\u7f16\u8005\u6309<\/p>\n<\/p>\n
\u8fd1\u65e5\uff0c\u5728\u7ed3\u76f4\u80a0\u529f\u80fd\u91cd\u5efa\u8d28\u91cf\u63a7\u5236\u4e0e\u521b\u65b0\u8bba\u575b\u4e0a\uff0c\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u674e\u6e05\u56fd\u6559\u6388\u505a\u4e86\u9898\u4e3a\u201c\u91cd\u89c6\u76f4\u80a0\u764c\u524d\u5207\u7efc\u5408\u5f81\u7684\u8bca\u6cbb\u201d\u7684\u62a5\u544a\u3002\u300a\u80bf\u7624\u77ad\u671b-\u6d88\u5316\u65f6\u8baf\u300b\u73b0\u5c06\u62a5\u544a\u5185\u5bb9\u6574\u7406\u5982\u4e0b\uff0c\u4ee5\u98e8\u8bfb\u8005\u3002<\/p>\n<\/p>\n
\u4e00\u3001LARS\u7684\u5b9a\u4e49\u4e0e\u8bca\u65ad<\/p>\n
\u76f4\u80a0\u764c\u662f\u6211\u56fd\u5e38\u89c1\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\uff0c\u968f\u7740\u76f4\u80a0\u764c\u8bca\u7597\u6280\u672f\u7684\u53d1\u5c55\uff0c\u4f4e\u4f4d\u6216\u8d85\u4f4e\u4f4d\u4fdd\u809b\u5df2\u8d8a\u6765\u8d8a\u6210\u4e3a\u53ef\u80fd\uff0c\u6c38\u4e45\u6027\u9020\u53e3\u7684\u6bd4\u4f8b\u968f\u4e4b\u51cf\u5c11\uff0c\u60a3\u8005\u7684\u751f\u5b58\u65f6\u95f4\u5f97\u4ee5\u5ef6\u957f\uff0c\u4f46\u76f4\u80a0\u764c\u4f4e\u4f4d\u524d\u5207\u9664\u672f\u53ca\u8d85\u4f4e\u4f4d\u4fdd\u809b\u672f\u540e\uff0c\u7ea6\u670970%~90%\u7684\u60a3\u8005\u4f1a\u51fa\u73b0\u4e00\u7cfb\u5217\u4e0d\u540c\u7a0b\u5ea6\u7684\u6392\u4fbf\u76f8\u5173\u80a0\u9053\u529f\u80fd\u6539\u53d8\u7684\u75c7\u72b6\u7fa4\uff0c\u4e25\u91cd\u5f71\u54cd\u4e86\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\uff0c\u8fd9\u4e00\u7cfb\u5217\u75c7\u5019\u7fa4\u88ab\u79f0\u4e3a\u524d\u5207\u9664\u7efc\u5408\u5f81\uff08ARS\uff09\u6216\u4f4e\u4f4d\u524d\u5207\u9664\u7efc\u5408\u5f81\uff08LARS\uff09\u30022012\u5e74Lancet Oncol\u5c06LARS\u5b9a\u4e49\u4e3a\u201c\u76f4\u80a0\u4f4e\u524d\u5207\u9664\u672f\u540e\u80a0\u529f\u80fd\u7d0a\u4e71\uff0c\u5bfc\u81f4\u751f\u6d3b\u8d28\u91cf\u53d7\u635f\u201d\uff0c\u4f46\u56e0\u8be5\u5b9a\u4e49\u8f83\u4e3a\u5bbd\u6cdb\uff0c\u6ca1\u6709\u660e\u786e\u7684\u6807\u51c6\uff0c\u5bf9\u4e8e\u4e2a\u4f53\u75c7\u72b6\u5dee\u5f02\u5316\u660e\u663e\u7684LARS\u60a3\u8005\u5b9e\u7528\u6027\u4e0d\u5f3a\u3002\u56e0\u6b64\uff0c2020\u5e74LARS International Collaborative