{"id":32730,"date":"2024-05-07T04:01:26","date_gmt":"2024-05-07T04:01:26","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=32730"},"modified":"2024-05-07T04:01:26","modified_gmt":"2024-05-07T04:01:26","slug":"%e7%bb%8f%e5%85%b8%e5%9e%8b%e9%9c%8d%e5%a5%87%e9%87%91%e6%b7%8b%e5%b7%b4%e7%98%a4%e7%9a%84%e8%af%8a%e6%96%ad%e5%92%8c%e9%89%b4%e5%88%ab%e8%af%8a%e6%96%ad","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=32730","title":{"rendered":"\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u8bca\u65ad\u548c\u9274\u522b\u8bca\u65ad"},"content":{"rendered":"

\u4e00\u3001\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08HL\uff09\u708e\u6027\u80cc\u666f+RS\u7ec6\u80de1\u3001\u7ed3\u8282\u786c\u5316\u578b\uff08NSCHL\uff09\uff1a\u9700\u8981\u548c\u970d\u5947\u91d1\u578b\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\uff08ALCL\uff09\u9274\u522b\u30022\u3001\u6df7\u5408\u7ec6\u80de\u6027(MCCHL)\uff1a\u9700\u8981\u548c\u4ee5\u4e0b\u80bf\u7624\u9274\u522b\u3002\uff081\uff09EBV+\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff082\uff09T\u7ec6\u80de\/\u7ec4\u7ec7\u7ec6\u80de\u4e30\u5bcc\u7684\u5f25\u6f2b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff083\uff09\u6210\u719fT\u7ec6\u80de\u6dcb\u5df4\u7624\u4f34RS\u6837\u5927\u7ec6\u80de\uff08\u5c24\u5176\u662f\u8840\u7ba1\u514d\u75ab\u6bcd\u7ec6\u80de\u6027T\u7ec6\u80de\u6dcb\u5df4\u7624\uff09<\/p>\n

3\u3001\u6dcb\u5df4\u7ec6\u80de\u524a\u51cf\u578b(LDCHL)\uff1a\u9700\u548c\u5927\u7ec6\u80de\u578bT\/B\u7ec6\u80de\u6dcb\u5df4\u7624\u3001\u751a\u81f3\u8089\u7624\u9274\u522b\u3002<\/p>\n

