{"id":28761,"date":"2024-04-03T08:02:33","date_gmt":"2024-04-03T08:02:33","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=28761"},"modified":"2024-04-03T08:02:33","modified_gmt":"2024-04-03T08:02:33","slug":"%e6%9c%80%e6%96%b0%e7%99%ab%e7%97%ab%e8%af%8a%e7%96%97%e6%8c%87%e5%8d%97%e5%8f%91%e5%b8%83%ef%bc%81%e5%90%a1%e4%bb%91%e5%b8%95%e5%a5%88%e8%a2%ab%e6%8e%a8%e8%8d%90%e4%b8%ba%e4%b8%80%e7%ba%bf%e6%b2%bb","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=28761","title":{"rendered":"\u6700\u65b0\u766b\u75eb\u8bca\u7597\u6307\u5357\u53d1\u5e03\uff01\u5421\u4ed1\u5e15\u5948\u88ab\u63a8\u8350\u4e3a\u4e00\u7ebf\u6cbb\u7597\u7528\u836f"},"content":{"rendered":"

*\u4ec5\u4f9b\u533b\u5b66\u4e13\u4e1a\u4eba\u58eb\u9605\u8bfb\u53c2\u8003<\/p>\n<\/p>\n

\u5421\u4ed1\u5e15\u5948\u88ab\u6211\u56fd\u6700\u65b0\u766b\u75eb\u6307\u5357\u63a8\u8350\u4e3a\u5c40\u7076\u6027\u53d1\u4f5c\u60a3\u8005\u7684\u4e00\u7ebf\u7528\u836f\uff01<\/p>\n

\u4eca\u5e743\u6708\u4efd\uff0c\u6211\u56fd\u300a\u4e34\u5e8a\u8bca\u7597\u6307\u5357\u00b7\u766b\u75eb\u75c5\u5206\u518c\uff082023 \u4fee\u8ba2\u7248\uff09\u300b\u6b63\u5f0f\u53d1\u5e03[1]<\/sup>\uff0c\u5176\u4e2d\u66f4\u65b0\u4e86\u7528\u836f\u63a8\u8350\uff1a\u5421\u4ed1\u5e15\u5948\u53ef\u4f5c\u4e3a\u4e00\u7ebf\u7528\u836f\u7528\u4e8e\u65b0\u8bca\u65ad\u5c40\u7076\u6027\u53d1\u4f5c\u7684\u60a3\u8005\uff1b\u6b64\u5916\u8fd8\u88ab\u63a8\u8350\u7528\u4e8e\u5176\u4ed6\u591a\u79cd\u53d1\u4f5c\u7c7b\u578b\u6216\u766b\u75eb\u7efc\u5408\u5f81\u3002<\/p>\n

\u88681 \u300a\u4e34\u5e8a\u8bca\u7597\u6307\u5357\u00b7\u766b\u75eb\u75c5\u5206\u518c\uff082023 \u4fee\u8ba2\u7248\uff09\u300b\u5bf9\u5421\u4ed1\u5e15\u5948\u7684\u63a8\u8350<\/p>\n

