{"id":31413,"date":"2024-04-26T00:00:54","date_gmt":"2024-04-26T00:00:54","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=31413"},"modified":"2024-04-26T00:00:54","modified_gmt":"2024-04-26T00:00:54","slug":"%e7%bb%b4%e7%94%9f%e7%b4%a0d%e5%9c%a8%e8%87%aa%e8%ba%ab%e5%85%8d%e7%96%ab%e6%80%a7%e8%82%9d%e7%97%85%e4%b8%ad%e7%9a%84%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=31413","title":{"rendered":"\u7ef4\u751f\u7d20D\u5728\u81ea\u8eab\u514d\u75ab\u6027\u809d\u75c5\u4e2d\u7684\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"

<\/h2>\n

\u539f\u521b \u6bb5\u91d1\u6960 \u76db\u5409\u82b3 \u7b49 \u4e2d\u56fd\u5fae\u751f\u6001\u5b66\u6742\u5fd7 2021-12-01 16:17 \u53d1\u8868\u4e8e\u8fbd\u5b81<\/p>\n

\u7ef4\u751f\u7d20D\u662f\u4e00\u79cd\u4eba\u4f53\u5fc5\u9700\u7684\u8102\u6eb6\u6027\u7ef4\u751f\u7d20\uff0c\u5176\u8fdb\u5165\u4eba\u4f53\u540e\u53ef\u901a\u8fc7\u4e24\u6b21\u7f9f\u5316\u4f5c\u7528\u8f6c\u5316\u4e3a\u6709\u6d3b\u6027\u76841,25-(OH)2<\/sub>D3<\/sub>\u5f62\u5f0f\uff0c\u6d3b\u5316\u7684\u7ef4\u751f\u7d20D\u53ef\u901a\u8fc7\u4e0e\u7ef4\u751f\u7d20D\u53d7\u4f53\uff08VDR\uff09\u76f8\u7ed3\u5408\u53d1\u6325\u591a\u79cd\u6d3b\u6027\u4f5c\u7528\u3002\u514d\u75ab\u8c03\u8282\u662f\u7ef4\u751f\u7d20D\u7684\u91cd\u8981\u4f5c\u7528\u4e4b\u4e00\uff0c\u7814\u7a76\u8868\u660e\u514d\u75ab\u7ec6\u80de\u81ea\u8eab\u53ef\u8868\u8fbel\u03b1-\u7f9f\u5316\u9176\u6d3b\u5316\u7ef4\u751f\u7d20D\uff0c\u6d3b\u5316\u7684\u7ef4\u751f\u7d20D\u8fdb\u4e00\u6b65\u4e0e\u514d\u75ab\u7ec6\u80deVDR\u7ed3\u5408\u53d1\u6325\u5bf9\u56fa\u6709\u514d\u75ab\u4e0e\u83b7\u5f97\u6027\u514d\u75ab\u7684\u8c03\u8282\u4f5c\u7528\u3002\u901a\u8fc7\u514d\u75ab\u8c03\u8282\uff0c\u7ef4\u751f\u7d20D\u53ef\u5bf9\u514d\u75ab\u76f8\u5173\u6027\u75be\u75c5\u4ea7\u751f\u91cd\u8981\u5f71\u54cd\uff0c\u5927\u91cf\u6587\u732e\u8868\u660e\u7ef4\u751f\u7d20D\u662f\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u548c\u591a\u53d1\u6027\u786c\u5316\u7b49\u514d\u75ab\u76f8\u5173\u75be\u75c5\u7684\u91cd\u8981\u5f71\u54cd\u56e0\u7d20\u3002\u81ea\u8eab\u514d\u75ab\u6027\u809d\u75c5\uff08autoimmune liver disease\uff0cAILD\uff09\u662f\u514d\u75ab\u76f8\u5173\u75be\u75c5\uff0c\u5176\u4e3b\u8981\u53ef\u5206\u4e3a\u539f\u53d1\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e\u3001\u539f\u53d1\u6027\u786c\u5316\u6027\u80c6\u7ba1\u708e\u3001\u81ea\u8eab\u514d\u75ab\u6027\u809d\u708e\u3001\u91cd\u53e0\u7efc\u5408\u5f81\u548c\u514d\u75ab\u7403\u86cb\u767dG4\u76f8\u5173\u786c\u5316\u6027\u80c6\u7ba1\u708e5\u79cd\u7c7b\u578b\u3002\u8fd1\u5e74\u6765\u968f\u7740\u68c0\u6d4b\u624b\u6bb5\u7684\u63d0\u5347\uff0cAILD\u68c0\u51fa\u7387\u9010\u5e74\u5347\u9ad8\uff0c\u9010\u6e10\u6210\u4e3a\u6162\u6027\u809d\u75c5\u9886\u57df\u7684\u7814\u7a76\u70ed\u70b9\u4e4b\u4e00\uff0c\u4f46\u7ef4\u751f\u7d20D\u5728\u4e0d\u540c\u7c7b\u578bALID\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca\u8865\u5145\u7ef4\u751f\u7d20D\u662f\u5426\u5bf9\u60a3\u8005\u6709\u76ca\u5c1a\u65e0\u5b9a\u8bba\u3002<\/p>\n

