{"id":28984,"date":"2024-04-05T04:01:19","date_gmt":"2024-04-05T04:01:19","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=28984"},"modified":"2024-04-05T04:01:19","modified_gmt":"2024-04-05T04:01:19","slug":"%e5%86%a0%e7%8a%b6%e5%8a%a8%e8%84%89%e9%92%99%e5%8c%96%e7%a0%94%e7%a9%b6%e7%9a%84%e6%96%b0%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=28984","title":{"rendered":"\u51a0\u72b6\u52a8\u8109\u9499\u5316\u7814\u7a76\u7684\u65b0\u8fdb\u5c55"},"content":{"rendered":"

\u51a0\u72b6\u52a8\u8109\u9499\u5316\u662f\u9499\u76d0\u5f02\u5e38\u6c89\u79ef\u4e8e\u51a0\u72b6\u52a8\u8109\u8840\u7ba1\u58c1\u7684\u4e34\u5e8a\u73b0\u8c61\uff0c\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u8840\u7ba1\u9499\u5316\u53d1\u751f\u7387\u4e5f\u9010\u5e74\u589e\u52a0\u3002\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u53d1\u73b0\uff0c\u572870\u5c81\u4ee5\u4e0a\u4eba\u7fa4\u4e2d\uff0c93%\u7684\u7537\u6027\u548c75%\u7684\u5973\u6027\u6709\u4e0d\u540c\u7a0b\u5ea6\u7684\u8840\u7ba1\u9499\u5316[1]<\/sup>\u3002\u51a0\u72b6\u52a8\u8109\u9499\u5316\u901a\u5e38\u88ab\u8ba4\u4e3a\u662f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u81ea\u7136\u8fdb\u5c55\u8fc7\u7a0b\uff0c\u662f\u5176\u4e00\u79cd\u5e38\u89c1\u75c5\u7406\u8868\u73b0\u5f62\u5f0f\u3002\u800c\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u5bf9\u5176\u53d1\u75c5\u673a\u5236\u53ca\u4e0e\u4e34\u5e8a\u4e8b\u4ef6\u5173\u8054\u6027\u7684\u6df1\u5165\u7814\u7a76\uff0c\u4eba\u4eec\u5bf9\u51a0\u72b6\u52a8\u8109\u9499\u5316\u7684\u8ba4\u8bc6\u4e0d\u65ad\u66f4\u65b0\u3002\u672c\u6587\u5c06\u5bf9\u8fd1\u5e74\u51a0\u72b6\u52a8\u8109\u9499\u5316\u7814\u7a76\u4e2d\u7684\u65b0\u8ba4\u8bc6\u505a\u4e00\u7efc\u8ff0\u3002<\/p>\n

1\u3000\u8840\u7ba1\u9499\u5316\u7684\u7ed3\u6784\u548c\u7279\u70b9<\/p>\n

\u8840\u7ba1\u9499\u5316\u66fe\u88ab\u8ba4\u4e3a\u662f\u4e0e\u8870\u8001\u76f8\u5173\u7684\u9000\u884c\u6027\u75be\u75c5\u7684\u4e00\u79cd\u8868\u73b0\u5f62\u5f0f\uff0c\u8fd1\u6765\u53d1\u73b0\u8840\u7ba1\u9499\u5316\u4e0e\u9aa8\u53d1\u80b2\u548c\u5f62\u6210\u7684\u8fc7\u7a0b\u76f8\u4f3c\uff0c\u5e38\u4f34\u968f\u8840\u7ba1\u58c1\u7ec6\u80de\u6210\u9aa8\u6837\u8868\u578b\u8f6c\u5316\uff0c\u662f\u4e00\u4e2a\u53ef\u4ee5\u8c03\u8282\u7684\u8fc7\u7a0b\u3002<\/p>\n

\u6839\u636e\u9499\u5316\u7076\u5927\u5c0f\uff0c\u9499\u5316\u75c5\u53d8\u53ef\u5206\u4e3a\u6781\u5fae\u9499\u5316(0.5 \u03bcm\u2264\u76f4\u5f84<15 \u03bcm)\u3001\u6591\u70b9\u72b6\u9499\u5316(\u76f4\u5f84\u22642 mm)\u3001\u788e\u7247\u72b6\u9499\u5316(2 mm<\u76f4\u5f84<5 mm)\u548c\u5f25\u6f2b\u6027\u9499\u5316(\u8fde\u7eed\u9499\u5316\u22655 mm)\uff0c\u5176\u4e2d\u5fae\u9499\u5316\u6216\u70b9\u7076\u72b6\u9499\u5316\u6cdb\u6307\u6781\u5fae\u548c\u6591\u70b9\u72b6\u9499\u5316\uff0c\u5927\u9499\u5316\u6cdb\u6307\u788e\u7247\u72b6\u548c\u5f25\u6f2b\u6027\u9499\u5316\u3002<\/p>\n

\u6839\u636e\u8840\u7ba1\u9499\u5316\u7684\u4f4d\u7f6e\u4e0d\u540c\uff0c\u51a0\u72b6\u52a8\u8109\u9499\u5316\u53ef\u5206\u4e3a\u4e2d\u819c\u9499\u5316\u548c\u5185\u819c\u9499\u5316\u3002\u5176\u4e2d\uff0c\u4e2d\u819c\u9499\u5316\u4e5f\u79f0M\u00f6nckeberg\u578b\u52a8\u8109\u4e2d\u5c42\u786c\u5316\u75c7\uff0c\u8d77\u59cb\u4e8e\u5185\u5f39\u529b\u819c\u95f4\u9699\u533a\uff0c\u6269\u5c55\u81f3\u4e2d\u819c\uff0c\u53ef\u5448\u540c\u5fc3\u5706\u72b6\u5f25\u6f2b\u5206\u5e03\uff0c\u5e38\u4f34\u968f\u5e73\u6ed1\u808c\u7ec6\u80de\u6210\u9aa8\u6837\u8f6c\u5316\u7684\u8fc7\u7a0b\uff0cX\u7ebf\u68c0\u67e5\u53ef\u89c1\u7279\u5f81\u6027\u7684\u94c1\u8f68\u5f81[2]<\/sup>\u3002\u52a8\u8109\u4e2d\u819c\u9499\u5316\u5e38\u89c1\u4e8e\u5c0f\u52a8\u8109\uff0c\u4e5f\u53ef\u89c1\u4e8e\u4e3b\u52a8\u8109\u58c1\uff0c\u5176\u53d1\u751f\u53ef\u72ec\u7acb\u4e8e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u8fc7\u7a0b\u4e4b\u5916\uff0c\u5177\u6709\u968f\u5e74\u9f84\u589e\u957f\u53d1\u75c5\u7387\u5347\u9ad8\u7684\u7279\u70b9\u3002\u4e34\u5e8a\u4e0a\uff0c\u4e2d\u819c\u9499\u5316\u5f80\u5f80\u53cd\u6620\u51a0\u72b6\u52a8\u8109\u786c\u5316\u7684\u7a0b\u5ea6\uff0c\u4f7f\u8840\u7ba1\u58c1\u5bf9\u751f\u7406\u6027\u523a\u6fc0\u7684\u8212\u7f29\u53cd\u5e94\u4e0b\u964d\uff0c\u4ece\u800c\u5f71\u54cd\u51a0\u72b6\u52a8\u8109\u8840\u6d41\u91cf\u7684\u6b63\u5e38\u8c03\u8282\u3002\u800c\u5185\u819c\u9499\u5316\u5219\u662f\u5728\u7ca5\u6837\u6591\u5757\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\uff0c\u7531\u4e8e\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u529f\u80fd\u5931\u8c03\u3001\u6c27\u5316\u5e94\u6fc0\u53ca\u708e\u75c7\u7b49\u591a\u79cd\u56e0\u7d20\u4f5c\u7528\uff0c\u5bfc\u81f4\u9499\u78f7\u7ed3\u6676\u5728\u7ca5\u6837\u6591\u5757\u7684\u8102\u8d28\u574f\u6b7b\u6838\u5185\u6c89\u79ef\u5e76\u53d1\u5c55\u7684\u8fc7\u7a0b\u3002\u5927\u90e8\u5206\u9499\u76d0\u7ed3\u6676\u6c89\u79ef\u4e8e\u8fd1\u52a8\u8109\u4e2d\u5c42\u7684\u6591\u5757\u57fa\u5e95\u90e8\uff0c\u800c\u63a5\u8fd1\u7ba1\u8154\u8868\u9762\u7684\u9499\u5316\u5219\u53ef\u80fd\u4e0e\u6591\u5757\u7a33\u5b9a\u6027\u6709\u5173\u3002<\/p>\n

