{"id":28512,"date":"2024-04-01T12:00:56","date_gmt":"2024-04-01T12:00:56","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=28512"},"modified":"2024-04-01T12:00:56","modified_gmt":"2024-04-01T12:00:56","slug":"%e5%a4%b4%e5%ad%a2%e4%bb%96%e5%95%b6-%e9%98%bf%e7%bb%b4%e5%b7%b4%e5%9d%a6","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=28512","title":{"rendered":"\u5934\u5b62\u4ed6\u5576-\u963f\u7ef4\u5df4\u5766"},"content":{"rendered":"

\u6458\u8981<\/p>\n

\u7ec6\u83cc\u7684\u78b3\u9752\u9709\u70ef\u8010\u836f\u6027\u662f\u5168\u7403\u516c\u5171\u5065\u5eb7\u9762\u4e34\u7684\u4e00\u4e2a\u91cd\u5927\u6311\u6218\uff0c\u7531\u78b3\u9752\u9709\u70ef\u8010\u836f\u83cc\uff08CRO\uff09\u5f15\u8d77\u7684\u4e34\u5e8a\u611f\u67d3\u901a\u5e38\u6709\u5f88\u9ad8\u7684\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u3002<\/p>\n

\u5934\u5b62\u4ed6\u5576-\u963f\u7ef4\u5df4\u5766\uff08CAZ-AVI\uff09\u662f\u4e00\u79cd\u65b0\u578b\u5934\u5b62\u83cc\u7d20\/\u03b2-\u5185\u9170\u80fa\u9176\u6291\u5236\u5242\uff0c\u4e3a\u4e34\u5e8a\u6cbb\u7597CRO\u611f\u67d3\u63d0\u4f9b\u4e86\u4e00\u9879\u91cd\u8981\u9009\u62e9\u3002<\/p>\n

\u636e\u62a5\u9053\uff0cCAZ-AVI \u80fd\u591f\u6291\u5236Ambler A\u7c7b\u3001C\u7c7b\u4ee5\u53ca\u90e8\u5206D\u7c7b\u9176\u7684\u6d3b\u6027\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u836f\u7269\u5728\u4e34\u5e8a\u4f7f\u7528\u540e\u4e0d\u4e45\uff0c\u7ec6\u83cc\u7684\u8010\u836f\u6027\u5c31\u5df2\u7ecf\u51fa\u73b0\uff0c\u5e76\u4e14\u5448\u4e0a\u5347\u8d8b\u52bf\u3002\u4e86\u89e3\u7ec6\u83cc\u5bf9CAZ-AVI \u7684\u8010\u836f\u673a\u5236\uff0c\u5bf9\u4e8e\u6307\u5bfc\u5f00\u53d1\u65b0\u578b\u6cbb\u7597\u65b9\u6cd5\u3001\u5e2e\u52a9\u9884\u6d4b\u6f5c\u5728\u7684\u8010\u836f\u673a\u5236\u81f3\u5173\u91cd\u8981\u3002\u672c\u6587\u65e8\u5728\u7cfb\u7edf\u603b\u7ed3CAZ-AVI \u8010\u836f\u83cc\u682a\u7684\u6d41\u884c\u75c5\u5b66\u53d1\u5c55\u8fc7\u7a0b\u548c\u6700\u8fd1\u53d1\u73b0\u7684CAZ-AVI \u8010\u836f\u673a\u5236\uff1b\u5c06\u91cd\u70b9\u5173\u6ce8\u03b2-\u5185\u9170\u80fa\u9176\u7a81\u53d8\u4f53\u7684\u4ea7\u751f\u3001\u03b2-\u5185\u9170\u80fa\u9176\u9ad8\u8868\u8fbe\u3001\u7ec6\u80de\u8868\u9762\u901a\u900f\u6027\u964d\u4f4e\u4ee5\u53ca\u836f\u7269\u5916\u6392\u6cf5\u7684\u8fc7\u8868\u8fbe\u3002\u77ed\u65f6\u95f4\u5185\u591a\u79cdCAZ-AVI\u8010\u836f\u673a\u5236\u7684\u4ea7\u751f\uff0c\u5f3a\u8c03\u4e86\u4e34\u5e8a\u5408\u7406\u7528\u836f\u7684\u91cd\u8981\u6027\u4ee5\u53ca\u76d1\u6d4bCAZ-AVI \u8010\u836f\u6027\u75c5\u539f\u4f53\u7684\u5fc5\u8981\u6027\u3002<\/p>\n

