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&nbsp; &nbsp;\u88ab\u79f0\u4e3a\u201c\u52a8\u8109\u5185\u819c\u5468\u56f4\u5f15\u6d41\u901a\u8def\u201d\uff08intramural periarterial drainage pathway\uff0cIPAD\uff09\u7684\u53e6\u4e00\u79cd\u8111\u6e05\u9664\u7cfb\u7edf\u6a21\u578b\u62a5\u9053\u4e86ISF\u548c\u6eb6\u8d28\u7684\u8f6c\u8fd0\u662f\u6cbf\u7740\u6bdb\u7ec6\u8840\u7ba1\u7684\u57fa\u5e95\u819c\u53ca\u4e0e\u52a8\u8109\u8840\u6d41\u76f8\u53cd\u7684\u65b9\u5411\u7684\u5c0f\u52a8\u8109\u548c\u52a8\u8109\u7684tunica\u819c\uff08tunica media\uff09\u53d1\u751f\u7684\uff0c\u8fdb\u4e00\u6b65\u901a\u8fc7\u9888\u90e8\u7684\u52a8\u8109\u5411\u9888\u90e8\u6dcb\u5df4\u7ed3\u8f6c\u8fd0\u3002\u5bf9\u4e8eIPAD\u7cfb\u7edf\uff0c\u5df2\u7ecf\u63d0\u51fa\u8840\u7ba1\u640f\u52a8\u662f\u4e3b\u8981\u7684\u52a8\u529b\u3002\u7531\u4e8e\u8fd9\u79cd\u6db2\u4f53\u6d41\u52a8\u53d1\u751f\u5728\u6cbf\u7740\u52a8\u8109\u58c1\u7684\u5fae\u89c2\u6c34\u5e73\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695aIPAD\u7cfb\u7edf\u7684\u6539\u53d8\u662f\u5426\u5bf9\u5e94\u4e8eMRI\u53ef\u89c1PVS\u7684\u6269\u5927\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp; \u6b64\u5916\uff0c\u5c1a\u4e0d\u6e05\u695aMRI\u53ef\u89c1PVS\u4e0e\u8111\u5b9e\u8d28\u5916\u90e8\u6e05\u9664\u9014\u5f84\u7684\u5173\u7cfb\uff0c\u5305\u62ec\uff1a\u86db\u7f51\u819c\u9897\u7c92\uff08\u5176\u5c06\u86db\u7f51\u819c\u4e0b\u8154\u8fde\u63a5\u5230\u8111\u9759\u8109\u7cfb\u7edf\uff09\uff1b\u8111\u819c\u6dcb\u5df4\u7ba1\uff08\u4f4d\u4e8e\u9759\u8109\u7aa6\u9644\u8fd1\u7684\u786c\u8111\u819c\u4e2d\u7684\u6dcb\u5df4\u7ba1\uff0c\u53ef\u4ee5\u5c06\u6db2\u4f53\u5f15\u6d41\u81f3\u9885\u5916\u9888\u6df1\u6dcb\u5df4\u7ed3\uff09\uff1b\u6cbf\u7740\u9885\u795e\u7ecf\u548c\u810a\u795e\u7ecf\u7684\u795e\u7ecf\u5468\u95f4\u9699\u3002<\/p>\n<p>3. 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&nbsp;\u7531\u4e8eMRI\u5728\u68c0\u6d4b\u8111\u5185\u6db2\u4f53\u7684\u7ed3\u6784\u548c\u751f\u7269\u7269\u7406\u7279\u6027\u65b9\u9762\u5177\u6709\u9ad8\u7075\u654f\u5ea6\uff0c\u56e0\u6b64\u5b83\u662f\u68c0\u6d4bPVS\u7684\u7406\u60f3\u795e\u7ecf\u6210\u50cf\u65b9\u5f0f\u3002\u7ed3\u6784MRI\u663e\u793aPVS\u4e3a\u7ba1\u72b6\u3001\u5145\u6ee1\u6db2\u4f53\u7684\u7ed3\u6784\u3002MRI\u53ef\u89c1\u7684PVS\u4e3b\u8981\u4f4d\u4e8e\u57fa\u5e95\u8282\u548c\u534a\u5375\u5706\u4e2d\u5fc3\u3002MRI\u53ef\u89c1\u7684PVS\u4e5f\u53ef\u4ee5\u4f4d\u4e8e\u5176\u4ed6\u90e8\u4f4d\uff0c\u5305\u62ec\u6d77\u9a6c\u3001\u4e2d\u8111\u3001\u8111\u6865\u548c\u5c0f\u8111\u3002\u867d\u7136PVS\u5185\u6db2\u4f53\u7684\u7ec4\u6210\u5c1a\u4e0d\u6e05\u695a\uff0c\u4f46\u662fMRI\u53ef\u89c1\u7684PVS\u901a\u5e38\u5177\u6709\u4e0eCSF\u7684\u76f8\u4f3c\u7684\u4fe1\u53f7\uff0c\u5373\u5728T1\u52a0\u6743\u56fe\u50cf\u4e0a\u5448\u4f4e\u4fe1\u53f7\uff0c\u5728T2\u52a0\u6743\u56fe\u50cf\u4e0a\u5448\u9ad8\u4fe1\u53f7\uff0c\u8fd9\u8868\u660ePVS\u5185\u7684\u6db2\u4f53\u548cCSF\u5177\u6709\u76f8\u540c\u7684\u7279\u6027\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp; \u5e94\u8be5\u6ce8\u610f\u7684\u662f\uff0cPVS\u5728MRI\u4e0a\u7684\u53ef\u89c1\u6027\u53d6\u51b3\u4e8ePVS\u5185\u662f\u5426\u5b58\u5728\u6db2\u4f53\u3002\u4e8b\u5b9e\u4e0a\uff0c\u7ed3\u6784MRI\u662f\u5bf9PVS\u5185\u7684\u6db2\u4f53\u800c\u4e0d\u662fPVS\u672c\u8eab\u8fdb\u884c\u53ef\u89c6\u5316\uff0c\u5982\u679cPVS\u662f\u7a7a\u7684\uff0c\u5219PVS\u672c\u8eab\u5c06\u5177\u6709\u4e0d\u540c\u7684MRI\u4fe1\u53f7\u5206\u5e03\uff0c\u96be\u4ee5\u68c0\u6d4b\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u6700\u8fd1\u6709\u5173\u5468\u7ec6\u80de\u7f3a\u9677\u5c0f\u9f20\u548c\u8111\u6dc0\u7c89\u6837\u8840\u7ba1\u75c5\uff08CAA\uff09\u60a3\u8005\u7684\u7ec4\u7ec7\u5b66\u7814\u7a76\u5df2\u7ecf\u8868\u660e\uff0c\u6269\u5927\u7684PVS\u53ef\u80fd\u4e0d\u4ec5\u542b\u6709\u6db2\u4f53\uff0c\u800c\u4e14\u8fd8\u542b\u6709\u5176\u4ed6\u7269\u8d28\uff0c\u4f8b\u5982\u7ea4\u7ef4\u86cb\u767d\/\u7ea4\u7ef4\u86cb\u767d\u539f\u3001\u7ec6\u80de\u5916\u57fa\u8d28\u548c\u542b\u94c1\u8840\u9ec4\u7d20\u6c89\u79ef\u7269\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u6c89\u79ef\u7269\u5bf9PVS\u5728MRI\u6210\u50cf\u4e0a\u7684\u53ef\u89c1\u6027\u7684\u5f71\u54cd\u4ecd\u7136\u96be\u4ee5\u6349\u6478\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp; MRI\u53ef\u89c1\u7684PVS\u5728\u5e73\u884c\u4e8e\u56fe\u50cf\u91c7\u96c6\u5e73\u9762\u65f6\u663e\u793a\u4e3a\u7ebf\u72b6\u7ed3\u679c\uff0c\u5728\u5782\u76f4\u4e8e\u56fe\u50cf\u91c7\u96c6\u5e73\u9762\u65f6\u663e\u793a\u4e3a\u70b9\u72b6\u7ed3\u6784\u3002\u901a\u5e38\uff0cPVS\u7684\u6a2a\u622a\u9762\u76f4\u5f84\u5c0f\u4e8e2 