0f\u80f8\u817a\u7624\u901a\u5e38\u8868\u73b0\u4e3a\u591a\u7076\u6027\uff1c1 mm\u7684\u80f8\u817a\u4e0a\u76ae\u589e\u751f\uff0c2004\u7248WHO\u5206\u7c7b\u5176ICD-O\u7f16\u7801\u4e3a1\uff08\u6076\u6027\u6f5c\u80fd\u672a\u5b9a\uff09\uff0c2015\u7248\u5206\u7c7b\u4e2d\u5176ICD-O\u7f16\u7801\u8c03\u6574\u4e3a0\uff08\u826f\u6027\u80bf\u7624\uff09\u3002\u65b0\u7248\u5206\u7c7b\u8ba4\u4e3a\u7531\u4e8e\u65e0\u6cd5\u786e\u5b9a\u5fae\u5c0f\u80f8\u817a\u7624\u662f\u80bf\u7624\u6027\u75c5\u53d8\uff0c\u8fd8\u662f\u5176\u4ed6\u80f8\u817a\u7624\u7684\u524d\u9a71\u6027\u75c5\u53d8\uff0c\u6545\u4e88\u4ee5\u5220\u9664\u3002\u2462\u5220\u9664\u4e86\u65e7\u7248\u4e2d\u7684\u786c\u5316\u6027\u80f8\u817a\u7624\uff0c\u65e7\u7248\u5206\u7c7b\u4e2d\u5176\u88ab\u63cf\u8ff0\u4e3a\u4e00\u79cd\u5177\u6709\u666e\u901a\u80f8\u817a\u7624\u7279\u5f81\u4f34\u660e\u663e\u95f4\u8d28\u786c\u5316\u7684\u7f55\u89c1\u80f8\u817a\u7624\uff0c\u65b0\u7248\u5206\u7c7b\u8ba4\u4e3a\u8be5\u80bf\u7624\u4e0d\u662f\u72ec\u7acb\u7684\u7c7b\u578b\uff0c\u6545\u4e88\u4ee5\u5220\u9664\u3002\u2463\u80f8\u817a\u7624\u5177\u6709\u4e0e\u80f8\u817a\u764c\u622a\u7136\u4e0d\u540c\u76843\u79cd\u5206\u5b50\u4e9a\u578b\uff08A\u578b\u3001AB\u578b\u4e0eB\u578b\uff09\uff0c\u5176\u4e2dA\u578b\u4e0eAB\u578b\u95f4\u5b58\u5728\u4e00\u5b9a\u7684\u91cd\u53e0\u3002\u80f8\u817a\u7624\u4e2d\u6700\u5e38\u89c1\u7684\u57fa\u56e0\u6539\u53d8\u4e3aGTF2I p.L424H\u9519\u4e49\u7a81\u53d8\uff0c\u8be5\u7a81\u53d8\u4ec5\u89c1\u4e8eA\u3001AB\u578b\u80f8\u817a\u7624\uff0c\u5e76\u4e0e\u91cd\u75c7\u808c\u65e0\u529b\u7684\u53d1\u751f\u53ca\u826f\u597d\u7684\u9884\u540e\u5177\u6709\u76f8\u5173\u6027\u3002HRAS\u57fa\u56e0\u7a81\u53d8\u4e5f\u5e38\u89c1\u4e8eA\u578b\u53caAB\u578b\u80f8\u817a\u7624\uff0cNRAS\u548cTP53\u7a81\u53d8\u5219\u66f4\u5e38\u89c1\u4e8eB2\u3001B3\u578b\u80f8\u817a\u7624\u53ca\u80f8\u817a\u764c\u3002FOXC1\u80bf\u7624\u6291\u5236\u57fa\u56e0\u76846p25.2-p25.3\u57fa\u56e0\u7f3a\u5931\u5219\u53ef\u53d1\u751f\u4e8e\u6240\u6709\u4e9a\u578b\u7684\u80f8\u817a\u7624\u53ca\u80f8\u817a\u764c\u3002\u7a0b\u5e8f\u6027\u6b7b\u4ea1\uff3b\u86cb\u767d\uff3d-1\uff08programmed 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\u53c2\u8003\u6587\u732e<\/p>\n

\u5f15\u7528\u672c\u6587\uff1a\u6b66\u6625\u71d5\uff0c\u8c22\u60e0\u5eb7\uff0c\u674e\u3000\u5a9b. WHO\u80f8\u90e8\u80bf\u7624\u5206\u7c7b\uff08\u7b2c5\u7248\uff09\u4e2d\u80f8\u819c\u3001\u5fc3\u5305\u53ca\u80f8\u817a\u80bf\u7624\u90e8\u5206\u89e3\u8bfb\uff3bJ\uff3d. \u4e2d\u56fd\u764c\u75c7\u6742\u5fd7, 2021, 31(9): 769-774.<\/p>\n

1. WHO Classification of Tumours Editorial Board. WHO classification of tumours. Thoracic tumours\uff3bM\uff3d. 5th ed. Lyon: IARC Press, 2021.<\/p>\n

2. WILLIAM D T, ELISABETH B, ALLEN P B, et al. WHO classification of tumours of the lung, pleura, thymus and heart (4th edition)\uff3bM\uff3d. IARC: Lyon, 2015: 1-151.<\/p>\n

3. DACIC S, STANG N L, HUSAIN A, et al. Interobserver variation in the assessment of the sarcomatoid and transitional components in biphasic mesotheliomas\uff3bJ\uff3d. Mod Pathol, 2020, 33(2): 255-262.<\/p>\n

4. HMELJAK J, SANCHEZ-VEGA F, HOADLEY K A, et al. Integrative molecular characterization of malignant pleural mesothelioma\uff3bJ\uff3d. Cancer Discov, 2018, 8(12): 1548-1565.<\/p>\n

5. TSUCHIDA M, UMEZU H, HASHIMOTO T, et al. Absence of gene mutations in KIT-positive thymic epithelial tumors\uff3bJ\uff3d. Lung Cancer, 2008, 62(3): 321-325.<\/p>\n","protected":false},"excerpt":{"rendered":"

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