\u5173\u952e\u8bcd<\/p>\n

\u5934\u5b62\u4ed6\u5576-\u963f\u7ef4\u5df4\u5766 ; \u8010\u836f\u673a\u5236 ; \u78b3\u9752\u9709\u70ef\u8010\u836f\u6027 ; \u03b2-\u5185\u9170\u80fa\/\u03b2-\u5185\u9170\u80fa\u9176\u6291\u5236\u5242 <\/p>\n

\u6b63\u6587<\/p>\n

1\u3001 \u5f15\u8a00<\/p>\n

\u7531\u591a\u91cd\u8010\u836f\uff08MDR\uff09\u7684\u9769\u5170\u6c0f\u9634\u6027\u83cc\uff08GNB\uff09\u5bfc\u81f4\u7684\u4e25\u91cd\u4e34\u5e8a\u611f\u67d3\u5df2\u5bf9\u5168\u7403\u516c\u5171\u536b\u751f\u5065\u5eb7\u6784\u6210\u4e25\u91cd\u5a01\u80c1[1]\u3002\u76ee\u524d\u5bf9\u7531\u4ea7\u03b2-\u5185\u9170\u80fa\u9176\u7684\u9769\u5170\u6c0f\u9634\u6027\u83cc\uff0c\u7279\u522b\u662f\u78b3\u9752\u9709\u70ef\u8010\u836f\u7ec6\u83cc\u5f15\u8d77\u7684\u611f\u67d3\u7684\u6cbb\u7597\u7b56\u7565\u6709\u9650\u3002\u201c\u6700\u540e\u4e00\u7ebf\u201d\uff08last-line\uff09\u836f\u7269\uff08\u5982\u591a\u9ecf\u83cc\u7d20\u3001\u66ff\u52a0\u73af\u7d20\uff09\u7684\u6cbb\u7597\u6548\u679c\u53ef\u80fd\u4f1a\u53d7\u5230\u8010\u836f\u6027\u3001\u6b21\u4f18\u836f\u4ee3\u52a8\u529b\u5b66\u548c\uff08\u6216\uff09\u83cc\u682a\u9ad8\u6bd2\u6027\u7684\u5f71\u54cd[2\u20124]\u30022015\u5e742\u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u4e86\u4e00\u79cd\u65b0\u578b\u5934\u5b62\u83cc\u7d20\/\u03b2-\u5185\u9170\u80fa\u9176\u6291\u5236\u590d\u5408\u7269\u2014\u2014\u5934\u5b62\u4ed6\u5576-\u963f\u7ef4\u5df4\u5766\uff08CAZ-AVI\uff09\uff0c\u8fd9\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u7f13\u89e3\u4e86MDR GNB\u6cbb\u7597\u624b\u6bb5\u532e\u4e4f\u7684\u73b0\u72b6[5\u20127]\u3002<\/p>\n