\u766b\u75eb\uff08epilepsy\uff09\u662f\u4e34\u5e8a\u5e38\u89c1\u7684\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u636e\u4f30\u7b97\u76ee\u524d\u6211\u56fd\u7ea6\u6709640\u4e07\u7684\u6d3b\u52a8\u6027\u766b\u75eb\u60a3\u8005[1]<\/sup>\u3002\u957f\u671f\u766b\u75eb\u53d1\u4f5c\u3001\u8f83\u9ad8\u9891\u7387\u7684\u766b\u75eb\u53d1\u4f5c\u6216\u766b\u75eb\u6301\u7eed\u72b6\u6001\u4f1a\u5bf9\u60a3\u8005\u7684\u8ba4\u77e5\u3001\u8bb0\u5fc6\u3001\u751f\u6d3b\u8d28\u91cf\u3001\u793e\u4f1a\u5fc3\u7406\u53ca\u513f\u7ae5\u7684\u751f\u957f\u53d1\u80b2\u7b49\u9020\u6210\u4e25\u91cd\u5f71\u54cd[1]<\/sup>\u3002\u4e3a\u4e86\u786e\u4fdd\u7597\u6548\uff0c\u540c\u65f6\u964d\u4f4e\u6bd2\u526f\u4f5c\u7528\u3001\u63d0\u9ad8\u7528\u836f\u4fbf\u5229\u5ea6\uff0c\u6297\u766b\u75eb\u6cbb\u7597\u5e94\u5c3d\u53ef\u80fd\u9009\u7528\u4e00\u7ebf\u6cbb\u7597\u836f\u7269\u8fdb\u884c\u5355\u836f\u6cbb\u7597\u3002<\/p>\n

\u770b\u5404\u5927\u6307\u5357\u5982\u4f55\u6307\u5bfc\u5421\u4ed1\u5e15\u5948\u7684\u4e34\u5e8a\u5b9e\u8df5\u5e94\u7528<\/p>\n

2021\u5e74\uff0c\u5421\u4ed1\u5e15\u5948\u65b0\u9002\u5e94\u75c7\u62d3\u5c55\uff0c\u83b7\u6279\u7528\u4e8e\u6210\u4eba\u548c4\u5c81\u53ca\u4ee5\u4e0a\u513f\u7ae5\u766b\u75eb\u90e8\u5206\u6027\u53d1\u4f5c\u60a3\u8005\uff08\u4f34\u6709\u6216\u4e0d\u4f34\u6709\u7ee7\u53d1\u5168\u9762\u6027\u53d1\u4f5c\uff09\u7684\u6cbb\u7597\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u5176\u6307\u5357\u63a8\u8350\u7b49\u7ea7\u4e5f\u5728\u9010\u6b65\u63d0\u5347[2-7]<\/sup>\u3002<\/p>\n

\u88682 \u5386\u5e74\u6307\u5357\u5bf9\u4e8e\u5421\u4ed1\u5e15\u5948\u7684\u63a8\u8350<\/p>\n

\u826f\u597d\u7684\u7597\u6548\u3001\u5b89\u5168\u6027\u4e0e\u5e7f\u8c31\u7279\u6027\uff0c\u662f\u5421\u4ed1\u5e15\u5948\u88ab\u56fd\u5185\u5916\u6307\u5357\u63a8\u8350\u7684\u5f3a\u5927\u4f9d\u636e<\/p>\n

\u8fd1\u5e74\u6765\uff0c\u6297\u53d1\u4f5c\u836f\u7269\uff08ASMs\uff09\u5df2\u8fdb\u51653.0\u65f6\u4ee3\u3002\u5421\u4ed1\u5e15\u5948\u662f\u7b2c\u4e09\u4ee3ASMs\u4e2d\u7684\u4ee3\u8868\u8005\u4e4b\u4e00\uff0c\u5177\u5907\u5168\u65b0\u4f5c\u7528\u673a\u5236\uff0c\u4f5c\u4e3a\u9996\u4e2a\u9ad8\u9009\u62e9\u6027\u3001\u975e\u7ade\u4e89\u6027\u7684AMPA\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u53ef\u901a\u8fc7\u62ee\u6297AMPA\u53d7\u4f53\uff0c\u6291\u5236\u5174\u594b\u6027\u9012\u8d28\u8c37\u6c28\u9178\u4f20\u9012\uff0c\u4ece\u800c\u6291\u5236\u540c\u6b65\u5316\u653e\u7535\u7684\u65e9\u671f\u9636\u6bb5\uff0c\u63d0\u793a\u5176\u5728\u4e34\u5e8a\u4e0a\u6709\u201c\u5e7f\u8c31\u201d\u6297\u766b\u75eb\u53d1\u4f5c\u7684\u6f5c\u529b\uff0c\u5373\u5bf9\u591a\u79cd\u766b\u75eb\u53d1\u4f5c\u7c7b\u578b\u5747\u6709\u6548\uff0c\u4e14\u4e0d\u52a0\u91cd\u808c\u9635\u631b\u53ca\u5931\u795e\u53d1\u4f5c[8,9]<\/sup>\u3002<\/p>\n