\/\/<\/p>\n

1  \u7ef4\u751f\u7d20D\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528<\/p>\n

1.1  \u7ef4\u751f\u7d20D\u4e0e\u5355\u6838-\u5de8\u566c\u7ec6\u80de  \u5355\u6838-\u5de8\u566c\u7ec6\u80de\u662f\u56fa\u6709\u514d\u75ab\u7684\u91cd\u8981\u7ec6\u80de\u6210\u5206\uff0c\u7ef4\u751f\u7d20D\u53ef\u4fc3\u8fdb\u5355\u6838\u7ec6\u80de\u5206\u5316\u4e3a\u6210\u719f\u7684\u5de8\u566c\u7ec6\u80de\uff0c\u8bf1\u5bfc\u5355\u6838-\u5de8\u566c\u7ec6\u80de\u6740\u4f24\u75c5\u539f\u5fae\u751f\u7269\u3002\u5355\u6838-\u5de8\u566c\u7ec6\u80de\u8868\u8fbeToll\u6837\u53d7\u4f53\uff08TLR\uff09\uff0cTLR\u88ab\u75c5\u539f\u4f53\u76f8\u5173\u5206\u5b50\u6a21\u5f0f\uff08PAMP\uff09\u6fc0\u6d3b\u5bfc\u81f4VDR\u548c1\u03b1\u7f9f\u5316\u9176\u8868\u8fbe\u4e0a\u8c03\uff0c\u4fc3\u8fdb\u5c40\u90e825-(OH)D3\u7f9f\u5316\u62101,25-(OH)2D3\u30021,25-(OH)2D3\u901a\u8fc7\u4fc3\u8fdbcathelicidin \u6297\u83cc\u80bd\uff08CAMP\uff09\u7684\u6fc0\u6d3b\u3001\u4e0a\u8c03\u6709\u4e1d\u5206\u88c2\u539f\u6fc0\u6d3b\u7684\u6fc0\u9176\u78f7\u9178\u91761\uff08MKP-1\uff09\u548c\u4e0b\u8c03\u5355\u6838\u7ec6\u80de\u4e2dTLR2\u548cTLR4\u4ea7\u751f\u6297\u708e\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u7ef4\u751f\u7d20D\u4e5f\u901a\u8fc7\u6fc0\u6d3b\u5e76\u589e\u5f3a\u5355\u6838-\u5de8\u566c\u7ec6\u80de\u7684\u6c27\u5316\u53cd\u5e94\uff0c\u4fc3\u8fdb\u7ec6\u80de\u5185\u6d3b\u6027\u6c27\u53ca\u81ea\u7531\u57fa\u7684\u91ca\u653e\uff0c\u7834\u574f\u75c5\u539f\u5fae\u751f\u7269\u7684\u7ec6\u80de\u7ed3\u6784\uff0c\u6e05\u9664\u673a\u4f53\u5185\u7684\u75c5\u539f\u4f53\u3002<\/p>\n