mm\u3002\u968f\u7740\u8840\u7ba1\u5728\u8111\u5b9e\u8d28\u4e2d\u7a7f\u900f\u5f97\u66f4\u6df1\uff0cPVS\u7684\u76f4\u5f84\u9010\u6e10\u51cf\u5c0f\u3002MRI\u4e0aPVS\u7684\u53ef\u89c1\u6027\u53d7\u78c1\u573a\u5f3a\u5ea6\u548c\u56fe\u50cf\u5206\u8fa8\u7387\u7684\u663e\u8457\u5f71\u54cd\u3002\u4e8b\u5b9e\u4e0a\uff0c\u867d\u7136\u5f53PVS\u672a\u88ab\u653e\u5927\u65f6\u53ef\u80fd\u96be\u4ee5\u75281.5T MRI\u5bdf\u89c9\uff0c\u4f46\u8f83\u9ad8\u573a\uff08\u2265 3.0 T\uff09\u7684MRI\u63d0\u4f9b\u4e86\u8db3\u591f\u7684\u5206\u8fa8\u7387\u548c\u4fe1\u566a\u6bd4\uff08SNR\uff09\u8fdb\u884c\u51e0\u4e4e\u5728\u6240\u6709\u4e2a\u4f53\u4e2d\uff08\u751a\u81f3\u5305\u62ec\u5065\u5eb7\u7684\u9752\u5c11\u5e74\uff09PVS\u7684\u53ef\u89c6\u5316\uff0c\u8fd9\u79cdMRI\u53ef\u89c1PVS\u4e0d\u4e00\u5b9a\u6697\u793a\u7740\u6f5c\u5728\u7684\u75c5\u7406\u6539\u53d8\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp; \u5c3d\u7ba1\u7ec4\u7ec7\u5b66\u7814\u7a76\u63cf\u8ff0\u4e86\u52a8\u8109\u5468\u56f4\u548c\u9759\u8109\u5468\u56f4\u7684PVS\uff0c\u4f46\u6700\u8fd1\u4e00\u4e9b7.0 T MRI\u7814\u7a76\u8868\u660e\uff0c\u534a\u5375\u5706\u4e2d\u5fc3\u7684\u5927\u591a\u6570MRI\u53ef\u89c1\u7684PVS\u662f\u52a8\u8109\u5468\u56f4\u95f4\u9699\uff0c\u800c\u975e\u9759\u8109\u5468\u56f4\u95f4\u9699\u3002\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u4e3a\u4ec0\u4e48\u5728MRI\u4e0a\u9759\u8109\u5468\u56f4\u95f4\u9699\u6bd4\u52a8\u8109\u5468\u56f4\u95f4\u9699\u66f4\u4e0d\u660e\u663e\uff0c\u4f46\u8fd9\u53ef\u80fd\u4e0e\u9759\u8109\u5468\u56f4\u95f4\u9699\u7684\u5c3a\u5bf8\u8f83\u5c0f\u4ee5\u53ca\u9759\u8109\u5468\u56f4\u95f4\u9699\u5185\u6db2\u4f53\u7684\u542b\u91cf\u548c\/\u6216\u6210\u5206\u7684\u5dee\u5f02\u6709\u5173\u3002\u4f8b\u5982\uff0c\u9759\u8109\u5468\u56f4\u95f4\u9699\u7684\u4fe1\u53f7\u5f3a\u5ea6\u53ef\u80fd\u4e0e\u76f8\u90bb\u8111\u5b9e\u8d28\u7684\u4fe1\u53f7\u5f3a\u5ea6\u76f8\u4f3c\uff0c\u4f7f\u5f97\u5b83\u4eec\u5728MRI\u4e0a\u96be\u4ee5\u53ef\u89c6\u5316\u3002\u5728CAA\u60a3\u8005\u4e2d\uff0cPVS\u7684\u6269\u5927\u4e5f\u66f4\u5e38\u53d1\u751f\u5728\u5c0f\u52a8\u8109\u5468\u56f4\u800c\u4e0d\u662f\u5c0f\u9759\u8109\u5468\u56f4\u3002<\/p>\n<p>3.1 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&nbsp;\u89c6\u89c9\u8bc4\u5b9a\u91cf\u8868\u662f\u8fc4\u4eca\u4e3a\u6b62\u7814\u7a76PVS\u6700\u5e38\u7528\u7684\u65b9\u6cd5\u3002\u5728\u8fc7\u53bb\u7684\u4e09\u5341\u5e74\u91cc\uff0c\u51e0\u79cd\u7c7b\u578b\u7684\u89c6\u89c9\u8bc4\u7ea7\u7cfb\u7edf\u5df2\u7ecf\u88ab\u5e7f\u6cdb\u91c7\u7528\u3002\u5927\u90e8\u5206\u91cf\u8868\u6839\u636ePVS\u5728\u4e0d\u540c\u8111\u533a\u7684\u8ba1\u6570\u8fdb\u884c\u5206\u7c7b\u3002\u4f8b\u5982\uff0c\u6700\u5e38\u7528\u7684\u4e00\u79cdPVS\u89c6\u89c9\u8bc4\u5b9a\u91cf\u8868\u4f7f\u7528\u4ee5\u4e0b\u5206\u6570\u5bf9\u6bcf\u4e2a\u5730\u533a\u7684PVS\u8fdb\u884c\u8bc4\u7ea7\uff1a\u5982\u679cPVS\u4e0d\u53ef\u89c1\uff0c\u5219\u4e3a0\u7ea7\uff1b\u5982\u679c\u67091-10\u4e2aPVS\uff0c\u5219\u4e3a1\u7ea7\uff1b\u5982\u679c\u670911-20\u4e2aPVS\uff0c\u5219\u4e3a2\u7ea7\uff1b\u5982\u679c\u670921-40\u4e2aPVS\uff0c\u5219\u4e3a3\u7ea7\uff1b\u5982\u679c\u6709\uff1e40\u4e2aPVS\uff0c\u5219\u4e3a4\u7ea7\u3002\u901a\u5e38\uff0c\u57fa\u5e95\u795e\u7ecf\u8282\u548c\u534a\u5375\u5706\u4e2d\u5fc3\u8fdb\u884c\u72ec\u7acb\u8bc4\u5206\u3002\u6709\u65f6\u4e5f\u8bc4\u4f30\u5176\u4ed6\u533a\u57df\uff0c\u5305\u62ec\u4e2d\u8111\u3001\u6d77\u9a6c\u548c\u5c9b\u4e0b\u767d\u8d28\u3002\u5bf9\u4e8e\u6bcf\u4e2a\u533a\u57df\uff0c\u8bc4\u4f30\u4e00\u4e2a\u6216\u51e0\u4e2a\u5c42\u9762\uff08\u901a\u5e38\u662f\u5305\u62ec\u6700\u591a\u7684PVS\u6570\u91cf\u7684\u5c42\u9762\uff09\uff0c\u5e76\u5728\u53cc\u4fa7\u5927\u8111\u534a\u7403\u4e0a\u5206\u522b\u5bf9PVS\u8fdb\u884c\u8bc4\u5206\uff0c\u7136\u540e\u91c7\u7528\u4e24\u4e2a\u534a\u7403\u4e2d\u8f83\u9ad8\u7684\u5206\u6570\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u57fa\u5e95\u8282PVS\u901a\u5e38\u5728\u524d\u8fde\u5408\u4e0a\u65b9\u8bc4\u5206\uff0c\u56e0\u4e3a\u524d\u8fde\u5408\u4e0b\u65b9\u7684PVS\u4e0d\u88ab\u8ba4\u4e3a\u662f\u75c5\u7406\u6027\u7684\u3002\u5b9e\u9645\u4e0a\uff0c\u8fd9\u4e9bPVS\u53cd\u6620\u4e86\u8c46\u7eb9\u52a8\u8109\u4ece\u4fa7\u88c2\u6c60\u7684\u86db\u7f51\u819c\u4e0b\u8154\u8fdb\u5165\u8111\u5b9e\u8d28\uff0c\u5e76\u4e14\u901a\u5e38\u57281.5T