\u4f5c\u8005\uff1a\u66f9\u82d1\uff0c\u5d14\u4e3d\u82f1<\/p>\n
\u5355\u4f4d\uff1a\u5317\u4eac\u534f\u548c\u533b\u9662\u795e\u7ecf\u79d1<\/p>\n
\u901a\u4fe1\u4f5c\u8005\uff1a\u5d14\u4e3d\u82f1<\/p>\n
\u6587\u7ae0\u6765\u6e90\uff1a\u534f\u548c\u533b\u5b66\u6742\u5fd7\uff0c2020\uff0c11 (2) : 121-126.<\/p>\n
\u8840\u6813\u6027\u75be\u75c5\u662f\u4e34\u5e8a\u4e0a\u4e00\u7c7b\u5e38\u89c1\u4e14\u91cd\u8981\u7684\u75be\u75c5\uff0c\u9759\u8109\u8840\u6813\u6027\u75be\u75c5\u4e3b\u8981\u5305\u62ec\u6df1\u9759\u8109\u8840\u6813\u5f62\u6210\u3001\u80ba\u8840\u6813\u6813\u585e\u7b49\uff1b\u52a8\u8109\u8840\u6813\u6027\u75be\u75c5\u4e3b\u8981\u5305\u62ec\u6025\u6027\u5fc3\u808c\u6897\u6b7b\uff08AMI\uff09\u3001\u6025\u6027\u7f3a\u8840\u6027\u5352\u4e2d\uff08AIS\uff09\u7b49\uff0c\u5177\u6709\u60a3\u75c5\u7387\u3001\u81f4\u6b8b\u7387\u3001\u75c5\u6b7b\u7387\u5747\u9ad8\u7684\u7279\u70b9\uff0c\u4e25\u91cd\u5371\u5bb3\u4eba\u7c7b\u5065\u5eb7\u3002\u6eb6\u6813\u836f\u7269\u53c8\u79f0\u4e3a\u7ea4\u7ef4\u86cb\u767d\u6eb6\u89e3\u5242\uff0c\u5728\u6cbb\u7597\u6025\u6027\u671f\u8840\u6813\u6027\u75be\u75c5\u3001\u6062\u590d\u7ec4\u7ec7\u704c\u6ce8\u4e2d\u8d77\u5230\u975e\u5e38\u5173\u952e\u7684\u4f5c\u7528\u3002\u672c\u6587\u65e8\u5728\u56de\u987e\u6eb6\u6813\u836f\u7269\u7684\u53d1\u5c55\u5386\u7a0b\u3001\u9610\u8ff0\u5176\u4f5c\u7528\u673a\u5236\u5e76\u5bf9\u672a\u6765\u53d1\u5c55\u8fdb\u884c\u5c55\u671b\u3002 <\/p>\n
1 \u5386\u53f2\u6cbf\u9769<\/p>\n
1933\u5e74\uff0cTillett\u548cGarner\u5728\u5904\u7406\u53d1\u70ed\u60a3\u8005\u7684\u8840\u6db2\u6807\u672c\u65f6\u5076\u7136\u53d1\u73b0\uff0c\u8840\u6d46\u4e2d\u805a\u96c6\u7684\u6eb6\u8840\u578b\u94fe\u7403\u83cc\u53ef\u4ee5\u964d\u89e3\u7ea4\u7ef4\u86cb\u767d\uff0c\u81ea\u6b64\u201c\u6eb6\u6813\u201d\u7684\u6982\u5ff5\u8bde\u751f\uff3b1\uff3d\u3002\u800c\u8fd9\u79cd\u6765\u6e90\u4e8e\u6eb6\u8840\u578b\u94fe\u7403\u83cc\u7684\u4ea7\u7269\u540e\u6765\u88ab\u547d\u540d\u4e3a\u94fe\u6fc0\u9176\uff08SK\uff09\u30021956\u5e74\uff0c\u5eb7\u7eb3\u5c14\u5927\u5b66\u7684Cliffton\u7b2c\u4e00\u6b21\u7b80\u5355\u9610\u8ff0\u4e86SK\u8840\u7ba1\u5185\u6eb6\u6813\u6cbb\u7597\u7684\u6709\u6548\u6027\uff0c\u4f46\u4e5f\u53d1\u73b0\u4e86\u968f\u4e4b\u800c\u6765\u7684\u51fa\u8840\u4e0d\u826f\u4e8b\u4ef6\uff3b2\uff3d\u30021947\u5e74Macfarlane\u548cPilling \u7b2c\u4e00\u6b21\u63cf\u8ff0\u4e86\u4eba\u7684\u5c3f\u6db2\u5177\u6709\u6eb6\u89e3\u7ea4\u7ef4\u86cb\u767d\u7684\u529f\u80fd\uff0c1952\u5e74\u8fd9\u79cd\u6709\u6548\u6210\u5206\u5728\u5c3f\u6db2\u4e2d\u88ab\u6210\u529f\u5206\u79bb\uff0c\u5e76\u88ab\u547d\u540d\u4e3a\u5c3f\u6fc0\u9176\uff08UK\uff09\uff3b3\uff3d\u3002McNamara\u548cFischer\u7b2c\u4e00\u6b21\u8bc1\u5b9e\u4e86\u4f7f\u7528\u9ad8\u5242\u91cfUK\u8fdb\u884c\u52a8\u8109\u5185\u6eb6\u6813\u6cbb\u7597\u7684\u6709\u6548\u6027\uff0c\u5176\u8840\u6813\u5b8c\u5168\u6eb6\u89e3\u7387\u4e3a83%\uff3b4\uff3d\u3002<\/p>\n
\u7ec4\u7ec7\u578b\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u5242\uff08t-PA\uff09\u662f\u4ea7\u751f\u4e8e\u4eba\u4f53\u5185\u76ae\u7ec6\u80de\u7684\u5929\u7136\u6eb6\u6813\u836f\u7269\uff0c1979\u5e74Rijken\u7b49\uff3b5\uff3d\u5728\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u7cfb\u4e2d\u6210\u529f\u57f9\u517b\u51fat-PA\uff0c\u5f00\u542f\u4e86\u6eb6\u6813\u6cbb\u7597\u7684\u65b0\u7bc7\u7ae0\u30021987\u5e74\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6t-PA\u7528\u4e8e\u6cbb\u7597AMI\uff0c\u968f\u540e\u57281990\u5e74\u6279\u51c6\u7528\u4e8e\u80ba\u6813\u585e\u7684\u6eb6\u6813\u6cbb\u7597\u3002\u7531\u4e8et-PA\u7684\u57f9\u517b\u65b9\u5f0f\u6781\u5927\u9650\u5236\u4e86\u5176\u751f\u4ea7\u6570\u91cf\uff0c\u4e9f\u9700\u65b0\u6280\u672f\u8fdb\u884c\u6539\u826f\u3002\u4ed3\u9f20\u5375\u7ec6\u80de\u7cfb\u57fa\u56e0\u514b\u9686\u6280\u672f\u4f7f\u91cd\u7ec4t-PA\uff08rt-PA\uff09\u5f97\u4ee5\u5e7f\u6cdb\u751f\u4ea7\uff0c\u5e76\u88ab\u6279\u51c6\u7528\u4e8eAMI\u3001\u5927\u9762\u79ef\u80ba\u6813\u585e\u53caAIS\u7684\u6eb6\u6813\u6cbb\u7597\uff3b6-7\uff3d\u3002\u968f\u7740\u751f\u7269\u5de5\u7a0b\u6280\u672f\u7684\u6210\u719f\uff0ct-PA\u7684\u7ed3\u6784\u88ab\u4e0d\u65ad\u6539\u8fdb\uff0c\u8bde\u751f\u4e86\u534a\u8870\u671f\u66f4\u957f\u3001\u7ea4\u7ef4\u86cb\u767d\u7279\u5f02\u6027\u66f4\u9ad8\u7684\u65b0\u4e00\u4ee3\u6eb6\u6813\u836f\u7269\uff0c\u5982\u66ff\u5948\u666e\u9176\u3001\u745e\u66ff\u666e\u9176\u7b49\uff0c\u4e3a\u6eb6\u6813\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u9009\u62e9\uff08\u56fe1\uff09\u3002<\/p>\n
