\u3010\u51fa\u5904\u3011\u59cb\u8f7d\u4e8e\u300a\u690d\u7269\u5206\u7c7b\u5b66\u62a5\u300b\u3002<\/p>\n
\u3010\u62fc\u97f3\u540d\u3011H\u00e9 T\u00e0o D\u00e0i Hu\u00e1n\u0261<\/p>\n
\u3010\u522b\u540d\u3011\u4e3a\u84fc\u79d1\u690d\u7269\u6cb3\u5957\u5927\u9ec4\u7684\u6839\u53ca\u6839\u830e\u3002<\/p>\n
\u3010\u6765\u6e90\u3011
\u836f\u6750\u57fa\u6e90\uff1a\u4e3a\u84fc\u79d1\u690d\u7269\u6cb3\u5957\u5927\u9ec4\u7684\u6839\u53ca\u6839\u830e\u3002
\u62c9\u4e01\u690d\u7269\u52a8\u7269\u77ff\u7269\u540d\uff1aRheum hotaoense C. Y. Cheng et C. T. Kao
\u91c7\u6536\u548c\u50a8\u85cf\uff1a\u79cb\u5b63\u91c7\u6316\uff0c\u6d17\u51c0\uff0c\u5207\u7247\uff0c\u6652\u5e72\u3002<\/p>\n
\u3010\u539f\u5f62\u6001\u3011\u9ad8\u5927\u8349\u672c\uff0c\u830e\u591a\u633a\u76f4\uff0c\u9ad880-20cm\u3002\u57fa\u751f\u53f6\uff0c\u53f6\u67c4\u534a\u5706\u67f1\u72b6\uff1b\u53f6\u7247\u53ca\u7070\u7eff\u8272\uff0c\u5375\u5fc3\u5f62\u81f3\u5bbd\u5375\u5f62\uff0c\u5148\u7aef\u949d\u6025\u5c16\uff0c\u57fa\u90e8\u5fc3\u5f62\uff0c\u8fb9\u7f18\u7a0d\u6ce2\u72b6\u5230\u7a0d\u76b1\u6ce2\u72b6\uff0c\u4e24\u9762\u5149\u6ed1\u65e0\u6bdb\uff1b\u830e\u751f\u53f6\u8f83\u5c0f\uff0c\u53f6\u4e24\u8f83\u77ed\uff0c\u53f6\u7247\u5375\u5f62\u81f3\u5375\u72b6\u62ab\u9488\u5f62\uff1b\u6258\u53f6\u9798\u62b1\u830e\uff0c\u957f5-8cm\uff0c\u5916\u9762\u7c97\u7cd9\u3002\u5927\u5706\u9525\u82b1\u5e8f\uff0c2-3\u6b21\u5206\u679d\uff1b\u82b1\u8f83\u5927\uff0c\u5c0f\u82b1\u6897\u7ea4\u7ec6\uff1b\u82b1\u88ab\u7247\u957f\u692d\u5706\u5f62\uff0c\u80cc\u90e8\u7eff\u8272\uff0c\u5177\u7a00\u7f51\u72b6\u8109\uff0c\u8fb9\u7f18\u8fd1\u767d\u8272\uff1b\u96c4\u854a\u4e0e\u82b1\u88ab\u8fd1\u7b49\u957f\uff1b\u96cc\u854a\u82b1\u67f1\u8f83\u77ed\uff0c\u6a2a\u5c55\uff0c\u67f1\u5934\u5c0f\uff0c\u5706\u5934\u72b6\u3002\u679c\u5b9e\u5706\u5f62\u81f3\u8fd1\u5706\u5f62\uff0c\u957f\u5bbd\u8fd1\u76f8\u7b49\u3002\u79cd\u5b50\u5bbd\u5375\u5f62\u3002<\/p>\n
\u3010\u751f\u5883\u5206\u5e03\u3011
\u751f\u6001\u73af\u5883\uff1a\u751f\u4e8e\u9634\u6e7f\u5c71\u5761\u53ca\u5c71\u6c9f\u3002
\u8d44\u6e90\u5206\u5e03\uff1a\u5206\u5e03\u4e8e\u9655\u897f\u3001\u7518\u8083\u3001\u9752\u6d77\u3002<\/p>\n
\u3010\u6027\u72b6\u3011
