{"id":29551,"date":"2024-04-09T08:01:04","date_gmt":"2024-04-09T08:01:04","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=29551"},"modified":"2024-04-09T08:01:04","modified_gmt":"2024-04-09T08:01:04","slug":"cell%e5%ad%90%e5%88%8a%e5%b0%81%e9%9d%a2%ef%bc%9a%e9%98%b4%e9%98%b3%e7%9b%b8%e7%94%9f-%e7%ba%bf%e7%b2%92%e4%bd%93%e5%8a%a8%e6%80%81%e5%8f%98%e5%8c%96%e4%b8%8e%e7%bb%86%e8%83%9e%e5%8a%9f%e8%83%bd","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=29551","title":{"rendered":"Cell\u5b50\u520a\u5c01\u9762\uff1a\u9634\u9633\u76f8\u751f–\u7ebf\u7c92\u4f53\u52a8\u6001\u53d8\u5316\u4e0e\u7ec6\u80de\u529f\u80fd\uff0c\u70ed\u91cf\u9650\u5236\u80fd\u591f\u5ef6\u957f\u5bff\u547d\uff1f"},"content":{"rendered":"

\u6c47\u62a5\u4eba\uff1aLuYin Lab \u535a\u58eb\u7814\u7a76\u751f\u4e00\u5e74\u7ea7 \u4f59\u82cf\u4e91<\/p>\n

\u80cc\u666f\u4ecb\u7ecd<\/p>\n

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\u7814\u7a76\u5185\u5bb9<\/p>\n

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      \u5728\u8bc1\u660e\u4e86\u7ebf\u7c92\u4f53\u878d\u5408\u5728AMPK\u8c03\u8282\u957f\u5bff\u4e2d\u7684\u91cd\u8981\u6027\u540e\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u731c\u60f3\u5728\u5176\u4ed6\u8c03\u8282\u957f\u5bff\u7684\u4fe1\u53f7\u901a\u8def\u4e2d\u7ebf\u7c92\u4f53\u878d\u5408\u662f\u5426\u4e00\u6837\u91cd\u8981\uff1f<\/p>\n

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      \u9274\u4e8e\u7ebf\u7c92\u4f53\u878d\u5408\u5728AMPK\u548c\u63a7\u5236\u996e\u98df\u4ecb\u5bfc\u7684\u957f\u5bff\u4e2d\u5177\u6709\u91cd\u8981\u4f5c\u7528\uff0c\u4e14\u7ebf\u7c92\u4f53\u878d\u5408\u86cb\u767d\u5e7f\u6cdb\u8868\u8fbe\u4e8e\u6240\u6709\u7ec6\u80de\uff0c\u90a3\u5b83\u7684\u8fd9\u79cd\u529f\u80fd\u662f\u5426\u5b58\u5728\u7ec4\u7ec7\u7279\u5f02\u6027\uff1f<\/p>\n