\u56fe1 \u6eb6\u6813\u836f\u7269\u53d1\u5c55\u5386\u53f2<\/p>\n
t-PA\uff1a\u7ec4\u7ec7\u578b\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u5242\uff1brt-PA\uff1a\u91cd\u7ec4\u7ec4\u7ec7\u578b\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u5242\uff1bFDA\uff1a\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff1bAMI\uff1a\u6025\u6027\u5fc3\u808c\u6897\u6b7b\uff1bAIS\uff1a\u6025\u6027\u7f3a\u8840\u6027\u5352\u4e2d<\/p>\n
2 \u6eb6\u6813\u836f\u7269\u7684\u5206\u7c7b\u53ca\u4f5c\u7528\u673a\u5236<\/p>\n
\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0c\u8840\u6813\u7684\u6eb6\u89e3\u4f9d\u8d56\u4e8e\u7ea4\u7ef4\u86cb\u767d\u6eb6\u89e3\uff08\u7b80\u79f0\u7ea4\u6eb6\uff09\u7cfb\u7edf\u3002\u7ea4\u6eb6\u9176\u539f\u5728\u6fc0\u6d3b\u7269\u7684\u4f5c\u7528\u4e0b\u751f\u6210\u7ea4\u6eb6\u9176\uff0c\u5c06\u7ea4\u7ef4\u86cb\u767d\u5206\u89e3\u4e3a\u53ef\u6eb6\u6027\u4ea7\u7269\u3002\u5185\u6e90\u6027\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u5242\u4e3b\u8981\u6709\u6765\u81ea\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u4ea7\u751f\u7684t-PA\u548c\u6765\u81ea\u80be\u5c0f\u7ba1\u53ca\u96c6\u5408\u7ba1\u4e0a\u76ae\u7ec6\u80de\u4ea7\u751f\u7684\u5c3f\u6fc0\u9176\u578b\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u5242\uff08u-PA\uff09\u3002\u540c\u65f6\u4f53\u5185\u591a\u79cd\u7269\u8d28\u53ef\u6291\u5236\u7ea4\u6eb6\u7cfb\u7edf\u7684\u6d3b\u6027\uff0c\u4e3b\u8981\u5305\u62ec\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u5242\u6291\u5236\u5242-1\uff08PAI-1\uff09\u548c\u03b12-\u6297\u7ea4\u6eb6\u9176\uff08\u03b12-PA\uff09\uff08\u56fe2\uff09\u3002<\/p>\n
\u56fe2 \u6eb6\u6813\u836f\u7269\u4f5c\u7528\u673a\u5236<\/p>\n
t-PA\uff1a\u540c\u56fe1\uff1bu-PA\uff1a\u5c3f\u6fc0\u9176\u578b\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u5242<\/p>\n
\u65e0\u8bbaSK\u3001UK\uff0c\u8fd8\u662ft-PA\u53ca\u5176\u884d\u751f\u7269\uff0c\u5747\u4e0d\u80fd\u76f4\u63a5\u4f5c\u7528\u4f7f\u7ea4\u7ef4\u86cb\u767d\u6eb6\u89e3\uff0c\u800c\u662f\u901a\u5e38\u4f5c\u4e3a\u8f85\u9176\u6216\u5176\u4ed6\u9176\u6fc0\u6d3b\u5185\u6e90\u6027\u7ea4\u6eb6\u7cfb\u7edf\u3002<\/p>\n
\u7406\u60f3\u7684\u6eb6\u6813\u836f\u7269\u5e94\u5177\u5907\u4ee5\u4e0b\u7279\u70b9\uff1a<\/p>\n
\uff081\uff09\u6eb6\u6813\u9ad8\u6548\uff0c\u63d0\u9ad8\u518d\u901a\u7387\uff0c\u964d\u4f4e\u6b7b\u4ea1\u7387\u3002<\/p>\n
\uff082\uff09\u9ad8\u5ea6\u9009\u62e9\u6027\uff0c\u4e0d\u6613\u5f15\u8d77\u51fa\u8840\u6027\u5e76\u53d1\u75c7\u3002\u8840\u7ba1\u5185\u8840\u6813\u7531\u7ea4\u7ef4\u86cb\u767d\u6784\u6210\uff0c\u5e76\u7531\u8d56\u6c28\u9178\u4fa7\u94fe\u4e92\u76f8\u8fde\u63a5\u3002\u6eb6\u6813\u836f\u7269\u6eb6\u89e3\u8840\u7ba1\u5e8a\u4e0a\u9644\u7740\u7684\u8840\u6813\u4e3b\u8981\u901a\u8fc7\u6fc0\u6d3b\u7ea4\u6eb6\u9176\u539f\u8f6c\u5316\u751f\u6210\u7ea4\u6eb6\u9176\uff0c\u7ee7\u800c\u5728\u8840\u6813\u9644\u7740\u5904\u88c2\u89e3\u8840\u6813\u3002\u6eb6\u6813\u836f\u7269\u7684\u7279\u5f02\u6027\u4e3b\u8981\u4f9d\u8d56\u4e8e\u5bf9\u8d56\u6c28\u9178\u8fde\u63a5\u7ed3\u6784\u7684\u8bc6\u522b\u3002\u7ea4\u6eb6\u9176\u539f\u5bf9\u4e8e\u8d56\u6c28\u9178\u4fa7\u94fe\u5177\u6709\u5f88\u5f3a\u7684\u4eb2\u548c\u529b\uff0c\u56e0\u6b64\u5728\u8840\u6813\u5f62\u6210\u5904\u4e5f\u6709\u5927\u91cf\u7684\u7ea4\u6eb6\u9176\u539f\u805a\u96c6\u3002\u4e00\u65e6\u7ea4\u6eb6\u9176\u539f\u8f6c\u5316\u6210\u7ea4\u6eb6\u9176\uff0c\u4f1a\u5c06\u7ea4\u7ef4\u86cb\u767d\u88c2\u89e3\u4e3a\u53ef\u6eb6\u6027\u4ea7\u7269\u3002\u56e0\u6b64\u6eb6\u6813\u836f\u7269\u7684\u4e00\u4e2a\u91cd\u8981\u7279\u6027\u5373\u662f\u5bf9\u4e8e\u7ea4\u7ef4\u86cb\u767d\u7684\u7279\u5f02\u6027\uff0c\u5176\u51b3\u5b9a\u7740\u6cbb\u7597\u7684\u5b89\u5168\u6027\u3002<\/p>\n
\uff083\uff09\u65e0\u514d\u75ab\u539f\u6027\uff0c\u7528\u540e\u4e0d\u4ea7\u751f\u76f8\u5e94\u6297\u4f53\uff0c\u4e0d\u53d1\u751f\u8fc7\u654f\u53cd\u5e94\u3002<\/p>\n