\u56fe1 \u5421\u4ed1\u5e15\u5948\u4f5c\u7528\u673a\u5236<\/p>\n

\u6709\u7814\u7a76\u8bc1\u5b9e\uff0c\u5421\u4ed1\u5e15\u5948\u5728\u6cbb\u7597\u6210\u4eba\u53ca\u513f\u7ae5\u766b\u75eb\u4e2d\u5747\u8868\u73b0\u51fa\u826f\u597d\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u3002\u4e00\u9879FREEDOM\u7814\u7a76\uff08342\u7814\u7a76\uff09\u7ed3\u679c\u663e\u793a[10]<\/sup>\uff0c\u5728\u5e74\u9f84\u226512\u5c81\u7684\u5c40\u7076\u6027\u53d1\u4f5c\uff08FOS\uff09\u60a3\u8005\u4e2d\uff0c\u5421\u4ed1\u5e15\u5948\u5355\u836f\u6cbb\u7597\u7ec4\u7684\u65e0\u53d1\u4f5c\u7387\u8fbe74%\u3002\u53e6\u4e00\u9879311\u7814\u7a76\u7ed3\u679c\u5219\u663e\u793a[11]<\/sup>\uff0c\u5728180\u4f8bFOS\u6216\u539f\u53d1\u6027\u5168\u9762\u6027\u5f3a\u76f4\u9635\u631b\u6027\u53d1\u4f5c\uff08pGTCS\uff09\u63a7\u5236\u4e0d\u4f73\u7684\u513f\u7ae5\uff084~12\u5c81\uff09\u60a3\u8005\u4e2d\uff0c\u5421\u4ed1\u5e15\u5948\u6dfb\u52a0\u6cbb\u7597\u513f\u7ae5\u60a3\u8005\u5c40\u7076\u81f3\u53cc\u4fa7\u5f3a\u76f4-\u9635\u631b\u53d1\u4f5c\uff08FBTCS\uff09\u6709\u6548\u7387\u7ea665%\u3002\u53e6\u4e00\u9879\u56de\u987e\u6027\u7814\u7a76\u8868\u660e\u5421\u4ed1\u5e15\u5948\u6cbb\u7597\u8fd8\u53ef\u51cf\u5c11\u5e74\u9f84\u226512\u5c81\u60a3\u8005\u8111\u7535\u56fe\u4e0a\u7684\u766b\u75eb\u6837\u653e\u7535\uff0c\u4e14\u4e0e\u766b\u75eb\u53d1\u4f5c\u9891\u7387\u964d\u4f4e\u76f8\u5173[12]<\/sup>\u3002<\/p>\n

\u56fe2\uff1a\u5de6\u56fe342\u7814\u7a76\u7ed3\u679c\uff0c\u53f3\u56fe311\u7814\u7a76\u7ed3\u679c<\/p>\n