2\u3000\u51a0\u72b6\u52a8\u8109\u9499\u5316\u548c\u51a0\u72b6\u52a8\u8109\u72ed\u7a84\u7684\u5173\u7cfb<\/p>\n

\u51a0\u72b6\u52a8\u8109\u9499\u5316\u66fe\u88ab\u8ba4\u4e3a\u662f\u51a0\u72b6\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u4e00\u79cd\u8868\u73b0\u5f62\u5f0f\uff0c\u8840\u7ba1\u9499\u5316\u548c\u7ba1\u8154\u72ed\u7a84\u4e5f\u5bb9\u6613\u88ab\u8054\u7cfb\u5728\u4e00\u8d77\u3002\u4e34\u5e8a\u4e0a\u76f8\u5bf9\u4e8e\u65e0\u75c7\u72b6\u60a3\u8005\uff0c\u51a0\u72b6\u52a8\u8109\u9499\u5316\u66f4\u5e38\u89c1\u4e8e\u6709\u75c7\u72b6\u7684\u51a0\u5fc3\u75c5\u60a3\u8005\uff1b\u540c\u65f6\uff0c\u6765\u6e90\u4e8e\u5c38\u68c0\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u51a0\u72b6\u52a8\u8109\u9499\u5316\u7a0b\u5ea6\u786e\u5b9e\u4e0e\u7ca5\u6837\u786c\u5316\u8d1f\u8377\u6709\u5173[2]<\/sup>\u3002\u56e0\u6b64\uff0c\u65e9\u671f\u7684\u7814\u7a76\u591a\u8ba4\u4e3a\u51a0\u72b6\u52a8\u8109\u9499\u5316\u53ef\u4ee5\u4f5c\u4e3a\u9884\u6d4b\u6591\u5757\u8d1f\u8377\u548c\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u7684\u6307\u6807\uff0c\u51a0\u72b6\u52a8\u8109\u96f6\u9499\u5316\u4e5f\u66fe\u88ab\u7528\u4e8e\u6392\u9664\u963b\u585e\u6027\u51a0\u5fc3\u75c5[3]<\/sup>\u3002\u7136\u800c\uff0c\u51a0\u72b6\u52a8\u8109\u9499\u5316\u867d\u7136\u5e38\u89c1\u4e8e\u7ca5\u6837\u786c\u5316\u6591\u5757\uff0c\u9499\u5316\u79ef\u5206\u9884\u6d4b\u51a0\u72b6\u52a8\u8109\u72ed\u7a84\u7684\u654f\u611f\u6027\u9ad8\uff0c\u4f46\u7279\u5f02\u6027\u5374\u5f88\u4f4e[4]<\/sup>\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u51a0\u72b6\u52a8\u8109\u9499\u5316\u4e25\u91cd\u7a0b\u5ea6\u4e0e\u51a0\u72b6\u52a8\u8109\u72ed\u7a84\u7a0b\u5ea6\u4e4b\u95f4\u5e76\u975e\u76f4\u7ebf\u76f8\u5173\uff0c\u9499\u5316\u548c\u72ed\u7a84\u662f\u76f8\u5bf9\u72ec\u7acb\u7684\u4e24\u79cd\u75c5\u53d8\uff0c\u51a0\u72b6\u52a8\u8109\u9499\u5316\u7a0b\u5ea6\u9ad8\u7684\u60a3\u8005\uff0c\u51a0\u72b6\u52a8\u8109\u8840\u6d41\u4e0d\u4e00\u5b9a\u53d7\u5f88\u5927\u5f71\u54cd[5,6]<\/sup>\u3002<\/p>\n

3\u3000\u51a0\u72b6\u52a8\u8109\u9499\u5316\u9884\u6d4b\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u53d1\u751f\u7684\u4ef7\u503c<\/p>\n

\u4f20\u7edf\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5371\u9669\u56e0\u7d20\uff0c\u5305\u62ec\u8840\u8102\u7d0a\u4e71\u3001\u9ad8\u8840\u538b\u3001\u7cd6\u5c3f\u75c5\u3001\u80a5\u80d6\u3001\u5438\u70df\u3001\u7f3a\u5c11\u8fd0\u52a8\u7b49\uff0c\u5728\u9884\u6d4b\u51a0\u5fc3\u75c5\u53d1\u751f\u7387\u65b9\u9762\u7684\u4ef7\u503c\u65e9\u5df2\u88ab\u5e7f\u6cdb\u63a5\u53d7\u3002\u7136\u800c\uff0c\u4e0a\u8ff0\u56e0\u7d20\u5728\u8bc4\u4f30\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u53d1\u751f\u7387\u65b9\u9762\u5374\u5e76\u4e0d\u5341\u5206\u7406\u60f3\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u4f20\u7edf\u7684\u5371\u9669\u56e0\u7d20\u4ec5\u80fd\u9884\u6d4b60%\uff5e65%\u7684\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u98ce\u9669\uff0c\u4f46\u4e34\u5e8a\u4e0a\u7ea635%\uff5e40%\u6ca1\u6709\u5371\u9669\u56e0\u7d20\u7684\u60a3\u8005\u4e5f\u7ecf\u5386\u8fc7\u5fc3\u8840\u7ba1\u4e8b\u4ef6[5]<\/sup>\uff1b\u800c\u5728\u9996\u6b21\u53d1\u751f\u6025\u6027\u5fc3\u808c\u6897\u6b7b\u4f46\u5e73\u65f6\u65e0\u75c7\u72b6\u7684\u60a3\u8005\u4e2d\uff0c75%\u672a\u88ab\u91cd\u89c6\uff0c\u4e5f\u5e38\u5e38\u672a\u63a5\u53d7\u8fc7\u4ed6\u6c40\u7b49\u836f\u7269\u6cbb\u7597\u3002\u4f20\u7edf\u5371\u9669\u56e0\u7d20\u9884\u6d4b\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u7684\u5c40\u9650\u6027\u4fc3\u4f7f\u4eba\u4eec\u53bb\u7814\u7a76\u51a0\u72b6\u52a8\u8109\u9499\u5316\u80fd\u5426\u8f85\u52a9\u63d0\u9ad8\u9884\u6d4b\u65e0\u75c7\u72b6\u60a3\u8005\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u7684\u4ef7\u503c\u3002\u591a\u9879\u7814\u7a76\u5747\u8868\u660e\uff0c\u72ec\u7acb\u4e8e\u4f20\u7edf\u5371\u9669\u56e0\u7d20\uff0c\u51a0\u72b6\u52a8\u8109\u9499\u5316\u662f\u4e00\u4e2a\u66f4\u597d\u7684\u9884\u6d4b\u5168\u56e0\u6b7b\u4ea1\u548c\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u7684\u6307\u6807[7]<\/sup>\u3002<\/p>\n