1.2  \u7ef4\u751f\u7d20D\u4e0e\u6811\u7a81\u72b6\u7ec6\u80de  \u6811\u7a81\u72b6\u7ec6\u80de\uff08DCs\uff09\u53ef\u8bc6\u522b\u548c\u52a0\u5de5\u5904\u7406\u6297\u539f\uff0c\u5e76\u4e14\u4ee5\u6297\u539f\u80bd-\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269\uff08MHC\uff09\u5206\u5b50\u590d\u5408\u7269\u7684\u5f62\u5f0f\u5c06\u6297\u539f\u80bd\u5448\u9012\u7ed9T\u7ec6\u80de\uff0c\u4ece\u800c\u53d1\u6325\u514d\u75ab\u529f\u80fd\u3002\u7ef4\u751f\u7d20D\u53ef\u4fc3\u8fdbDCs\u4ea7\u751f\u8010\u53d7\u6027\u8868\u578b\uff0c\u8010\u53d7\u6027\u7684DCs\u4e0d\u4ec5\u964d\u4f4eMHC\u2161\u548c\u5171\u523a\u6fc0\u5206\u5b50\u5982CD86\u3001CD80\u548cCD40\u7b49\u5728\u7ec6\u80de\u8868\u9762\u4e0a\u7684\u8868\u8fbe\uff0c\u8fd8\u53ef\u51cf\u5c11\u767d\u7ec6\u80de\u4ecb\u7d20-12\uff08IL-12\uff09\u548cTNF-\u03b1\u7684\u5206\u6ccc\uff0c\u589e\u52a0IL-10\u7684\u4ea7\u751f\u3002\u6b64\u5916\uff0c\u7ef4\u751f\u7d20D\u4e5f\u53ef\u4e0a\u8c03DCs\u8868\u9762\u514d\u75ab\u7403\u86cb\u767d\u6837\u8f6c\u5f55\u7269\uff08ILT\uff09\u548c\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f531\uff08PD-L1\uff09\u7684\u8868\u8fbe\uff0c\u8bf1\u5bfc\u8c03\u8282\u6027T\u7ec6\u80de\u53ca\u81ea\u8eab\u53cd\u5e94\u514d\u75ab\u6027T\u7ec6\u80de\u7684\u51cb\u4ea1\u3002\u7136\u800c\u4e5f\u6709\u7814\u7a76\u53d1\u73b0\u7ef4\u751f\u7d20D\u53ef\u5728\u5355\u6838\u7ec6\u80de\u5206\u5316\u4e3aDC\u8fc7\u7a0b\u4e2d\u4fc3\u8fdbIL-6\u3001IL-1\u03b2\u548cIL-23\u7b49\u4fc3\u708e\u56e0\u5b50\u5206\u6ccc\uff0c\u5e76\u63a8\u52a8\u7279\u5b9a\u529f\u80fdT\u7ec6\u80de\u4ea7\u751f\u5206\u5316\u3002\u56e0\u6b64\uff0c\u7ef4\u751f\u7d20D\u53ef\u80fd\u901a\u8fc7\u590d\u6742\u7684\u5e73\u8861\u673a\u5236\u8c03\u8282\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

1.3  \u7ef4\u751f\u7d20D\u5bf9\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u7684\u5f71\u54cd  NK\u7ec6\u80de\u5728\u56fa\u6709\u514d\u75ab\u53ca\u7279\u5f02\u6027\u514d\u75ab\u4e2d\u5747\u53d1\u6325\u514d\u75ab\u529f\u80fd\uff0c\u4e0d\u9700\u8981\u514d\u75ab\u8bb0\u5fc6\u548c\u6297\u539f\u523a\u6fc0\u5373\u53ef\u5728\u514d\u75ab\u53cd\u5e94\u65e9\u671f\u9636\u6bb5\u5bf9\u6297\u75c5\u539f\u4f53\u548c\u6076\u6027\u80bf\u7624\u3002\u76ee\u524d\u5173\u4e8e\u7ef4\u751f\u7d20D\u4e0eNK\u7ec6\u80de\u529f\u80fd\u7684\u5173\u7cfb\u5177\u6709\u77db\u76fe\u6027\uff0c\u6709\u62a5\u9053\u79f0\u7ef4\u751f\u7d20D3\u6291\u5236NK\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u800cLee\u7b49\u5b9e\u9a8c\u8868\u793a\u8865\u5145\u7ef4\u751f\u7d20D\u53ef\u589e\u5f3a\u6b63\u5e38\u5c0f\u9f20NK\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u4ece\u800c\u8c03\u8282\u56fa\u6709\u514d\u75ab\uff0c\u4f46\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\u672a\u80fd\u89c2\u5bdf\u5230NK\u7ec6\u80de\u6d3b\u6027\u7684\u589e\u5f3a\u3002<\/p>\n