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      \u65e2\u7136\u7ebf\u7c92\u4f53\u878d\u5408\u5728AMPK\u4ecb\u5bfc\u7684\u957f\u5bff\u4e2d\u5177\u6709\u91cd\u8981\u4f5c\u7528\uff0c\u90a3\u4e48\u4fc3\u8fdb\u7ebf\u7c92\u4f53\u878d\u5408\u662f\u5426\u5c31\u80fd\u76f4\u63a5\u5ef6\u957f\u5bff\u547d\uff1f\u56e0\u6b64\uff0c\u4f5c\u8005\u53c8\u6784\u5efa\u4e86\u7ebf\u7c92\u4f53\u88c2\u53d8\u529f\u80fd\u7f3a\u5931\u7684\u7ebf\u866b\u6a21\u578b\uff08drp-1 tm1108\uff09\uff0c\u4f46\u5176\u5bff\u547d\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\u65e0\u663e\u8457\u6027\u5dee\u5f02\u3002\u57fa\u4e8e\u8fd9\u6837\u7684\u7ed3\u679c\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u65b0\u7684\u731c\u60f3\uff1aAMPK\u5ef6\u957f\u5bff\u547d\u53ef\u80fd\u5e76\u4e0d\u662f\u901a\u8fc7\u4fc3\u8fdb\u7ebf\u7c92\u4f53\u878d\u5408\u6765\u5b9e\u73b0\u7684\uff0c\u800c\u662f\u901a\u8fc7\u4fdd\u8bc1\u88c2\u53d8\u548c\u878d\u5408\u4e4b\u95f4\u7684\u5e73\u8861\u6765\u7ef4\u6301\u7ebf\u7c92\u4f53\u7a33\u6001\u3002\u5b9e\u9a8c\u7ed3\u679c\u4e5f\u8bc1\u5b9e\u4e86\u8fd9\u6837\u7684\u731c\u60f3\uff0c\u5728\u7ebf\u7c92\u4f53\u88c2\u53d8\u80fd\u529b\u7f3a\u5931\u7684\u6761\u4ef6\u4e0b\uff0cAMPK\u5bf9\u5bff\u547d\u7684\u5ef6\u957f\u4f5c\u7528\u4e5f\u6d88\u5931\u4e86\uff0c\u5e76\u4e14\u8fd9\u79cd\u73b0\u8c61\u4ec5\u5b58\u5728\u4e8eAMPK\u6fc0\u6d3b\u53ca\u63a7\u5236\u996e\u98df\u7684\u6761\u4ef6\u4e0b\uff0c\u5176\u4ed6\u6761\u4ef6\u672a\u80fd\u89c2\u5bdf\u5230\u7c7b\u4f3c\u7684\u7ed3\u679c\u3002\u4e0a\u8ff0\u7ed3\u679c\u8868\u660e\uff0cAMPK\u548c\u996e\u98df\u63a7\u5236\u901a\u8fc7\u7ef4\u6301\u7ebf\u7c92\u4f53\u878d\u5408\u548c\u88c2\u53d8\u4e4b\u95f4\u7684\u5e73\u8861\u6765\u5ef6\u957f\u5bff\u547d\u3002<\/p>\n

\u7b2c\u4e94\u6b65\uff1a\u7ef4\u6301\u7ebf\u7c92\u4f53\u7f51\u7edc\u7a33\u6001\u5bf9\u4e8e\u5ef6\u957f\u5bff\u547d\u81f3\u5173\u91cd\u8981<\/p>\n

      \u4e3a\u4e86\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u7ebf\u7c92\u4f53\u7a33\u6001\u4e0e\u5bff\u547d\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u4f5c\u8005\u53c8\u6784\u5efa\u4e86\u548cfoz-1\u53cc\u57fa\u56e0\u7a81\u53d8\u6a21\u578b\uff08\u5373\u7ebf\u7c92\u4f53\u7684\u88c2\u53d8\u548c\u878d\u5408\u80fd\u529b\u90fd\u4e27\u5931\uff09\u3002\u6709\u8da3\u7684\u662f\uff0c\u4ec5\u5728drp-1\u7a81\u53d8\u6216foz-1\u7a81\u53d8\u7684\u60c5\u51b5\u4e0b\uff0c\u7ebf\u7c92\u4f53\u7684\u7ed3\u6784\u90fd\u4f1a\u968f\u7740\u5e74\u9f84\u589e\u957f\u800c\u7834\u788e\uff1b\u4f46\u5728\u4e24\u4e2a\u57fa\u56e0\u540c\u65f6\u7a81\u53d8\u7684\u60c5\u51b5\u4e0b\uff0c\u7ebf\u7c92\u4f53\u7f51\u7edc\u5904\u4e8e\u4e00\u79cd\u7a33\u6001\uff0c\u4e14\u4e0d\u968f\u5e74\u9f84\u800c\u6539\u53d8\u3002\u968f\u5373\uff0c\u4f5c\u8005\u68c0\u6d4b\u4e86\u7ebf\u7c92\u4f53\u7a33\u6001\u5931\u8861\u5bf9\u5176\u529f\u80fd\u7684\u5f71\u54cd\uff0c\u53d1\u73b0\u5728\u53cc\u57fa\u56e0\u7a81\u53d8\u7ec4\uff0c\u7ebf\u866b\u7ec6\u80de\u548c\u7684\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u7684\u57fa\u7840\u547c\u5438\u90fd\u5347\u9ad8\uff0c\u4e14\u5176\u5bff\u547d\u663e\u8457\u5ef6\u957f\u3002\u4ee5\u4e0a\u7ed3\u679c\u8868\u660e\uff0c\u7ef4\u6301\u673a\u4f53\u7ebf\u7c92\u4f53\u7f51\u7edc\u7684\u7a33\u6001\u5373\u53ef\u5ef6\u957f\u5bff\u547d\u3002<\/p>\n