MRI\u4e0a\u53d1\u73b0\uff0c\u751a\u81f3\u5728\u5065\u5eb7\u4eba\uff08\u5305\u62ec\u5e74\u8f7b\u4eba\u548c\u6210\u5e74\u4eba\uff09\u76843.0 T MRI\u4e0a\u53d1\u73b0\u66f4\u591a\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp;\u5728\u4e00\u4e9b\u60c5\u51b5\u4e0b\uff0c\u8bc4\u5206\u7cfb\u7edf\u4e5f\u8003\u8651PVS\u5c3a\u5bf8\u3002\u4f8b\u5982\uff0c\u6700\u8fd1\u4e00\u9879\u7814\u7a76\u57fa\u4e8e\u6a2a\u622a\u9762\u76f4\u5f84\u5927\u4e8e3 mm\u7684PVS\uff08\u4ed6\u4eec\u79f0\u4e4b\u4e3a\u5de8\u5927PVS\uff09\u7684\u5b58\u5728\u6216\u4e0d\u5b58\u5728\u6765\u5bf9PVS\u8fdb\u884c\u8bc4\u5206\u3002<\/p>\n<p>&nbsp; &nbsp; \u89c6\u89c9\u8bc4\u5b9a\u91cf\u8868\u5177\u6709\u4ee5\u4e0b\u51e0\u4e2a\u4f18\u70b9\uff1a\u5b83\u4eec\u5b66\u4e60\u548c\u4f7f\u7528\u76f8\u5bf9\u5bb9\u6613\uff0c\u53ef\u4ee5\u7528\u4e8eT1\u52a0\u6743\u548cT2\u52a0\u6743\u56fe\u50cf\uff0c\u4e0d\u9700\u89813D\u6216\u5404\u5411\u540c\u6027\u91c7\u96c6\uff0c\u5e76\u4e14\u53ef\u4ee5\u76f4\u63a5\u5728\u56fe\u50cf\u4e0a\u8bc4\u4f30\uff0c\u800c\u4e0d\u9700\u8981\u4e13\u95e8\u7684\u5de5\u4f5c\u7ad9\u6216\u8ba1\u7b97\u5de5\u5177\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp;\u867d\u7136\u8fd9\u4e9b\u8bc4\u5206\u7cfb\u7edf\u63d0\u4f9b\u4e86PVS\u4e25\u91cd\u7a0b\u5ea6\u7684\u5b9a\u6027\u4f30\u8ba1\uff0c\u4f46\u662f\u4ecd\u7136\u9700\u8981\u624b\u52a8\u8ba1\u6570\u6765\u8fdb\u884c\u8bc4\u7ea7\u5e76\u4e14\u7f3a\u4e4f\u4e00\u5b9a\u7cbe\u786e\u5ea6\uff0c\u7279\u522b\u662f\u5728PVS\u8ba1\u6570\u63a5\u8fd1\u533a\u5206\u4e24\u4e2a\u7c7b\u522b\u89c6\u89c9\u7b49\u7ea7\u91cf\u8868\u7684\u5176\u4ed6\u5c40\u9650\u6027\u5305\u62ec\u8f83\u4f4e\u7684\u7075\u654f\u5ea6\u3001\u8f83\u4f4e\u7684\u5185\u90e8\u548c\u5916\u90e8\u4e00\u81f4\u6027\u548c\u6709\u9650\u7684PVS\u6570\u91cf\u3002\u6b64\u5916,\u8f83\u5c0f\u5c3a\u5bf8\u7684PVS\u96be\u4ee5\u4f7f\u7528\u89c6\u89c9\u8bc4\u5206\u7cfb\u7edf\u8fdb\u884c\u8bc4\u4f30\uff0c\u89c6\u89c9\u8bc4\u5b9a\u91cf\u8868\u5728\u5927\u578b\u6570\u636e\u96c6\u7684\u5e94\u7528\u8f83\u4e3a\u7e41\u7410\u548c\u8017\u65f6\u3002\u4e3a\u4e86\u5ba2\u670d\u8fd9\u4e9b\u5c40\u9650\u6027\uff0c\u6700\u8fd1\u5f00\u53d1\u4e86\u7528\u4e8e\u5c06\u57fa\u5e95\u795e\u7ecf\u8282\u4e2d\u7684PVS\u8d1f\u8377\u8bc4\u5b9a\u4e3a\u4f4e\u6216\u9ad8\u7684\u81ea\u52a8\u8bc4\u5206\u7cfb\u7edf\uff1a\u8be5\u7cfb\u7edf\u4f7f\u7528\u57fa\u4e8e\u89c6\u89c9\u8bcd\u888b\u6a21\u578b\u7684\u63cf\u8ff0\u7b26\u7684\u652f\u6301\u5411\u91cf\u673a\u5206\u7c7b\u5668\uff0c\u4f7f\u7528\u4ece\u5177\u6709\u5c3a\u5ea6\u4e0d\u53d8\u7279\u5f81\u53d8\u6362\uff08SIFT\uff09\u7279\u6027\u7684\u5bc6\u96c6\u7f51\u683c\u4e2d\u83b7\u5f97\u7684\u5173\u952e\u70b9\uff0c\u5177\u6709\u9ad8\u8fbe80%\u7684\u51c6\u786e\u5ea6\u3002<\/p>\n<p>3.1.2.PVS\u5206\u5272\u548c\u5f62\u6001\u6d4b\u91cf<\/p>\n<p>&nbsp; &nbsp; &nbsp;\u6700\u8fd1\u7684\u6280\u672f\u8fdb\u6b65\u5141\u8bb8\u5f00\u53d1\u4e00\u4e9b\u81ea\u52a8\u548c\u534a\u81ea\u52a8\u7684PVS\u5206\u5272\u548c\u91cf\u5316\u65b9\u6cd5\u3002\u636e\u6211\u4eec\u6240\u77e5\uff0cDescombes\u7b49\u4eba\u662f\u7b2c\u4e00\u4e2a\u8fdb\u884cPVS\u8ba1\u7b97\u673a\u8f85\u52a9\u5206\u5272\u7684\u56e2\u961f\u3002\u4ed6\u4eec\u7684\u65b9\u6cd5\u57fa\u4e8e\u6807\u8bb0\u70b9\u8fc7\u7a0b\u6846\u67b6\uff0c\u8be5\u6846\u67b6\u5c06PVS\u7684\u5178\u578b\u7ba1\u72b6\u5f62\u72b6\u4e0e\u5b83\u4eec\u7684\u5c40\u90e8\u5316\u548c\u805a\u7c7b\u8d8b\u52bf\u76f8\u7ed3\u5408\uff0c\u5e76\u901a\u8fc7Markov chain Monte Carlo method\u65b9\u6cd5\u8fdb\u884c\u4f18\u5316\u3002Uchiyama\u7b49\u4eba\u4f7f\u7528\u767d\u8272\u9876\u5e3d\u53d8\u6362\u6765\u589e\u5f3a\u7ba1\u72b6\u7ed3\u6784\u7684\u5f3a\u5ea6\u5e76\u901a\u8fc7\u5f3a\u5ea6\u9608\u503c\u5316\u6765\u63d0\u53d6\u5b83\u4eec\u3002\u6700\u8fd1\uff0c\u91c7\u7528Frangi\u6ee4\u6ce2\u5668\u7684\u51e0\u4e2a\u5c0f\u7ec4\u5df2\u7ecf\u91c7\u7528\u4e86\u7c7b\u4f3c\u7684\u65b9\u6cd5\u7528\u4e8e\u57282D\u548c3D\u56fe\u50cf\u4e0a\u68c0\u6d4b\u7ba1\u72b6\u7ed3\u6784\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp;Wuerfel\u53ca\u5176\u540c\u4e8b\u662f\u7b2c\u4e00\u4e2a\u8fdb\u884cPVS\u5206\u5272\u7684\u4e34\u5e8a\u7814\u7a76\u7684\u56e2\u961f\uff08Wuerfel\u7b49\u4eba\uff0c2008\uff09\u3002\u4ed6\u4eec\u4f7f\u7528\u4e86\u57fa\u4e8e\u9608\u503c\u7684\u534a\u81ea\u52a8\u65b9\u6cd5\uff0c\u8be5\u65b9\u6cd5\u6700\u521d\u662f\u4e3a\u4e86\u5b9a\u91cf\u8bc4\u4f30\u8111\u635f\u4f24\u800c\u5f00\u53d1\u7684\uff0c\u5176\u4e2d\u4f7f\u7528\u57fa\u4e8e\u624b\u52a8\u786e\u5b9a\u7684PVS\u6765