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&nbsp; &nbsp; &nbsp;&nbsp;\u8102\u80aa\u8089\u7624(\u9ad8\u5206\u5316\/\u53bb\u5206\u5316)\u6700\u5e38\u89c1(85%)<\/p>\n<p>&nbsp; &nbsp; &nbsp; &nbsp; \u5185\u819c\u8089\u7624(5%)<\/p>\n<p>&nbsp; &nbsp; &nbsp; &nbsp; \u5f52\u7c7b\u4e3a\u8089\u7624NOS\u7684\u80bf\u7624(5%)<\/p>\n<p>&nbsp; &nbsp; -\u80f6\u8d28\u7624(4%)<\/p>\n<p>&nbsp; &nbsp; -\u9ed1\u8272\u7d20\u7624(2%)<\/p>\n<p>&nbsp; &nbsp; -\u80ba\u817a\u764c(1%)<\/p>\n<p>&nbsp; &nbsp; &nbsp; &#8230;<\/p>\n<\/p>\n<p>\u9274\u522b\u8bca\u65ad<\/p>\n<p>\u9884\u540e<\/p>\n<ul>\n<li>\u6700\u521d\u88ab\u8ba4\u4e3a\u662f\u826f\u6027<\/li>\n<li>\u540e\u53d1\u73b0\u5177\u6709\u5c40\u90e8\u590d\u53d1\u3001\u533a\u57df\u548c\u665a\u671f\u8fdc\u5904\u8f6c\u79fb\u7684\u6076\u6027\u6f5c\u80fd\uff08\u533a\u57df\u8f6c\u79fb\u548c\u8fdc\u5904\u8f6c\u79fb\u7684\u98ce\u9669\u5206\u522b\u4e3a5%\u548c20%\uff09<\/li>\n<li>\u76ee\u524d\u624b\u672f\u4ecd\u662f\u4e3b\u8981\u6cbb\u7597\u65b9\u5f0f<\/li>\n<\/ul>\n<p>\u53ef\u80fd\u6210\u4e3a\u6f5c\u5728\u6cbb\u7597\u9776\u70b9<\/p>\n<ul>\n<li>GLI1\u88abSMO\u8c03\u63a7\u6fc0\u6d3b<\/li>\n<li>\u76ee\u524dSMO\u6291\u5236\u5242Vismodegib\u548cErismodegib\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u57fa\u5e95\u7ec6\u80de\u764c\uff0c\u4e00\u7cfb\u5217\u9488\u5bf9\u5404\u79cd\u764c\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d<\/li>\n<li>SHH\u901a\u8def\u6291\u5236\u5242\u53ef\u80fd\u4e3a\u5177\u6709GLI1\u6fc0\u6d3b\u7684\u80bf\u7624\u63d0\u4f9b\u6f5c\u5728\u7684\u9776\u5411\u6cbb\u7597<\/li>\n<\/ul>\n<p>\u76ee\u524d\u5934\u9888\u65b0\u7248WHO\u6b63\u6587\u8fd8\u672a\u89c1\u5230\uff0c\u5f85\u4e66\u4e2d\u7684\u5b98\u65b9\u8bb2\u89e3<\/p>\n<p>\u5bf9\u4e8eGLI\u57fa\u56e0\u8c03\u63a7\u673a\u5236\u7684\u7814\u7a76\u5f88\u591a\uff0c\u4f46\u5173\u4e8e\u5176\u6613\u4f4d\u76f8\u5173\u7684\u80bf\u7624\u8fd8\u5728\u88ab\u6316\u6398\u4e2d<\/p>\n<p>\u82e5\u5e72\u5e74\u540e\u518d\u6765\u8003\u53e4\u8fd9\u4e2a\u5b66\u4e60\u7b14\u8bb0\u5185\u5bb9\u53ef\u80fd\u662f\u8fc7\u65f6\u7684\u751a\u81f3\u662f\u9519\u8bef\u7684<\/p>\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<p>1. Ozgur Mete, Ozgur Mete. Update from the 5th Edition of the World Health<br \/>\nOrganization Classification of Head and Neck Tumors: Soft Tissue Tumors[J]. Head<br \/>\nNeck Pathol\uff0c 2022;16(1):123-142.<\/p>\n<p>2.Cristina R Antonescu,Narasimhan P Agaram,&nbsp;Yun-Shao Sung,et al. A Distinct Malignant Epithelioid Neoplasm<br \/>\nwith GLI1 Gene Rearrangements, Frequent S100 Protein Expression and Metastatic<br \/>\nPotential: Expanding the Spectrum of Pathologic Entities with<br \/>\nACTB1\/MALAT1\/PTCH1-GLI1 Fusions[J]. Am J Surg Pathol.&nbsp;2018;42(4):553-560.<\/p>\n<p>3.Narasimhan P Agaram,Lei Zhang,&nbsp;Yun-Shao Sung, et al. GLI1-Amplifications Expands the Spectrum<br \/>\nof Soft Tissue Neoplasms Defined by GLI1 Gene Fusions[J]. Mod Pathol,&nbsp; 2019;32(11):1617-1626.<\/p>\n<p>4.Jiahan Liu,Rongjun Mao,&nbsp;I Weng Lao ,et al. GLI1\u2011altered mesenchymal<br \/>\ntumor: a clinicopathological and molecular analysis of ten additional cases of<br \/>\nan emerging entity[J]. Virchows Arch, 2022;480(5):1087-1099.<\/p>\n<p>5.Bin Xu. Proceedings of the North American Society of Head and<br \/>\nNeck Pathology, Los Angeles, CA, March 20, 2022. Emerging Bone and Soft Tissue<br \/>\nNeoplasms in the Head and Neck Region[J]. Head Neck Pathol,2022;16(1):158-167.<\/p>\n<p>\uff08\u82e5\u4fb5\u6743\uff0c\u8bf7\u8054\u7cfb\uff1b\u4e0d\u8db3\u4e4b\u5904\uff0c\u6b22\u8fce\u6279\u8bc4\u6307\u6b63\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>GLI1\u662f\u8bfb\u7247\u4f1a\u7684\u5341\u516b\u7ebf\u660e\u661f\uff0c\u5374\u6ca1\u600e\u4e48\u78b0\u5230\u8fc7 \u4f46\u8981\u907f\u7684\u5751\u53ef\u4e0d\u5c11,\u5c24\u5176\u662f\u53d1\u751f\u5728\u820c\u6839 &hellip; <a href=\"http:\/\/zydq.1006ss.com\/?p=31139\">\u7ee7\u7eed\u9605\u8bfb <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-31139","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/31139","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=31139"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/31139\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=31139"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=31139"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=31139"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}