\uff084\uff09\u836f\u7269\u7684\u534a\u8870\u671f\u957f\uff0c\u7528\u836f\u6b21\u6570\u5c11\u3002\u5982rt-PA\u7684\u534a\u8870\u671f\u4e3a4\uff5e8 min\u5de6\u53f3\uff0c\u8fd9\u4f7f\u5f97\u5728\u8d1f\u8377\u7528\u836f\u540e\u9700\u8981\u6301\u7eed\u9759\u8109\u6ef4\u6ce8\u7ee7\u7eed\u6cbb\u7597\uff1b\u800c\u53bb\u6c28\u666e\u9176\u7684\u534a\u8870\u671f\u4e3a138 min\u5de6\u53f3\uff0c\u5355\u72ec\u4e00\u6b21\u7528\u836f\u5373\u53ef\uff0c\u4f7f\u6cbb\u7597\u66f4\u52a0\u65b9\u4fbf\u3002<\/p>\n
\uff085\uff09\u51cf\u5c11\u5bf9PAI-1\u7684\u518d\u8bf1\u5bfc\u3002\u5982UK\u548crt-PA\u5177\u6709\u5bf9PAI-1\u7684\u518d\u8bf1\u5bfc\u4f5c\u7528\uff0c\u4e0e\u66ff\u5948\u666e\u9176\u548c\u53bb\u6c28\u666e\u9176\u76f8\u6bd4\u6eb6\u6813\u6548\u7387\u66f4\u4f4e\u3002<\/p>\n
\uff086\uff09\u51cf\u5c11\u5bf9\u8840\u8111\u5c4f\u969c\u7684\u5f71\u54cd\u3002\u8fd9\u5bf9\u4e8e\u7f3a\u8840\u6027\u5352\u4e2d\u6025\u6027\u671f\u6eb6\u6813\u6cbb\u7597\u5177\u6709\u66f4\u4e3a\u91cd\u8981\u7684\u610f\u4e49\u3002\u4f53\u5916\u5b9e\u9a8c\u8bc1\u5b9e\uff0crt-PA\u901a\u8fc7\u4e0a\u8c03\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u91d1\u5c5e\u86cb\u767d\u9176\u4f7f\u5f97\u8840\u8111\u5c4f\u969c\u88ab\u7834\u574f\uff0c\u7834\u574f\u8840\u8111\u5c4f\u969c\u4f7f\u5f97\u5352\u4e2d\u540e\u6c34\u80bf\u4ee5\u53ca\u51fa\u8840\u8f6c\u5316\u7684\u53d1\u751f\u7387\u589e\u9ad8\uff0c\u964d\u4f4e\u4e86\u6eb6\u6813\u7684\u5b89\u5168\u6027\u3002\u6eb6\u6813\u836f\u7269\u81ea\u8bde\u751f\u4ee5\u6765\uff0c\u636e\u5176\u53d1\u5c55\u5386\u7a0b\u5927\u81f4\u53ef\u5f52\u7ed3\u5982\u4e0b\uff08\u88681\uff09\u3002<\/p>\n
\u88681 \u6eb6\u6813\u836f\u7269\u53ca\u5176\u7279\u70b9<\/p>\n
2.1 \u7b2c\u4e00\u4ee3\u6eb6\u6813\u836f\u7269<\/p>\n
\u7b2c\u4e00\u4ee3\u6eb6\u6813\u836f\u7269\u65e0\u7ea4\u7ef4\u86cb\u767d\u7279\u5f02\u6027\uff0c\u5178\u578b\u4ee3\u8868\u4e3aSK\u3001UK\u7b49\uff0c\u4f46\u5176\u4f5c\u7528\u673a\u5236\u5e76\u4e0d\u5b8c\u5168\u76f8\u540c\u3002SK\u4e0d\u76f4\u63a5\u6fc0\u6d3b\u7ea4\u6eb6\u9176\u539f\uff0c\u800c\u662f\u901a\u8fc7\u5f62\u62101\u22361\u7684SK-\u7ea4\u6eb6\u9176\u539f\u590d\u5408\u7269\uff0c\u4f7f\u7ea4\u6eb6\u9176\u539f\u8f6c\u5316\u4e3a\u7ea4\u6eb6\u9176\u3002UK\u5177\u6709\u6fc0\u9176\u6d3b\u6027\uff0c\u4e0d\u4ec5\u53ef\u76f4\u63a5\u6fc0\u6d3b\u7ea4\u6eb6\u9176\u539f\u4f7f\u4e4b\u8f6c\u5316\u4e3a\u7ea4\u6eb6\u9176\uff0c\u8fd8\u80fd\u63d0\u9ad8\u8840\u7ba1ADP\u9176\u6d3b\u6027\uff0c\u6291\u5236ADP\u8bf1\u5bfc\u7684\u8840\u5c0f\u677f\u805a\u96c6\u3002\u4f46\u6b64\u7c7b\u836f\u7269\u5728\u6eb6\u6813\u7684\u540c\u65f6\u4f1a\u964d\u4f4e\u8840\u6db2\u4e2d\u7ea4\u7ef4\u86cb\u767d\u539f\u53ca\u51dd\u8840\u56e0\u5b50\u7684\u6570\u91cf\uff0c\u5bfc\u81f4\u51fa\u8840\u7b49\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u7684\u53d1\u751f\u3002<\/p>\n
2.2 \u7b2c\u4e8c\u4ee3\u6eb6\u6813\u836f\u7269<\/p>\n
\u7b2c\u4e8c\u4ee3\u6eb6\u6813\u836f\u7269\u4ee5t-PA\u4e3a\u4ee3\u8868\uff0c\u4e3b\u8981\u7279\u70b9\u4e3a\u5177\u6709\u4e00\u5b9a\u7a0b\u5ea6\u7684\u7ea4\u7ef4\u86cb\u767d\u7279\u5f02\u6027\uff0c\u4f46\u534a\u8870\u671f\u8f83\u77ed\uff0c\u4e34\u5e8a\u5e94\u7528\u65f6\u9700\u8fde\u7eed\u6ef4\u6ce8\u3002t-PA\u901a\u8fc7\u6fc0\u6d3b\u7ea4\u6eb6\u9176\u539f\u4f7f\u4e4b\u8f6c\u5316\u4e3a\u7ea4\u6eb6\u9176\u800c\u8d77\u6548\uff0c\u80fd\u9ad8\u6548\u7279\u5f02\u5730\u6eb6\u89e3\u8840\u6813\u800c\u4e0d\u6613\u51fa\u73b0\u7cfb\u7edf\u6027\u7ea4\u6eb6\u72b6\u6001\uff0c\u51fa\u8840\u98ce\u9669\u8f83\u7b2c\u4e00\u4ee3\u6eb6\u6813\u836f\u4f4e\u3002\u4f46t-PA\u8fdb\u5165\u8840\u6db2\u7cfb\u7edf\u540e\u6613\u4e0ePAI-1\u7ed3\u5408\u800c\u8fc5\u901f\u5931\u53bb\u6d3b\u6027\uff0c\u540c\u65f6t-PA\u7684\u534a\u8870\u671f\u77ed\uff0c\u6cbb\u7597\u6240\u9700\u5242\u91cf\u9ad8\u3002<\/p>\n
2.3 \u7b2c\u4e09\u4ee3\u6eb6\u6813\u836f\u7269<\/p>\n