\u8c03\u6574\u8fde\u901a\u6027\u548c\u9608\u503c\u3002Ramirez\u7b49\u4eba\u91c7\u7528\u4e86\u7c7b\u4f3c\u7684\u57fa\u4e8e\u9608\u503c\u7684\u65b9\u6cd5\uff0c\u901a\u8fc7\u91c7\u7528T1\u52a0\u6743\u3001T2\u52a0\u6743\u548c\u8d28\u5b50\u5bc6\u5ea6\u52a0\u6743\u56fe\u50cf\u7684\u6539\u8fdb\u75c5\u53d8\u8fdb\u884c\u63d0\u53d6\u7b97\u6cd5\u548c\u5206\u5272PVS\u3002Wang\u7b49\u4eba\u57283\u4e2a\u9636\u6bb5\uff08\u6807\u51c6\u5316\u3001\u4f3d\u9a6c\u6821\u6b63\u548c\u7ebf\u6027\u6620\u5c04\uff09\u4e2d\u6267\u884c\u7ebf\u6027\u5f3a\u5ea6\u81ea\u9002\u5e94\u8c03\u6574\u540e\uff0c\u80fd\u591f\u5728\u534a\u5375\u5706\u4e2d\u5fc3\u548c\u57fa\u5e95\u795e\u7ecf\u8282\u7684\u624b\u52a8\u8ffd\u8e2a\u5375\u5f62\u533a\u57df\u4e2d\u7684\u5355\u4e00\u5c42\u9762\u4e0a\u5206\u5272PVS\u3002<\/p>\n<p>&nbsp; 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&nbsp; &nbsp;\u5728\u7ed3\u6784MRI\u4e0a\u8bc6\u522b\u548c\u5206\u5272PVS\u6709\u65f6\u53ef\u80fd\u5177\u6709\u6311\u6218\u6027\uff0c\u7279\u522b\u662f\u5728\u8870\u8001\u3001CSVD\u548c\u5176\u4ed6\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u80cc\u666f\u4e0b\uff0c\u56e0\u4e3a\u8111\u767d\u8d28\u9ad8\u4fe1\u53f7\uff08WMH\uff09\u3001\u8154\u9699\u548c\u56ca\u80bf\u7684\u5b58\u5728\u53ef\u80fd\u4e0ePVS\u76f8\u6df7\u6dc6\u3002\u4e86\u89e3PVS\u7684\u89e3\u5256\u5206\u5e03\u3001\u7ed3\u6784\u548c\u6b63\u5e38\u5f71\u50cf\u5b66\u8868\u73b0\u5341\u5206\u91cd\u8981\u3002\u4e8b\u5b9e\u4e0a\uff0c\u533a\u5206PVS\u4e0e\u5176\u4ed6\u7c7b\u578b\u75c5\u53d8\u7684\u6700\u91cd\u8981\u7279\u5f81\u662f\u4fe1\u53f7\u5f3a\u5ea6\u3001\u5f62\u72b6\u548c\u4f4d\u7f6e\/\u5206\u5e03\u3002<\/p>\n<p>&nbsp; &nbsp; 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&nbsp; &nbsp;\u589e\u52a0PVS\u5bf9\u6bd4\u5ea6\u662f\u4e00\u79cd\u6539\u5584MRI\u53ef\u89c1\u7684PVS\u7684\u53ef\u89c6\u5316\u548c\u91cf\u5316\u8bc4\u4f30\u7684\u6709\u524d\u666f\u7684\u89e3\u51b3\u65b9\u6848\u3002\u5728\u8fc7\u53bb\u7684\u51e0\u5e74\u4e2d\uff0c\u5df2\u7ecf\u5f00\u53d1\u4e86\u51e0\u79cd\u65b9\u6cd5\u6765\u514b\u670d\u53ef\u89c1\u6027\u9650\u5236\u3002\u6700\u8fd1\u5f00\u53d1\u7684\u4e00\u79cd\u6280\u672f\u5728\u540e\u5904\u7406\u9636\u6bb5\u589e\u5f3aPVS\u5bf9\u6bd4\u5ea6\uff0c\u8be5\u6280\u672f\u57fa\u4e8e\u5c06\u9884\u5904\u7406\u548c\u975e\u5c40\u90e8\u5747\u503c\u6ee4\u6ce2\u7684T1\u52a0\u6743\u548cT2\u52a0\u6743\u56fe\u50cf\u7ec4\u5408\u4ee5\u53bb\u9664\u9ad8\u9891\u7a7a\u95f4\u566a\u58f0\u3002\u8fd9\u79cd\u65b9\u6cd5\u5141\u8bb8\u53ef\u89c6\u5316\u8f83\u5c0f\u7684PVS\uff08\u76f4\u5f84\uff1c1mm\uff09\uff0c\u5373\u4f7f\u5728\u5065\u5eb7\u4eba\u7fa4\u4e2d\u4e5f\u662f\u5982\u6b64\u3002Hou\u7b49\u4eba\u4f7f\u7528\u975e\u5c40\u90e8\u7acb\u65b9\u4f53\u7684Haar\u53d8\u6362\u6765\u653e\u5927\u5f31\u4fe1\u53f7\uff0c\u5e76\u901a\u8fc7\u5728PVS\u5206\u5272\u4e4b\u524d\u6267\u884c\u5757\u5339\u914d4D\u6ee4\u6ce2\u6765\u53bb\u9664\u566a\u58f0\u3002\u6b64\u5916\uff0c\u5bc6\u96c6\u8fde\u63a5\u7684\u6df1\u5ea6CNN\u5df2\u7ecf\u88ab\u8bc1\u660e\u53ef\u4ee5\u5728\u6ca1\u6709\u542f\u53d1\u5f0f\u53c2\u6570\u8c03\u6574\u7684\u60c5\u51b5\u4e0b\u51c6\u786e\u5730\u9884\u6d4b\u589e\u5f3a\u56fe\u50cf\uff0c\u5e76\u4e14\u901a\u8fc7\u8003\u8651\u4ece\u4f4e\u7ea7\u5230\u9ad8\u7ea7\u7279\u5f81\u5bfc\u51fa\u7684\u4e0a\u4e0b\u6587\u4fe1\u606f\u6765\u53bb\u9664\u566a\u58f0\u3002.\u5f53FLAIR\u56fe\u50cf\u53ef\u7528\u65f6\uff0c\u53ef\u4ee5\u901a\u8fc7\u6392\u9664WMH\u6765\u6539\u5584PVS\u7684\u8bc6\u522b\u548c\u5206\u5272\uff0c\u4ece\u800c\u51cf\u5c11\u5047\u9633\u6027\u7684PVS\u3002Sepehrband\u7b49\u4eba\u572825\u4e2a\u624b\u52a8\u6ce8\u91ca\u7684MRI\u6570\u636e\u4e0a\u68c0\u67e5\u4e86PVS\u5206\u5272\u51c6\u786e\u6027\uff1a\u5f53FLAIR\u6570\u636e\u7528\u4e8e\u53bb\u9664\u5e74\u9f84\u572865\u5c81\u53ca\u4ee5\u4e0a\u3001\u8ba4\u77e5\u672a\u53d7\u635f\u6216\u5177\u6709\u8f7b\u5ea6\u8ba4\u77e5\u529f\u80fd\u969c\u788d\uff08MCI\uff09\u7684\u4e2a\u4f53\u7684\u961f\u5217\u4e2d\u7684\u5047\u9633\u6027\u65f6\uff0cPVS\u5206\u5272\u7684\u7279\u5f02\u6027\u4ece\u7ea665%\u589e\u52a0\u523090%\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp;\u53e6\u4e00\u79cd\u89e3\u51b3\u65b9\u6848\u662f\u5e94\u7528UHF\u6280\u672f\u3002\u5b9e\u9645\u4e0a\uff0c\u5feb\u901f\u81ea\u65cb\u56de\u6ce2\u5e8f\u5217\u548c3\u7ef4\u5feb\u901f\u81ea\u65cb\u56de\u6ce2\u5e8f\u5217\u5177\u6709\u5404\u5411\u540c\u6027\u7a7a\u95f4\u5206\u8fa8\u7387\u548c\u77ed\u626b\u63cf\u65f6\u95f4\u7684\u4f18\u70b9\uff08\u88682\uff09\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp;\u56fe3\u62a5\u544a\u4e86\u5728\u4f7f\u7528PTX\u7ebf\u5708\uff08Nova 