1.4  \u7ef4\u751f\u7d20D\u5bf9T\u7ec6\u80de\u7684\u7279\u5b9a\u4f5c\u7528  T\u7ec6\u80de\u5728AILD\u7684\u83b7\u5f97\u6027\u514d\u75ab\u53cd\u5e94\u4e2d\u626e\u6f14\u91cd\u8981\u7684\u89d2\u8272\uff0cTreg\u7ec6\u80de\u4e0eTh\u7ec6\u80de\u5171\u540c\u53c2\u4e0e\u4eba\u4f53\u514d\u75ab\u5e73\u8861\u7684\u5efa\u7acb\u3002\u7ef4\u751f\u7d20D\u53ef\u901a\u8fc7\u76f4\u63a5\u523a\u6fc0T\u7ec6\u80de\u6216\u95f4\u63a5\u5f71\u54cd\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08APC\uff09\u7684\u8868\u578b\uff0c\u4fc3\u8fdbT\u7ec6\u80de\u6210\u719f\u5206\u5316\uff0c\u6291\u5236\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u7684\u5206\u6ccc\uff0c\u8c03\u8282AILD\u7684\u83b7\u5f97\u6027\u514d\u75ab\u53cd\u5e94\u53ca\u51cf\u8f7b\u673a\u4f53\u708e\u75c7\u635f\u4f24\uff0c\u5f71\u54cd\u75be\u75c5\u7684\u53d1\u751f\u53d1\u5c55\u3002<\/p>\n

1.4.1  \u7ef4\u751f\u7d20D\u4e0eTh\u7ec6\u80de  Th\u7ec6\u80de\u5747\u8868\u8fbeCD4+<\/sup>\uff0c\u521d\u59cbCD4+<\/sup>T\u7ec6\u80de\u53d7\u523a\u6fc0\u540e\u4e3b\u8981\u5206\u5316\u6210Th1\u3001Th2\u548cTh17\u7ec6\u80de\uff0c\u800c\u4e14VDR\u5728CD4+<\/sup>T\u7ec6\u80de\u6fc0\u6d3b\u540e\u589e\u52a0\u3002CD4+<\/sup>T\u7ec6\u80de\u662f1,25-(OH)2D3 \u76f4\u63a5\u4f5c\u7528\u9776\u6807\uff0c\u7ef4\u751f\u7d20D3\u53ef\u6291\u5236Thl\u7ec6\u80deIFN-\u03b3\u3001TNF\u3001IL-2 \u548cIL-6\u4ea7\u751f\uff0c\u5e76\u901a\u8fc7\u6291\u5236Th17 \u76f8\u5173\u7ec6\u80de\u56e0\u5b50\u548c\u8f6c\u5f55\u56e0\u5b50\u5982IL-17A\u3001IL-17F\u3001RORC\u548cCCR6\u7684\u4ea7\u751f\u6765\u6291\u5236Th17\u7684\u6fc0\u6d3b\u5206\u5316\u3002\u5728Th2\u7ec6\u80de\u4e2d\uff0c\u7ef4\u751f\u7d20D3\u4fc3\u8fdbTh2\u7ec6\u80de\u7684IL-4\u3001IL-5\u3001IL-10\u548cIL-13\u7b49\u6297\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u5206\u6ccc\u3002\u540c\u65f6\u7ef4\u751f\u7d20D3\u4e5f\u53ef\u4fc3\u8fdbTh1\u5411Th2\u8f6c\u6362\u3002<\/p>\n

