{"id":28785,"date":"2024-04-03T12:00:45","date_gmt":"2024-04-03T12:00:45","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=28785"},"modified":"2024-04-03T12:00:45","modified_gmt":"2024-04-03T12:00:45","slug":"snp%e4%bb%8e%e6%97%a0%e5%88%b0%e6%9c%89%ef%bc%9f","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=28785","title":{"rendered":"SNP\u4ece\u65e0\u5230\u6709\uff1f"},"content":{"rendered":"

\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08Genome Wide Association Studies\uff0cGWAS\uff09\u662f\u4e00\u79cd\u68c0\u6d4b\u7279\u5b9a\u7269\u79cd\u4e2d\u4e0d\u540c\u4e2a\u4f53\u95f4\u7684\u5168\u90e8\u6216\u5927\u90e8\u5206\u57fa\u56e0\uff0c\u4ece\u800c\u4e86\u89e3\u4e0d\u540c\u4e2a\u4f53\u95f4\u7684\u57fa\u56e0\u53d8\u5316\u6709\u591a\u5927\u7684\u4e00\u79cd\u65b9\u6cd5\u3002\u901a\u8fc7GWAS\u5206\u6790\u53ef\u4ee5\u627e\u51fa\u4e0e\u75be\u75c5\u76f8\u5173\u8054\u7684SNP\u4f4d\u70b9\uff0c\u7136\u800c\u6211\u4eec\u7684\u6839\u672c\u76ee\u7684\u662f\u627e\u51fa\u53ef\u80fd\u5bfc\u81f4\u75be\u75c5\u53d1\u751f\u7684SNP\u4f4d\u70b9\uff0c\u8fd9\u4e9b\u4f4d\u70b9\u4f4d\u4e8eGWAS\u5206\u6790\u7ed3\u679c\u4e2d\uff0c\u5b8c\u6210\u4e86GWAS\u5206\u6790\u4e4b\u540e\uff0c\u6211\u4eec\u8fd8\u9700\u8981\u501f\u52a9\u4e0b\u6e38\u5206\u6790\u5bf9GWAS\u7684\u5206\u6790\u7ed3\u679c\u8fdb\u4e00\u6b65\u6ce8\u91ca\u548c\u6316\u6398\uff0c\u7b5b\u9009\u53ef\u80fd\u81f4\u75c5\u7684SNP\u4f4d\u70b9\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5982\u679c\u60f3\u8981\u4e86\u89e3\u4e0e\u67d0\u4e2a\u75be\u75c5\u76f8\u5173\u7684SNP\u4f4d\u70b9\uff0c\u9664\u4e86\u4e00\u7bc7\u7bc7\u67e5\u9605\u6587\u732e\uff0c\u8fd8\u6709\u4ec0\u4e48\u66f4\u5feb\u7684\u65b9\u6cd5\u5462?\u6b64\u5916\uff0c\u4e5f\u53ef\u5bf9\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u7b5b\u9009\u5230\u7684\u5de5\u5177\u53d8\u91cf\u7684SNP\u8fdb\u884c\u529f\u80fd\u6ce8\u91ca\uff0c\u67e5\u627e\u5176\u4e0e\u57fa\u56e0\u7684\u5173\u7cfb\uff0c\u4ece\u800c\u83b7\u53d6\u66f4\u591a\u75be\u75c5\u7684\u6f5c\u5728\u751f\u7269\u5b66\u4f5c\u7528\u673a\u5236\u7b49\u65b9\u9762\u7684\u4fe1\u606f\u3002<\/p>\n