8 Tx\/32 Rx\uff09\u5728UHF\u4e0b\u91c7\u96c6\u7684T1\u52a0\u6743\u548cT2\u52a0\u6743\u56fe\u50cf\u4e0a\u589e\u52a0PVS\u5bf9\u6bd4\u5ea6\u4e4b\u540e\u6267\u884c\u7684PVS\u81ea\u52a8\u5206\u5272\u7684\u793a\u4f8b\u3002<\/p>\n<p>\u88682. \u57283T\u548c7T MRI\u4e0a\u7814\u7a76PVS\u7ed3\u6784\u548c\u5f62\u6001\u6240\u91c7\u7528\u7684\u53c2\u6570\u3002<\/p>\n<p>\u56fe3. \u589e\u5f3aPVS\u5bf9\u6bd4\u5ea6\uff08EPC\uff09\u540e\u5904\u7406\u6280\u672f\u7684\u793a\u4f8b\uff1a\u57287T MRI\u4e0b25\u5c81\u5065\u5eb7\u5973\u6027\u53d7\u8bd5\u8005\u83b7\u5f97\u7684T1\u52a0\u6743\u548cT2\u52a0\u6743\u56fe\u50cf\uff0c\u5177\u4f53\u53c2\u6570\u89c1\u88682\u3002<\/p>\n<p>\u5982\u679c\u60a8\u5bf9\u8111\u5f71\u50cf\u7b49\u6570\u636e\u5206\u6790\u611f\u5174\u8da3\uff0c\u8bf7\u6d4f\u89c8\u601d\u5f71\u4ee5\u4e0b\u94fe\u63a5\uff08\u76f4\u63a5\u70b9\u51fb\u5373\u53ef\u6d4f\u89c8\uff09\uff0c\u611f\u8c22\u8f6c\u53d1\u652f\u6301\u3002(\u53ef\u6dfb\u52a0\u5fae\u4fe1\u53f7siyingyxf\u621618983979082\u54a8\u8be2)\uff1a<\/p>\n<p>\u5357\u4eac\uff1a\u7b2c\u4e09\u5341\u4e8c\u5c4a\u6269\u6563\u6210\u50cf\u6570\u636e\u5904\u7406\u73ed(\u5357\u4eac\uff0c5.9-14\uff09\u7b2c\u516b\u5341\u4e8c\u5c4a\u78c1\u5171\u632f\u8111\u5f71\u50cf\u57fa\u7840\u73ed(\u5357\u4eac\uff0c5.20-25\uff09\u7b2c\u4e09\u5341\u516b\u5c4a\u78c1\u5171\u632f\u8111\u7f51\u7edc\u6570\u636e\u5904\u7406\u73ed\uff08\u5357\u4eac\uff0c6.7-12\uff09\u7b2c\u4e8c\u5341\u4e5d\u5c4a\u8111\u5f71\u50cf\u673a\u5668\u5b66\u4e60\u73ed\uff08\u5357\u4eac\uff0c6.15-20\uff09<\/p>\n<p>\u5317\u4eac\uff1a<\/p>\n<p>\u7b2c\u4e8c\u5341\u4e03\u5c4a\u8111\u5f71\u50cf\u673a\u5668\u5b66\u4e60\u73ed\uff08\u5317\u4eac\uff0c5.5-10\uff09\u7b2c\u5341\u4e09\u5c4a\u4efb\u52a1\u6001\u529f\u80fd\u78c1\u5171\u632f\u6570\u636e\u5904\u7406\u73ed(\u5317\u4eac\uff0c5.24-29\uff09\u7b2c\u5341\u5c4a\u5f71\u50cf\u7ec4\u5b66\u73ed(\u5317\u4eac\uff0c6.11-16\uff09\u7b2c\u4e09\u5341\u4e5d\u5c4a\u78c1\u5171\u632f\u8111\u7f51\u7edc\u6570\u636e\u5904\u7406\u73ed\uff08\u5317\u4eac\uff0c6.20-25\uff09\u7b2c\u516b\u5341\u56db\u5c4a\u78c1\u5171\u632f\u8111\u5f71\u50cf\u57fa\u7840\u73ed\uff08\u5317\u4eac\uff0c6.28-7.3\uff09\u4e0a\u6d77\uff1a\u7b2c\u516b\u5341\u4e00\u5c4a\u78c1\u5171\u632f\u8111\u5f71\u50cf\u57fa\u7840\u73ed\uff08\u4e0a\u6d77\uff0c5.6-11\uff09\u7b2c\u4e8c\u5341\u516b\u5c4a\u8111\u5f71\u50cf\u673a\u5668\u5b66\u4e60\u73ed\uff08\u4e0a\u6d77\uff0c5.14-19\uff09\u7b2c\u4e8c\u5341\u4e94\u5c4a\u78c1\u5171\u632f\u8111\u5f71\u50cf\u7ed3\u6784\u73ed\uff08\u4e0a\u6d77\uff0c5.23-28\uff09\u7b2c\u4e09\u5341\u4e09\u5c4a\u6269\u6563\u6210\u50cf\u6570\u636e\u5904\u7406\u73ed(\u4e0a\u6d77\uff0c6.22-27\uff09\u7b2c\u516b\u5341\u4e94\u5c4a\u78c1\u5171\u632f\u8111\u5f71\u50cf\u57fa\u7840\u73ed\uff08\u4e0a\u6d77\uff0c6.28-7.3\uff09\u91cd\u5e86\uff1a\u7b2c\u4e5d\u5c4a\u5f71\u50cf\u7ec4\u5b66\u73ed\uff08\u66f4\u65b0\uff1a\u91cd\u5e86\uff0c5.20-25\uff09\u7b2c\u516b\u5341\u4e09\u5c4a\u78c1\u5171\u632f\u8111\u5f71\u50cf\u57fa\u7840\u73ed(\u91cd\u5e86\uff0c6.9-14\uff09\u6570\u636e\u5904\u7406\u4e1a\u52a1\u4ecb\u7ecd\uff1a\u601d\u5f71\u79d1\u6280\u529f\u80fd\u78c1\u5171\u632f(fMRI)\u6570\u636e\u5904\u7406\u4e1a\u52a1\u601d\u5f71\u79d1\u6280\u5f25\u6563\u52a0\u6743\u6210\u50cf\uff08DWI\uff09\u6570\u636e\u5904\u7406\u601d\u5f71\u79d1\u6280\u8111\u7ed3\u6784\u78c1\u5171\u632f\uff08T1)\u6210\u50cf\u6570\u636e\u5904\u7406\u4e1a\u52a1&nbsp;\u601d\u5f71\u79d1\u6280\u556e\u9f7f\u7c7b\u52a8\u7269\uff08\u5927\u5c0f\u9f20\uff09\u795e\u7ecf\u5f71\u50cf\u6570\u636e\u5904\u7406\u4e1a\u52a1&nbsp;\u601d\u5f71\u79d1\u6280\u5b9a\u91cf\u78c1\u654f\u611f\uff08QSM)\u6570\u636e\u5904\u7406\u4e1a\u52a1\u601d\u5f71\u79d1\u6280\u5f71\u50cf\u7ec4\u5b66\uff08Radiomics\uff09\u6570\u636e\u5904\u7406\u4e1a\u52a1\u601d\u5f71\u79d1\u6280DTI-ALPS\u6570\u636e\u5904\u7406\u4e1a\u52a1\u601d\u5f71\u6570\u636eASL\u6570\u636e\u5904\u7406\u4e1a\u52a1\u601d\u5f71\u79d1\u6280\u7075\u957f\u7c7b\u52a8\u7269fMRI\u5206\u6790\u4e1a\u52a1&nbsp;\u601d\u5f71\u79d1\u6280\u8111\u5f71\u50cf\u673a\u5668\u5b66\u4e60\u6570\u636e\u5904\u7406\u4e1a\u52a1\u4ecb\u7ecd\u601d\u5f71\u79d1\u6280\u5fae\u751f\u7269\u83cc\u7fa4\u5206\u6790\u4e1a\u52a1&nbsp;\u601d\u5f71\u79d1\u6280EEG\/ERP\u6570\u636e\u5904\u7406\u4e1a\u52a1&nbsp;\u601d\u5f71\u79d1\u6280\u8fd1\u7ea2\u5916\u8111\u529f\u80fd\u6570\u636e\u5904\u7406\u670d\u