1.4.2  \u7ef4\u751f\u7d20D\u4e0eTreg\u7ec6\u80de  Treg\u7ec6\u80de\u5728\u7ef4\u6301\u514d\u75ab\u7a33\u6001\u548c\u81ea\u6211\u8010\u53d7\u65b9\u9762\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u7ef4\u751f\u7d20D\u65e2\u53ef\u901a\u8fc7\u8c03\u63a7\u7ec6\u80de\u56e0\u5b50\u7684\u8868\u8fbe\u4ea7\u751f\u8010\u53d7\u6027\u6811\u7a81\u72b6\u7ec6\u80de\uff0c\u8fdb\u800c\u4fc3\u8fdbT\u7ec6\u80de\u5411Treg\u7ec6\u80de\u8f6c\u5316\uff0c\u4e5f\u53ef\u76f4\u63a5\u4f5c\u7528\u4e8eCD4+<\/sup>CD25+<\/sup>T\u7ec6\u80de\uff0c\u4fc3\u8fdbFoxp3+<\/sup>Treg\u7684\u589e\u6b96\u548c\u514d\u75ab\u6291\u5236\u529f\u80fd\u3002<\/p>\n

1.5  \u7ef4\u751f\u7d20D\u5bf9B\u7ec6\u80de\u7684\u7279\u5b9a\u4f5c\u7528  B\u6dcb\u5df4\u7ec6\u80de\u5206\u5316\u4e3a\u6d46\u7ec6\u80de\u548c\u8bb0\u5fc6B\u7ec6\u80de\uff0c\u662f\u91cd\u8981\u7684\u6297\u539f\u9012\u5448\u7ec6\u80de\u3002\u7ef4\u751f\u7d20D\u53ef\u76f4\u63a5\u7279\u5f02\u6027\u7ed3\u5408B\u7ec6\u80de\u8868\u9762\u7684VDR\u6291\u5236B\u7ec6\u80de\u7684\u589e\u6b96\u5206\u5316\u53ca\u514d\u75ab\u7403\u86cb\u767d\u7684\u4ea7\u751f\uff0c\u5e76\u5728\u76f8\u5173\u523a\u6fc0\u4e0b\uff0c\u7ef4\u751f\u7d20D\u8bf1\u5bfc\u6d3b\u5316B\u6dcb\u5df4\u7ec6\u80de\u53d1\u751f\u51cb\u4ea1\uff0c\u4ece\u800c\u6291\u5236\u6297\u4f53\u4ecb\u5bfc\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u8fdb\u5c55\u3002\u7ef4\u751f\u7d20D\u8fd8\u53ef\u4e0a\u8c03B\u6dcb\u5df4\u7ec6\u80de\u7684\u6297\u708e\u7ec6\u80de\u56e0\u5b50\uff08IL-10\u548cCCR10\uff09\u4ea7\u751f\uff0c\u4ece\u800c\u4ea7\u751f\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u3002<\/p>\n