\u7b2c\u4e09\u4ee3\u6eb6\u6813\u836f\u7269\u662f\u5229\u7528\u73b0\u4ee3\u5206\u5b50\u751f\u7269\u5b66\u548c\u751f\u7269\u5de5\u7a0b\u6280\u672f\u5bf9t-PA\u8fdb\u884c\u7ed3\u6784\u6539\u8fdb\uff0c\u5728\u7ea4\u7ef4\u86cb\u767d\u7279\u5f02\u6027\u3001\u534a\u8870\u671f\u53ca\u6eb6\u6813\u6548\u679c\u65b9\u9762\u8f83t-PA\u5747\u6709\u8f83\u5927\u63d0\u9ad8\u7684\u65b0\u578b\u6eb6\u6813\u836f\u7269\u3002\u5176\u4ee3\u8868\u4e3b\u8981\u6709rt-PA\u3001\u66ff\u5948\u666e\u9176\u3001\u745e\u66ff\u666e\u9176\u7b49\uff0c\u5747\u53ef\u76f4\u63a5\u6fc0\u6d3b\u7ea4\u6eb6\u9176\u539f\u3002\u65e2\u5f80\u6709\u7814\u7a76\u5c06rt-PA\u5f52\u4e3a\u7b2c\u4e8c\u4ee3\u6eb6\u6813\u836f\u7269\uff0c\u8003\u8651\u5230rt-PA\u662f\u91c7\u7528\u57fa\u56e0\u91cd\u7ec4\u6280\u672f\u5bf9t-PA\u8fdb\u884c\u7684\u518d\u751f\u4ea7\uff0c\u672c\u6587\u5c06rt-PA\u5f52\u4e3a\u7b2c\u4e09\u4ee3\u6eb6\u6813\u836f\u7269\u3002\u9759\u8109\u7ed9\u836f\u65f6\uff0c\u6eb6\u6813\u836f\u7269\u5728\u8840\u6db2\u4e2d\u4e3a\u76f8\u5bf9\u975e\u6d3b\u6027\u72b6\u6001\uff0c\u4e00\u65e6\u4e0e\u7ea4\u7ef4\u86cb\u767d\u7ed3\u5408\u5373\u88ab\u6fc0\u6d3b\uff0c\u8bf1\u5bfc\u7ea4\u6eb6\u9176\u539f\u8f6c\u5316\u4e3a\u7ea4\u6eb6\u9176\uff0c\u5bfc\u81f4\u7ea4\u7ef4\u86cb\u767d\u6813\u964d\u89e3\u3002<\/p>\n
2.4 \u5176\u4ed6<\/p>\n
\u9664\u4e0a\u8ff0\u4e09\u4ee3\u6eb6\u6813\u836f\u7269\u5916\uff0c\u8fd8\u6709\u975et-PA\u6765\u6e90\u7684\u57fa\u56e0\u5de5\u7a0b\u836f\u7269\u3002\u8461\u6fc0\u9176\u7684\u4f5c\u7528\u673a\u5236\u7c7b\u4f3c\u4e8eSK\uff0c\u9700\u8981\u4e0e\u7ea4\u6eb6\u9176\u539f\u5f62\u62101\u22361\u590d\u5408\u7269\uff0c\u6fc0\u6d3b\u751f\u6210\u7ea4\u6eb6\u9176\u964d\u89e3\u7ea4\u7ef4\u86cb\u767d\u6813\uff0c\u5176\u7ea4\u7ef4\u86cb\u767d\u9009\u62e9\u6027\u9ad8\uff0c\u4f46\u5bb9\u6613\u4ea7\u751f\u6297\u4f53\u3002\u5c3f\u6fc0\u9176\u539f\u5728\u4f53\u5185\u86cb\u767d\u9176\u7684\u4f5c\u7528\u4e0b\u53ef\u5206\u89e3\u6210\u6709\u6d3b\u6027\u7684UK\uff0c\u5bf9\u7ea4\u7ef4\u86cb\u767d\u7684\u7279\u5f02\u6027\u5927\u4e8eUK\u3002\u53bb\u6c28\u666e\u9176\uff08\u5438\u8840\u8759\u8760\u553e\u6db2\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u5242\uff09\u7531\u54fa\u4e73\u52a8\u7269\u57f9\u517b\u4ea7\u751f\uff0c\u4e0et-PA\u5177\u670985%\u7684\u540c\u6e90\u6027\uff0c\u4f5c\u7528\u673a\u5236\u7c7b\u4f3c\uff0c\u6eb6\u6813\u80fd\u529b\u66f4\u5f3a\uff0c\u5bf9\u7ea4\u7ef4\u86cb\u767d\u6709\u9ad8\u5ea6\u7279\u5f02\u6027\u3002<\/p>\n
\u968f\u7740\u5bfc\u7ba1\u6280\u672f\u7684\u8fdb\u5c55\uff0c\u5bf9\u4e8e\u76f4\u63a5\u6eb6\u6813\u836f\u7269\u7684\u63a2\u7d22\u4e5f\u662f\u76ee\u524d\u6eb6\u6813\u836f\u7269\u7814\u5236\u7684\u65b9\u5411\u3002\u7ea4\u6eb6\u9176\u662f\u76f4\u63a5\u6eb6\u6813\u836f\u7269\u7684\u5178\u578b\u4ee3\u8868\uff0c\u5728\u5168\u8eab\u7cfb\u7edf\u4e2d\uff0c\u7ea4\u6eb6\u9176\u88ab\u03b12-PA\u6291\u5236\u800c\u65e0\u6eb6\u6813\u4f5c\u7528\uff0c\u56e0\u6b64\u51fa\u8840\u98ce\u9669\u5c0f\uff0c\u4e14\u5176\u4e0d\u4f9d\u8d56\u4e8e\u4f53\u5185\u7ea4\u6eb6\u9176\u539f\u6570\u91cf\u7684\u9650\u5236\uff0c\u4f7f\u6eb6\u6813\u6709\u6548\u6027\u63d0\u9ad8\u3002\u5bfc\u7ba1\u8f93\u9001\u91ca\u653e\u7ea4\u6eb6\u9176\uff0c\u53ef\u907f\u514d\u7ea4\u6eb6\u9176\u5728\u5168\u8eab\u8840\u6db2\u5faa\u73af\u4e2d\u88ab\u03b12-PA\u6291\u5236\uff0c\u4ece\u800c\u6eb6\u89e3\u7ea4\u7ef4\u86cb\u767d\u6813\u3002\u5176\u4ed6\u7ea4\u6eb6\u9176\u884d\u751f\u7269\u5982\u5c0f\u7ea4\u6eb6\u9176\u3001\u0394\u7ea4\u6eb6\u9176\u3001\u5fae\u5c0f\u7ea4\u6eb6\u9176\u7b49\uff0c\u5747\u5728\u4f53\u5916\u6216\u52a8\u7269\u6a21\u578b\u4e2d\u63d0\u793a\u80fd\u6709\u6548\u7ed3\u5408\u7ea4\u7ef4\u86cb\u767d\u5e76\u4f7f\u5176\u964d\u89e3\uff0c\u4e3a\u672a\u6765\u5bfb\u627e\u65b0\u578b\u6eb6\u6813\u836f\u7269\u63d0\u4f9b\u4e86\u65b9\u5411\u548c\u601d\u8def\uff3b8-11\uff3d\u3002\u672a\u6765\u76f4\u63a5\u6eb6\u6813\u836f\u7269\u5907\u53d7\u671f\u5f85\uff0c\u5176\u4f5c\u7528\u4e0d\u4f9d\u8d56\u4e8e\u7ea4\u6eb6\u9176\u539f\u7684\u6fc0\u6d3b\uff0c\u5e76\u53ef\u4ee5\u964d\u4f4e\u51fa\u8840\u98ce\u9669\uff0c\u4e3a\u8fdb\u4e00\u6b65\u4e34\u5e8a\u8bc4\u4f30\u63d0\u4f9b\u4e86\u4f9d\u636e\u3002<\/p>\n
3 \u6eb6\u6813\u6cbb\u7597\u7684\u4e34\u5e8a\u7814\u7a76<\/p>\n
1958\u5e74\uff0cFletcher\u7b49\uff3b12\uff3d\u5bf9AMI\u60a3\u8005\u9759\u8109\u6ce8\u5165SK\uff0c\u5f00\u59cb\u4e86AMI\u7684\u6eb6\u6813\u6cbb\u7597\u3002<\/p>\n
1983\u5e74\uff0c\u7b2c\u4e00\u9879t-PA\u6cbb\u7597AMI\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c85.7%\uff086\/7\uff09\u7684\u60a3\u8005\u8840\u6d41\u518d\u901a\uff3b13\uff3d\u3002<\/p>\n