\u6027\u72b6\u9274\u522b \u6839\u830e\u5448\u7c7b\u5706\u9525\u5f62\uff0c\u957f5-20cm\uff0c\u76f4\u5f842-7cm\uff1b\u591a\u7eb5\u5207\u6210\u6761\u72b6\u6216\u5757\u7247\u72b6\u3002\u5e26\u6813\u76ae\u8005\u5448\u7070\u8910\u8272\u6216\u7070\u9ed1\u8272\uff0c\u8868\u9762\u591a\u62bd\u6c9f\u53ca\u7eb5\u76b1\u7eb9\uff0c\u53bb\u6813\u76ae\u540e\u8868\u9762\u9ec4\u8910\u8272\u3002
\u8d28\u575a\u786c\uff0c\u4e0d\u6613\u6298\u65ad\uff0c\u6a2a\u65ad\u9762\u6de1\u9ec4\u68d5\u8272\uff0c\u65e0\u661f\u70b9\u3002\u65b0\u9c9c\u65ad\u9762\u6de1\u9ec4\u81f3\u6697\u68d5\u8272\uff0c\u5728\u7d2b\u5916\u5149\u4e0b\u663e\u7d2b\u8272\u8367\u5149\u3002
\u663e\u5fae\u9274\u522b \u6839\u53ca\u6839\u830e\u6a2a\u5207\u9762\u4e0e\u5927\u9ec4\u533a\u522b\uff1a\u5c04\u7ebf1\u5217\u7ec6\u80de\uff0c\u65e0\u661f\u70b9\uff1b\u8349\u9178\u9499\u7c07\u54c1\u76f4\u5f8422-60\u03bcm\uff1b\u6dc0\u7c89\u7c92\u76f4\u5f843-24\u03bcm\uff0c\u590d\u7c92\u4e3a2-6\u5206\u7c92\u7ec4\u6210\u3002
\u7406\u5316\u9274\u522b \u53d6\u672c\u54c1\u7c89\u672b0\uff0e2g\uff0c\u52a0\u7532\u91872ml\uff0c\u6e29\u6d7810min\uff0c\u653e\u51b7\uff0c\u53d6\u4e0a\u6e05\u6db210\u03bcl\u70b9\u4e8e\u6ee4\u7eb8\u4e0a\uff0c\u4ee545\uff05\u4e59\u9187\u5c55\u5f00\uff0c\u53d6\u51fa\uff0c\u667e\u5e72\uff0c\u653e\u7f6e10min\uff0c\u7f6e\u7d2b\u5916\u5149\u706f\uff08365nm\uff09\u4e0b\u68c0\u89c6\uff0c\u663e\u4eae\u7d2b\u8272\u8367\u5149\u3002<\/p>\n
\u3010\u5316\u5b66\u6210\u4efd\u3011\u6cb3\u5957\u5927\u9ec4\u6839\u53ca\u6839\u830e\u4e2d\u542b\u603b\u84bd\u918c1\uff0e66\uff05\uff0c\u5176\u4e2d\u4ee5\u82a6\u835f\u5927\u9ec4\u7d20\uff08aloe\uff0demodin\uff09\uff0c\u5927\u9ec4\u7d20\uff08emodin\uff09\uff0c\u5927\u9ec4\u7d20\u7532\u919a\uff08hyscion\uff09\uff0c\u5927\u9ec4\u915a\uff08chrysophanol\uff09\u4e3a\u7519\u5143\u7684\u7ed3\u5408\u578b\u84bd\u918c1\uff0e54\uff05\uff0c\u6e38\u79bb\u578b0\uff0e12\uff05\uff0c\u8fd8\u542b\u98df\u7528\u5927\u9ec4\u7519\uff08rhapontin\uff09\u53ca\u591a\u91cf\u97a3\u8d28[1]\u3001\u6cb3\u5957\u5927\u9ec4\u591a\u7cd6\uff08RHP\uff09[2]\u3001\u5355\u7cd6\u81f3\u591a\u7cd6RHP\uff0dA\u548cRHp\uff0dB\uff3b3\u300d\u3002<\/p>\n
\u3010\u836f\u7406\u4f5c\u7528\u3011