\u7b2c\u516d\u6b65\uff1a\u7ebf\u7c92\u4f53\u7f51\u7edc\u53ef\u5851\u6027\u5bf9\u4e8e\u95f4\u6b47\u6027\u996e\u98df\u5ef6\u957f\u5bff\u547d<\/p>\n

      \u7ebf\u7c92\u4f53\u7684\u878d\u5408\u548c\u88c2\u53d8\u5bf9\u4e8e\u4f17\u591a\u751f\u7269\u5b66\u8fc7\u7a0b\u90fd\u6709\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u4f46\u5728\u5e72\u6270\u4e86\u7ebf\u7c92\u4f53\u7684\u88c2\u53d8\u548c\u878d\u5408\u80fd\u529b\u540e\uff0c\u7ebf\u866b\u7684\u5bff\u547d\u5374\u5f97\u5230\u4e86\u5ef6\u957f\u3002\u6839\u636e\u8fd9\u4e00\u73b0\u8c61\uff0c\u4f5c\u8005\u53c8\u63d0\u51fa\u4e86\u4e00\u4e2a\u65b0\u7684\u5047\u8bbe\uff1a\u5728\u6b63\u5e38\u7a33\u5b9a\u7684\u5b9e\u9a8c\u6761\u4ef6\u4e0b\uff0c\u8fd9\u79cd\u7ebf\u7c92\u4f53\u5e73\u8861\u6216\u8bb8\u662f\u6709\u5229\u7684\uff1b\u4f46\u662f\u5f53\u73af\u5883\u6761\u4ef6\u53d1\u751f\u6539\u53d8\uff0c\u9700\u8981\u7ec6\u80de\u505a\u51fa\u9002\u5e94\u6027\u7684\u4ee3\u8c22\u53d8\u5316\u65f6\uff0c\u7ebf\u7c92\u4f53\u7f51\u7edc\u53ef\u5851\u6027\u7684\u7f3a\u4e4f\u53ef\u80fd\u5c31\u662f\u6709\u5bb3\u7684\u3002\u6240\u4ee5\u4f5c\u8005\u89c2\u5bdf\u5728\u95f4\u6b47\u6027\u996e\u98df\uff08Intermittent fasting, IF\uff09\u6761\u4ef6\u4e0b\u7684\u53d8\u5316\uff0cIF\u524d\u671f\u66fe\u88ab\u62a5\u9053\u80fd\u591f\u5ef6\u957f\u5bff\u547d\uff0c\u5e76\u4e14\u5bf9\u54fa\u4e73\u52a8\u7269\u7684\u5065\u5eb7\u662f\u6709\u76ca\u7684\u3002\u91ce\u751f\u578b\u7f51\u7edc\u91cd\u5851\uff0c\u800c\u53cc\u6572\u7ec4\u5219\u6ca1\u6709\u660e\u663e\u53d8\u5316\u3002\u5728\u91ce\u751f\u578b\uff0cIF\u80fd\u5ef6\u957f\u5bff\u547d\uff0c\u4f46\u662f\u5728\u53cc\u6572\u7684\u6761\u4ef6\u4e0b\uff0c\u5219\u65e0\u6548\uff0c\u8bf4\u660e\u7ebf\u7c92\u4f53\u7f51\u7edc\u7684\u53ef\u5851\u6027\u7684\u91cd\u8981\u6027\u3002<\/p>\n

\u7b2c\u4e8c\u9636\u6bb5\uff1a\u7ebf\u7c92\u4f53\u7a33\u6001\u5ef6\u957f\u5bff\u547d\u7684\u673a\u5236\u63a2\u8ba8<\/p>\n