1985\u5e74\uff0c\u7b2c\u4e00\u7bc7\u7eb3\u516533\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u7684\u835f\u8403\u5206\u6790\u7ed3\u679c\u63d0\u793a\uff0c\u9759\u8109\u5e94\u7528SK\u6216UK\u6cbb\u7597\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u53ef\u964d\u4f4e22%\u7684\u6b7b\u4ea1\u98ce\u9669\uff08P\uff1c0.001\uff09\uff3b14\uff3d\u3002<\/p>\n
1993\u5e74\uff0cGUSTO-\u2160\u8bd5\u9a8c\u7eb3\u5165\u4e8642 021\u4f8bAMI\u60a3\u8005\uff0c90 min\u5185\u4e88100 mg rt-PA\u4e0e60 min\u5185\u4e88150\u4e07IU SK\u8fdb\u884c\u5bf9\u6bd4\uff0c30 d\u6b7b\u4ea1\u7387\u5206\u522b\u4e3a6.3%\u548c7.3%\uff08P\uff1c0.001\uff09\uff0c\u4e14rt-PA\u6cbb\u7597\u540e60 min\u548c90 min\u8840\u7ba1\u518d\u901a\u7387\u5747\u9ad8\u4e8eSK\uff3b15\uff3d\u3002GUSTO-\u2160\u8bd5\u9a8c\u540ert-PA\u5f00\u59cb\u4e86\u5927\u89c4\u6a21\u5e94\u7528\u3002\u5927\u578b\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u660e\u4e86\u745e\u66ff\u666e\u9176\u6cbb\u7597AMI\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n
1995\u81f31996\u5e74\u5728RAPID\u2160\u548c\u2161\u5355\u76f2\u968f\u673a\u8bd5\u9a8c\u4e2d\uff0c\u745e\u66ff\u666e\u9176\u768460 min\u518d\u901a\u7387\u5747\u7a0d\u9ad8\u4e8et-PA\uff0878%\u6bd466%\uff0c82%\u6bd466%\uff09\uff0c\u5dee\u5f02\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u4f46\u603b\u518d\u901a\u7387\u745e\u66ff\u666e\u9176\u4e0et-PA\u76f8\u4f3c\u6216\u7a0d\u9ad8\uff0c\u518d\u6897\u6b7b\u7387\u4e8c\u8005\u65e0\u663e\u8457\u5dee\u522b\uff3b16-17\uff3d\u3002<\/p>\n
INJECT\u7814\u7a76\u5bf96010\u4f8bAMI\u60a3\u8005\u8fdb\u884c\u745e\u66ff\u666e\u9176\u4e0eSK\u53cc\u76f2\u968f\u673a\u5e73\u884c\u7597\u6548\u6bd4\u8f83\uff0c\u7ed3\u679c35 d\uff089% \u6bd4 9.5%\uff09\u548c180 d\uff0811%\u6bd412%\uff09\u6b7b\u4ea1\u7387\u5747\u65e0\u663e\u8457\u6027\u5dee\u5f02\uff0c\u4f46\u745e\u66ff\u666e\u9176\u8fc7\u654f\u8f83\u5c11\uff0c\u76f8\u6bd4SK\u4e0d\u826f\u53cd\u5e94\u51cf\u5c11\uff3b18\uff3d\u3002<\/p>\n
\u5728TIMI 10B\u8bd5\u9a8c\u4e2d\uff0c\u53d1\u75c512 h\u5185\u7684866\u4f8bAMI\u60a3\u8005\u5206\u522b\u63a5\u53d7\u66ff\u5948\u666e\u917630\uff5e50 mg\u548ct-PA\u7ed9\u836f\u65b9\u6848\uff0c\u7ed3\u679c\u663e\u793a\u7ed9\u4e88\u66ff\u5948\u666e\u917640 mg\u6cbb\u7597\u7ec490 min\u518d\u901a\u7387\u4e0et-PA\u76f8\u6bd4\u65e0\u663e\u8457\u6027\u5dee\u5f02\uff0862.8%\u6bd462.7%\uff09\uff3b19\uff3d\u3002<\/p>\n
\u572829\u4e2a\u56fd\u5bb61021\u4e2a\u4e34\u5e8a\u5355\u4f4d\u5f00\u5c55\u7684\u968f\u673a\u53cc\u76f2\u5bf9\u7167\u8bd5\u9a8c\u2162\u671f\u4e34\u5e8a\u65b0\u6eb6\u6813\u5242\u5b89\u5168\u4e0e\u7597\u6548\u8bc4\u4ef7\uff08ASSENT \u2161\uff09\u4e2d\uff0c\u5171\u7eb3\u516516 949\u4f8b\u53d1\u75c56 h\u5185\u7684AMI\u60a3\u8005\uff0c\u4e88\u66ff\u5948\u666e\u9176\u548c\u4e88t-PA\u8fdb\u884c\u5bf9\u6bd4\uff0c\u53d1\u73b030 d\u6b7b\u4ea1\u7387\uff086.18%\u6bd46.15%\uff09\u548c\u9885\u5185\u51fa\u8840\u7387\uff080.93%\u6bd40.94%\uff09\u5e76\u65e0\u663e\u8457\u6027\u5dee\u5f02\uff3b20\uff3d\u3002<\/p>\n
\u5c3d\u7ba1\u76ee\u524d\u7ecf\u76ae\u51a0\u72b6\u52a8\u8109\u4ecb\u5165\u6cbb\u7597\uff08PCI\uff09\u5df2\u6210\u719f\u5f00\u5c55\uff0c\u4f46PCI\u7684\u6709\u6548\u6027\u4e0e\u65f6\u95f4\u7a97\u5173\u7cfb\u5bc6\u5207\uff0c\u6eb6\u6813\u836f\u7269\u5bf9\u4e8eAMI\u60a3\u8005\u65e9\u671f\u5c3d\u5feb\u6062\u590d\u704c\u6ce8\u4ecd\u6709\u4e0d\u53ef\u66ff\u4ee3\u7684\u91cd\u8981\u610f\u4e49\u3002<\/p>\n
\u81ea20\u4e16\u7eaa80\u5e74\u4ee3\u8d77\uff0c\u5728AMI\u5e94\u7528\u6eb6\u6813\u6cbb\u7597\u53d6\u5f97\u663e\u8457\u6210\u7ee9\u540e\uff0c\u56fd\u9645\u4e0a\u53c8\u91cd\u65b0\u91cd\u89c6\u6eb6\u6813\u6cbb\u7597\u6025\u6027\u8111\u6897\u6b7b\u7684\u79ef\u6781\u4f5c\u7528\u3002<\/p>\n
1995\u5e74\u7684\u968f\u673a\u3001\u53cc\u76f2NINDS-2\u8bd5\u9a8c\u7eb3\u5165624\u4f8b3 h\u65f6\u95f4\u7a97\u5185\u7684AIS\u60a3\u8005\uff0c\u7ed9\u4e88rt-PA0.9 mg\/kg\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c3\u4e2a\u6708\u9884\u540e\u663e\u8457\u6539\u5584\uff0c\u75c7\u72b6\u6027\u9885\u5185\u51fa\u8840\u7387\u4e3a6.4%\uff3b21\uff3d\u3002<\/p>\n