\u963f\u7ef4\u5df4\u5766\uff08\u539f\u540dAVE1330A\u6216NXL104\uff09\u662f\u4e00\u7c7b\u4e8c\u6c2e\u6742\u53cc\u73af\u8f9b\u70f7\uff08DBO\uff09\u03b2-\u5185\u9170\u80fa\u9176\u6291\u5236\u5242[8]\u3002\u8be5\u6291\u5236\u5242\u53ef\u4ee5\u5feb\u901f\u9170\u5316\u5404\u79cd\u03b2-\u5185\u9170\u80fa\u9176\uff0c\u540c\u65f6\u964d\u4f4e\u03b2-\u5185\u9170\u80fa\u9176\u7684\u6c34\u89e3\u80fd\u529b\u3002\u56e0\u6b64\uff0cCAZ-AVI\u5bf9\u4ea7Ambler A\u7c7b[\u8d85\u5e7f\u8c31\u03b2-\u5185\u9170\u80fa\u9176\uff08ESBL\uff09\u548c\u80ba\u708e\u514b\u96f7\u4f2f\u83cc\u8010\u78b3\u9752\u9709\u70ef\u9176\uff08KPC\uff09]\u3001C\u7c7b\uff08AmpC \u03b2-\u5185\u9170\u80fa\u9176\uff09\u53ca\u67d0\u4e9b\u7c7bD\u7c7b[\u82ef\u5511\u897f\u6797\u9176\uff08OXA-48\uff09] \u03b2-\u5185\u9170\u80fa\u9176\u7684\u83cc\u682a\u5177\u6709\u6291\u5236\u80fd\u529b\uff0c\u4f46\u662f\u5bf9\u4ea7B\u7c7b\u91d1\u5c5e\u5185\u9170\u80fa\u9176\uff08MBL\uff09[\u65b0\u5fb7\u91cc\u91d1\u5c5e\u03b2-\u5185\u9170\u80fa\u9176\uff08NDM\uff09\u3001\u7ef4\u7f57\u7eb3\u6574\u5408\u5b50\u7f16\u7801\u7684\u91d1\u5c5e\u03b2-\u5185\u9170\u80fa\u9176\uff08VIM\uff09\u3001\u4e9a\u80fa\u57f9\u5357\u7ec6\u83cc\u91d1\u5c5e\u03b2-\u5185\u9170\u80fa\u9176\uff08IMP\uff09]\u7684\u83cc\u682a\u65e0\u6548[9]\u3002<\/p>\n

\u7136\u800c\uff0c\u4f7f\u7528\u6297\u83cc\u836f\u7269\u7684\u4e00\u4e2a\u6f5c\u5728\u5371\u9669\u662f\u7ec6\u83cc\u7684\u8010\u836f\u6027\u3002\u81eaCAZ-AVI\u5f00\u59cb\u5e94\u7528\u4e8e\u4e34\u5e8a\uff0c\u5168\u7403\u8303\u56f4\u5185\u5df2\u9646\u7eed\u6709\u4e0e\u8010\u836f\u83cc\u682a\u4ea7\u751f\u76f8\u5173\u7684\u62a5\u9053[10\u201214]\u3002\u56e0\u6b64\uff0c\u8feb\u5207\u9700\u8981\u4e86\u89e3\u77ed\u65f6\u95f4\u5185\u83cc\u682a\u4ea7\u751fCAZ-AVI\u8010\u836f\u6027\u7684\u9057\u4f20\u673a\u5236\u3002\u672c\u6587\u7cfb\u7edf\u56de\u987e\u4e86CAZ-AVI\u7684\u6d41\u884c\u75c5\u5b66\u3001\u8010\u836f\u673a\u5236\u53ca\u5176\u4e34\u5e8a\u5e94\u7528\uff0c\u5e76\u8ba8\u8bba\u4e86\u5e94\u5bf9CAZ-AVI\u8010\u836fGNB\u611f\u67d3\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u4ee5\u4fbf\u7814\u7a76\u65b0\u7b56\u7565\u3001\u5e94\u5bf9\u65b0\u95ee\u9898\u3002<\/p>\n

2\u3001 \u5df2\u6279\u51c6\u7528\u4e8e\u4e34\u5e8a\u7684\u963f\u7ef4\u5df4\u5766\u53ca\u5176\u4ed6\u03b2-\u5185\u9170\u80fa\u9176\u6291\u5236\u5242\u7684\u7279\u6027<\/p>\n