\u7136\u800c\uff0c\u4e5f\u4e0d\u80fd\u5938\u5927\u51a0\u72b6\u52a8\u8109\u9499\u5316\u5728\u9884\u6d4b\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u4e2d\u7684\u4f5c\u7528\u3002\u968f\u7740\u5f71\u50cf\u5b66\u68c0\u67e5\u7684\u8fdb\u6b65\u548c\u8bc1\u636e\u79ef\u7d2f\uff0c\u8840\u7ba1\u9499\u5316\u5728\u6591\u5757\u7a33\u5b9a\u6027\u548c\u7ee7\u53d1\u8840\u7ba1\u4e8b\u4ef6\u4e2d\u7684\u4f5c\u7528\u5c1a\u5b58\u4e89\u8bae\u3002\u8fd1\u671f\uff0cYoon\u7b49[8]<\/sup>\u7814\u7a76\u53d1\u73b0\uff0c\u6709\u75c7\u72b6\u8005\u51a0\u72b6\u52a8\u8109\u9499\u5316\u79ef\u5206\u9ad8\uff0c\u7531\u6b64\u63a8\u6d4b\u9499\u5316\u79ef\u5206\u53ef\u7528\u4e8e\u5bf9\u60a3\u8005\u75c7\u72b6\u7684\u9884\u6d4b\u3002\u540c\u65f6\uff0cYamamoto\u7b49[9]<\/sup>\u7814\u7a76\u53d1\u73b0\uff0c\u9499\u5316\u79ef\u5206\u5927\u4e8e100\u65f6\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u53ca\u5352\u4e2d\u98ce\u9669\u589e\u52a0\uff0c\u6545\u63a8\u6d4b\u9499\u5316\u79ef\u5206\u53ef\u7528\u4e8e\u4e2d\u8fdc\u671f\u5fc3\u8840\u7ba1\u98ce\u9669\u7684\u8bc4\u4f30\u3002\u4e5f\u6709\u7814\u7a76\u53d1\u73b0\uff0c\u6025\u6027\u51a0\u72b6\u52a8\u8109\u7efc\u5408\u5f81\u60a3\u8005\u4e2d\u65e0\u8840\u7ba1\u9499\u5316\u7684\u60a3\u8005\u660e\u663e\u591a\u4e8e\u6709\u9499\u5316\u7684\u4eba\u7fa4\uff0c\u540c\u65f6\u6025\u6027\u5fc3\u808c\u6897\u6b7b\u60a3\u8005\u51a0\u72b6\u52a8\u8109\u9499\u5316\u8bc4\u5206\u4e0e\u7ca5\u6837\u6591\u5757\u5185\u708e\u75c7\u6d3b\u6027\u5448\u8d1f\u76f8\u5173\uff0c\u6545\u6709\u5b66\u8005\u8ba4\u4e3a\u5185\u819c\u9499\u5316\u4e5f\u53ef\u80fd\u662f\u4e00\u79cd\u673a\u4f53\u81ea\u6211\u4fdd\u62a4\u548c\u9632\u5fa1\u673a\u5236\uff0c\u9499\u5316\u53ef\u80fd\u901a\u8fc7\u7a33\u5b9a\u6591\u5757\u4ece\u800c\u51cf\u5c11\u6025\u6027\u51a0\u72b6\u52a8\u8109\u7efc\u5408\u5f81\u53d1\u751f[2,6]<\/sup>\u3002\u4e5f\u6709\u7814\u7a76\u8ba4\u4e3a\uff0c\u6591\u5757\u7684\u7a33\u5b9a\u6027\u4e0e\u5185\u819c\u9499\u5316\u7684\u5927\u5c0f\u548c\u5f62\u6001\u6709\u5173\u3002\u7c97\u5927\u9499\u5316\u53ef\u80fd\u6709\u52a9\u4e8e\u6591\u5757\u7a33\u5b9a\uff0c\u800c\u591a\u53d1\u6027\u70b9\u7076\u72b6\u5fae\u9499\u5316\u7531\u4e8e\u6539\u53d8\u4e86\u7ca5\u6837\u6591\u5757\u4e0e\u5468\u56f4\u7ec4\u7ec7\u7684\u5e94\u529b\u5e73\u8861\uff0c\u53cd\u800c\u66f4\u6613\u5bfc\u81f4\u6591\u5757\u7834\u88c2\uff0c\u76f8\u5173\u8bc1\u636e\u6765\u81ea\u5bf9\u51a0\u5fc3\u75c5\u731d\u6b7b\u60a3\u8005\u7684\u75c5\u7406\u7814\u7a76\uff0c70%\u7684\u7834\u88c2\u6591\u5757\u4e2d\u6709\u6591\u70b9\u72b6\u9499\u5316\uff0c\u800c\u5e38\u89c4\u7684\u5f71\u50cf\u5b66\u68c0\u67e5\u4ec5\u80fd\u53d1\u73b0\u76f4\u5f84\u5927\u4e8e15 \u03bcm\u7684\u9499\u5316\uff0c\u5bf9\u4e8e\u5fae\u9499\u5316\u6216\u70b9\u72b6\u9499\u5316\u5206\u8fa8\u7387\u4e0d\u8db3\u53ef\u80fd\u662f\u9650\u5236\u4e34\u5e8a\u5224\u65ad\u7684\u4e3b\u8981\u539f\u56e0\u3002<\/p>\n

4\u3000\u8840\u7ba1\u635f\u4f24\u4e0e\u51a0\u72b6\u52a8\u8109\u9499\u5316<\/p>\n

\u4f5c\u4e3a\u52a8\u8109\u7ca5\u6837\u786c\u5316\u53d1\u751f\u673a\u5236\u91cd\u8981\u5047\u8bf4\u4e4b\u4e00\u7684’\u8840\u7ba1\u635f\u4f24\u53cd\u5e94\u5b66\u8bf4’\u4e00\u76f4\u4e3a\u4eba\u4eec\u6240\u91cd\u89c6\u3002\u5185\u76ae\u635f\u4f24\u4e0d\u4ec5\u80fd\u89e6\u53d1\u52a8\u8109\u7ca5\u6837\u786c\u5316\u8fc7\u7a0b\uff0c\u8fd8\u80fd\u901a\u8fc7\u91ca\u653e\u51cb\u4ea1\u5c0f\u4f53\u53ca\u5305\u542b\u7ec6\u80de\u788e\u7247\u7684\u57fa\u8d28\u56ca\u6ce1\u7b49\u7269\u8d28\u542f\u52a8\u8840\u7ba1\u5185\u819c\u548c\u4e2d\u819c\u9499\u5316[10]<\/sup>\u3002Iyemere\u7b49[11]<\/sup>\u7814\u7a76\u53d1\u73b0\uff0c\u8840\u7ba1\u635f\u4f24\u540e\u5e73\u6ed1\u808c\u7ec6\u80de\u7531\u6536\u7f29\u8868\u578b\u8f6c\u6362\u6210\u5408\u6210\u8868\u578b\u3001\u8fc1\u79fb\u81f3\u8840\u7ba1\u635f\u4f24\u90e8\u4f4d\u3001\u589e\u751f\u5e76\u5206\u6ccc\u57fa\u8d28\u7b49\u6210\u5206\u5f62\u6210\u7ea4\u7ef4\u5e3d\uff0c\u4ece\u800c\u4f7f\u5bcc\u542b\u8102\u8d28\u3001\u4fc3\u51dd\u7684\u6591\u5757\u6838\u5fc3\u4e0e\u8840\u6db2\u9694\u79bb\u3002\u901a\u5e38\u8fd9\u4e2a\u8fc7\u7a0b\u5b8c\u6210\u540e\uff0c\u5e73\u6ed1\u808c\u4f1a\u6062\u590d\u6536\u7f29\u8868\u578b\uff0c\u4f46\u5982\u679c\u635f\u4f24\u523a\u6fc0\u6301\u7eed\u5b58\u5728\u65f6\uff0c\u5e73\u6ed1\u808c\u5c31\u53ef\u80fd\u4f1a\u8f6c\u6362\u4e3a\u6210\u9aa8\u3001\u8f6f\u9aa8\u6216\u8102\u80aa\u7ec6\u80de\u8868\u578b\uff0c\u542f\u52a8\u9499\u5316\u7684\u8fc7\u7a0b\u3002Chellan\u7b49[12]<\/sup>\u53d1\u73b0\uff0c\u9176\u4fee\u9970\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u8bf1\u5bfc\u51a0\u72b6\u52a8\u8109\u5e73\u6ed1\u808c\u7ec6\u80de\u53ca\u6ce1\u6cab\u7ec6\u80de\uff0c\u5e76\u4ecb\u5bfc\u5176\u8fc1\u79fb\u548c\u6210\u9aa8\u7ec6\u80de\u57fa\u56e0\u8c31\u7684\u8868\u578b\u8f6c\u6362\u8bf1\u5bfc\u9499\u5316\u5f62\u6210\u3002\u4efb\u4f55\u5f62\u5f0f\u7684\u8840\u7ba1\u635f\u4f24\uff0c\u90fd\u6709\u5f15\u8d77\u708e\u75c7\u548c\u514d\u75ab\u53cd\u5e94\u7684\u53ef\u80fd\uff0c\u5728\u635f\u4f24\u90e8\u4f4d\u9644\u8fd1\u5f80\u5f80\u4e5f\u4f1a\u53d1\u73b0T\u7ec6\u80de\u3001\u5355\u6838\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u7b49\u6210\u5206\uff0c\u5b83\u4eec\u53ef\u80fd\u4e5f\u53c2\u4e0e\u4e86\u8840\u7ba1\u9499\u5316\u7684\u8c03\u8282\u3002<\/p>\n