4\u3001\u6dcb\u5df4\u7ec6\u80de\u4e30\u5bcc\u578b(LRCHL)\uff1a\u9700\u8981\u548c\u4ee5\u4e0b\u80bf\u7624\u9274\u522b\u3002\uff081\uff09\u7ed3\u8282\u6027\u6dcb\u5df4\u7ec6\u80de\u4e3a\u4e3b\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624(NLPHL)\uff082\uff09\u8fdb\u884c\u6027\u8f6c\u5316\u4e2d\u5fc3\u578b\u6ee4\u6ce1\u578bT\u7ec6\u80de\u6dcb\u5df4\u7624(PTGC\u578bFTCL)\u4f34RS\u6837\u5927\u7ec6\u80de\u4e8c\u3001CHL VS ALK\u9634\u6027\u7684ALCL\u4e09\u3001CHL VS 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VS CHLAITL\u4e2d\u7684\u975e\u80bf\u7624RS\u6837\u5927\u7ec6\u80de\u5728\u5f62\u6001\u548c\u8868\u578b\u4e0a\u53ef\u4ee5\u548cCHL\u7624\u7ec6\u80de\u975e\u5e38\u63a5\u8fd1\uff0cCD20\u9634\u6027\u6216\u5f31+\uff0cCD30+\uff0cCD15+\uff0c\u4e22\u5931OCT2\u548c\/\u6216BOB1\u7684\u8868\u8fbe\u3002\u4e34\u5e8a\u8868\u73b0:T\u7ec6\u80de\u662f\u5426\u662f\u80bf\u7624:\uff081\uff09\u5f02\u578b\u6027:\u5c24\u5176\u662f\u80de\u6d46\u900f\u660e\u7684T\u7ec6\u80de;\u4f46\u6709\u65f6\u80bf\u7624\u6027T\u7ec6\u80de\u65e0\u660e\u663e\u5f02\u578b\u6027\u3002\uff082\uff09\u5f02\u5e38\u589e\u751f\u3001\u5206\u5e03\u7d0a\u4e71\u7684FDC\u7f51\u3002\uff083\uff09\u514d\u75ab\u8868\u578b:CD10\uff1a\u7279\u5f02\u6027\u5f3a\uff0c\u9633\u6027\u5f3a\u70c8\u652f\u6301\u80bf\u7624\uff0c\u4f46\u8868\u8fbe\u7387\u4f4e\uff0c\u654f\u611f\u6027\u4f4e\uff1bPD1\uff0cICOS\uff0cCXCL13\uff1a\u654f\u611f\u6027\u9ad8\uff0c\u7279\u5f02\u6027\u5dee\uff0c\u9700\u7ed3\u5408\u5f62\u6001\u5b66\uff1bBcl-6\uff1a\u5927\u91cfT\u7ec6\u80de\u9633\u6027\uff0c\u652f\u6301\u80bf\u7624\uff08\u53cd\u5e94\u6027\u6dcb\u5df4\u7ec4\u7ec7\u4e2d\uff0c\u6ee4\u6ce1\u95f4\u533a\u67095%-10%T\u7ec6\u80de\u9633\u6027\uff09PDL1\uff1a\u5927\u7ec6\u80de\u9633\u6027\u652f\u6301CHL\uff0c\u5927\u7ec6\u80de\u9634\u6027\u652f\u6301AITL\u4f34RS\u6837\u5927\u7ec6\u80de\uff08\u80cc\u666f\u7ec4\u7ec7\u7ec6\u80de\u9633\u6027\uff0c\u6709\u65f6\u5224\u65ad\u56f0\u96be\uff09\uff1bKi-67\uff1aKI-67\u9633\u6027\u6307\u6570\u9ad8\u652f\u6301\u80bf\u7624\uff08\u5c11\u6570\u60c5\u51b5CHL\u7684\u80cc\u666fT\u7ec6\u80de\u53ef\u589e\u751f\u6d3b\u8dc3\uff1bAITL\u6709\u65f6\u4e5f\u53ef\u589e\u6b96\u6307\u6570\u8f83\u4f4e\uff09\uff1bCD30\uff1a\u90e8\u5206AITL\u75c5\u4f8b\u7684\u7624\u7ec6\u80de\u8868\u8fbeCD30\u3002EBER\u539f\u4f4d\u6742\u4ea4:\uff081\uff09\u53ea\u6709RS\u6837\u5927\u7ec6\u80de\u9633\u6027\uff1a\u53ef\u4ee5\u662fCHL\uff0c\u4e5f\u53ef\u4ee5\u662fAITL\uff1b\uff082\uff09\u5927\u7ec6\u80de\u9633\u6027+\u80cc\u666f\u4e2d\u3001\u5c0f\u7ec6\u80de\u9633\u6027\uff0c\u652f\u6301AITL\uff08\u5c11\u89c1\u65f6\uff0cCHL\u540c\u65f6\u6709EBV\u611f\u67d3\u76f8\u5173\u75be\u75c5\u65f6\uff0c\u4e5f\u53ef\u51fa\u73b0\u80cc\u666f\u4e2d\u3001\u5c0f\u7ec6\u80de\u9633\u6027\uff09\u3002AITL\u7684\u514d\u75ab\u7ed3\u6784\u7279\u70b9\uff1a\u80bf\u7624\u6027TFH\u7ec6\u80de+\u52df\u96c6B\u7ec6\u80de+\u4fc3\u8fdbFDC\u7f51\u589e\u751f=\u5047\u6ee4\u6ce1\u6027\u7ed3\u6784\u3002\u4e94\u3001LRCHL VS PTCG\u578bFTCL\u4f34RS\u6837\u5927\u7ec6\u80de\u7ecf\u5178\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u6dcb\u5df4\u7ec6\u80de\u4e30\u5bcc\u578b(LRCHL)lgD\u9633\u6027\u7ae5\u8d1eB\u7ec6\u80de\u6784\u6210\u7684\u7ed3\u8282\uff0c\u53ef\u6709\u840e\u7f29\u7684\u751f\u53d1\u4e2d\u5fc3\uff0cRS\u7624\u7ec6\u80de\u6563\u5728\u5206\u5e03\u5728\u6269\u5927\u7684\u5957\u533a\u4e2d\u30022017\u5e74WHO\u5206\u7c7bTFH\u7ec6\u80de\u8d77\u6e90\u80bf\u76241\u3001\u8840\u7ba1\u514d\u75ab\u6bcd\u7ec6\u80de\u6027T\u7ec6\u80de\u6dcb\u5df4\u76242\u3001\u6ee4\u6ce1\u578bT\u7ec6\u80de\u6dcb\u5df4\u7624\uff08follicular T-cell lymphoma, FTCL\uff09\uff081\uff09PTGC\u578bFTCL\uff082\uff09FL\u578bFTCL3\u3001\u5177\u6709TFH\u7ec6\u80de\u8868\u578b\u7684\u6dcb\u5df4\u7ed3\u5916\u5468T\u7ec6\u80de\u6dcb\u5df4\u7624\u8fdb\u884c\u6027\u8f6c\u5316\u4e2d\u5fc3\u578b\u6ee4\u6ce1\u578bT\u7ec6\u80de\u6dcb\u5df4\u7624 (PTGC\u578bFTCL)lgD+\u7684\u7ae5\u8d1eB\u7ec6\u80de\u5f62\u6210\u4e0d\u89c4\u5219\u7684\u5927\u7ed3\u8282\uff1b\u8868\u8fbeTFH\u6807\u8bb0\u7269\u7684\u80bf\u7624\u7ec6\u80de\u6027T\u7ec6\u80de(\u6709\u65f6\u80de\u6d46\u900f\u660e)\u5448\u7076\u72b6\u5206\u5e03\u5176\u4e2d\uff1b\u6709\u65f6\u53ef\u89c1\u975e\u80bf\u7624\u6027RS\u6837\u5927\u7ec6\u80de\u6563\u5728\u5206\u5e03\u5728B\u7ec6\u80de\u7ed3\u8282\u4e2d\u3002\u5f53\u7624\u7ec6\u80de\u5f02\u578b\u6027\u4e0d\u660e\u663e\uff0c\u53c8\u6709RS\u6837\u5927\u7ec6\u80de\u65f6\uff0c\u6781\u6613\u548cLRCHL\u6df7\u6dc6\u3002LRCHL VS PTCG\u578bFTCL\u4f34RS\u6837\u5927\u7ec6\u80de1\u3001\u8868\u8fbeTFH\u6807\u8bb0\u7269\u7684T\u7ec6\u80de\u6709\u660e\u663e\u5f02\u578b\u6027\u30022\u3001PDL1:\u5927\u7ec6\u80de\u8868\u8fbePDL1\u652f\u6301CHL\u30023\u3001EBER:\uff081\uff09\u6563\u5728\u5c0f\u3001\u4e2d\u3001\u5927\u7ec6\u80de\u9633\u6027\u7ec6\u80de\u652f\u6301FTCL\uff1b\uff082\uff09\u5c11\u89c1\u65f6\uff0cCHL\u5408\u5e76EBV\u611f\u67d3\u76f8\u5173\u75be\u75c5\uff0c\u9633\u6027\u7ec6\u80de\u4e0d\u5c40\u9650\u4e8e\u5927\u7ec6\u80de\u3002\u516d\u3001\u7ed3\u8282\u786c\u5316\u578b\u7ecf\u5178\u970d\u5947\u91d1\u6dcb\u5df4\u7624(NSCHL)<\/p>\n