\u5982\u8fd9\u7bc7\u6587\u7ae0\u8ba8\u8bba\u90e8\u5206\u5373\u63d0\u5230\u4e86SNP\u6ce8\u91ca\u5230\u57fa\u56e0\uff0c\u53ca\u57fa\u56e0\u5728\u75be\u75c5\u53d1\u751f\u4e2d\u7684\u6f5c\u5728\u751f\u7269\u5b66\u673a\u5236\uff1aWe found 3 EIF-4E proxy SNPs namely, rs11084300, rs3848582, rs62143198, and 4 EIF-4A predicting SNPs, namely, rs3859507, rs11084300, rs34436714, rs146117463, that are associated with the NLRP12 gene. \u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u662f\u5bf9\u5df2\u6709SNP\u8fdb\u884c\u7684\u63a2\u8ba8 \uff0c\u800c\u5bf9\u4e8e\u6ca1\u6709\u81ea\u5df1\u610f\u5411\u66b4\u9732\/\u7ed3\u5c40\u7684\u6570\u636e\uff0c\u8fd8\u9700\u8981\u4e0d\u65ad\u6316\u6398SNP\uff0c\u5b8c\u6210SNP\u4ece\u65e0\u5230\u6709\u7684\u8fc7\u7a0b\uff01\uff01\u63a5\u4e0b\u6765\u533b\u8c4c\u8c46\u5c0f\u7f16\u4e3a\u5927\u5bb6\u5e26\u6765\u51e0\u4e2aSNP\u6570\u636e\u5e93\u7684\u5206\u6790\u8bb2\u89e3\uff01<\/p>\n

\n

 SNP –> \u57fa\u56e0\uff1b\u75be\u75c5\u8bf4\u767d\u4e86\u5c31\u662fGWAS\u5206\u6790\u4e4b\u540e\u5bf9SNP\u7684\u529f\u80fd\u6ce8\u91ca<\/p>\n

  • GWAS4D<\/li>\n

    \u7b80\u4ecb\uff1aGWAS4D\u662f\u901a\u8fc7\u7ec4\u7ec7\/\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u548c\u975e\u7f16\u7801\u8c03\u63a7\u53d8\u5f02\u7684\u4f18\u5148\u6392\u5e8f\uff0c\u6765\u9884\u6d4b\u7279\u5b9a\u590d\u6742\u75be\u75c5\u548c\u6027\u72b6\u7684\u6f5c\u5728\u81f4\u75c5\u673a\u5236\u3002\u7f51\u5740\uff1ahttp:\/\/mulinlab.\/gwas4d\u64cd\u4f5c\uff1a\u6211\u4eec\u5c06GWAS summary\u6570\u636e\u5bfc\u5165\uff0c\u4fbf\u53ef\u4ee5\u8f93\u51faSNP\u4f4d\u70b9\u7684\u4f18\u5148\u6392\u5e8f\u3001SNP\u4f4d\u70b9\u5728\u57fa\u56e0\u7ec4\u533a\u57df\u7684\u53ef\u89c6\u5316\u4ee5\u53caSNP\u529f\u80fd\u9884\u6d4b\u548c\u6ce8\u91ca\u7b49\u7ed3\u679c\uff08\u5982\u4e0b\u56fe\uff09\u3002<\/p>\n

    2.FUMA<\/p>\n

    \u7b80\u4ecb\uff1a\u6574\u5408\u578b\u7684\u5728\u7ebf\u7f51\u7ad9, \u5bf9\u5e94\u7684\u6587\u7ae0\u53d1\u8868\u5728nature communications\u4e0a\uff0c\u94fe\u63a5\u3010https:\/\/www.\/articles\/s41467-017-01261-5\u3011<\/p>\n

    \u7f51\u5740\uff1ahttps:\/\/fuma.\/<\/p>\n

    \u64cd\u4f5c\uff1a\u901a\u8fc7\u8be5\u7f51\u7ad9\uff0c\u53ef\u4ee5\u5bf9GWAS\u5206\u6790\u7ed3\u679c\u4e2d\u7684SNP\u4f4d\u70b9\u8fdb\u884c\u529f\u80fd\u6ce8\u91ca\uff0c\u57fa\u56e0\u4f18\u5148\u7ea7\u6392\u5e8f\uff0c\u5e76\u63d0\u4f9b\u4e86\u7ed3\u679c\u7684\u4ea4\u4e92\u5f0f\u5c55\u793a\uff0c\u5171\u5305\u542b\u4ee5\u4e0b\u4e24\u4e2a\u6a21\u5757<\/p>\n