5\u3000\u5f71\u54cd\u8840\u7ba1\u9499\u5316\u53d1\u751f\u7684\u56e0\u7d205.1\u3000\u526a\u5207\u5e94\u529b\u548c\u5185\u76ae\u635f\u4f24\u4e0e\u4fee\u590d<\/p>\n

\u526a\u5207\u5e94\u529b\u6765\u6e90\u4e8e\u8840\u6d41\u4e0e\u8840\u7ba1\u5185\u819c\u4e4b\u95f4\u7684\u6469\u64e6\uff0c\u662f\u8840\u6db2\u7c98\u5ea6\u3001\u526a\u5207\u901f\u7387\u548c\u8840\u7ba1\u58c1\u7efc\u5408\u4f5c\u7528\u7684\u7ed3\u679c\u3002\u526a\u5207\u5e94\u529b\u80fd\u4fc3\u8fdb\u6591\u5757\u7684\u5f62\u6210\u548c\u8fdb\u5c55\uff0c\u5185\u76ae\u7ec6\u80de\u8868\u9762\u7684\u673a\u68b0\u53d7\u4f53\u80fd\u611f\u77e5\u8840\u7ba1\u8154\u8840\u6d41\u526a\u5207\u529b\u7684\u53d8\u5316\uff0c\u901a\u8fc7\u7ec6\u80de\u9aa8\u67b6\u5c06\u526a\u5207\u529b\u523a\u6fc0\u4f20\u5bfc\u81f3\u7ec6\u80de\u6838\uff0c\u8fdb\u800c\u89e6\u53d1\u4fe1\u53f7\u7ea7\u8054\u53cd\u5e94\uff0c\u6d89\u53ca\u708e\u75c7\u3001\u7c98\u9644\u5206\u5b50\u3001\u6d3b\u6027\u6c27\u53ca\u4e00\u4e9b\u9176\u7c7b\u7b49\u7684\u53d8\u5316\uff0c\u6253\u7834\u5185\u76ae\u7ec6\u80de\u7a33\u6001\u3001\u4fc3\u8fdb\u6591\u5757\u5f62\u6210\u548c\u9499\u5316\u3002\u800c\u6591\u5757\u7ea4\u7ef4\u5e3d\u7684\u5f62\u6001\u3001\u6210\u5206\u548c\u7f9f\u78f7\u7070\u77f3\u6c89\u79ef\u90e8\u4f4d\u7b49\u4e5f\u53ef\u663e\u8457\u6539\u53d8\u5c40\u90e8\u8840\u7ba1\u526a\u5207\u5e94\u529b\u3002\u4e0e\u539a\u7ea4\u7ef4\u5e3d\u76f8\u6bd4\uff0c\u7f9f\u78f7\u7070\u77f3\u6c89\u79ef\u4e8e\u8584\u7ea4\u7ef4\u5e3d\u5f62\u6210\u70b9\u72b6\u9499\u5316\u65f6\uff0c\u5c40\u90e8\u7684\u526a\u5207\u5e94\u529b\u80fd\u589e\u52a047.5%[13]<\/sup>\u3002\u800c\u6591\u5757\u7834\u88c2\u4e5f\u5bb9\u6613\u53d1\u751f\u5728\u526a\u5207\u5e94\u529b\u9ad8\u7684\u90e8\u4f4d\uff0c\u5982\u8f6f\u6591\u5757\u548c\u9499\u5316\u6591\u5757\u76f8\u63a5\u5904\u3002\u53e6\u4e00\u65b9\u9762\u526a\u5207\u529b\u53ef\u4fc3\u8fdb\u8bf1\u5bfc\u8840\u7ba1\u5185\u76ae\u4fee\u590d\uff0cKutikhin\u7b49[14]<\/sup>\u7814\u7a76\u663e\u793a\uff0c\u5355\u5411\u5c42\u6d41\u526a\u5207\u5e94\u529b\u53ef\u663e\u8457\u4fc3\u8fdb\u5faa\u73af\u5185\u76ae\u7956\u7ec6\u80de\u5411\u5185\u76ae\u635f\u4f24\u90e8\u4f4d\u7684\u5f52\u5de2\uff0c\u8bf1\u5bfc\u5185\u76ae\u7956\u7ec6\u80de\u7684\u6297\u8840\u6813\u5f62\u6210\u548c\u6297\u52a8\u8109\u7ca5\u6837\u786c\u5316\u8868\u578b\uff0c\u589e\u52a0\u5176\u5728\u4f53\u5916\u5f62\u6210\u6bdb\u7ec6\u7ba1\u6837\u7ba1\u7684\u80fd\u529b\uff0c\u5e76\u589e\u5f3a\u5185\u76ae\u7956\u7ec6\u80de\u5206\u5316\u4e3a\u6210\u719f\u5185\u76ae\u7ec6\u80de\u3002<\/p>\n

5.2\u3000\u6c27\u5316\u5e94\u6fc0<\/p>\n

\u6c27\u5316\u5e94\u6fc0\u5e38\u89c1\u4e8e\u9ad8\u8840\u538b\u3001\u7cd6\u5c3f\u75c5\u3001\u8840\u8102\u7d0a\u4e71\u3001\u5438\u70df\u7b49\u60c5\u51b5\uff0c\u662f\u5f15\u8d77\u5185\u76ae\u635f\u4f24\u7684\u91cd\u8981\u539f\u56e0\u3002\u6c27\u5316\u5e94\u6fc0\u5e38\u5e38\u8868\u73b0\u4e3a\u7cd6\u57fa\u5316\u7ec8\u4ea7\u7269(advanced glycation end products\uff0cAGEs)\u589e\u591a\uff0c\u4e34\u5e8a\u4e0a\u6700\u5e38\u68c0\u6d4b\u7684\u6307\u6807\u5373\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u3002AGEs\u4e0e\u5176\u53d7\u4f53RAGE\u76f8\u4e92\u4f5c\u7528\u540e\uff0c\u4f1a\u8fdb\u4e00\u6b65\u5bfc\u81f4\u8840\u7ba1\u5185\u76ae\u91ca\u653e\u708e\u75c7\u56e0\u5b50\u548c\u7ec6\u80de\u6210\u9aa8\u8868\u578b\u8f6c\u5316\uff0c\u4fc3\u8fdb\u8840\u7ba1\u9499\u5316[2,15]<\/sup>\u3002AGEs\u548cRAGE\u4e0d\u4ec5\u53d7\u8840\u7cd6\u8c03\u8282\uff0c\u8fd8\u53d7\u8840\u8102\u8c03\u8282\uff0c\u6c27\u5316\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u4e0e\u8840\u7ba1\u9499\u5316\u3001\u6591\u5757\u5f62\u6210\u548c\u6591\u5757\u7834\u88c2\u7684\u5173\u7cfb\u4e5f\u6709\u8f83\u591a\u7814\u7a76\u3002Farrar\u7b49[16]<\/sup>\u7814\u7a76\u53d1\u73b0\uff0c\u6c27\u5316\u5e94\u6fc0\u53cd\u5e94\u65f6\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u03b1\u53ca\u8d85\u6c27\u5316\u7269\u6025\u6027\u589e\u52a0\uff0c\u5e76\u4e14\u589e\u52a0\u5185\u76ae\u578b\u4e00\u6c27\u5316\u6c2e\u5408\u9176\u548c\u8840\u7ba1\u5185\u76ae\u9499\u7c98\u86cb\u767d\u542b\u91cf\uff0c\u7531\u6b64\u63a8\u6d4b\u6c27\u5316\u5e94\u6fc0\u662f\u4fc3\u8fdb\u8840\u7ba1\u9499\u5316\u7684\u56e0\u7d20\u3002<\/p>\n