\u5b9a\u4e49\uff1a\u80bf\u7624\u88ab\u7ea4\u7ef4\u6761\u5e26\u5206\u9694\u5448\u7ed3\u8282\u72b6\uff0c\u6216\u8005\u81f3\u5c11\u6709\u4e00\u4e2a\u7ed3\u8282\u88ab\u80f6\u539f\u7ea4\u7ef4\u5e26\u56f4\u7ed5\uff0c\u80bf\u7624\u7ec6\u80de\u4e3b\u8981\u4e3a\u9677\u7a9d\u7ec6\u80de\uff0c\u6563\u5728\u5206\u5e03\u4e8e\u6df7\u5408\u6027\u708e\u75c7\u7ec6\u80de\u80cc\u666f\u4e2d\u3002<\/p>\n

\u4e34\u5e8a\u7279\u5f81\uff1a\u6700\u5e38\u89c1\u7ecf\u5178\u578b\u970d\u5947\u91d1(CHL)\u4e9a\u578b\uff0c\u7ea6\u536050%\uff1b\u597d\u53d1\u4e8e\u9752\u5e74\uff0c15-34\u5c81\uff1b\u5973\u6027\u8f83\u591a\u89c1\uff1b\u5e38\u8868\u73b0\u4e3a\u7eb5\u9694\u5360\u4f4d\uff0c\u53ef\u4f34\u9501\u9aa8\u4e0a\u6dcb\u5df4\u7ed3\u80bf\u5927\uff1b40%\u60a3\u8005\u51fa\u73b0B\u75c7\u72b6\uff1b\u8179\u8154\u810f\u5668\u3001\u9aa8\u53ca\u9aa8\u9ad3\u53d7\u7d2f\u5c11\u89c1\uff1b\u5de8\u5927\u7eb5\u9694\u80bf\u7624\u662f\u4e00\u9879\u4e0d\u826f\u9884\u540e\u56e0\u7d20\u3002  <\/p>\n