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      \u4f5c\u8005\u8fdb\u4e00\u6b65\u5bf9\u7ebf\u7c92\u4f53\u7a33\u6001\u4e0e\u5bff\u547d\u4e4b\u95f4\u7684\u673a\u5236\u8fdb\u884c\u63a2\u8ba8\uff0c\u5728\u6392\u9664\u4e86\u7a33\u6001\u5bf9\u7ebf\u7c92\u4f53\u81ea\u566c\u7684\u5f71\u54cd\u540e\uff0c\u731c\u60f3\u7ebf\u7c92\u4f53\u7a33\u6001\u53ef\u80fd\u662f\u901a\u8fc7\u4ee3\u8c22\u91cd\u7f16\u7a0b\u6765\u5ef6\u957f\u5bff\u547d\u3002\u5bf9\u4e0d\u540c\u7ebf\u7c92\u4f53\u72b6\u6001\u7684\u7ec6\u80de\u4ee3\u8c22\u4ea7\u7269\u8fdb\u884c\u5206\u6790\uff0c\u53d1\u73b0\u968f\u7740\u7ebf\u7c92\u4f53\u7f51\u7edc\u7ed3\u6784\u7834\u574f\uff0c\u5176\u7ec6\u80de\u4ee3\u8c22\u529f\u80fd\u786e\u5b9e\u51fa\u73b0\u7d0a\u4e71\u3002\u4e14\u5728drp-1\u548cfoz-1\u4e24\u4e2a\u57fa\u56e0\u540c\u65f6\u7a81\u53d8\u7684\u60c5\u51b5\u4e0b\uff0c\u7ebf\u866b\u7ec6\u80de\u7684\u4ee3\u8c22\u53d8\u5316\u66f4\u4e3a\u660e\u663e\uff0c\u591a\u4e2a\u4e09\u7fa7\u9178\u5faa\u73af\u7684\u4e2d\u95f4\u4ee3\u8c22\u4ea7\u7269\u90fd\u4e0b\u964d\uff0c\u957f\u94fe\u9170\u57fa\u8089\u78b1\u53d1\u751f\u4e86\u663e\u8457\u7684\u6539\u53d8\uff0c\u8bf4\u660e\u8102\u80aa\u9178\u7684\u6c27\u5316\u8fc7\u7a0b\u53d1\u751f\u4e86\u6539\u53d8\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u63a2\u7d22\u8102\u80aa\u9178\u6c27\u5316\u5728\u5176\u4e2d\u7684\u4f5c\u7528\uff0c\u53d1\u73b0\u7ebf\u866b\u5728\u7ed9\u4e88\u6d3e\u514b\u66ff\u6797\uff08\u68d5\u6988\u9170\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242\uff09\u4e4b\u540e\uff0c\u53cc\u57fa\u56e0\u7a81\u53d8\u7ebf\u866b\u6a21\u578b\u5bf9\u5bff\u547d\u7684\u5ef6\u957f\u4f5c\u7528\u88ab\u6291\u5236\u4e86\uff0c\u8bf4\u660e\u7ebf\u7c92\u4f53\u7a33\u6001\u5bf9\u5bff\u547d\u7684\u5ef6\u957f\u4f5c\u7528\u662f\u901a\u8fc7\u589e\u52a0\u8102\u80aa\u9178\u6c27\u5316\u6765\u5b9e\u73b0\u7684\u3002<\/p>\n

      \u901a\u5e38\u60c5\u51b5\u4e0b\uff0c\u5bf9\u8102\u80aa\u9178\u7684\u8c03\u8282\u662f\u901a\u8fc7\u7ebf\u7c92\u4f53\u4e0e\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u76f8\u4e92\u4f5c\u7528\u6765\u5b9e\u73b0\u7684\u3002\u4f5c\u8005\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u5728\u957f\u5bff\u4e2d\u7684\u4f5c\u7528\uff0c\u53d1\u73b0\u5728\u53cc\u57fa\u56e0\u7a81\u53d8\u7684\u7ebf\u866b\u4f53\u5185\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u878d\u5408\u5ea6\u66f4\u9ad8\uff0c\u4f53\u79ef\u66f4\u5927\u3002\u800c\u5728\u5e72\u6270\u4e86\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u7684\u529f\u80fd\u4e4b\u540e\uff0c\u5bf9\u5bff\u547d\u7684\u5ef6\u957f\u4f5c\u7528\u6d88\u5931\uff0c\u8bf4\u660e\u7ebf\u7c92\u4f53\u548c\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u80fd\u591f\u5171\u540c\u589e\u52a0\u8102\u80aa\u9178\u6c27\u5316\uff0c\u7ef4\u6301\u7ebf\u7c92\u4f53\u7a33\u6001\uff0c\u4ece\u800c\u5ef6\u957f\u5bff\u547d\u3002<\/p>\n

\u7b2c\u4e8c\u6b65\uff1a\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u5728AMPK\u548c\u63a7\u5236\u996e\u98df\u4ecb\u5bfc\u7684\u957f\u5bff\u4e2d\u5177\u6709\u91cd\u8981\u4f5c\u7528<\/p>\n

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Weir H J, Yao P, Huynh F K, et al. Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling[J]. Cell Metabolism, 2017.<\/p>\n

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