5.3\u3000\u57fa\u56e0\u548c\u9057\u4f20\u56e0\u7d20<\/p>\n

\u4e0d\u540c\u79cd\u65cf\u52a8\u8109\u9499\u5316\u6613\u611f\u6027\u7684\u5dee\u5f02\u63d0\u793a\u57fa\u56e0\u548c\u9057\u4f20\u56e0\u7d20\u5728\u8840\u7ba1\u9499\u5316\u53d1\u751f\u4e2d\u8d77\u4e00\u5b9a\u4f5c\u7528\uff0c\u5982\u4e0e\u975e\u88d4\u7f8e\u56fd\u4eba\u76f8\u6bd4\uff0c\u767d\u79cd\u4eba\u66f4\u6613\u53d1\u751f\u52a8\u8109\u9499\u5316[2]<\/sup>\u3002\u5728\u9ad8\u8840\u538b\u53d1\u751f\u98ce\u9669\u9ad8\u7684\u4e2a\u4f53\u4e2d\uff0c\u8840\u7ba1\u9499\u5316\u7684\u53d1\u751f\u5f80\u5f80\u4e0e\u8c03\u8282\u80f6\u539f\u7684\u57fa\u56e0\u3001\u9aa8\u5f62\u6210\u86cb\u767d\u53d7\u4f531A\u3001\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u91769\u548c\u9aa8\u6865\u86cb\u767d\u7b49\u57fa\u56e0\u76f8\u5173\uff0c\u800c\u8fd9\u4e9b\u57fa\u56e0\u5747\u53c2\u4e0e\u4e86\u8840\u7ba1\u9499\u5316\u7684\u5f62\u6210\u3002\u5728\u4e00\u4e9b\u5c11\u89c1\u7684\u9057\u4f20\u6027\u75be\u75c5\uff0c\u5982\u6d89\u53caENPP1\u3001ABCC6\u3001NT5E\u7b49\u53d8\u5f02\u65f6\uff0c\u4e5f\u4f1a\u5f15\u8d77\u8840\u7ba1\u9499\u5316[17]<\/sup>\u3002Divers\u7b49[18]<\/sup>\u7814\u7a76\u53d1\u73b0\uff0c\u4f4d\u4e8e\u67d3\u8272\u4f53\u4e0a\u76842q22.1\uff0c6p22.3\uff0c9q31.2\uff0c16p13.3\u53ca18q12\u57fa\u56e0\u4e0e\u51a0\u72b6\u52a8\u8109\u9499\u5316\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n

5.4\u3000\u996e\u98df\u548c\u73af\u5883<\/p>\n

\u996e\u98df\u4e0e\u8840\u7ba1\u9499\u5316\u7684\u53d1\u751f\u548c\u4e25\u91cd\u7a0b\u5ea6\u6709\u5173\u3002\u6c34\u679c\u548c\u852c\u83dc\u4e2d\u542b\u6709\u5927\u91cf\u7684\u9541\u3001\u53f6\u9178\u3001\u7ef4\u751f\u7d20K\u53ca\u6297\u6c27\u5316\u7269\u3002CARDIA\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u5e74\u8f7b\u65f6\u591a\u6444\u5165\u6c34\u679c\u852c\u83dc\u80fd\u5ef6\u7f1320\u5e74\u540e\u51a0\u72b6\u52a8\u8109\u9499\u5316\u7684\u8fdb\u5c55[19]<\/sup>\u3002\u5bcc\u542b\u6c34\u679c\u3001\u852c\u83dc\u3001\u9c7c\u6cb9\u7684\u5730\u4e2d\u6d77\u996e\u98df\u4e0d\u4ec5\u6709\u76ca\u4e8e\u9884\u9632\u51a0\u72b6\u52a8\u8109\u9499\u5316\uff0c\u8fd8\u80fd\u964d\u4f4e\u5fc3\u808c\u6897\u6b7b\u3001\u5fc3\u529b\u8870\u7aed\u548c\u5168\u56e0\u6b7b\u4ea1\u7387\u3002\u53cd\u5f0f\u8102\u80aa\u9178\u3001\u7cd6\u548c\u9ad8\u540c\u578b\u534a\u80f1\u6c28\u9178\u80fd\u589e\u5f3a\u6c27\u5316\u5e94\u6fc0\u3001\u4fc3\u8fdb\u8840\u7ba1\u9499\u5316\uff0c\u800c\u8840\u6e05\u540c\u578b\u534a\u80f1\u6c28\u9178\u6d53\u5ea6\u8d85\u8fc712 \u03bcmol\/L\u662f\u9884\u6d4b\u8840\u7ba1\u9499\u5316\u7684\u56e0\u7d20\u3002\u7eff\u8336\u4e2d\u7684\u513f\u8336\u7d20\u5bf9\u8840\u7ba1\u9499\u5316\u4e5f\u6709\u4fdd\u62a4\u4f5c\u7528\u3002<\/p>\n

\u8840\u7ba1\u9499\u5316\u7684\u53d1\u751f\u4e0e\u4e2a\u4f53\u6240\u5904\u7684\u73af\u5883\u4e5f\u6709\u5173\u3002\u6c7d\u8f66\u5c3e\u6c14\u548c\u73af\u5883\u6c61\u67d3\u4f7f\u4eba\u4eec\u5bf9PM2.5<\/sub>\u7684\u8ba4\u8bc6\u9010\u6e10\u52a0\u6df1\uff0c\u8fd1\u671f\u7814\u7a76\u53d1\u73b0\u5438\u5165PM2.5<\/sub>\u80fd\u4fc3\u8fdb\u8840\u7ba1\u5185\u76ae\u635f\u4f24\u3001\u4fc3\u8fdb\u51a0\u72b6\u52a8\u8109\u9499\u5316\u8fdb\u5c55[20]<\/sup>\u3002\u5b9e\u9a8c\u7814\u7a76\u4e2d\uff0c\u7837\u66b4\u9732\u80fd\u4fc3\u8fdb\u5927\u9f20\u4e3b\u52a8\u8109\u9499\u5316\uff0c\u4e0e\u4fc3\u8fdb\u78f7\u9178\u76d0\u4ecb\u5bfc\u7684\u9499\u6c89\u79ef\u6709\u5173\u3002<\/p>\n

5.5\u3000\u611f\u67d3<\/p>\n

\u4eba\u4eec\u5728\u80ba\u708e\u8863\u539f\u4f53\u611f\u67d3\u7684\u5e73\u6ed1\u808c\u7ec6\u80de\u53d1\u73b0\u4e86\u9499\u5316\uff0c\u901a\u8fc7\u6ce8\u5c04\u817a\u75c5\u6bd2\u76f8\u5173\u7684\u8f7d\u4f53\u80fd\u8bf1\u5bfc\u5c0f\u9f20\u4e3b\u52a8\u8109\u9499\u5316\u3002Longenecker\u7b49[21]<\/sup>\u7814\u7a76\u53d1\u73b0\uff0c\u611f\u67d3\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\u7684\u60a3\u8005\u5b58\u5728\u8840\u7ba1\u9499\u5316\u7684\u51e0\u7387\u66f4\u9ad8\uff0c\u56e0\u6b64\u63a8\u6d4b\u8fd9\u4e0eCD14\u3001\u9ad8\u654fC\u53cd\u5e94\u86cb\u767d\u3001\u7ea4\u7ef4\u86cb\u767d\u539f\u53ca\u9499\u5316\u5bc6\u5207\u76f8\u5173\u3002\u7136\u800c\uff0c\u9499\u5316\u5230\u5e95\u662f\u6613\u4e8e\u4f7f\u708e\u75c7\u52a0\u91cd\u7684\u539f\u56e0\uff0c\u8fd8\u662f\u4fc3\u4f7f\u611f\u67d3\u5c40\u9650\u7684\u81ea\u6211\u9632\u5fa1\u53cd\u5e94\u5c1a\u5b58\u4e89\u8bae\u3002<\/p>\n