2  \u514d\u75ab\u53cd\u5e94\u4e0e\u81ea\u8eab\u514d\u75ab\u6027\u809d\u75c5\u7684\u5173\u7cfb2.1  \u514d\u75ab\u53cd\u5e94\u4e0e\u539f\u53d1\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e  \u83b7\u5f97\u6027\u514d\u75ab\u53cd\u5e94\u662f\u539f\u53d1\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e\uff08PBC\uff09\u4e3b\u8981\u7684\u53d1\u75c5\u673a\u5236\uff0c\u5f53\u7ebf\u7c92\u4f53PDC-E2\u4e9a\u57fa\u4e27\u5931\u514d\u75ab\u8010\u53d7\u65f6\uff0c\u6297\u7ebf\u7c92\u4f53\u6297\u4f53\uff08AMA\uff09\u5c06\u9776\u5411\u8bc6\u522b\u80c6\u7ba1\u4e0a\u76ae\u5f02\u5e38PDC-E2\u4e9a\u57fa\uff0c\u5f62\u6210\u6297\u539f-\u6297\u4f53\u590d\u5408\u7269\uff0c\u5bfc\u81f4\u80c6\u7ba1\u4e0a\u76ae\u7ec6\u80de\u53d7\u635f\u3002\u6b64\u5916\uff0c\u809d\u5185\u514d\u75ab\u53cd\u5e94\u5931\u8c03\u4e5f\u53ef\u5bfc\u81f4\u60a3\u8005\u80c6\u9053\u53d7\u635f\uff0c\u7814\u7a76\u8868\u660ePBC\u60a3\u8005\u80c6\u9053\u7cfb\u7edf\u4e2d\u5b58\u5728\u5305\u62ecCD4+<\/sup>T\u7ec6\u80de\u3001CD8+<\/sup>T\u7ec6\u80de\u548cTh17\u7ec6\u80de\u5728\u5185\u7684\u591a\u79cd\u4fc3\u708eT\u7ec6\u80de\u7684\u5347\u9ad8\u4ee5\u53caTreg\u7ec6\u80de\u4e0e\u6ee4\u6ce1\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u4e0b\u964d\uff0c\u540e\u8005\u4f1a\u5bfc\u81f4\u5bf9\u5f02\u5e38\u514d\u75ab\u8c03\u8282\u80fd\u529b\u7684\u4e0b\u964d\uff0c\u4ece\u800c\u4e0d\u80fd\u6291\u5236\u81ea\u8eab\u514d\u75ab\u5bf9\u80c6\u9053\u7684\u653b\u51fb\u3002<\/p>\n

2.2  \u514d\u75ab\u53cd\u5e94\u4e0e\u539f\u53d1\u6027\u786c\u5316\u6027\u80c6\u7ba1\u708e  \u5df2\u6709\u8bc1\u636e\u8868\u660e\u539f\u53d1\u6027\u786c\u5316\u6027\u80c6\u7ba1\u708e\uff08PSC\uff09\u60a3\u8005\u80c6\u9053\u4e2d\u5b58\u5728\u5927\u91cfT\u7ec6\u80de\u6d78\u6da6\uff0cCD8+<\/sup>\u548cCD4+<\/sup>T\u7ec6\u80de\u5747\u88ab\u8bc1\u660e\u53c2\u4e0e\u80c6\u9053\u7ea4\u7ef4\u5316\uff0c\u4f46T\u7ec6\u80de\u4e9a\u7fa4\u7684\u7ec4\u6210\u6210\u5206\u5206\u6790\u7ed3\u679c\u5e76\u4e0d\u4e00\u81f4\u3002Liaskou\u7b49\u5728\u4f53\u5916\u5b9e\u9a8c\u4e2d\u8bc1\u5b9eCD28-T\u7ec6\u80de\u52a0\u91cdPSC\u60a3\u8005\u809d\u635f\u4f24\uff0c\u4f46\u8fd9\u79cd\u635f\u4f24\u53ef\u88ab\u7ef4\u751f\u7d20D\u7f13\u89e3\u3002\u56e0\u6b64\u6df1\u4eba\u7814\u7a76PSC\u60a3\u8005T\u7ec6\u80de\u4e9a\u578b\u53ca\u5176\u4e0e\u7ef4\u751f\u7d20D\u7684\u5173\u7cfb\u53ef\u80fd\u6709\u52a9\u4e8ePSC\u7684\u6cbb\u7597\u3002<\/p>\n