\u8fc4\u4eca\u5171\u67096\u79cd\u03b2-\u5185\u9170\u80fa\u9176\u6291\u5236\u5242\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u4e34\u5e8a\u3002\u8212\u5df4\u5766\u548c\u4ed6\u5511\u5df4\u5766\u5c5e\u4e8e\u9752\u9709\u70f7\u781c\u7c7b\uff0c\u514b\u62c9\u7ef4\u9178\u662f\u6c27\u6c2e\u53cc\u73af\u5e9a\u916e\u3002\u8fd9\u4e09\u79cd\u6291\u5236\u5242\u5177\u6709\u201c\u81ea\u6740\u201d\uff08suicide\uff09\u5931\u6d3b\u7684\u4f5c\u7528\uff0c\u5229\u7528\u4fdd\u5b88\u7684\u6d3b\u6027\u6b8b\u57fa\u4e0e\u5176\u9776\u4f4d\u76f8\u4e92\u4f5c\u7528\uff0c\u5bfc\u81f4\u9776\u5411\u03b2-\u5185\u9170\u80fa\u9176\u7684\u4e0d\u53ef\u9006\u5931\u6d3b\u3002\u8fd9\u4e9b\u6291\u5236\u5242\u7684\u4f7f\u7528\u8303\u56f4\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4ec5\u9650\u4e8e\u4e00\u4e9bA\u7c7b\u4e1d\u6c28\u9178\u03b2-\u5185\u9170\u80fa\u9176\uff0c\u5982TEM-1 [15]\u3002\u6700\u8fd1\u88ab\u6279\u51c6\u7684\u5176\u4ed6\u4e09\u79cd\u6291\u5236\u5242\u662fDBO\uff08\u963f\u7ef4\u5df4\u5766\u548c\u745e\u6765\u5df4\u5766\uff09[16\u201217]\u548c\u787c\u9178\uff08\u6cd5\u787c\u5df4\u5766\uff09[18]\u3002\u4e0e\u201c\u81ea\u6740\u201d\u5931\u6d3b\u7684\u4f5c\u7528\u673a\u7406\u4e0d\u540c\uff0c\u540e\u4e09\u79cd\u6291\u5236\u5242\u4f5c\u4e3a\u7ade\u4e89\u6027\u6291\u5236\u5242\uff0c\u4ee5\u7f13\u6162\u53ef\u9006\u7684\u5171\u4ef7\u7ed3\u5408\u65b9\u5f0f\u4e0e\u76ee\u6807\u03b2-\u5185\u9170\u80fa\u9176\u7ed3\u5408\uff0c\u56e0\u6b64\u53ef\u4ee5\u91cd\u65b0\u751f\u6210\u6709\u6d3b\u6027\u7684\u03b2-\u5185\u9170\u80fa\u9176\u4ee5\u53ca\u90e8\u5206\u6291\u5236\u5242[16,19]\u3002\u867d\u7136\u6cd5\u787c\u5df4\u5766\u6700\u521d\u88ab\u7528\u4e8e\u6291\u5236KPC\uff0c\u4f46\u5b83\u4e5f\u53ef\u5bf9\u5176\u4ed6A\u7c7b\u3001C\u7c7b\u03b2-\u5185\u9170\u80fa\u9176\u7684\u6d3b\u6027\u8d77\u5230\u6291\u5236\u4f5c\u7528[19]\u3002\u4e0d\u8fc7\uff0c\u7f8e\u7f57\u57f9\u5357-\u6cd5\u787c\u5df4\u5766\u5bf9\u7f3a\u4e4f\u5b54\u86cb\u767d\u6216\u8fc7\u8868\u8fbe\u836f\u7269\u5916\u6392\u6cf5\u7684\u83cc\u682a\u7684\u6291\u5236\u80fd\u529b\u6bd4\u8f83\u4f4e[18]\u3002FDA\u57282019\u5e74\u6279\u51c6\u745e\u6765\u5df4\u5766\u4e0e\u4e9a\u80fa\u57f9\u5357\u3001\u897f\u53f8\u4ed6\u4e01\u53ef\u8054\u5408\u4f7f\u7528\u3002\u4e9a\u80fa\u57f9\u5357-\u745e\u6765\u5df4\u5766\u5bf9\u4ea7KPC\u548cC\u7c7b\u03b2-\u5185\u9170\u80fa\u9176\u7684\u78b3\u9752\u9709\u70ef\u8010\u836f\u80a0\u6746\u83cc\u79d1\u7ec6\u83cc\uff08CRE\uff09\u548c\u94dc\u7eff\u5047\u5355\u80de\u83cc\uff08CRPA\uff09\u8d77\u4f5c\u7528\u3002\u4e9a\u80fa\u57f9\u5357-\u745e\u6765\u5df4\u5766\u5bf9\u7f3a\u4e4f\u5b54\u86cb\u767d\u7684\u78b3\u9752\u9709\u70ef\u8010\u836f\u83cc\uff0c\u5982OprD\u5931\u6d3b\u7684\u94dc\u7eff\u5047\u5355\u80de\u83cc\u548c\u5916\u819c\u86cb\u767dOmpF\/OmpK35\u5931\u6d3b\u7684CRE\u5177\u6709\u826f\u597d\u7684\u6291\u5236\u80fd\u529b[17,20]\u3002\u6cd5\u787c\u5df4\u5766\u548c\u745e\u6765\u5df4\u5766\u90fd\u4e0d\u80fd\u6291\u5236B\u7c7b\u3001D\u7c7b\u03b2-\u5185\u9170\u80fa\u9176\u3002<\/p>\n