1996\u5e74\u7f8e\u56fdFDA\u57fa\u4e8eNINDS-2\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u6279\u51c6rt-PA\u7528\u4e8e\u6cbb\u7597AIS\u3002<\/p>\n
\u4e4b\u540e\u57281998\u81f32008\u5e74\u95f4\uff0cECASS\u2160\uff5e\u2162\u3001ATLANTIS\u548cEPITHET\u8bd5\u9a8c\u5747\u5e0c\u671b\u8fdb\u4e00\u6b65\u9a8c\u8bc1rt-PA\u5bf9\u4e8eAIS\u6cbb\u7597\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u4f46\u4ec5ECASS \u2162\u8bd5\u9a8c\u5f97\u5230\u4e86\u9633\u6027\u7ed3\u679c\uff3b22-27\uff3d\u3002<\/p>\n
ECASS \u2162\u8bd5\u9a8c\u662f\u57283\uff5e4.5 h\u7684\u65f6\u95f4\u7a97\u5185\u8fdb\u884c\u7684\u4e00\u9879\u5b89\u6170\u5242\u5bf9\u7167\u53cc\u76f2\u8bd5\u9a8c\uff0c\u5171\u7eb3\u5165821\u4f8bAIS\u60a3\u8005\uff0crt-PA\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c90 d \u6539\u826fRankin\u91cf\u8868\uff08mRS\uff09\u8bc4\u5206\u6539\u5584\u5177\u6709\u663e\u8457\u6027\u5dee\u5f02\uff0c\u4e3a\u6307\u5357\u63a8\u83503\uff5e4.5 h\u65f6\u95f4\u7a97\u6eb6\u6813\u6cbb\u7597\u63d0\u4f9b\u4e86\u57fa\u672c\u4f9d\u636e\u3002<\/p>\n
\u672a\u6765\u5bf9\u4e8e\u6eb6\u6813\u65f6\u95f4\u7a97\u7684\u8fdb\u4e00\u6b65\u63a2\u7d22\uff0c\u53ef\u80fd\u4f1a\u8ba9\u66f4\u591a\u7684AIS\u60a3\u8005\u83b7\u76ca\uff0c\u4f46UK\u4ecd\u662f\u6211\u56fd\u57fa\u5c42\u533b\u9662\u5e38\u7528\u7684\u6eb6\u6813\u836f\u7269\u3002<\/p>\n
2002\u5e74\u56fd\u5bb6 \u201c\u4e5d\u4e94\u201d \u653b\u5173\u8bfe\u9898 \u201c\u6025\u6027\u8111\u6897\u6b7b\uff086 h\u5185\uff09\u7684\u9759\u8109\u6eb6\u6813\u6cbb\u7597\u201d \u7684\u4e8c\u9636\u6bb5\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u53d1\u5e03\uff0cAIS\u60a3\u8005\u53d1\u75c56 h\u5185\u7ed9\u4e88UK\uff08150\u4e07IU\u548c100\u4e07IU\uff09\u6cbb\u7597\u8f83\u5b89\u6170\u5242\u7ec4\u6b27\u6d32\u5352\u4e2d\u91cf\u8868\u8bc4\u5206\u663e\u8457\u589e\u9ad8\uff0c\u800c\u51fa\u8840\u53d1\u751f\u7387\u53ca\u6b7b\u4e8e\u8111\u5185\u51fa\u8840\u7684\u6bd4\u4f8b\u672a\u5f97\u51fa\u663e\u8457\u6027\u5dee\u5f02\uff3b28\uff3d\u3002<\/p>\n
\u964d\u7ea4\u9176\u662f\u4e00\u79cd\u9ad8\u7eaf\u5ea6\u5355\u7ec4\u5206\u7684\u86c7\u6bd2\u5236\u5242\uff0c2000\u5e74\u6211\u56fd\u56fd\u4ea7\u964d\u7ea4\u9176\u6cbb\u7597AIS\u518d\u8bc4\u4ef7\u7684\u7b2c\u4e00\u9636\u6bb5\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff0c\u964d\u7ea4\u9176\u80fd\u6709\u6548\u964d\u4f4e\u8840\u6d46\u7ea4\u7ef4\u86cb\u767d\u539f\u6c34\u5e73\uff0c\u6cbb\u7597\u540e1\u5e74\u5352\u4e2d\u590d\u53d1\u7387\u660e\u663e\u964d\u4f4e\uff0c\u4f46\u60a3\u80051\u4e2a\u6708\u65f6\u7684\u65e5\u5e38\u751f\u6d3b\u80fd\u529b\u53ca2\u5468\u65f6\u7684\u795e\u7ecf\u529f\u80fd\u7f3a\u635f\u4e0e\u5b89\u6170\u5242\u7ec4\u6bd4\u8f83\u672a\u89c1\u663e\u8457\u6539\u5584\uff3b29\uff3d\u3002<\/p>\n
2005\u5e74\u7b2c\u4e8c\u9636\u6bb5\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff0c\u964d\u7ea4\u9176\u80fd\u6709\u6548\u6539\u5584\u53d1\u75c5\u572812 h\u4ee5\u5185AIS\u60a3\u8005\u7684\u751f\u5b58\u72b6\u6001\uff0c\u4f46\u589e\u52a0\u4e86\u9885\u5185\u5916\u51fa\u8840\u4e8b\u4ef6\u7684\u98ce\u9669\uff3b30\uff3d\u3002\u4e4b\u540e\u7531\u4e8e\u7f3a\u4e4f\u5927\u578b\u4e34\u5e8a\u7814\u7a76\u652f\u6301\uff0c\u964d\u7ea4\u9176\u7684\u6709\u6548\u6027\u53ca\u5b89\u5168\u6027\u4ecd\u6709\u5f85\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n
\u76ee\u524d\u6211\u56fd\u6025\u6027\u7f3a\u8840\u6027\u5352\u4e2d\u8bca\u6cbb\u6307\u5357\u4e2d\u63a8\u8350\u5bf9\u7f3a\u8840\u6027\u5352\u4e2d\u53d1\u75c53 h\u5185\uff08I\u7ea7\u63a8\u8350\uff0cA\u7ea7\u8bc1\u636e\uff09\u548c3\uff5e4.5 h\uff08I\u7ea7\u63a8\u8350\uff0cB\u7ea7\u8bc1\u636e\uff09\u7684\u60a3\u8005\uff0c\u5e94\u6309\u7167\u9002\u5e94\u8bc1\u3001\u7981\u5fcc\u8bc1\u548c\u76f8\u5bf9\u7981\u5fcc\u8bc1\u4e25\u683c\u7b5b\u9009\u60a3\u8005\uff0c\u5c3d\u5feb\u9759\u8109\u7ed9\u4e88rt-PA\u6eb6\u6813\u6cbb\u7597\uff0c\u800c\u53d1\u75c5\u57286 h\u5185\uff0c\u53ef\u7ed9\u4e88UK\u9759\u8109\u6eb6\u6813\uff08\u2161\u7ea7\u63a8\u8350\uff0cB\u7ea7\u8bc1\u636e\uff09\uff3b31\uff3d\u3002 <\/p>\n