52a1&nbsp;\u601d\u5f71\u79d1\u6280\u8111\u7535\u673a\u5668\u5b66\u4e60\u6570\u636e\u5904\u7406\u4e1a\u52a1\u601d\u5f71\u6570\u636e\u5904\u7406\u670d\u52a1\u516d\uff1a\u8111\u78c1\u56fe\uff08MEG\uff09\u6570\u636e\u5904\u7406\u601d\u5f71\u79d1\u6280\u773c\u52a8\u6570\u636e\u5904\u7406\u670d\u52a1&nbsp;\u62db\u8058\u53ca\u4ea7\u54c1\uff1a\u601d\u5f71\u79d1\u6280\u62db\u8058\u6570\u636e\u5904\u7406\u5de5\u7a0b\u5e08(\u5317\u4eac\uff0c\u4e0a\u6d77\uff0c\u5357\u4eac\uff0c\u91cd\u5e86\uff09BIOSEMI\u8111\u7535\u7cfb\u7edf\u4ecb\u7ecd\u76ee\u955c\u5f0f\u529f\u80fd\u78c1\u5171\u632f\u523a\u6fc0\u7cfb\u7edf\u4ecb\u7ecd<\/p>\n<p>4.PVS\u7684\u529f\u80fd\u6210\u50cf<\/p>\n<p>4.1.\u6d41\u52a8\u52a8\u529b\u5b66\u6210\u50cf<\/p>\n<p>&nbsp; &nbsp; &nbsp; 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&nbsp; &nbsp;\u76f8\u4f4d\u5bf9\u6bd4MRI\uff08PC-MRI\uff09\u662f\u4e00\u79cd\u975e\u4fb5\u5165\u6027\u7684MRI\u65b9\u6cd5\uff0c\u5b83\u4e0d\u9700\u8981\u9020\u5f71\u5242\u6ce8\u5c04\uff0c\u53ef\u4ee5\u7528\u4e8e\u6d4b\u91cfCSF\u548c\u8840\u6db2\u7684\u6d41\u52a8\u529b\u5b66\u4ee5\u53ca\u8840\u7ba1\u640f\u52a8\u6027\u3002\u6700\u8fd1\u7684\u7814\u7a76\u5df2\u7ecf\u8868\u660e\uff0c\u9759\u8109\u7aa6\u4e2d\u8f83\u9ad8\u7684\u8840\u7ba1\u640f\u52a8\u6027\u4e0e\u57fa\u5e95\u8282\u533aPVS\u7684\u8f83\u9ad8\u53ef\u89c1\u6027\u548c\u6795\u9aa8\u5927\u5b54\u4e2d\u8f83\u4f4e\u7684CSF\u6bcf\u640f\u8f93\u51fa\u91cf\u76f8\u5173\uff0c\u8fd9\u8868\u660e\u8111\u8840\u7ba1\u640f\u52a8\u6027\u7684\u6539\u53d8\u53ef\u80fd\u5f71\u54cdPVS\u5185\u6db2\u4f53\u7684\u8f6c\u8fd0\u3002\u76ee\u524d\uff0c\u7528\u4e8e\u5b9a\u91cf\u6d4b\u91cfCSF\u6d41\u91cf\u7684\u6700\u5e38\u89c1\u89e3\u5256\u4f4d\u7f6e\u662f\u6795\u9aa8\u5927\u5b54\u6c34\u5e73\u7684\u5bfc\u6c34\u7ba1\uff0c\u4f46\u662f\u672a\u6765\u7684\u7814\u7a76\u53ef\u80fd\u4f1a\u4f7f\u7528\u7c7b\u4f3c\u7684\u65b9\u6cd5\u76f4\u63a5\u6d4b\u91cfPVS\u4e2d\u7684\u6db2\u4f53\u6d41\u91cf\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp;\u8fd1\u671f\uff0c\u9798\u5185\u6ce8\u5c04\u9486\u57fa\u9020\u5f71\u5242\u7684\u5bf9\u6bd4\u589e\u5f3aMRI\u5df2\u88ab\u7528\u4e8e\u8bc4\u4f30\u5927\u9f20\u548c\u4eba\u8111\u4e2d\u7684\u8111\u7c7b\u6dcb\u5df4\u7cfb\u7edf\u529f\u80fd\u548cCSF\u7684\u6d41\u52a8\u3002\u5728\u5927\u9f20\u4e2d\uff0cMRI\u65b9\u6848\u91c7\u7528\u8fde\u7eed\u91c7\u96c64-6\u5c0f\u65f6\uff08\u7ea6\u6bcf5\u5206\u949f\u91c7\u96c61\u5f20\u56fe\u50cf\uff09\u7684\u57fa\u4e8e3D T1\u52a0\u6743\u56fe\u50cf\u7684\u52a8\u6001\u626b\u63cf\uff0c\u8fdb\u884c3\u6b21\u57fa\u7ebf\u9020\u5f71\u524d\u626b\u63cf\uff0c\u7136\u540e\u901a\u8fc7\u9798\u5185\u6ce8\u5c04\u7f13\u6162\u8f93\u6ce880\ud835\udf07\u987a\u78c1\u5242\uff08\u8f93\u6ce8\u901f\u7387\u4e3a1.6\ud835\udf07l\/min\uff0c\u603b\u8f93\u6ce8\u65f6\u95f4\u4e3a50 min\uff09\u3002\u8840\u7ba1\u65c1\u548c\u8111\u5ba4\u4e2d\u7684\u4fe1\u53f7\u5f3a\u5ea6\u968f\u65f6\u95f4\u53d8\u5316\u7684\u8fc7\u7a0b\uff08\u901a\u8fc7k\u5747\u503c\u805a\u7c7b\u7b97\u6cd5\u5206\u5272\uff09\u7528\u4e8e\u8ba1\u7b97\u9020\u5f71\u5242\u6e05\u9664\u901f\u7387\u5e38\u6570\uff0c\u7528\u6765\u53cd\u5e94\u8111\u7c7b\u6dcb\u5df4\u7cfb\u7edf\u4e2dCSF-ISF\u4ea4\u6362\u548c\u6eb6\u8d28\u6e05\u9664\u7684\u6548\u7387\u3002\u4e0e\u975e\u7cd6\u5c3f\u75c5\u5927\u9f20\u76f8\u6bd4\uff0c2\u578b\u7cd6\u5c3f\u75c5\u5927\u9f20\u4e2d\u663e\u793a\u51fa\u8f83\u4f4e\u7684\u6e05\u9664\u7387\u3002<\/p>\n<p>&nbsp; &nbsp; 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&nbsp; &nbsp;\u9759\u8109\u5185\u6216\u9798\u5185\u6ce8\u5c04\u653e\u5c04\u6027\u6838\u7d20\u7684\u52a8\u6001\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf\uff08PET\uff09\u4e5f\u5df2\u7528\u4e8e\u7814\u7a76PVS\u5185\u6db2\u4f53\u7684\u6e05\u9664\u548c\u5f15\u6d41\u9014\u5f84\uff1b\u7136\u800cPET\u626b\u63cf\u5177\u6709\u8f83\u4f4e\u7684\u5206\u8fa8\u7387\uff0c\u76ee\u524d\u65e0\u6cd5\u5b9e\u73b0PVS\u7684\u7ec6\u8282\u7684\u53ef\u89c6\u5316\u3002<\/p>\n<p>4.2.PVS\u5f25\u6563\u6210\u50cf<\/p>\n<p>&nbsp; &nbsp; 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&nbsp;\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u4e2d\uff0cMRI\u6280\u672f\u7684\u8fdb\u6b65\u4fc3\u8fdb\u4e86\u5065\u5eb7\u548c\u75be\u75c5\u4e2dPVS\u7ed3\u6784\u7684\u7814\u7a76\u3002\u867d\u7136\u4ee5\u524d\u88ab\u8ba4\u4e3a\u662f\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u6807\u5fd7\u7269\uff0c\u4f46\u4e0e\u65e2\u5f80\u7814\u7a76\u76f8\u6bd4\uff0c\u4f7f\u7528\u65b0\u578bMRI\u5e8f\u5217\u548c\u66f4\u9ad8\u573a\u5f3a\u7684\u626b\u63cf\u4eea\u83b7\u5f97\u7684SNR\u548c\/\u6216\u7a7a\u95f4\u5206\u8fa8\u7387\u7684\u589e\u76ca\u5141\u8bb8\u68c0\u6d4b\u51fa\u66f4\u591a\u7684PVS\u3002\u5982\u4eca\uff0cMRI\u53ef\u89c1\u7684PVS\u5728\u5065\u5eb7\u4e2a\u4f53\u4e2d\u4e5f\u5f88\u5bb9\u6613\u68c0\u6d4b\u5230\uff0c\u5b83\u4eec\u4e0d\u4e00\u5b9a\u4ee3\u8868\u7740\u75c5\u7406\u6027\u7684\u6269\u5927\u3002\u51e0\u9879\u795e\u7ecf\u6210\u50cf\u7814\u7a76\u5df2\u7ecf\u8bc1\u660e\uff0c\u5728\u8001\u5e74\u4eba\u4e2d\u53ef\u4ee5\u89c2\u5bdf\u5230\u66f4\u591a\u6570\u91cf\u7684PVS\uff08\u56fe4\uff09\u3002<\/p>\n<p>\u56fe4. 