1\uff0e\u6297\u708e\u548c\u9547\u75db\u4f5c\u7528 \u672c\u54c1\u6d78\u818f1\uff0e5g\uff0fkg\u30010\uff0e5g\uff0fkg\u548c0\uff0e17g\uff0fkg\u8179\u8154\u6ce8\u5c04\u5bf9\u5927\u9f20\u86cb\u6e05\u6027\u8db3\u80bf\u6709\u663e\u7740\u6291\u5236\u4f5c\u7528\uff1b\u540c\u4e0a\u5242\u91cf\u704c\u80c3\u7ed9\u836f\u5bf9\u7532\u919b\u81f4\u708e\u7684\u5927\u9f20\u8db3\u80bf\u4e5f\u6709\u4e00\u5b9a\u7684\u6291\u5236\u4f5c\u7528\uff1b\u672c\u54c1\u6d78\u818f1\uff0e5g\uff0fkg\u704c\u80c3\u5bf9\u918b\u9178\u6240\u81f4\u5c0f\u9f20\u8179\u819c\u708e\u4e5f\u6709\u663e\u7740\u6291\u5236\u4f5c\u7528\uff3b1\uff3d\u3002\u6cb3\u5957\u5927\u9ec4\u591a\u7cd6\uff08RHP\uff09100mg\uff0fkg\u548c200mg\uff0fkg\u704c\u80c3\uff0c\u5bf9\u5c0f\u9f20\u89d2\u53c9\u83dc\u80f6\u6027\u8db3\u80bf\u6709\u660e\u663e\u6291\u5236\u4f5c\u7528\uff0c\u6291\u5236\u7387\u5747\u4e3a78\uff0e4\uff05[2]\u3002\u672c\u54c1\u6d78\u818f1\uff0e5g\uff0fkg\u704c\u80c3\uff0c\u5bf9\u5c0f\u9f20\u918b\u9178\u626d\u4f53\u53cd\u5e94\u6709\u663e\u7740\u6291\u5236\u4f5c\u7528\uff0c\u4f46\u70ed\u677f\u6cd5\u8bd5\u9a8c\u65e0\u660e\u663e\u9547\u75db\u4f5c\u7528[1]\u3002
2\uff0e\u5bf9\u8840\u6db2\u7cfb\u7edf\u7684\u5f71\u54cd \u672c\u54c1\u6d78\u818f1\uff0e125g\uff0fkg\u30010\uff0e375g\uff0fkg\uff0e125g\uff0fkg\u704c\u80c3\u6216\u8179\u8154\u6ce8\u5c04\uff0c\u5bf9\u5c0f\u9f20\u65ad\u5c3e1\uff0e5mm\u957f\u6bdb\u7ec6\u8840\u7ba1\u6e17\u8840\u6709\u663e\u7740\u6b62\u8840\u4f5c\u7528\uff1b\u4f53\u5916\u8bd5\u9a8c\uff0c\u54c1\u6d78\u818f\u5bf9\u51dd\u8840\u9176\u7684\u51dd\u8840\u4f5c\u7528\u6709\u663e\u7740\u534f\u540c\u4f5c\u7528\uff0c\u80fd\u7f29\u77ed\u51dd\u56fa\u65f6\u95f4\u4e00\u534a\u4ee5\u4e0a[1]\u3002\u4f46RHP\u6709\u6297\u51dd\u8840\u4f5c\u7528\uff0c\u57280\uff0e2ml\u6df7\u5408\u6d46\u4e2d\u52a0\u5165\u4e0d\u540c\u91cf\u7684RHP\uff0c\u52a0\u51651mg\u65f6\u53ef\u5b8c\u5168\u6291\u5236\u8840\u6db2\u51dd\u56fa\uff0c\u52a0\u51650\uff0e8mg\u65f6\uff0c\u4f7f\u8840\u6d46\u51dd\u56fa\u65f6\u95f4\u5ef6\u957f250\uff05\uff0c\u4f7f\u51dd\u8840\u9176\u539f\u65f6\u95f4\u5ef6\u957f264\uff05\uff0c\u5e76\u4e14\u8fd9\u4e9b\u4f5c\u7528\u6709\u5242\u91cf\u4f9d\u8d56\u6027\u3002RHP100mg\uff0fkg\u548c200mg\uff0fkg\u8179\u8154\u6ce8\u5c04\u6216\u704c\u80c3\uff0c\u6bdb\u7ec6\u7ba1\u6cd5\u8bd5\u9a8c\uff0c30min\u540e\u80fd\u5ef6\u957f\u6b63\u5e38\u5c0f\u9f20\u7684\u8840\u51dd\u65f6\u95f4\uff0c\u8179\u8154\u6ce8\u5c04\u5ef6\u957f101\uff05\u548c116\uff0c\u704c\u80c3\u5ef6\u957f93\uff05\u548c 110\uff05\u3002 