\u4e3aAIS\u60a3\u8005\u5bfb\u627e\u53ef\u66ff\u4ee3\u6eb6\u6813\u836f\u7269\u7684\u7814\u7a76\u4ecd\u9700\u8fdb\u4e00\u6b65\u7b49\u5f85\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u30022010\u5e74\u4e00\u9879\u5173\u4e8e\u66ff\u5948\u666e\u9176\u6cbb\u7597AIS\u7684\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u4e34\u5e8a\u8bd5\u9a8c\u5ba3\u544a\u63d0\u524d\u7ec8\u6b62\uff0c\u539f\u56e0\u5728\u4e8e2006\u81f32008\u5e74\u95f4\u4ec5\u6709112\u4f8b\u60a3\u8005\u5165\u7ec4\uff3b32\uff3d\u3002\u4f46\u6839\u636e\u5df2\u6709\u6570\u636e\u5206\u6790\uff0c\u66ff\u5948\u666e\u9176\u4e0ert-PA\u5bf9\u4e8e90 d\u9884\u540e\u65e0\u663e\u8457\u6027\u5dee\u5f02\u3002<\/p>\n
2017\u5e74NOR-TEST\u8bd5\u9a8c\u7eb3\u5165\u4e861107\u4f8b\u53d1\u75c54.5 h\u5185\u7684AIS\u60a3\u8005\uff0c\u7ed3\u679c\u53d1\u73b00.4 mg\/kg\u66ff\u5948\u666e\u9176\u4e0e0.9 mg\/kg rt-PA\u6cbb\u759790 d\u540e\uff0cmRS\u8bc4\u5206\u4e3a0\uff5e2\u5206\u7684\u60a3\u8005\u6bd4\u4f8b\u5206\u522b\u4e3a64%\u548c51%\uff08P=0.06\uff09\uff0c\u5404\u67091\u4f8b\u75c7\u72b6\u6027\u9885\u5185\u51fa\u8840\u4e8b\u4ef6\u53d1\u751f\uff08P=0.08\uff09\uff0c\u6709\u6548\u6027\u53ca\u5b89\u5168\u6027\u65e0\u663e\u8457\u6027\u5dee\u5f02\uff3b33\uff3d\u3002\u4f46\u7531\u4e8e\u7eb3\u5165\u7684\u60a3\u8005\u5927\u591a\u4e3a\u8f7b\u578b\u5352\u4e2d\uff08\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u5352\u4e2d\u91cf\u8868\u4e2d\u4f4d\u8bc4\u5206=4\uff09\u60a3\u8005\uff0c\u7f8e\u56fd\u5fc3\u810f\u534f\u4f1a\/\u7f8e\u56fd\u5352\u4e2d\u534f\u4f1a\u65b0\u7248\u6307\u5357\u4ec5\u63a8\u8350\u66ff\u5948\u666e\u9176\u6cbb\u7597\u8f7b\u578b\u5352\u4e2d\uff08\u2161b\u7ea7\u63a8\u8350\uff0cB\u7ea7\u8bc1\u636e\uff09\u3002\u800c\u6211\u56fd\u6307\u5357\u540c\u6837\u63a8\u8350\u5bf9\u4e8e\u8f7b\u5ea6\u795e\u7ecf\u529f\u80fd\u7f3a\u635f\u4e14\u4e0d\u4f34\u6709\u9885\u5185\u5927\u8840\u7ba1\u95ed\u585e\u7684\u60a3\u8005\uff0c\u53ef\u8003\u8651\u5e94\u7528\u66ff\u5948\u666e\u9176(\u2161\u7ea7\u63a8\u8350\uff0cB\u7ea7\u8bc1\u636e)\uff3b31\uff3d\u3002<\/p>\n
2004\u5e74\u7b2c\u4e00\u9879\u5173\u4e8e\u745e\u66ff\u666e\u9176\u6cbb\u7597AIS\u7684\u524d\u77bb\u6027\u8bd5\u9a8c\u53d1\u8868\uff0c\u7ed3\u679c\u663e\u793a\u7ed9\u4e88\u52a8\u8109\u745e\u66ff\u666e\u9176\u8054\u5408\u9759\u8109\u963f\u897f\u5355\u514b\u9686\u6297\u4f53\u6cbb\u75973\uff5e6 h\u65f6\u95f4\u7a97\u7684AIS\u60a3\u8005\u662f\u5b89\u5168\u7684\uff3b34\uff3d\u3002\u5728\u7eb3\u5165\u768420\u4f8b\u60a3\u8005\u4e2d\uff0c13\u4f8b\u65e9\u671f\u795e\u7ecf\u529f\u80fd\u6539\u5584\uff0c\u90e8\u5206\u6216\u5b8c\u5168\u518d\u901a\u7387\u4e3a65%\u3002<\/p>\n
\u76ee\u524d\u53e6\u4e00\u9879\u745e\u66ff\u666e\u9176\u548c\u963f\u6614\u5355\u514b\u9686\u6297\u4f53\u6cbb\u7597AIS\u7684\u8bd5\u9a8c\uff08https:\/\/\/ct2\/show\/NCT00046293?term=00046293\uff09\u4ecd\u5728\u8fdb\u884c\u4e2d\uff0c\u7814\u7a76\u7eb3\u5165\u53d1\u75c53\uff5e24 h\u7684AIS\u60a3\u8005\uff0c\u8fdb\u4e00\u6b65\u63a2\u7a76\u745e\u66ff\u666e\u9176\u8054\u5408\u963f\u6614\u5355\u514b\u9686\u6297\u4f53\u6cbb\u7597\u7684\u5242\u91cf\u53ca\u5b89\u5168\u6027\u3002<\/p>\n
DIAS\u7814\u7a76\u548cDEDAS\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff0c\u5bf9\u4e8e\u53d1\u75c59 h\u5185\u7684AIS\u60a3\u8005\uff0c\u7ed3\u5408\u5f71\u50cf\u5b66\u7b5b\u9009\uff0c\u53bb\u6c28\u666e\u9176\u6eb6\u6813\u6cbb\u7597\u53ef\u8ba9\u66f4\u591a\u7684AIS\u60a3\u800590 d\u83b7\u76ca\uff3b35-36\uff3d\u3002<\/p>\n
\u968f\u540e\u7684DIAS-2\u8bd5\u9a8c\u53d1\u73b0\u53bb\u6c28\u666e\u9176\u6cbb\u7597\u53d1\u75c53\uff5e9 h\u7684AIS\u60a3\u8005\u5e76\u672a\u6539\u558490 d\u4e34\u5e8a\u9884\u540e\uff0c\u4f46\u7ed3\u679c\u652f\u630190 \u03bcg\/kg\u5242\u91cf\u7684\u5b89\u5168\u6027\u5341\u5206\u4f18\u5f02\uff3b37\uff3d\u3002<\/p>\n
\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u5352\u4e2d\u540e3\uff5e9 h\u4f7f\u7528\u53bb\u6c28\u666e\u9176\u6cbb\u7597\u7684\u76f8\u5173\u7814\u7a76\u63d0\u4f9b\u4e86\u7406\u8bba\u4f9d\u636e\uff0c\u7136\u800cDIAS-3\u7814\u7a76\u7ed3\u679c\u8868\u660e\u53bb\u6c28\u666e\u9176\u4e0e\u5b89\u6170\u5242\u5b89\u5168\u6027\u76f8\u5f53\uff0c\u65e0\u4e34\u5e8a\u83b7\u76ca\uff0c\u8fd9\u4e00\u7ed3\u679c\u4f7f\u5f97\u8fdb\u884c\u4e2d\u7684DIAS-4\u7814\u7a76\u63d0\u524d\u7ec8\u6b62\uff3b38\uff3d\u3002<\/p>\n
4 \u5c0f\u7ed3\u4e0e\u5c55\u671b<\/p>\n