\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0c\u60a3\u8005\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u5934\u6655\u3001\u5934\u75db\u7b49\uff0c\u5927\u591a\u6570\u4e3a\u8f7b\u81f3\u4e2d\u5ea6\uff0c\u540c\u65f6\u5bf9\u8ba4\u77e5\u529f\u80fd\u65e0\u8d1f\u9762\u5f71\u54cd\uff0c\u4e0d\u5f71\u54cd\u60a3\u513f\u7684\u8eab\u9ad8\u3001\u4f53\u91cd\u7b49\u751f\u957f\u53d1\u80b2\uff0c\u6574\u4f53\u8010\u53d7\u6027\u826f\u597d\u3002\u6b64\u5916\uff0c\u5421\u4ed1\u5e15\u5948\u4e00\u5929\u4ec5\u9700\u53e3\u670d\u4e00\u6b21\uff0c\u5e76\u4e14\u5df2\u7eb3\u5165\u533b\u4fdd\u76ee\u5f55\uff0c\u4f5c\u4e3a\u56fd\u8c08\u4ea7\u54c1\uff0c\u4f18\u5316\u7684\u7ed9\u836f\u65b9\u5f0f\u53ca\u76f8\u5bf9\u4f4e\u5ec9\u7684\u4ef7\u683c\u6781\u5927\u5730\u63d0\u9ad8\u4e86\u60a3\u8005\u7684\u7528\u836f\u4fbf\u5229\u5ea6\u548c\u836f\u7269\u53ef\u53ca\u6027\u3002<\/p>\n

\u7ed3\u8bed<\/p>\n

\u4f5c\u4e3a\u7b2c\u4e09\u4ee3\u65b0\u578bASMs\uff0c\u5421\u4ed1\u5e15\u5948\u5177\u5907\u5168\u65b0\u673a\u5236\uff0c\u5bf9\u4e8e\u4e0d\u540c\u5e74\u9f84\u6bb5\u60a3\u8005\u5747\u53ef\u6709\u6548\u63a7\u5236\u766b\u75eb\u53d1\u4f5c\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\uff0c\u83b7\u5f97\u56fd\u5185\u5916\u6743\u5a01\u6307\u5357\/\u5171\u8bc6\u4e00\u81f4\u63a8\u8350\uff0c\u800c\u6211\u56fd\u4eca\u5e74\u6700\u65b0\u53d1\u5e03\u7684\u766b\u75eb\u8bca\u7597\u6307\u5357\u66f4\u662f\u5c06\u5176\u63a8\u8350\u4e3a\u65b0\u8bca\u65ad\u5c40\u7076\u6027\u60a3\u8005\u7684\u4e00\u7ebf\u7528\u836f\uff0c\u8868\u660e\u5176\u7597\u6548\u4e0e\u5b89\u5168\u6027\u5df2\u5f97\u5230\u5e7f\u6cdb\u8ba4\u53ef\u4e0e\u4fe1\u4efb\u3002\u66f4\u91cd\u8981\u7684\u662f\u5421\u4ed1\u5e15\u5948\u7528\u836f\u4fbf\u5229\u3001\u6027\u4ef7\u6bd4\u9ad8\uff0c\u672a\u6765\u5c06\u52a9\u529b\u66f4\u591a\u766b\u75eb\u60a3\u8005\u56de\u5f52\u6b63\u5e38\u751f\u6d3b\u3002<\/p>\n

\u66f4\u591a\u795e\u7ecf\u79d1\u4e34\u5e8a\u77e5\u8bc6\u54ea\u91cc\u770b\uff1f\u5feb\u6765\u201c\u533b\u751f\u7ad9\u7f51\u9875\u7248\u201d\u77a7\u4e00\u77a7\ud83d\udc47<\/p>\n

\u957f\u6309\u8bc6\u522b\u4e8c\u7ef4\u7801<\/p>\n

\u6216\u70b9\u51fb\u9605\u8bfb\u539f\u6587<\/p>\n

\u7cbe\u5f69\u8d44\u8baf\u7b49\u4f60\u6765<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/p>\n

[1]\u4e2d\u56fd\u6297\u766b\u75eb\u534f\u4f1a. \u4e34\u5e8a\u8bca\u7597\u6307\u5357:\u766b\u75eb\u75c5\u5206\u518c[J]. \u4eba\u6c11\u536b\u751f\u51fa\u7248\u793e, 2023.<\/p>\n

[2]Fong J K, Chan E L, Leung H, et al. An update of the Hong Kong Epilepsy Guideline: consensus statement on the use of antiepileptic drugs in Hong Kong[J]. Hong Kong Med J, 2017,23(1):74-88.<\/p>\n