5.6\u3000\u836f\u7269<\/p>\n

\u836f\u7269\u4e5f\u662f\u5f71\u54cd\u8840\u7ba1\u9499\u5316\u7684\u4e00\u4e2a\u56e0\u7d20\u3002\u4ee5\u7ef4\u751f\u7d20K\u62ee\u6297\u5242\u534e\u6cd5\u6797\u53ca\u4ed6\u6c40\u7c7b\u836f\u7269\u4e3a\u4ee3\u8868\uff0c\u534e\u6cd5\u6797\u662f\u5fc3\u8840\u7ba1\u75c5\u60a3\u8005\u5e38\u7528\u7684\u6297\u51dd\u836f\uff0c\u7136\u800c\u6709\u7814\u7a76\u8868\u660e\u5176\u80fd\u4fc3\u8fdb\u52a8\u8109\u9499\u5316\uff0c\u53ef\u80fd\u4e0e\u534e\u6cd5\u6797\u95f4\u63a5\u4fc3\u8fdb\u6c27\u5316\u5e94\u6fc0\u6709\u5173[22,23]<\/sup>\u3002\u8d8a\u6765\u8d8a\u591a\u7814\u7a76\u8868\u660e\uff0c\u8fd0\u7528\u4ed6\u6c40\u6cbb\u7597\u7684\u60a3\u8005\u53ef\u51fa\u73b0\u51a0\u72b6\u52a8\u8109\u9499\u5316\uff0c\u4e14\u5242\u91cf\u8d8a\u5927\u9499\u5316\u8d8a\u4e25\u91cd\uff0c\u4f46\u4ed6\u6c40\u5bfc\u81f4\u8840\u7ba1\u9499\u5316\u7684\u673a\u5236\u5c1a\u4e0d\u660e\u786e[24]<\/sup>\u3002<\/p>\n

5.7\u3000\u5e74\u9f84\u548c\u6027\u522b<\/p>\n

\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u51a0\u72b6\u52a8\u8109\u9499\u5316\u660e\u663e\u589e\u52a0\uff0c\u5176\u5728\u6027\u522b\u65b9\u9762\u4e5f\u5b58\u5728\u660e\u663e\u5dee\u5f02\u3002\u53e6\u5916\uff0c\u5e74\u8f7b\u7537\u6027\u548c\u5973\u6027\u7684\u7f6a\u72af\u8840\u7ba1\u5f62\u6001\u76f8\u4f3c\uff0c\u800c\u5728\u7537\u6027\u75c5\u53d8\u8840\u7ba1\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u66f4\u5bb9\u6613\u7834\u88c2\uff0c\u4f46\u6591\u5757\u6210\u5206\u5728\u5973\u6027\u4e2d\u4fdd\u6301\u4e0d\u53d8[25]<\/sup>\u3002Coutinho\u7b49[26]<\/sup>\u7814\u7a76\u53d1\u73b0\uff0c\u8f83\u4f4e\u7684\u52a8\u8109\u987a\u5e94\u6027\u4e0e\u5973\u6027\u51a0\u72b6\u52a8\u8109\u6591\u5757\u548c\u9499\u5316\u7684\u8d1f\u62c5\u6709\u8f83\u5927\u76f8\u5173\u6027\uff0c\u4f46\u7537\u6027\u5219\u4e0d\u7136\u3002<\/p>\n

6\u3000\u51a0\u72b6\u52a8\u8109\u9499\u5316\u7684\u9006\u8f6c\u53ca\u5e72\u9884<\/p>\n

\u8840\u7ba1\u9499\u5316\u66fe\u88ab\u8ba4\u4e3a\u662f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u4e9a\u4e34\u5e8a\u8868\u73b0\u5f62\u5f0f\uff0c\u4eba\u4eec\u66fe\u4e00\u5ea6\u5bf9\u4ed6\u6c40\u7c7b\u836f\u7269\u9006\u8f6c\u8840\u7ba1\u9499\u5316\u5bc4\u4e88\u5e0c\u671b\u3002Okuyama\u7b49[27]<\/sup>\u63a8\u6d4b\uff0c\u8fd9\u53ef\u80fd\u4e0e\u4ed6\u6c40\u51cf\u5c11\u8f85\u9176Q10\u548c\u8840\u7ea2\u7d20A\uff0c\u4ece\u800c\u5f71\u54cd\u7ebf\u7c92\u4f53\u529f\u80fd\u6709\u5173\u3002<\/p>\n

\u6c27\u5316\u5e94\u6fc0\u662f\u51a0\u72b6\u52a8\u8109\u9499\u5316\u5f62\u6210\u7684\u91cd\u8981\u56e0\u7d20\u4e4b\u4e00\uff0c\u56e0\u7ef4\u751f\u7d20K\u80fd\u589e\u5f3a\u5185\u6e90\u6027\u6297\u6c27\u5316\u9176\u6d3b\u6027\uff0c\u6545\u5176\u5728\u51a0\u72b6\u52a8\u8109\u9499\u5316\u6d88\u9000\u4e2d\u7684\u4f5c\u7528\u5f15\u8d77\u4e86\u4eba\u4eec\u7684\u5173\u6ce8\u3002\u5df2\u6709\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0c\u8865\u5145\u7ef4\u751f\u7d20K2\u80fd\u51cf\u8f7b\u8001\u5e74\u4eba\u51a0\u72b6\u52a8\u8109\u9499\u5316\u8fdb\u5c55\u548c\u9888\u52a8\u8109\u5185\u819c\u53ca\u4e2d\u819c\u539a\u5ea6\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u60a3\u6709\u5fc3\u8840\u7ba1\u75c5\u7684\u60a3\u8005\uff0c\u8865\u5145\u7ef4\u751f\u7d20K\u53ef\u80fd\u4f1a\u5e72\u6270\u51dd\u8840\u7ea7\u8054\u8fc7\u7a0b\uff0c\u4ece\u800c\u9650\u5236\u4e86\u5b83\u7684\u5e94\u7528\u3002\u76ee\u524d\u8fd8\u672a\u53d1\u73b0\u6cbb\u7597\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u836f\u7269\u80fd\u540c\u65f6\u5ef6\u7f13\u8840\u7ba1\u9499\u5316\u8fdb\u5c55\u3002\u90b5\u5a1f\u7b49[28]<\/sup>\u7528\u8840\u7ba1\u7d27\u5f20\u7d20\u2161\u53d7\u4f531\u963b\u65ad\u5242\u6c2f\u6c99\u5766\u6cbb\u7597\u5927\u9f20\u4e3b\u52a8\u8109\u9499\u5316\uff0c\u53d1\u73b0\u6cbb\u7597\u540e\u5927\u9f20\u4e3b\u52a8\u8109\u4e2d\u9aa8\u5f62\u6210\u86cb\u767d2(bone morphogenetic protein 2\uff0cBMP2)\u548cRunt\u76f8\u5173\u8f6c\u5f55\u56e0\u5b502(Runt-related transcription factor 2\uff0cRUNX2)\u7684mRNA\u548c\u86cb\u767d\u8868\u8fbe\u663e\u8457\u4e0b\u964d\uff0c\u56e0\u6b64\u63a8\u6d4b\u6c2f\u6c99\u5766\u53ef\u964d\u4f4e\u52a8\u8109\u9499\u5316\u5f62\u6210\u3002Sun\u7b49[29]<\/sup>\u7814\u7a76\u53d1\u73b0\uff0c\u5fae\u5c0fRNA-302b\u53ef\u8c03\u8282BMP-2\/RUNX2\/Osterix\u901a\u8def\uff0c\u6539\u5584\u9499\u78f7\u4ee3\u8c22\u800c\u6291\u5236\u8840\u7ba1\u9499\u5316\u3002Luong\u7b49[30]<\/sup>\u7528\u91cd\u7ec4\u4ebaFibulin-3\u86cb\u767d\u5904\u7406\u539f\u4ee3\u4eba\u4e3b\u52a8\u8109\u5e73\u6ed1\u808c\u7ec6\u80de\u540e\u53d1\u73b0\uff0c\u78b1\u6027\u78f7\u9178\u9176\u6d3b\u6027\u53ca\u6210\u9aa8\u548c\u8f6f\u9aa8\u5f62\u6210\u6807\u5fd7\u7269MSX2\u3001CBFA1\u3001SOX9\u548cALPL\u7684mRNA\u8868\u8fbe\u5747\u663e\u8457\u964d\u4f4e\uff0c\u6545\u63a8\u6d4b\u53ef\u901a\u8fc7\u8865\u5145Fibulin-3\u86cb\u767d\u9006\u8f6c\u8840\u7ba1\u9499\u5316\u3002<\/p>\n