\u5728\u5934\u5b62\u4ed6\u5576\u4e2d\u52a0\u5165\u963f\u7ef4\u5df4\u5766\u53ef\u4ee5\u6062\u590d\u5176\u6291\u5236\u4ea7\u591a\u79cdA\u7c7b\u548cC\u7c7b\u03b2-\u5185\u9170\u80fa\u9176\u7684\u80a0\u6746\u83cc\u79d1\u548c\u94dc\u7eff\u5047\u5355\u80de\u83cc\u7684\u6d3b\u6027[8,21]\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5728\u5df2\u6279\u51c6\u4f7f\u7528\u7684\u6291\u5236\u5242\u4e2d\uff0c\u963f\u7ef4\u5df4\u5766\u662f\u552f\u4e00\u4e00\u4e2a\u53ef\u4ee5\u5e2e\u52a9\u5934\u5b62\u4ed6\u5576\u6291\u5236D\u7c7b\u03b2-\u5185\u9170\u80fa\u9176\uff08\u5982OXA-48\uff09\u7684\u836f\u7269\u3002\u4f53\u5916\u7814\u7a76\u8868\u660e\uff0c\u963f\u7ef4\u5df4\u5766\u5bf9\u03b2-\u5185\u9170\u80fa\u9176\u6709\u8f83\u9ad8\u7684\u6291\u5236\u4f5c\u7528\uff0c\u4e00\u822c1~5\u4e2a\u963f\u7ef4\u5df4\u5766\u5206\u5b50\u8db3\u4ee5\u6291\u5236\u4e00\u4e2a\u03b2-\u5185\u9170\u80fa\u9176\u5206\u5b50\u7684\u6d3b\u6027\uff0c\u800c\u4ed6\u5511\u5df4\u5766\u5206\u5b50\u548c\u514b\u62c9\u7ef4\u9178\u5206\u5b50\u5219\u9700\u8981\u8fbe\u523055~214\u4e2a[8]\u3002\u6b64\u5916\uff0cKPC-2\u4e0e\u963f\u7ef4\u5df4\u5766\u7684\u53cd\u5e94\u662f\u4e0d\u53ef\u9006\u7684\uff0c\u5b83\u4eec\u7684\u7ed3\u5408\u4f1a\u5f62\u6210\u03b2-\u5185\u9170\u80fa\/\u03b2-\u5185\u9170\u80fa\u9176\u6291\u5236\u5242\u590d\u5408\u7269\uff0c\u4ece\u800c\u5bfc\u81f4\u963f\u7ef4\u5df4\u5766\u7684\u6c34\u89e3\u548c\u6e38\u79bbKPC-2\u7684\u518d\u751f[22]\u3002\u4e0e\u5176\u4ed6\u5df2\u6279\u51c6\u7684\u6291\u5236\u5242\u76f8\u6bd4\uff0c\u963f\u7ef4\u5df4\u5766\u5177\u6709\u9ad8\u6548\u6291\u5236\u03b2-\u5185\u9170\u80fa\u9176\u7279\u522b\u662fOXA-48\u578b\u78b3\u9752\u9709\u70ef\u9176\u7684\u4f18\u70b9\u3002<\/p>\n

3\u3001 \u5934\u5b62\u4ed6\u5576-\u963f\u7ef4\u5df4\u5766\u7684\u4e34\u5e8a\u5e94\u7528<\/p>\n