\u81ea1933\u5e74SK\u88ab\u53d1\u73b0\u4ee5\u6765\uff0c\u5173\u4e8e\u6eb6\u6813\u836f\u7269\u7684\u7814\u7a76\u4e0d\u65ad\u63a8\u8fdb\uff0c\u7597\u6548\u4e0d\u65ad\u63d0\u9ad8\uff0c\u5927\u5927\u964d\u4f4e\u4e86\u6025\u6027\u8840\u6813\u6027\u75be\u75c5\u7684\u81f4\u6b8b\u7387\u548c\u6b7b\u4ea1\u7387\u3002\u4f46\u5df2\u6709\u7684\u6eb6\u6813\u836f\u7269\u673a\u5236\u7c7b\u4f3c\uff0c\u6cbb\u7597\u6240\u5e26\u6765\u7684\u51fa\u8840\u4e8b\u4ef6\u7b49\u4e0d\u826f\u53cd\u5e94\u4ecd\u662f\u5236\u7ea6\u6eb6\u6813\u836f\u7269\u5e94\u7528\u7684\u5173\u952e\u201c\u74f6\u9888\u201d\u3002\u6eb6\u6813\u836f\u7269\u7684\u65f6\u95f4\u7a97\u9650\u5236\u4e5f\u662f\u5f71\u54cd\u6cbb\u7597\u7684\u91cd\u8981\u77ed\u677f\uff0c\u672a\u6765\u5bf9\u4e8e\u6eb6\u6813\u65f6\u95f4\u7a97\u7684\u8fdb\u4e00\u6b65\u63a2\u7d22\uff0c\u53ef\u80fd\u4f1a\u8ba9\u66f4\u591a\u60a3\u8005\u83b7\u76ca\u3002<\/p>\n
\u53c2\u8003\u6587\u732e<\/p>\n
\uff3b1\uff3dTillett WS\uff0cGarner RL. The fibrinolytic activity of hemolytic streptococci\uff3bJ\uff3d. J Exp Med, 1933, 58: 485-502.<\/p>\n
\uff3b2\uff3dCliffton EE. The use of plasmin in humans\uff3bJ\uff3d. Ann N Y Acad Sci, 1957, 68: 209-229.<\/p>\n
\uff3b3\uff3dMacfarlane RG\uff0cPilling J. Fibrinolytic activity of normal urine\uff3bJ\uff3d. Nature, 1947, 159: 779.<\/p>\n
\uff3b4\uff3dMcNamara TO\uff0cFischer JR. Thrombolysis of peripheral arterial and graft occlusions: Improved results using high-dose urokinase\uff3bJ\uff3d. AJR Am J Roentgenol, 1985, 144: 769-775.<\/p>\n
\uff3b5\uff3dRijken DC\uff0cCollen D. Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture\uff3bJ\uff3d. J Biol Chem, 1981, 256: 7035-7041.<\/p>\n
\uff3b6\uff3dZamarron C\uff0cLijnen HR\uff0cCollen D. Kinetics of the activation of plasminogen by natural and recombinant tissue-type plasminogen activator\uff3bJ\uff3d. J Biol Chem, 1984, 259: 2080-2083.<\/p>\n
\uff3b7\uff3dVan de Werf F\uff0cBergmann SR\uff0cFox KA\uff0cet al. Coronary thrombolysis with intravenously administered human tissue-type plasminogen activator produced by recombinant DNA technology\uff3bJ\uff3d. Circulation, 1984, 69: 605-610.<\/p>\n
\uff3b8\uff3dNovokhatny V\uff0cTaylor K\uff0cZimmerman TP. Thrombolytic potency of acid-stabilized plasmin: Superiority over tissue-type plasminogen activator in an in vitro model of catheter-assisted thrombolysis\uff3bJ\uff3d. J Thromb Haemost, 2003, 1: 1034-1041.<\/p>\n
\uff3b9\uff3dFu J\uff0cRen J\uff0cZou L\uff0cet al. The thrombolytic effect of miniplasmin in a canine model of femoral artery thrombosis\uff3bJ\uff3d. Thromb Res, 2008, 122: 683-690.<\/p>\n
\uff3b10\uff3dLee S\uff0cBrait VH\uff0cArumugam TV\uff0cet al. Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo\uff3bJ\uff3d. Exp Transl Stroke Med, 2012, 4: 16.<\/p>\n
\uff3b11\uff3dRasmussen RS\uff0cOvergaard K\uff0cPakola S\uff0cet al. Effects of microplasmin on recovery in a rat embolic stroke model\uff3bJ\uff3d. Neurol Res, 2008, 30: 75-81.<\/p>\n
\uff3b12\uff3dFletcher AP\uff0cAlkjaersig N\uff0cSmyrniotis FE\uff0cet al. The treatment of patients suffering from early myocardial infarction with massive and prolonged streptokinase therapy\uff3bJ\uff3d. Trans Assoc Am Physicians, 1958, 71: 287-296.<\/p>\n
\uff3b13\uff3dVan de Werf F\uff0cLudbrook PA\uff0cBergmann SR\uff0cet al. Coronary thrombolysis with tissue-type plasminogen activator in patients with evolving myocardial infarction\uff3bJ\uff3d. N Engl J Med, 1984, 310: 609-613.<\/p>\n
\uff3b14\uff3dYusuf S\uff0cCollins R\uff0cPeto R\uff0cet al. Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: Overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials\uff3bJ\uff3d. Eur Heart J, 1985, 6: 556-585.<\/p>\n
\uff3b15\uff3dGUSTO investigators.An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction\uff3bJ\uff3d. N Engl J Med, 1993, 329: 673-682.<\/p>\n
\uff3b16\uff3dSmalling RW\uff0cBode C\uff0cKalbfleisch J\uff0cet al. More rapid, complete, and stable coronary thrombolysis with bolus administration of reteplase compared with alteplase infusion in acute myocardial infarction. Rapid investigators\uff3bJ\uff3d. Circulation, 1995, 91: 2725-2732.<\/p>\n
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