\u5df2\u6709\u8bc1\u636e\u8868\u660e\uff0c\u6fc0\u7d20\u66ff\u4ee3\u6cbb\u7597\u80fd\u51cf\u5c11\u51a0\u72b6\u52a8\u8109\u9499\u5316\uff0c\u4f46\u5176\u5374\u589e\u52a0\u4e73\u817a\u764c\u3001\u5352\u4e2d\u548c\u80ba\u6897\u6b7b\u7684\u98ce\u9669\uff0c\u5e76\u4e0d\u662f\u4e00\u4e2a\u7406\u60f3\u7684\u6cbb\u7597\u65b9\u5f0f\u3002\u5bf9\u4e8e\u7532\u72b6\u65c1\u817a\u529f\u80fd\u4ea2\u8fdb\u7684\u60a3\u8005\u5207\u9664\u7532\u72b6\u65c1\u817a\u80fd\u4f7f\u8840\u7ba1\u9499\u5316\u6d88\u9000\uff0c\u4e5f\u4e0d\u9002\u7528\u4e8e\u5927\u591a\u6570\u65e0\u7532\u72b6\u65c1\u817a\u529f\u80fd\u4ea2\u8fdb\u7684\u666e\u901a\u60a3\u8005\u3002\u9488\u5bf9\u6162\u6027\u80be\u810f\u75c5\u60a3\u8005\uff0c\u4e00\u9879\u835f\u8403\u7814\u7a76\u53d1\u73b0\u4e86\u4e00\u79cd\u975e\u9499\u6027\u78f7\u9178\u76d0\u7ed3\u5408\u5242\u2014\u2014Sevelamer\uff0c\u80fd\u5728\u964d\u4f4e\u78f7\u9178\u76d0\u7684\u540c\u65f6\u51cf\u8f7b\u900f\u6790\u60a3\u8005\u52a8\u8109\u9499\u5316\uff0c\u53ef\u80fd\u4e0e\u5176\u51cf\u8f7b\u5c3f\u6bd2\u75c7\u7684\u6bd2\u6027\u6709\u5173[31]<\/sup>\u3002\u7136\u800c\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695aSevelamer\u80fd\u5426\u51cf\u8f7b\u975e\u80be\u810f\u75c5\u60a3\u8005\u7684\u8840\u7ba1\u9499\u5316\u3002\u6cbb\u7597\u9aa8\u8d28\u758f\u677e\u7684\u4e8c\u78f7\u9178\u76d0\u80fd\u6291\u5236\u52a8\u7269\u52a8\u8109\u9499\u5316\uff0c\u4f46\u5728\u4eba\u4f53\u4e0a\u7684\u4f5c\u7528\u5c1a\u672a\u8bc1\u5b9e\u3002<\/p>\n

\u51a0\u72b6\u52a8\u8109\u5185\u65cb\u78e8\u4f5c\u4e3a\u4e00\u79cd\u7269\u7406\u6cbb\u7597\u65b9\u5f0f\uff0c\u56e0\u80fd\u901a\u8fc7\u5bf9\u9499\u5316\u75c5\u53d8\u5851\u5f62\u3001\u6539\u5584\u652f\u67b6\u901a\u8fc7\u6027\u548c\u8d34\u58c1\u6027\uff0c\u63d0\u9ad8\u7ecf\u76ae\u51a0\u72b6\u52a8\u8109\u4ecb\u5165\u6cbb\u7597\u7684\u6210\u529f\u7387\u800c\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e34\u5e8a\u3002\u7136\u800c\uff0c\u76ee\u524d\u5c1a\u672a\u53d1\u73b0\u80fd\u6709\u6548\u6d88\u9000\u6216\u9006\u8f6c\u52a8\u8109\u9499\u5316\u7684\u836f\u7269\u3002\u800c\u5bf9\u4e8e\u52a8\u8109\u9499\u5316\u5728\u8840\u7ba1\u75be\u75c5\u53d1\u751f\u4e2d\u7a76\u7adf\u662f\u81f4\u75c5\u6027\u7684\uff1f\u8fd8\u662f\u4fdd\u62a4\u6591\u5757\u7a33\u5b9a\u6027\u7684\uff1f\u76ee\u524d\u5c1a\u65e0\u4e00\u81f4\u770b\u6cd5\uff0c\u56e0\u6b64\u51a0\u72b6\u52a8\u8109\u9499\u5316\u662f\u5426\u90fd\u9700\u8981\u5e72\u9884\u4e5f\u6301\u4e0d\u540c\u89c2\u70b9\u3002<\/p>\n

\u7efc\u4e0a\uff0c\u4f5c\u4e3a\u7cfb\u7edf\u6027\u75be\u75c5\u5728\u52a8\u8109\u8840\u7ba1\u90e8\u4f4d\u7684\u4e00\u79cd\u4e34\u5e8a\u8868\u73b0\uff0c\u51a0\u72b6\u52a8\u8109\u9499\u5316\u53d7\u4ee3\u8c22\u3001\u996e\u98df\u3001\u9057\u4f20\u751a\u81f3\u73af\u5883\u6c61\u67d3\u7b49\u591a\u79cd\u56e0\u7d20\u5f71\u54cd\u3002\u7136\u800c\uff0c\u76ee\u524d\u5bf9\u51a0\u72b6\u52a8\u8109\u9499\u5316\u7684\u4e34\u5e8a\u610f\u4e49\u548c\u53d1\u75c5\u673a\u5236\u8ba4\u8bc6\u5c1a\u4e0d\u591f\u6df1\u5165\uff0c\u5176\u53ef\u53d1\u751f\u5728\u51a0\u72b6\u52a8\u8109\u72ed\u7a84\u57fa\u7840\u4e0a\uff0c\u4f46\u4e0e\u51a0\u72b6\u52a8\u8109\u72ed\u7a84\u5e76\u65e0\u660e\u786e\u7684\u56e0\u679c\u5173\u7cfb\uff1b\u540c\u65f6\uff0c\u5728\u6591\u5757\u7a33\u5b9a\u6027\u548c\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u53d1\u751f\u65b9\u9762\uff0c\u51a0\u72b6\u52a8\u8109\u9499\u5316\u7a76\u7adf\u662f\u81ea\u6211\u4fdd\u62a4\u6027\u9632\u5fa1\u8fd8\u662f\u52a0\u91cd\u6216\u89e6\u53d1\u6027\u56e0\u7d20\uff0c\u76ee\u524d\u5c1a\u5b58\u4e89\u8bae\u3002\u9664\u4e86\u75c5\u56e0\u660e\u786e\u5982\u7532\u72b6\u65c1\u817a\u529f\u80fd\u4ea2\u8fdb\u7b49\u60c5\u51b5\u5916\uff0c\u4e34\u5e8a\u4e0a\u5e76\u65e0\u9006\u8f6c\u8840\u7ba1\u9499\u5316\u7684\u6709\u6548\u836f\u7406\u6cbb\u7597\u65b9\u6cd5\uff0c\u800c\u672a\u6765\u5982\u4f55\u5408\u7406\u5730\u5e72\u9884\u51a0\u72b6\u52a8\u8109\u9499\u5316\u5c1a\u6709\u5f85\u5bf9\u9499\u5316\u5f62\u6210\u548c\u53d1\u75c5\u673a\u5236\u7684\u6df1\u5165\u7814\u7a76\u3002<\/p>\n