RHP56mg\uff0fkg\u704c\u80c3\u53ef\u4f7f\u5bb6\u5154\u767d\u9676\u571f\u90e8\u5206\u51dd\u8840\u6d3b\u9176\u65f6\u95f4\uff08KPTT\uff09\u5ef6\u957f34\uff05[3]\u3002\u672c\u54c1\u6c34\u63d0\u53d6\u7269\u53c8\u80f6\u539f\u8bf1\u5bfc\u7684\u4eba\u8840\u5c0f\u677f\u805a\u96c6\u6709\u663e\u7740\u6291\u5236\u4f5c\u7528\uff0c\u5176IC50\u4e3a0\uff0e93mg\uff0fml\uff0c\u5f3a\u5ea6\u4f4e\u4e8e\u5510\u53e4\u7279\u5927\u9ec4\u76840\uff0e68mg\uff0fml\uff0c\u800c\u9ad8\u4e8e\u836f\u7528\u5927\u9ec4\u76842\uff0e07mg\uff0fml\u548c\u638c\u53f6\u5927\u9ec4\uff0e73mg\/ml[4].3\uff0e\u964d\u8840\u8102\u4f5c\u7528RHP100mg\uff0fkg\u548c200mg\uff0fkg\u704c\u80c3\uff0c\u53ef\u5206\u522b\u4f7f\u86cb\u9ec4\u8bf1\u5bfc\u7684\u9ad8\u8102\u8840\u75c7\u5c0f\u9f20\u7684\u8840\u6e05\u603b\u80c6\u56fa\u9187\uff08TC\uff09\u964d\u4f4e45\uff05\u548c46\uff05\uff0c\u4e09\u9170\u7518\u6cb9\uff08TG\uff09\u964d\u4f4e42\uff05\u548c67\uff05\uff0c\u809d\u810fTC\u964d\u4f4e63\uff05\u548c65\uff05\uff0cTG\u964d\u4f4e14\uff05\u548c55\uff05\uff0c\u4e19\u4e8c\u919b\uff08MDA\uff09\u964d\u4f4e49\uff05\u548c66\uff05\uff1b\u5bf9\u6b63\u5e38\u5c0f\u9f20\u8840\u6e05TC\u65e0\u660e\u663e\u5f71\u54cd\u3002RHP45mg\uff0fkg\u548c90mg\uff0fkg\u704c\u80c3\u53f6\u5206\u522b\u4f7f\u9ad8\u8102\u9972\u6599\u8bf1\u5bfc\u7684\u9ad8\u8102\u8840\u75c7\u5927\u9f20\u8840\u6e05TC\u964d\u4f4e48\uff05\u548c50\uff05\uff0cTG\u964d\u4f4e30\uff05\u548c31\uff05\uff0c\u809d\u810fTC\u964d\u4f4e57\uff05\u548c62\uff05\uff0cTG\u964d\u4f4e23\uff05\u548c30\uff05\uff0cMDA\u964d\u4f4e26\uff05\u548c41\uff05 [3]\u3002\u672c\u54c1\u6240\u542b\u98df\u7528\u5927\u9ec4\u7519\u5373\u4e0a\u5927\u9ec4\u751910mg\uff0f\uff08kg\u00b7d\uff09\uff0c\u8fde\u7eed\u5582\u98df2\uff5e4\u661f\u671f\uff0c\u5bf9\u5b9e\u9a8c\u6027\u9ad8\u8102\u8840\u75c7\u5bb6\u5154\u548c\u6b63\u5e38\u5bb6\u5154\uff0c\u5747\u80fd\u663e\u7740\u964d\u4f4e\u8840\u6e05\u4e2d\u603b\u8102\u3001\u603b\u80c6\u56fa\u9187\u3001\u4e09\u9170\u7518\u6cb9\u548c\u03b2-\u8102\u86cb\u767dLDL\uff09\uff0c\u63d0\u9ad8\u5b9e\u9a8c\u6027\u9ad8\u8102\u8840\u75c7\u5bb6\u5154\u8840\u6e05\u4e2da-\u8102\u86cb\u767d\uff08HDL\uff09\u548c\u78f7\u8102\uff0c\u63d0\u9ad8\u6b63\u5e38\u5bb6\u5154\u8840\u6e05\u4e2dHDL\uff0c\u5bf9\u78f7\u8102\u65e0\u663e\u7740\u5f71\u54cd[5]\u3002