2.3  \u514d\u75ab\u53cd\u5e94\u4e0e\u81ea\u8eab\u514d\u75ab\u6027\u809d\u708e  \u81ea\u8eab\u514d\u75ab\u6027\u809d\u708e\uff08AIH\uff09\u514d\u75ab\u8010\u53d7\u5931\u8861\u7684\u786e\u5207\u673a\u5236\u5c1a\u672a\u660e\u786e\uff0c\u4f46\u5927\u91cf\u8bc1\u636e\u8868\u660e\u9057\u4f20\u6613\u611f\u6027\u3001\u5206\u5b50\u6a21\u62df\u548c\u8c03\u8282\u6027-\u6548\u5e94\u6027\u514d\u75ab\u5931\u8861\u662f\u75be\u75c5\u53d1\u751f\u53d1\u5c55\u7684\u4e3b\u8981\u56e0\u7d20\u3002\u4ece\u514d\u75ab\u5fae\u73af\u5883\u800c\u8a00\uff0cAIH\u60a3\u8005\u540c\u6837\u5b58\u5728Treg\u7ec6\u80de\u7684\u4e0b\u8c03\u4e0eTh17\u7ec6\u80de\u7684\u4e0a\u8c03\uff0c\u5e76\u4e14\u5728Treg\u7ec6\u80de\u4e9a\u7ec4\u4e2d\u53d1\u73b0\u5927\u91cf\u514d\u75ab\u5e73\u8861\u529f\u80fd\u4f4e\u4e0b\u7684CD127 Treg\u7ec6\u80de\uff0c\u8fd9\u4e9b\u6539\u53d8\u88ab\u8bc1\u660e\u4e0eAIH\u60a3\u8005\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\u4ee5\u53ca\u6cbb\u7597\u53cd\u5e94\u76f8\u5173\u3002<\/p>\n

3  \u7ef4\u751f\u7d20D\u5728\u81ea\u8eab\u514d\u75ab\u6027\u809d\u75c5\u4e2d\u7684\u6cbb\u7597\u4f5c\u7528<\/p>\n

\u718a\u53bb\u6c27\u80c6\u9178\uff08UCDA\uff09\u662f\u9488\u5bf9PBC\u6cbb\u7597\u7684\u4e00\u7ebf\u836f\u7269\uff0c\u53ef\u6539\u5584\u60a3\u8005\u751f\u5b58\u7387\uff0c\u7136\u800c30%\uff5e40%\u60a3\u8005\u5bf9UCDA\u65e0\u751f\u5316\u53cd\u5e94\u3002\u7814\u7a76\u8868\u660e\u7ef4\u751f\u7d20D\u7f3a\u4e4f\u4f1a\u964d\u4f4ePBC\u60a3\u8005\u5bf9UDCA\u7684\u5e94\u7b54\u7387\uff0c\u589e\u52a0\u6b7b\u4ea1\u6216\u809d\u79fb\u690d\u98ce\u9669\u3002\u9648\u5c0f\u541b\u7b49\u53d1\u73b0\u76f8\u5bf9\u4e8e\u4ec5\u53e3\u670dUDCA\u7ec4\uff0c\u8054\u5408\u7ef4\u751f\u7d20D\u4e0eUDCA\u6cbb\u7597\u7ec4\u53ef\u63d0\u9ad8UDCA\u5e94\u7b54\u7387\uff0c\u63d0\u5347\u809d\u529f\u80fd\u7684\u6539\u5584\u7a0b\u5ea6\u3002\u6b64\u5916\uff0c\u8054\u5408\u53e3\u670d\u7ef4\u751f\u7d20D\u4e0d\u4ec5\u63d0\u9ad8UDCA\u5e94\u7b54\u7387\uff0c\u8fd8\u6709\u52a9\u4e8e\u7ef4\u6301\u80a0\u9ecf\u819c\u5c4f\u969c\u529f\u80fd\u3002\u4f46\u76ee\u524d\u6307\u5357\u4ec5\u63a8\u8350PBC\u60a3\u8005\u53e3\u670d\u7ef4\u751f\u7d20D\u7528\u4e8e\u6cbb\u7597\u9aa8\u8d28\u758f\u677e\uff0c\u7ef4\u751f\u7d20D\u7684\u8865\u5145\u662f\u5426\u53ef\u76f4\u63a5\u7f13\u89e3\u60a3\u8005\u75c7\u72b6\uff0c\u6539\u5584\u8fdc\u671f\u9884\u540e\u5c1a\u65e0\u5145\u5206\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n

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