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&nbsp; &nbsp;MRI\u53ef\u89c1PVS\u5728\u6574\u4e2a\u5bff\u547d\u671f\u95f4\u7684\u76f8\u5bf9\u5206\u5e03\u4f3c\u4e4e\u6ca1\u6709\u53d8\u5316\uff0c\u5728\u9752\u5c11\u5e74\u3001\u4e2d\u5e74\u4eba\u548c\u8001\u5e74\u4eba\u7684\u989d\u53f6\u548c\u9876\u53f6\u4e2d\u90fd\u89c2\u5bdf\u5230\u6700\u9ad8\u7684PVS\u8d1f\u8377\u3002\u53e6\u5916\uff0cPVS\u5728\u9752\u5c11\u5e74\u548c\u8001\u5e74\u4eba\u7684\u534a\u7403\u4e4b\u95f4\u7684\u5206\u5e03\u4e00\u822c\u662f\u5bf9\u79f0\u7684\uff0c\u5c3d\u7ba1\u5728\u67d0\u4e9b\u8111\u533a\u53ef\u80fd\u5b58\u5728\u4e0d\u5bf9\u79f0\u7684\u60c5\u51b5\u3002\u5728\u6b63\u5e38\u5927\u8111\u4e2d\uff0cMRI\u53ef\u89c1PVS\u7684\u6570\u76ee\u5b58\u5728\u5f88\u9ad8\u7684\u4e2a\u4f53\u5f02\u8d28\u6027\uff0c\u8fd9\u53ef\u80fd\u4e0e\u6027\u522b\u3001\u4f53\u91cd\u6307\u6570\uff08BMI\uff09\u3001\u6536\u7f29\u538b\u3001\u9057\u4f20\u56e0\u7d20\u6709\u5173\u3002\u6b64\u5916\uff0cPVS\u8d1f\u8377\u4e5f\u4e0e\u8f83\u5927\u7684\u9885\u5185\u4f53\u79ef\u663e\u8457\u76f8\u5173\u3002\u8f83\u5927\u7684\u9885\u9aa8\u9700\u8981\u8f83\u5927\u7684\u8109\u7ba1\u7cfb\u7edf\u5411\u5927\u8111\u4f9b\u5e94\u8840\u6db2\uff0c\u8fd9\u5c06\u5bfc\u81f4\u66f4\u591a\u548c\/\u6216\u66f4\u5927\u7684MRI\u53ef\u89c1\u7684PVS\uff1b\u7136\u800c\uff0c\u4e5f\u6709\u53ef\u80fd\u8f83\u5927\u7684\u8111\u4f53\u79ef\u53ef\u4ee5\u5bb9\u7eb3\u66f4\u591a\u7684PVS\u3002<\/p>\n<p>&nbsp; &nbsp; 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&nbsp; 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&nbsp; &nbsp;MRI\u53ef\u89c1PVS\u8d1f\u8377\u4e0e\u591a\u79cd\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u76f8\u5173\uff0c\u5305\u62ec\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3001\u8111\u8840\u7ba1\u75c5\u548c\u795e\u7ecf\u708e\u6027\u75be\u75c5\u3002\u4e0b\u9762\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86\u6765\u81eaMRI\u7814\u7a76\u7684\u8bc1\u636e\uff0c\u8fd9\u4e9b\u7814\u7a76\u8bd5\u56fe\u4e86\u89e3PVS\u8d1f\u8377\u5bf9\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u53ca\u5176\u76f8\u5173\u75c7\u72b6\u7684\u5f71\u54cd\u3002\u5c3d\u7ba1\u7814\u7a76\u65b9\u6cd5\u548c\u4eba\u7fa4\u5b58\u5728\u5f88\u5927\u5dee\u5f02\uff0c\u4f46\u8fd9\u4e9b\u8bc1\u636e\u8868\u660ePVS\u6269\u5927\u5bf9\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u5f71\u54cd\u5728\u4e0d\u540c\u89e3\u5256\u7ed3\u6784\u4e2d\u5b58\u5728\u5dee\u5f02\u3002\u4f8b\u5982\uff0c\u6dc0\u7c89\u6837\u86cb\u767d\u76f8\u5173\u75be\u75c5\u548c\u795e\u7ecf\u708e\u6027\u75be\u75c5\u4e0e\u76ae\u8d28\u4e0b\u767d\u8d28\u4e2d\u7684PVS\u589e\u5927\u5f3a\u70c8\u76f8\u5173\uff0c\u800c\u8111\u8840\u7ba1\u75c5\u548c\u795e\u7ecf\u9000\u884c\u6027\u75c5\u75c7\u4e3b\u8981\u5f71\u54cd\u57fa\u5e95\u795e\u7ecf\u8282\u4e2d\u7684PVS\u7ed3\u6784\u3002\u8fd9\u4e9b\u5dee\u5f02\u53ef\u80fd\u8868\u660e\uff0c\u5f15\u8d77PVS\u6269\u5927\u7684\u75c5\u7406\u751f\u7406\u673a\u5236\u53ef\u80fd\u56e0\u5176\u7a7a\u95f4\u4f4d\u7f6e\u800c\u4e0d\u540c\u3002<\/p>\n<p>5.2.1.\u8111\u5c0f\u8840\u7ba1\u75c5<\/p>\n<p>&nbsp; &nbsp; &nbsp;\u6269\u5927\u7684PVS\u4f20\u7edf\u4e0a\u88ab\u8ba4\u4e3a\u662fCSVD\u7684MRI\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5176\u901a\u5e38\u4f34\u968f\u4e2d\u98ce\u6216\u8ba4\u77e5\u8870\u9000\uff0c\u5e76\u4e14\u4e0e\u5176\u4ed6\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u5177\u6709\u9ad8\u5171\u75c5\u6027\u3002\u4e25\u91cd\u7684MRI\u53ef\u89c1\u7684PVS\uff0c\u5c24\u5176\u662f\u5728\u57fa\u5e95\u8282\u533a\u7684PVS\uff0c\u4e0e\u8154\u9699\u3001WMH\u4ee5\u53ca\u8111\u5fae\u51fa\u8840\u5bc6\u5207\u76f8\u5173\u3002\u51e0\u9879\u7814\u7a76\u8868\u660e\u9ad8\u8840\u538b\u4e5f\u4e0eMRI\u53ef\u89c1\u7684PVS\u76f8\u5173\uff0cPVS\u4f18\u5148\u53d1\u751f\u5728\u57fa\u5e95\u8282\uff0c\u800c\u4e0d\u662f\u8111\u767d\u8d28\u3002BG-PVS\u7684\u589e\u5927\u4e0eCSVD\u548c\u9ad8\u8840\u538b\u76f8\u5173\uff0c\u8fd9\u53ef\u80fd\u5f52\u56e0\u4e8e\u7ed3\u6784\u548c\u529f\u80fd\u6027\u8840\u7ba1\u5dee\u5f02\u3002\u7136\u800c\uff0c\u672a\u6765\u7684\u7814\u7a76\u5e94\u8fdb\u4e00\u6b65\u63a2\u7d22\u5177\u4f53\u7684\u75c5\u7406\u751f\u7406\u673a\u5236\u3002<\/p>\n<p>5.2.2.