4\uff0e\u964d\u8840\u7cd6\u4f5c\u7528 RHP100mg\/kg\u548c200mg\/kg\u704c\u80c3\uff0c\u53ef\u660e\u663e\u964d\u4f4e\u6b63\u5e38\u5c0f\u9f20\u8840\u7cd6\uff0c\u7ed9\u836f7h\u540e\u8840\u7cd6\u5206\u522b\u964d\u4f4e20\uff0e6\uff05\u548c43\uff0e8\uff05\u3002\u540c\u4e0a\u5242\u91cf\u8179\u8154\u6ce8\u5c04\uff0c\u53ef\u964d\u4f4e\u56db\u6c27\u5627\u5576\u6027\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u7684\u8840\u7cd6\uff0c\u7ed9\u836f\u540e7h\uff0c\u8840\u7cd6\u5206\u522b\u964d\u4f4e53\uff0e2\uff05\u548c57\uff0e9\uff05[2]\u3002
5\uff0e\u514d\u75ab\u589e\u5f3a\u4f5c\u7528 RHP100mg\uff0fkg\u548c200mg\uff0fkg\u704c\u80c3\uff0c\u80fd\u660e\u663e\u589e\u52a0\u5c0f\u9f20\u813e\u810f\u548c\u80f8\u817a\u7684\u91cd\u91cf\uff0c\u663e\u7740\u589e\u5f3a\u8179\u8154\u5de8\u566c\u7ec6\u80de\u7684\u541e\u566c\u80fd\u529b\uff0c\u4fc3\u8fdb\u5c0f\u9f20\u78b3\u7c92\u5ed3\u6e05\u901f\u7387\uff0c\u4fc3\u8fdb\u7ef5\u7f8a\u7ea2\u7ec6\u80de\uff08SRBC\uff09\u81f4\u654f\u5c0f\u9f20\u8840\u6e05\u6eb6\u8840\u7d20\u5f62\u6210\u548c\u5c0f\u9f20\u6297\u4f53\u5f62\u6210\u7ec6\u80de\u7684\u751f\u6210\u3002RHP\u5c1a\u80fd\u660e\u663e\u589e\u5f3a\u5200\u8c46\u7403\u86cb\u767dA\uff08ConA\uff09\u8bf1\u5bfc\u7684\u5c0f\u9f20\u813e\u6dcb\u5df4\u7ec6\u80deDNA\u7684\u5408\u6210\uff0c\u5176\u6700\u9002\u6d53\u5ea6\u4e3a20\u03bcg\uff0fml\uff1b\u5bf9ConA\u6d3b\u5316\u7684\u813e\u6dcb\u5df4\u7ec6\u80de\u86cb\u767d\u8d28\u5408\u6210\u4e5f\u6709\u660e\u663e\u4fc3\u8fdb\u4f5c\u7528\uff1b\u5bf9ConA\u8bf1\u5bfc\u7684\u6dcb\u5df4\u7ec6\u80de\u767d\u4ecb\u7d20-2\uff08IL-2\uff09\u4ea7\u751f\u4e5f\u6709\u660e\u663e\u589e\u5f3a\u4f5c\u7528[6]\u3002\u5355\u4e00\u591a\u7cd6RHP\uff0dA\u548cRHP\uff0dB\u7684\u514d\u75ab\u589e\u5f3a\u4f5c\u7528\u6bd4RHP\u66f4\u5f3a\uff0c\u4e09\u8005\u5bf9ConA\u6d3b\u5316\u7684\u5c0f\u9f20\u813e\u6dcb\u5df4\u7ec6\u80deDNA\u751f\u7269\u5408\u6210\u53caIL\uff0d2\u4ea7\u751f\u7684\u6700\u9002\u6d53\u5ea6\u5206\u522b\u4e3a2\uff0e5pg\uff0fml\u30012.5\u03bcg\uff0fml\u548c20\u03bcg\uff0fml[7]\u3002
6\uff0e\u5ef6\u7f13\u8870\u8001\u4f5c\u7528 RHPO\uff0e2\uff05\u548c0\uff0eL\uff05\u7ec4\u5747\u80fd\u660e\u663e\u5ef6\u957f\u4e24\u6027\u679c\u8747\u7684\u5e73\u5747\u5bff\u547d\u548c\u6700\u9ad8\u5bff\u547d\u3002RHP100mg\uff0fkg\u548c200mg\/kg\u8179\u8154\u6ce8\u5c04\uff0c\u8fde\u7eed30d\u5747\u53ef\u589e\u52a012\u6708\u9f84\u5c0f\u9f20\u7ea2\u7ec6\u80de\u548c\u8111\u4e2d\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176\uff08SOD\uff09\u6d3b\u529b\uff0c\u964d\u4f4e\u5fc3\u808c\u7ec4\u7ec7\u4e2d\u8102\u8910\u8d28\u542b\u91cf\uff0c\u964d\u4f4e\u6708\u7ec7\u4e2d\u8fc7\u6c27\u5316\u8102\u8d28\u542b\u91cf\uff0c\u6291\u5236\u8111\u4e2dB\u578b\u5355\u80fa\u6c27\u5316\u9176\uff08MAO-B\uff09\u6d3b\u529b\uff1bRHP100mg\uff0fkg\u548c200mg\uff0f\uff08kg\u00b7d\uff09\u8fde\u7eed 