CAZ-AVI\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u80be\u76c2\u80be\u708e\u5728\u5185\u7684\u590d\u6742\u7684\u5c3f\u8def\u611f\u67d3\uff08cUTI\uff09\u3001\u590d\u6742\u8179\u8154\u5185\u611f\u67d3\uff08cIAI\uff09\uff0c\u4ee5\u53ca\u5305\u62ec\u547c\u5438\u673a\u76f8\u5173\u80ba\u708e\uff08VAP\uff09\u5728\u5185\u7684\u533b\u9662\u83b7\u5f97\u6027\u80ba\u708e\uff08HAP\uff09[23\u201224]\u3002\u8be5\u590d\u5408\u7269\u5728\u6b27\u6d32\u4e5f\u88ab\u7528\u4e8e\u6cbb\u7597\u7531\u6cbb\u7597\u65b9\u6848\u6709\u9650\u7684\u9700\u6c27\u578bGNB\u5f15\u8d77\u7684\u6210\u5e74\u60a3\u8005\u611f\u67d3[24]\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8be5\u836f\u7269\u5df2\u83b7\u5f97\u5168\u740340\u591a\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u7684\u6279\u51c6\uff0c\u4e2d\u56fd\u4e8e2019\u5e745\u6708\u6279\u51c6\u4f7f\u7528\u8be5\u836f\u7269\u3002CAZ-AVI\u5bf9\u5065\u5eb7\u4eba\u7fa4\u548c\u533b\u9662\u60a3\u8005\uff08\u513f\u7ae5\u548c\u6210\u4eba\uff09\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u5927\u90e8\u5206\u526f\u4f5c\u7528\u7684\u5f3a\u5ea6\u4e3a\u8f7b\u5fae\u6216\u8005\u4e2d\u5ea6[25\u201226]\u3002\u636e\u62a5\u9053\uff0c\u5728\u7531\u5bf9\u78b3\u9752\u9709\u70ef\u4ea7\u751f\u8010\u836f\u6027\u7684\u80ba\u708e\u514b\u96f7\u4f2f\u83cc\uff08CRKP\uff09\u5f15\u8d77\u7684\u611f\u67d3\u4e2d\uff0c\u4e0e\u5176\u4ed6\u836f\u7269\u76f8\u6bd4\uff0c\u4f7f\u7528CAZ-AVI\u4e34\u5e8a\u6cbb\u7597\u7684\u6210\u529f\u7387\u548c\u5b58\u6d3b\u7387\u5747\u6709\u663e\u8457\u63d0\u9ad8[5]\u3002\u7814\u7a76\u8868\u660e\uff0c\u4f7f\u7528CAZ-AVI\u6216\u591a\u9ecf\u83cc\u7d20\u6cbb\u7597CRE\u611f\u67d3\u7684\u60a3\u8005\uff0c30\u5929\u6b7b\u4ea1\u7387\u5206\u522b\u4e3a9%\u548c32% [6]\uff0c\u8bf4\u660eCAZ-AVI\u6bd4\u591a\u9ecf\u83cc\u7d20\u66f4\u5177\u4f18\u52bf[5]\u3002\u6b64\u5916\uff0c\u63a5\u53d7CAZ-AVI\u6cbb\u7597\u7684\u60a3\u8005\u6bd4\u63a5\u53d7\u6c28\u57fa\u7cd6\u82f7\u7c7b\u8054\u5408\u7528\u836f\u6216\u591a\u9ecf\u83cc\u7d20\u8054\u5408\u7528\u836f\u7684\u5176\u4ed6\u60a3\u8005\u53d1\u751f\u6025\u6027\u80be\u8870\u7aed\u7684\u6982\u7387\u66f4\u4f4e\u3002\u8fd9\u4e9b\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u8bf4\u660e\uff0c\u5728\u7531\u78b3\u9752\u9709\u70ef\u8010\u836f\u83cc\u5f15\u8d77\u7684\u611f\u67d3\u4e2d\uff0cCAZ-AVI\u53ef\u4ee5\u4f5c\u4e3a\u201c\u6700\u540e\u4e00\u7ebf\u201d\u836f\u7269\u7684\u4e00\u4e9b\u6f5c\u5728\u66ff\u4ee3\u54c1\u3002\u622a\u6b62\u52302020\u5e744\u6708\uff0c\u5171\u5f00\u5c5521\u9879\u4e34\u5e8a\u7814\u7a76\u4ee5\u8bc4\u4f30CAZ-AVI\u7684\u836f\u6548\uff0c\u5176\u4e2d\u5305\u62ec\u4e00\u9879IV\u671f\u30016\u9879III\u671f\u30015\u9879II\u671f\u548c9\u9879I\u671f\u7684\u7814\u7a76\uff08\u89c1\u9644\u5f55A\u4e2d\u7684\u8868S1\uff09\u3002<\/p>\n