\u5229\u76ca\u51b2\u7a81<\/p>\n

\u5229\u76ca\u51b2\u7a81\uff1a<\/b>\u65e0<\/p>\n

\u53c2\u3000\u8003\u3000\u6587\u3000\u732e[1]WongND, KouwabunpatD, VoAN, et al. Coronary calcium and atherosclerosis by ultrafast computed tomography in asymptomatic men and women: relation to age and risk factors [J]. Am Heart J, 1994, 127(2): 422-430.[2]NicollR, HeneinM. Arterial calcification: A new perspective\uff1f[J]. Int J Cardiol, 2017, 228: 11-22. DOI\uff1a10.1016\/j.ijcard.2016.11.099.[3]De BackerG, AmbrosioniE, Borch-JohnsenK, et al. European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force of European and Other Societies on Cardiovascular Disease Prevention in Clinical Practice [J]. Eur Heart J, 2003, 24(17): 1601-1610.[4]GarciaMJ, LessickJ, HoffmannMH, et al. Accuracy of 16-row multidetector computed tomography for the assessment of coronary artery stenosis [J]. JAMA, 2006, 296(4): 403-411. DOI\uff1a10.1001\/jama.296.4.403.[5]BudoffMJ, GulKM. Expert review on coronary calcium[J]. Vasc Health Risk Manag, 2008, 4(2): 315-324.[6]NicollR, HeneinMY. Arterial calcification: friend or foe\uff1f[J]. Int J Cardiol, 2013, 167(2): 322-327. DOI\uff1a10.1016\/j.ijcard.2012.06.110.[7]NicollR, WiklundU, ZhaoY, et al. The coronary calcium score is a more accurate predictor of significant coronary stenosis than conventional risk factors in symptomatic patients: Euro-CCAD study[J]. Int J Cardiol, 2016, 207: 13-19. DOI\uff1a10.1016\/j.ijcard.2016.01.056.[8]YoonWJ, CrisostomoP, HalandrasP, et al. The Use of the Agatston Calcium Score in Predicting Carotid Plaque Vulnerability [J]. Ann Vasc Surg, 2019, 54: 22-26. DOI\uff1a10.1016\/j.avsg.2018.08.070.[9]YamamotoH, KitagawaT, KunitaE, et al. Impact of the Coronary Artery Calcium Score on Mid- to Long-Term Cardiovascular Mortality and Morbidity Measured With Coronary Computed Tomography Angiography[J]. Circ J, 2018, 82(9): 2342-2349. DOI\uff1a10.1253\/circj.CJ-18-0086.[10]TesauroM, MaurielloA, RovellaV, et al. Arterial ageing: from endothelial dysfunction to vascular calcification[J]. J Intern Med, 2017, 281(5): 471-482. DOI\uff1a10.1111\/joim.12605.[11]IyemereVP, ProudfootD, WeissbergPL, et al. Vascular smooth muscle cell phenotypic plasticity and the regulation of vascular calcification[J]. J Intern Med, 2006, 260(3): 192-210. DOI\uff1a10.1111\/j.1365-2796.2006.01692.x.[12]ChellanB, RojasE, ZhangC, et al. Enzyme-modifed non-oxidized LDL (ELDL) induces human coronary artery smooth muscle cell transformation to a migratory and osteoblast-like phenotype [J]. Sci Rep, 2018, 8(1): 11954. DOI\uff1a10.1038\/s41598-018-30073-w.[13]HuangH, VirmaniR, YounisH, et al. The impact of calcification on the biomechanical stability of atherosclerotic plaques [J]. Circulation, 2001, 103(8): 1051-1056.[14]KutikhinAG, SinitskyMY, YuzhalinAE, et al. Shear stress: An essential driver of endothelial progenitor cells [J]. J Mol Cell Cardiol, 2018, 118: 46-69. DOI\uff1a10.1016\/j.yjmcc.2018.03.007.[15]YamagishiS. Role of advanced glycation end products (AGEs) in osteoporosis in diabetes[J]. Curr Drug Targets, 2011, 12(14): 2096-2102.[16]FarrarEJ, HuntleyGD, ButcherJ. Endothelial-derived oxidative stress drives myofibroblastic activation and calcification of the aortic valve [J]. PLoS One, 2015, 10(4): e0123257. DOI\uff1a10.1371\/journal.pone.0123257.[17]NitschkeY, RutschF. Genetics in arterial calcification: lessons learned from rare diseases[J]. Trends Cardiovasc Med, 2012, 22(6): 145-149. DOI\uff1a10.1016\/j.tcm.2012.07.011.[18]DiversJ, PalmerND, LangefeldCD, et al. Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes [J]. BMC Genet, 2017, 18(1): 105. DOI\uff1a10.1186\/s12863-017-0572-9.[19]MiedemaMD, PetroneA, ShikanyJM, et al. Association of Fruit and Vegetable Consumption During Early Adulthood With the Prevalence of Coronary Artery Calcium After 20 Years of Follow-Up: The Coronary Artery Risk Development in Young Adults (CARDIA) Study [J]. Circulation, 2015, 132(21): 1990-1998. DOI\uff1a10.1161\/CIRCULATIONAHA.114.012562.[20]KaufmanJD, AdarSD, BarrRG, et al. Association between air pollution and coronary artery calcification within six metropolitan areas in the USA (the Multi-Ethnic Study of Atherosclerosis and Air Pollution): a longitudinal cohort study [J]. Lancet, 2016, 388(10045): 696-704. DOI\uff1a10.1016\/S0140-6736(16)00378-0.[21]LongeneckerCT, JiangY, OrringerCE, et al. Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection [J]. AIDS, 2014, 28(7): 969-977. DOI\uff1a10.1097\/QAD.0000000000000158.[22]PoteruchaTJ, GoldhaberSZ. Warfarin and Vascular Calcification [J]. Am J Med, 2016, 129(6): 635.e1-4. DOI\uff1a10.1016\/j.amjmed.2015.11.032.[23]AndrewsJ, PsaltisPJ, BayturanO, et al. Warfarin Use Is Associated With Progressive Coronary Arterial Calcification: Insights From Serial Intravascular Ultrasound[J]. JACC Cardiovasc Imaging, 2018, 11(9): 1315-1323. DOI\uff1a10.1016\/j.jcmg.2017.04.010.[24]AndrewsJ, PsaltisPJ, BartoloBAD, et al. Coronary Arterial Calcification: A Review of mechanisms, promoters and imaging [J]. Trends Cardiovasc Med, 2018, 28(8): 491-501. DOI\uff1a10.1016\/j.tcm.2018.04.007.[25]SchoenenbergerAW, UrbanekN, ToggweilerS, et al. Ultrasound-assessed non-culprit and culprit coronary vessels differ by age and gender [J]\uff0eWorld J Cardiol, 2013, 5(3): 42-48. DOI\uff1a10.4330\/wjc.v5.i3.42.[26]CoutinhoT, YamY, ChowBJW, et al. Sex Differences in Associations of Arterial Compliance With Coronary Artery Plaque and Calcification Burden [J]. J Am Heart Assoc, 2017, 6(8). pii: e006079. DOI\uff1a10.1161\/JAHA.117.006079.[27]OkuyamaH, LangsjoenPH, HamazakiT, et al. Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms [J]. Expert Rev Clin Pharmacol, 2015, 8(2): 189-199. DOI\uff1a10.1586\/17512433.2015.1011125.[28]\u90b5\u5a1f\uff0c\u5434\u6500\u5cf0\uff0c\u5434\u57fa\u826f\uff0c\u7b49. \u6c2f\u6c99\u5766\u6291\u5236\u5927\u9f20\u4e3b\u52a8\u8109\u8840\u7ba1\u9499\u5316\u7684\u673a\u5236[J]. \u7ec6\u80de\u4e0e\u5206\u5b50\u514d\u75ab\u5b66\u6742\u5fd7\uff0c2016, 32(8): 1060-1064.ShaoJ, WuPF, WuJL, et al. Mechanism of losartan suppressing vascular calcification in rat aortic artery[J]. Chinese Journal of Cellular and Molecular Immunology, 2016, 32(8): 1060-1064.[29]SunWL, WangN, XuY. Impact of miR-302b on Calcium-phosphorus Metabolism and Vascular Calcification of Rats with Chronic Renal Failure by Regulating BMP-2\/Runx2\/Osterix Signaling Pathway [J]. Arch Med Res, 2018, 49(3): 164-171. DOI\uff1a10.1016\/j.arcmed.2018.08.002.[30]LuongTTD, SchelskiN, BoehmeB, et al. Fibulin-3 Attenuates Phosphate-Induced Vascular Smooth Muscle Cell Calcification by Inhibition of Oxidative Stress [J]. Cell Physiol Biochem, 2018, 46(4): 1305-1316. DOI\uff1a10.1159\/000489144.[31]WangC, LiuX, ZhouY, et al. New Conclusions Regarding Comparison of Sevelamer and Calcium-Based Phosphate Binders in Coronary-Artery Calcification for Dialysis Patients: A Meta-Analysis of Randomized Controlled Trials[J]. PLoS One, 2015, 10(7): e0133938. DOI\uff1a10.1371\/journal.pone.0133938.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u51a0\u72b6\u52a8\u8109\u9499\u5316\u662f\u9499\u76d0\u5f02\u5e38\u6c89\u79ef\u4e8e\u51a0\u72b6\u52a8\u8109\u8840\u7ba1\u58c1\u7684\u4e34\u5e8a\u73b0\u8c61\uff0c\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u8840\u7ba1\u9499\u5316\u53d1\u751f … \u7ee7\u7eed\u9605\u8bfb →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-28984","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/28984","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=28984"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/28984\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=28984"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=28984"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=28984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}