7d\u8fd8\u53ef\u589e\u52a02\uff5e3\u6708\u9f84\u5c0f\u9f20\u7684\u6e38\u6cf3\u8010\u529b\u548c\u8010\u7f3a\u6c27\u80fd\u529b\uff0c\u4e0a\u8ff0\u8bd5\u9a8c\u8868\u660eRHP\u6709\u8f83\u660e\u663e\u7684\u5ef6\u7f13\u8870\u8001\u7684\u4f5c\u7528[8]\u3002
7\uff0e\u6297\u6c27\u5316\u4f5c\u7528 \u7528KO2\uff0bNBT\u95f4\u63a5\u6cd5\u8bd5\u9a8c\u8868\u660e\uff0c\u672c\u54c1\u6c34\u63d0\u53d6\u7269\u53ca\u5176\u6240\u542b\u571f\u5927\u9ec4\u7519\uff08rhaponticin\uff09\u6709\u8f83\u597d\u7684\u6297\u8d85\u6c27\u8d1f\u79bb\u5b50\u81ea\u7531\u57fa\u6d3b\u6027\u7684\u4f5c\u7528[9]\u3002
8\uff0e\u5bf9\u673a\u4f53\u7684\u4fdd\u62a4\u4f5c\u7528 RHP100mg\uff0fkg\u548c200mg\uff0f\uff08kg\u00b7d),\u8fde\u7eed3d\uff0c\u5bf9\u56db\u6c2f\u5316\u78b3\u6240\u81f4\u5c0f\u9f20\u809d\u635f\u4f24\u6709\u4fdd\u62a4\u4f5c\u7528\uff0c\u8840\u6e05\u4e19\u6c28\u9178\u8f6c\u6c28\u9176\uff08ALT\uff09\u5206\u522b\u964d\u4f4e30\uff0e4\uff05\u548c32\uff0e0\uff05\uff1bRHP 100mg\uff0fkg\u548c200mg\uff0f\uff08kg\u00b7d\uff09\uff0c\u8fde\u7eed7d\uff0c\u5bf9\u5c0f\u9f2060Cor\u5c04\u7ebf\u8f90\u5c04\u635f\u4f24\u6709\u4fdd\u62a4\u4f5c\u7528\uff0c\u6b7b\u4ea1\u7387\u5206\u522b\u964d\u4f4e30\uff05\u548c35\uff05\uff0c\u5e73\u5747\u5bff\u547d\u5206\u522b\u5ef6\u957f26\uff05\u548c39\uff05\uff1b\u540c\u4e0a\u5242\u91cf\u548c\u65f6\u95f4\uff0c\u5bf9\u73af\u78f7\u9178\u80fa\u6240\u81f4\u5c0f\u9f20\u767d\u7ec6\u80de\u51cf\u5c11\u548c\u9aa8\u9ad3\u5fae\u6838\u7387\u589e\u52a0\u5177\u6709\u5bf9\u6297\u4f5c\u7528\uff0c\u5bf9\u767d\u7ec6\u80de\u51cf\u5c11\u7684\u5bf9\u6297\u7387\u5206\u522b\u4e3a32\uff0e6\uff05\u548c5l\uff0e3\uff05\uff0c\u5bf9\u9aa8\u9ad3\u5fae\u6838\u7387\u589e\u52a0\u7684\u5bf9\u6297\u7387\u5206\u522b\u4e3a15\uff0e7\uff05\u548c31\uff0e6\uff05[2]\u3002
9\uff0e\u6297\u80f0\u9176\u4f5c\u7528 