\u514d\u75ab\u7ec4\u5316\uff1a<\/p>\n

1\u3001CD30\u548cCD15\uff1a\u9633\u6027\uff08\u6700\u53ef\u9760\u548c\u6700\u5e38\u7528\u6807\u8bb0\uff09\uff1b<\/p>\n

2\u3001PAX5\uff1a\u9633\u6027\uff1b<\/p>\n

3\u3001CD20\uff1a\u5c11\u6570\u75c5\u4f8b\u9633\u6027(\u4e0d\u7a33\u5b9a\u3001\u5f02\u8d28)\uff1b<\/p>\n

4\u3001CD3\uff1a\u5c11\u6570\u75c5\u4f8b\u9633\u6027(\u4e0d\u7a33\u5b9a\u3001\u5f02\u8d28)\uff1b<\/p>\n

5\u3001EBER\uff1a10-25%\u75c5\u4f8b\u9633\u6027\uff08\u4f4e\u4e8e\u5176\u4ed6CHL\uff09\uff1b<\/p>\n

6\u3001CD45\uff1a\u9634\u6027\uff1b<\/p>\n

7\u3001EMA\u3001ALK\uff1a\u9634\u6027\uff1b<\/p>\n

\u4e03\u3001\u6df7\u5408\u7ec6\u80de\u578b\u7ecf\u5178\u970d\u5947\u91d1\u6dcb\u5df4\u7624(MCCHL)<\/p>\n

\u5b9a\u4e49\uff1a\u80bf\u7624\u901a\u5e38\u5f25\u6f2b\u5206\u5e03\uff0c\u80cc\u666f\u4e3a\u6df7\u5408\u6027\u708e\u75c7\u7ec6\u80de\uff0c\u5176\u5185\u53ef\u89c1\u6570\u91cf\u8f83\u591a\u7684\u7ecf\u5178R-S\/\u970d\u5947\u91d1\u7ec6\u80de\uff0c\u7f3a\u4e4f\u660e\u663e\u80f6\u539f\u7ea4\u7ef4\u5e26\u3002<\/p>\n

\u4e34\u5e8a\u7279\u5f81\uff1a\u7b2c\u4e8c\u5e38\u89c1\u7ecf\u5178\u578b\u970d\u5947\u91d1(CHL)\uff0c\u7ea6\u536030%\uff1b\u5728HIV\u611f\u67d3\u8005\u548c\u53d1\u5c55\u4e2d\u56fd\u5bb6\u66f4\u5e38\u89c1\uff1b\u60a3\u8005\u4e2d\u4f4d\u5e74\u9f8438\u5c81\uff08\u4e5f\u53ef\u89c1\u4e8e\u513f\u7ae5\uff09\uff1b\u7537\u6027\u591a\u89c1\uff08\u7ea6\u536070%\uff09\uff1b\u5e38\u89c1\u5916\u5468\u6dcb\u5df4\u7ed3\u53d7\u7d2f\uff1b\u60a3\u8005\u591a\u4e3a\u2162\/\u2163\u671f\uff1bB\u75c7\u72b6\u5e38\u89c1\uff1b\u813e\u810f\u53d7\u7d2f\u536030%\uff1b\u5c11\u89c1\u7eb5\u8188\u3001\u9aa8\u9ad3\u3001\u813e\u810f\u53d7\u7d2f\u3002<\/p>\n

\u514d\u75ab\u7ec4\u5316\uff1a<\/p>\n

1\u3001CD30\u548cCD15\uff1a\u9633\u6027\uff08\u6700\u53ef\u9760\u548c\u6700\u5e38\u7528\u6807\u8bb0\uff09\uff1b<\/p>\n

2\u3001PAX5\uff1a\u9633\u6027\uff1b<\/p>\n

3\u3001CD20\uff1a\u5c11\u6570\u75c5\u4f8b\u9633\u6027(\u4e0d\u7a33\u5b9a\u3001\u5f02\u8d28)\uff1b<\/p>\n

4\u3001CD3\uff1a\u5c11\u6570\u75c5\u4f8b\u9633\u6027(\u4e0d\u7a33\u5b9a\u3001\u5f02\u8d28)\uff1b<\/p>\n

5\u3001EBER\uff1a75%\u75c5\u4f8b\u9633\u6027\uff08\u9ad8\u4e8e\u5176\u4ed6CHL\uff09\uff1b<\/p>\n

6\u3001CD45\uff1a\u9634\u6027\uff1b<\/p>\n

7\u3001EMA\u3001ALK\uff1a\u9634\u6027\uff1b<\/p>\n

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6\u3001CD45\uff1a\u9634\u6027\uff1b<\/p>\n

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