\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u548c\u5176\u4ed6\u86cb\u767d\u75c5<\/p>\n<p>&nbsp; &nbsp; &nbsp;\u5927\u91cf\u7684\u7814\u7a76\u8bc1\u636e\u652f\u6301\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\uff0c\u5305\u62ec\u5404\u79cd\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5176\u7279\u5f81\u5728\u4e8e\u8111\u5185\u975e\u5178\u578b\u6c89\u79ef\u7684A\ud835\udefd\uff0c\u4e0e\u76ae\u8d28\u4e0b\u767d\u8d28\u7684PVS\u6269\u5927\u6709\u5173\u3002AD\u4e0e\u8f83\u9ad8\u7684\u76ae\u8d28\u4e0b\u767d\u8d28\u4e2dMRI\u53ef\u89c1\u7684PVS\u7684\u4f53\u79ef\u3001\u6570\u91cf\u548c\u89c6\u89c9\u8bc4\u5206\u663e\u8457\u76f8\u5173\u3002\u5728\u4e00\u9879\u5229\u7528\u81ea\u52a8\u5206\u5272\u6280\u672f\u7684\u7814\u7a76\u4e2d\uff0cMCI\u60a3\u8005\u7684\u534a\u5375\u5706\u4e2d\u5fc3PVS\u4f53\u79ef\u5206\u6570\u9ad8\u4e8e\u8ba4\u77e5\u672a\u53d7\u635f\u7684\u5bf9\u7167\u7ec4\uff0c\u4f46\u4ec5\u5728\u5973\u6027\u4e2d\uff0c\u524d\u4e0a\u5185\u4fa7\u989e\u53f6\u7684PVS\u4f53\u79ef\u5206\u6570\u8f83\u4f4e\u3002.\u6b64\u5916\uff0cMRI\u53ef\u89c1\u7684PVS\u8d1f\u8377\u5728\u6b63\u5e38\u8001\u9f84\u6210\u4eba\u548cMCI\u60a3\u8005\u4e2d\u968f\u5e74\u9f84\u589e\u52a0\uff0c\u4f46\u5728AD\u60a3\u8005\u4e2d\u4e0d\u968f\u5e74\u9f84\u589e\u52a0\uff0c\u8fd9\u8868\u660e\u4e0e\u75f4\u5446\u76f8\u5173\u7684PVS\u6539\u53d8\u5728\u4e34\u5e8a\u75c7\u72b6\u53d1\u4f5c\u4e4b\u524d\u51fa\u73b0\u3002\u7136\u800c\uff0cMRI\u53ef\u89c1PVS\u548c\u8ba4\u77e5\u529f\u80fd\u4e0b\u964d\u4e4b\u95f4\u7684\u5173\u8054\u4ecd\u4e0d\u6e05\u695a\u3002\u4e8b\u5b9e\u4e0a\uff0c\u51e0\u9879\u7814\u7a76\u6ca1\u6709\u53d1\u73b0MRI\u53ef\u89c1PVS\u8d1f\u8377\u4e0e\u8ba4\u77e5\u4e4b\u95f4\u7684\u663e\u8457\u5173\u5173\u3002\u672a\u6765\uff0c\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76MRI\u53ef\u89c1PVS\u548c\u8ba4\u77e5\u529f\u80fd\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u4ee5\u66f4\u597d\u5730\u4e86\u89e3PVS\u8d1f\u8377\u7684\u4e34\u5e8a\u610f\u4e49\u548c\u5f71\u54cd\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp;CAA(\u6dc0\u7c89\u6837\u8111\u8840\u7ba1\u75c5)\u662f\u4e00\u79cd\u795e\u7ecf\u9000\u884c\u6027CSVD\uff0c\u5176\u7279\u5f81\u5728\u4e8eA\ud835\udefd\u5728\u8111\u52a8\u8109\u4e2d\u6c89\u79ef\u3002\u5148\u524d\u7684\u7814\u7a76\u5df2\u7ecf\u8bc1\u660e\uff0c\u4e0eAD\u4e00\u6837\uff0c\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0cCAA(\u6dc0\u7c89\u6837\u8111\u8840\u7ba1\u75c5)\u60a3\u8005\u4e2d\u767d\u8d28\u7684PVS\u8d1f\u62c5\u66f4\u4e25\u91cd\u3002\u4e25\u683c\u7684\u5927\u53f6\u6027\u8111\u5fae\u51fa\u8840\u4e0e\u66f4\u4e25\u91cd\u7684\u767d\u8d28\u4e2d\u7684PVS\u76f8\u5173\uff0c\u800c\u4e0e\u57fa\u5e95\u8282\u533a\u7684PVS\u65e0\u5173\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp;\u80f6\u8d28\u6dcb\u5df4\u7cfb\u7edf\u7684\u4e3b\u8981\u4f5c\u7528\u662f\u6e05\u9664\u5927\u8111\u4e2d\u7684\u6709\u6bd2\u4ee3\u8c22\u5e9f\u7269\uff0c\u5305\u62ecA\ud835\udefd\u3002\u56e0\u6b64\uff0cCAA\u4e2d\u7684A\ud835\udefd\u6c89\u79ef\u53ef\u80fd\u4e0ePVS\u75c5\u7406\u6027\u589e\u5927\u6240\u53cd\u6620\u7684\u8111\u7c7b\u6dcb\u5df4\u529f\u80fd\u969c\u788d\u6709\u5173\u3002\u7136\u800c\uff0c\u5728AD\u548cCAA\u4e2dA\u03b2\u6c89\u79ef\u548cPVS\u75c5\u7406\u4e4b\u95f4\u7684\u5173\u7cfb\u8fd8\u4e0d\u592a\u6e05\u695a\u3002\u5728\u4e00\u9879\u4f7f\u7528\u89c6\u89c9\u8bc4\u5b9a\u91cf\u8868\u7684\u7814\u7a76\u4e2d\uff0cPVS\u4e25\u91cd\u7a0b\u5ea6\u4e0ePET-PiB\u65e0\u5173\u3002\u5728\u53e6\u4e00\u9879\u7814\u7a76\u4e2d\uff0cMCI\u60a3\u8005\u5185\u4fa7\u989e\u53f6PVS\u4f53\u79ef\u5206\u6570\u964d\u4f4e\u4e0eA\u03b2-PET\u7684A\u03b2\u6444\u53d6\u7387\u65e0\u5173\uff0c\u4f46\u4e0eTau-PET\u6444\u53d6\u7387\u72ec\u7acb\u76f8\u5173\uff0cTau\u86cb\u767d\u6c89\u79ef\u662fAD\u7684\u53e6\u4e00\u4e2a\u5178\u578b\u75c5\u7406\u7279\u5f81\u3002\u5728\u4e00\u9879\u7ec4\u7ec7\u5b66\u7814\u7a76\u4e2d\uff0c\u6269\u5927\u7684PVS\u7684\u4e25\u91cd\u7a0b\u5ea6\u4e0e\u76ae\u8d28A\u03b2\u6c89\u79ef\u6709\u5173\u3002<\/p>\n<p>&nbsp; &nbsp; 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