RHP\u5bf9\u80f0\u86cb\u767d\u9176\u3001\u80f0\u8102\u80aa\u9176\u3001\u80f0\u6dc0\u7c89\u9176\u3001\u80f0\u5f39\u529b\u86cb\u767d\u9176\u548c\u80f0\u6fc0\u80bd\u91ca\u653e\u9176\u5747\u6709\u660e\u663e\u6291\u5236\u4f5c\u7528\uff0c\u5176IC50\u3002\u5206\u522b\u4e3a250\u03bcg\uff0fml\u300121\u03bcg\uff0fml\u300118\u03bcg\uff0fml\u3001189\u03bcg\uff0fml\u548c300\u03bcg\uff0fml\u3002\u52a8\u529b\u5b66\u7814\u7a76\u8868\u660eRHP\u5bf9\u80f0\u86cb\u767d\u9176\u548c\u80f0\u8102\u80aa\u9176\u7684\u6291\u5236\u5747\u662f\u975e\u7ade\u4e89\u6027\u7684\u3002\u725b\u8840\u6e05\u767d\u86cb\u767d\uff08BSA\uff09\u5bf9RHP\u6291\u5236\u80f0\u86cb\u767d\u9176\u548c\u80f0\u8102\u80aa\u9176\u6709\u62ee\u6297\u4f5c\u7528\u3002RHP\u6297\u80f0\u9176\u7684\u4f5c\u7528\u53ef\u80fd\u662f\u5927\u9ec4\u6cbb\u7597\u6025\u6027\u80f0\u817a\u708e\u7684\u836f\u7406\u57fa\u7840[10]\u3002
10\uff0e\u5bf9\u80be\u4ee3\u507f\u6027\u80a5\u5927\u7684\u5f71\u54cd \u672c\u54c1\u9187\u63d0\u53d6\u7269\u548c\u6c34\u63d0\u53d6\u7269150mg\uff0f\u53ea\uff0c\u8fde\u7eed\u7528\u836f7d\uff0c\u53ef\u6291\u5236\u5355\u4fa7\u80be\u5207\u9664\u540e\u5bf9\u4fa7\u80be\u4ee3\u507f\u6027\u80a5\u5927\uff0c\u4f46\u4e0d\u5982\u638c\u53f6\u5927\u9ec4\u3002\u76ee\u524d\u666e\u904d\u8ba4\u4e3a\u6b8b\u4f59\u80be\u5355\u4f4d\u7684\u4ee3\u507f\u6027\u80a5\u5927\u662f\u80be\u529f\u80fd\u8fdb\u884c\u6027\u51cf\u9000\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u5927\u9ec4\u6291\u5236\u80be\u4ee3\u507f\u6027\u80a5\u5927\u5c06\u4f1a\u5ef6\u7f13\u6162\u6027\u80be\u529f\u80fd\u8870\u7aed\uff08CRF\uff09\u7684\u8fdb\u5c55[11]\u3002
11\uff0e\u6297\u80bf\u7624\u4f5c\u7528 RHP150mg\/kg\u548c300mg\/(kg\u00b7d)\u704c\u80c3\uff0c\u8fde\u7eed8d,\u5bf9\u5c0f\u9f20S180\u79fb\u690d\u6027\u80bf\u7624\u6709\u660e\u663e\u6291\u5236\u4f5c\u7528\uff0c\u6291\u7624\u7387\u5206\u522b\u4e3a40\uff05\u548c48\uff05[2]\u3002
12\uff0e\u6297\u83cc\u4f5c\u7528 \u672c\u54c1\u6d78\u6db2\u5bf9\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u7684\u6291\u5236\u6d53\u5ea6\u4e3a0\uff0e25\uff05[12]\u3002\u672c\u54c1\u6d78\u818f\u6709\u6bd4\u76d0\u9178\u9ec4\u8fde\u7d20\u66f4\u5f3a\u7684\u6297\u83cc\u4f5c\u7528\uff0c\u5bf9\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u3001\u67af\u8349\u6746\u83cc\u3001\u516b\u53e0\u7403\u83cc\u548c\u75e2\u75be\u6746\u83cc\u7684\u6700\u4f4e\u6291\u83cc\u6d53\u5ea6\uff08MIC\uff09\u4e3a78\u03bcg\/ml\uff0c\u5bf9\u5927\u80a0\u6746\u83cc\u3001\u767d\u8272\u8461\u8404\u7403\u83cc\u548c\u767d\u8272\u5ff5\u73e0\u83cc\u7684MIC\u4e3a156\u03bcg\/ml\uff0c\u5bf9\u4ea7\u6c14\u548c\u7eff\u8113\u6746\u83ccMIC\u4e3a313\u03bcg\uff0fml[1]\u3002