[3]Kanner A M, Ashman E, Gloss D, et al. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the Guideline  Development, Dissemination, and Implementation Subcommittee of the American  Academy of Neurology and the American Epilepsy Society[J]. Neurology, 2018,91(2):82-90.<\/p>\n

[4]Scottish Intercollegiate Guidelines Network (SIGN). Epilepsies in children and young people: investigative procedures and management. Edinburgh: SIGN; 2020. (SIGN publication no. 159). [May 2021]. Available from URL: http:\/\/www.<\/p>\n

[5]Bonanni P, Gambardella A, Tinuper P, et al. Perampanel as first add-on antiseizure medication: Italian consensus clinical practice statements[J]. BMC Neurol, 2021,21(1):410.<\/p>\n

[6]\u4e2d\u56fd\u6297\u766b\u75eb\u534f\u4f1a\u521b\u65b0\u4e0e\u8f6c\u5316\u4e13\u59d4\u4f1a, \u5b63\u6d9b\u4e91, \u59dc\u7389\u6b66,\u7b49. Lennox-Gastaut\u7efc\u5408\u5f81\u8bca\u65ad\u6cbb\u7597\u7684\u4e2d\u56fd\u4e13\u5bb6\u5171\u8bc6[J]. \u766b\u75eb\u6742\u5fd7, 2022(003):008.<\/p>\n

[7]National Institute for Health and Clinical Excellence(NICE).Epilepsies in children, young people and adults.NICE guideline Published: 27 April 2022. Available from URL: www.nice.org.uk\/guidance\/ng217.<\/p>\n

[8]Hanada T. Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors. Biomolecules. 2020 Mar 18;10(3):464.<\/p>\n

[9]Trinka E, Lattanzi S, Carpenter K, et al. Exploring the Evidence for Broad-Spectrum Effectiveness of Perampanel: A Systematic Review of Clinical Data in Generalised Seizures[J]. CNS Drugs. 2021 Aug;35(8):821-837.<\/p>\n

[10]Yamamoto T, Lim S C, Ninomiya H, et al. Efficacy and safety of perampanel monotherapy in patients with focal-onset seizures with newly diagnosed epilepsy or recurrence of epilepsy after a period  of remission: The open-label Study 342 (FREEDOM Study)[J]. Epilepsia Open, 2020,5(2):274-284.<\/p>\n

[11]Fogarasi A, Flamini R, Milh M, et al. Open-label study to investigate the safety and efficacy of adjunctive perampanel in pediatric patients (4 to <12 years) with inadequately controlled focal  seizures or generalized tonic-clonic seizures[J]. Epilepsia, 2020,61(1):125-137.<\/p>\n

[12]Montoya G F, Diaz R M, Cervero A D. Electro-clinical analysis of epilepsy patients with generalized seizures on  adjunctive perampanel treatment[J]. Epilepsy Res, 2020,165:106378.<\/p>\n

*\u6b64\u6587\u4ec5\u7528\u4e8e\u5411\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u63d0\u4f9b\u79d1\u5b66\u4fe1\u606f\uff0c\u4e0d\u4ee3\u8868\u5e73\u53f0\u89c2\u70b9<\/p>\n","protected":false},"excerpt":{"rendered":"

*\u4ec5\u4f9b\u533b\u5b66\u4e13\u4e1a\u4eba\u58eb\u9605\u8bfb\u53c2\u8003 \u5421\u4ed1\u5e15\u5948\u88ab\u6211\u56fd\u6700\u65b0\u766b\u75eb\u6307\u5357\u63a8\u8350\u4e3a\u5c40\u7076\u6027\u53d1\u4f5c\u60a3\u8005\u7684\u4e00\u7ebf … \u7ee7\u7eed\u9605\u8bfb →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-28761","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/28761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=28761"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/28761\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=28761"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=28761"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=28761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}