    \u2460SNP2GENE, \u8be5\u6a21\u5757\u8f93\u5165GWAS\u5206\u6790\u7684\u7ed3\u679c\uff0c\u5bf9\u5176\u4e2d\u7684\u663e\u8457SNP\u4f4d\u70b9\u8fdb\u884c\u529f\u80fd\u6ce8\u91ca<\/p>\n

    \u2461GENE2FUNC, \u8be5\u6a21\u5757\u8f93\u5165\u4e3a\u57fa\u56e0\u5217\u8868\uff0c\u5bf9\u57fa\u56e0\u7684\u529f\u80fd\u8fdb\u884c\u6ce8\u91ca<\/p>\n

    \u6570\u636e\u5206\u6790\u7684pipeline\u793a\u610f\u5982\u4e0b<\/p>\n<\/p>\n

    \n

    \u57fa\u56e0\uff1b\u75be\u75c5 –> SNP1.SNPedia\u7b80\u4ecb\uff1aSNPedia\u662f\u4e00\u4e2aSNP\u767e\u79d1\u5168\u4e66\u7c7b\u7f51\u7ad9\uff0c\u5b83\u5f15\u7528\u5df2\u7ecf\u53d1\u5e03\u7684\u6587\u7ae0\u6216\u8005\u6570\u636e\u5e93\u4fe1\u606f\uff0c\u5bf9SNP\u4f4d\u70b9\u8fdb\u884c\u63cf\u8ff0\uff0c\u5171\u4eab\u7740\u4eba\u7c7b\u57fa\u56e0\u7ec4\u53d8\u5f02\u7684\u4fe1\u606f\u3002\u7f51\u5740\uff1ahttps:\/\/www.\/index.php\/SNPedia\u64cd\u4f5c\uff1a\u6211\u4eec\u53ef\u4ee5\u641c\u7d22\u67d0\u4e2aSNP\u4f4d\u70b9\u6765\u5bfb\u627e\u4e0e\u4e4b\u76f8\u5173\u7684\u4fe1\u606f\uff0c\u4e5f\u53ef\u4ee5\u6839\u636e\u76f8\u5173\u75be\u75c5\u548c\u75c7\u72b6\u6765\u5bfb\u627e\u76f8\u5173\u7684SNP<\/p>\n

    2.SNP4Disease\u7b80\u4ecb\uff1aa knowledge database to detect disease associated SNPs\u3010SNP\u4e0e\u75be\u75c5\u76f8\u5173\u6570\u636e\u5e93\u3011\u7f51\u5740\uff1ahttp:\/\/snp4disease.mpi-bn.\/\u64cd\u4f5c\uff1a\u53ef\u4ee5\u76f4\u63a5\u6839\u636e\u75be\u75c5\/\u57fa\u56e0\u8fdb\u884c\u67e5\u8be2\uff0c\u6bd4\u5982\u6211\u4eec\u9700\u8981\u67e5\u8be2\u7cd6\u5c3f\u75c5\u76f8\u5173\u7684SNP\u4f4d\u70b9\uff0c\u5c31\u53ef\u4ee5\u5728Disease\u641c\u7d22\u6846\u4e2d\u8f93\u5165Diabetes\uff0c\u5373\u81ea\u52a8\u8054\u60f3\u3002<\/p>\n

    \n

    \u8fd4\u4fee\u6307\u5bfc<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08Genome Wide Association Studies … \u7ee7\u7eed\u9605\u8bfb →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-28785","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/28785","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=28785"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/28785\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=28785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=28785"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=28785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}