4\u3001 \u5934\u5b62\u4ed6\u5576-\u963f\u7ef4\u5df4\u5766\u7684\u8010\u836f\u6027\u673a\u5236<\/p>\n

4.1 \u5934\u5b62\u4ed6\u5576-\u963f\u7ef4\u5df4\u5766\u66b4\u9732\u8bf1\u5bfc\u7684\u8010\u836f\u6027<\/p>\n

\u4f53\u5916\u548c\u4e34\u5e8a\u7814\u7a76\u5747\u62a5\u9053\u4e86\u83cc\u682a\u5bf9CAZ-AVI\u7684\u8010\u836f\u6027\u3002\u7b49\u8fdb\u884c\u4e86\u4e00\u9879\u4f53\u5916\u7814\u7a76\uff0c\u9884\u6d4b\u5bf9CAZ-AVI\u654f\u611f\u7684\u4ea7KPC-3\u7684\u9634\u6c9f\u80a0\u6746\u83cc\u548c\u80ba\u708e\u514b\u96f7\u4f2f\u83cc\u4e34\u5e8a\u83cc\u682a\u7684\u8010\u836f\u6027\u76f8\u5173\u7a81\u53d8\u3002\u4ed6\u4eec\u53d1\u73b0\u5728\u9ad8\u8fbe16\u500d\u6700\u5c0f\u6291\u83cc\u6d53\u5ea6\uff08MIC\uff09\u4e0b\uff0cCAZ-AVI\u8010\u836f\u83cc\u7684\u4ea7\u751f\u9891\u7387\u7ea6\u4e3a1 \u00d7 10-9<\/sup>\u3002\u9996\u4f8b\u5bf9CAZ-AVI\u4ea7\u751f\u8010\u836f\u6027\u7684\u83cc\u79cd\u662f\u4e00\u682a\u4ea7KPC\u7684\u80ba\u708e\u514b\u96f7\u4f2f\u83cc\uff08KPC-Kp\uff09\uff0c\u643a\u5e26\u8fd9\u682a\u83cc\u79cd\u7684\u60a3\u8005\u5728\u7528CAZ-AVI\u6cbb\u7597\u4e4b\u524d\u6ca1\u6709\u8be5\u836f\u7269\u7684\u66b4\u9732\u53f2[10]\u3002\u968f\u540e\uff0c\u5168\u7403\u591a\u5730\u51fa\u73b0\u4e86\u6709\u5173CAZ-AVI\u8010\u836f\u7684\u62a5\u9053[11\u201214]\u3002CAZ-AVI\u7684\u8010\u836f\u673a\u5236\u89c1\u88681 [11\u201213,28\u201244]\u548c\u9644\u5f55A\u4e2d\u7684\u8868S2\u3002CAZ-AVI\u8010\u836f\u673a\u5236\u590d\u6742\uff0c\u53ef\u80fd\u5728\u5355\u4e2a\u7ec6\u83cc\u4e2d\u540c\u65f6\u7531\u591a\u79cd\u673a\u5236\u4ecb\u5bfc\uff08\u56fe1\uff09\u3002\u4e0b\u9762\u5c06\u5bf9\u8fd9\u4e9b\u673a\u5236\u8fdb\u884c\u8be6\u7ec6\u4ecb\u7ecd\u3002<\/p>\n

\u300a\u88681\u300b<\/p>\n

\u88681 \u4eba\u4f53\u5185\u7684CAZ-AVI\u8010\u836f\u673a\u5236<\/p>\n

Protein nameResistance mechanismYearLocationCountrySpeciesReferenceKPC-8<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6458\u8981 \u7ec6\u83cc\u7684\u78b3\u9752\u9709\u70ef\u8010\u836f\u6027\u662f\u5168\u7403\u516c\u5171\u5065\u5eb7\u9762\u4e34\u7684\u4e00\u4e2a\u91cd\u5927\u6311\u6218\uff0c\u7531\u78b3\u9752\u9709\u70ef\u8010\u836f\u83cc\uff08C … \u7ee7\u7eed\u9605\u8bfb →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-28512","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/28512","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=28512"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/28512\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=28512"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=28512"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=28512"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}