13\uff0e\u5176\u4ed6\u4f5c\u7528 \u672c\u54c1\u7c89\u672b\u6df7\u60ac\u6db21\uff0e259\uff0fkg\u5c0f\u9f20\u704c\u80c3\uff0c\u672a\u89c1\u81f4\u6cfb\u4f5c\u7528[12]\u30021\uff05\u571f\u5927\u9ec4\u75190\uff0e2ml\uff0f\u53ea\u704c\u80c3\uff0c\u8fde\u7eed2\u661f\u671f\uff0c\u5bf9\u5e7c\u5e74\u96cc\u9f20\u7684\u5b50\u5bab\u5375\u5de2\u91cd\u91cf\u65e0\u660e\u663e\u5f71\u54cd[5]\u3002\u672c\u54c1\u6240\u542b\u84bd\u918c\u7c7b\u6210\u5206\u5927\u9ec4\u7d20\u7532\u919a\u3001\u5927\u9ec4\u915a\u548c\u82a6\u5957\u5927\u9ec4\u7d20\u7684\u836f\u7406\u4f5c\u7528\u53c2\u89c1\u5927\u9ec4\u6761\u300214\uff0e\u6bd2\u6027 RHP\u5c0f\u9f20\u8179\u8154\u6ce8\u5c04LD5o\u4e3a885\uff0e6mg\uff0fkg\uff3b2\uff3d\u3002\u571f\u5927\u9ec4\u7519500mg\/\uff08kg\u00b7d\uff09\u704c\u80c3\uff0c\u8fde\u7eed1\u661f\u671f\uff0c\u672a\u89c1\u5f02\u5e38\u53cd\u5e94\uff1b\u5176\u9971\u548c\u751f\u7406\u76d0\u6c34\u6eb6\u6db22ml\uff0fkg\u9759\u8109\u6ce8\u5c04\uff0c\u5bf9\u9ebb\u9189\u732b\u547c\u5438\u65e0\u660e\u663e\u5f71\u54cd\uff0c\u8840\u538b\u7a0d\u4e0b\u964d\uff0c5h\u540e\u6062\u590d\u6b63\u5e38\uff1b10mg\uff0f\uff08kg\u00b7d\uff09\uff0c\u62cc\u5165\u9972\u6599\uff0c\u8fde\u7eed5\u661f\u671f\uff0c\u5bf9\u5154\u8840\u5e38\u89c4\u3001\u809d\u80be\u529f\u80fd\u53ca\u5fc3\u3001\u809d\u3001\u813e\u3001\u80be\u3001\u80be\u4e0a\u817a\u7ec4\u7ec7\u7ed3\u6784\u5747\u65e0\u660e\u663e\u5f71\u54cd[5]\u3002<\/p>\n
\u3010\u6027\u5473\u3011\u82e6\uff1b\u6027\u5bd2<\/p>\n
\u3010\u529f\u80fd\u4e3b\u6cbb\u3011\u6d88\u98df\u5316\u6ede\uff1b\u901a\u8151\u6cc4\u70ed\u3002\u4e3b\u98df\u79ef\u4e0d\u5316\uff1b\u8118\u8179\u80c0\u6ee1\uff1b\u8179\u75db\u6cc4\u6cfb\u4e0d\u723d\uff1b\u70ed\u7ed3\u4fbf\u79d8<\/p>\n
\u3010\u7528\u6cd5\u7528\u91cf\u3011\u5185\u670d\uff1a\u714e\u6c64\uff0c3-9g\u3002<\/p>\n
\u3010\u5404\u5bb6\u8bba\u8ff0\u3011\u300a\u65b0\u534e\u672c\u8349\u7eb2\u8981\u300b\uff1a\u6709\u6cfb\u70ed\u3001\u6d88\u79ef\u7684\u529f\u80fd\u3002\u5927\u591a\u7528\u4e8e\u517d\u533b\u4f5c\u6cfb\u4e0b\u836f\u53ca\u6d88\u5bfc\u836f\u3002<\/p>\n
\u3010\u6458\u5f55\u3011\u300a\u4e2d\u534e\u672c\u8349\u300b<\/p>\n","protected":false},"excerpt":{"rendered":"
\u3010\u51fa\u5904\u3011\u59cb\u8f7d\u4e8e\u300a\u690d\u7269\u5206\u7c7b\u5b66\u62a5\u300b\u3002 \u3010\u62fc\u97f3\u540d\u3011H\u00e9 T\u00e0o D\u00e0i Hu\u00e1n\u0261 \u3010 … \u7ee7\u7eed\u9605\u8bfb