Group\u53d1\u8868\u5171\u8bc6\uff0c\u533a\u5206\u4e86LARS\u8bf8\u591a\u4e34\u5e8a\u8868\u73b0\u4e2d\u7684\u75c7\u72b6\u548c\u7ed3\u679c\uff0c\u91cd\u65b0\u5c06LARS\u5b9a\u4e49\u4e3a\u201c\u8fdb\u884c\u76f4\u80a0\u4f4e\u524d\u5207\u9664\u672f\u540e\uff0c\u60a3\u8005\u51fa\u73b0\u81f3\u5c11\u5177\u6709\u4e00\u79cd\u4e0a\u8ff0\u75c7\u72b6\u5e76\u5bfc\u81f4\u81f3\u5c11\u4e00\u79cd\u4e0a\u8ff0\u7ed3\u679c\uff0c\u5373\u75c7\u72b6\u548c\u7ed3\u679c\u95f4\u5b58\u5728\u56e0\u679c\u5173\u7cfb\u7684\u60a3\u8005\u624d\u80fd\u88ab\u8bca\u65ad\u4e3aLARS\u201d\u3002\u88681. \u75c7\u72b6<\/p>\n
\u88682. \u4f5c\u7528\/\u7ed3\u679c<\/p>\n<\/p>\n<\/p>\n
\u4e8c\u3001\u4f4e\u4f4d\u76f4\u80a0\u764c\u524d\u5207\u9664\u672f\u540e<\/p>\n
\u53d1\u751fLARS\u7684\u5371\u9669\u56e0\u7d20<\/p>\n
\u4f4e\u4f4d\u76f4\u80a0\u764c\u524d\u5207\u9664\u672f\u540eLARS\u662f\u4e0d\u540c\u75c5\u56e0\u548c\u75c5\u7406\u751f\u7406\u673a\u5236\u5bfc\u81f4\u7684\uff0c\u76ee\u524d\u8ba4\u4e3a\u4e0eLARS\u7684\u53d1\u751f\u5bc6\u5207\u76f8\u5173\u7684\u5371\u9669\u56e0\u7d20\u4e3b\u8981\u6709\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\uff1a\uff081\uff09\u543b\u5408\u53e3\u4f4d\u7f6e\u3002\u603b\u4f53\u800c\u8a00\u543b\u5408\u53e3\u4f4d\u7f6e\u8d8a\u4f4e\u51fa\u73b0LARS\u7684\u6982\u7387\u8d8a\u5927\uff0c\u4e0d\u540c\u6587\u732e\u62a5\u9053\u754c\u5b9a\u543b\u5408\u53e3\u8ddd\u809b\u95e8\u8ddd\u79bb\u548c\u4e25\u91cdLARS\u53d1\u751f\u7387\u7684\u5173\u7cfb\u6709\u5dee\u5f02\u3002\u4e00\u822c\u8ba4\u4e3a\u543b\u5408\u53e3\u8ddd\u809b\u95e8\uff1c5 cm\u60a3\u8005LARS\u53d1\u751f\u7387\u663e\u8457\u9ad8\u4e8e\u8ddd\u809b\u95e85\u2265 cm\u7684\u60a3\u8005\uff0c\u53d1\u751f\u6982\u7387\u76f8\u5dee5.3\u500d\u3002ISR\u5bf9\u6bd4TME\u624b\u672f\u540eLARS\u8bc4\u5206\u5927\u4e8e20\u5206\u5206\u522b\u4e3a73.2%\u548c58.4%\uff0cP=0.001\u3002\uff082\uff09\u65b0\u8f85\u52a9\u6cbb\u7597\u3002\u591a\u6570\u7814\u7a76\u8ba4\u4e3a\u653e\u7597\u4f1a\u5f71\u54cd\u76f4\u80a0\u809b\u95e8\u529f\u80fd\uff0c\u662fLARS\u53d1\u751f\u7684\u4e00\u4e2a\u72ec\u7acb\u5f71\u54cd\u56e0\u7d20\u3002\u5f53\u7136\u4e5f\u6709\u5b66\u8005\u8ba4\u4e3a\u653e\u7597\u867d\u7136\u4f1a\u589e\u52a0LARS\u53d1\u751f\u98ce\u9669\uff0c\u4f46\u5e76\u4e0d\u662f\u4e00\u4e2a\u72ec\u7acb\u7684\u5f71\u54cd\u56e0\u7d20\u3002\u800c\u65b0\u8f85\u52a9\u5316\u7597\u4e0d\u4f1a\u589e\u52a0LARS\u7684\u53d1\u751f\u6982\u7387\u3002\uff083\uff09\u9884\u9632\u6027\u672b\u7aef\u56de\u80a0\u9020\u53e3\u3002Meta\u5206\u6790\u663e\u793a\u9884\u9632\u6027\u672b\u7aef\u56de\u80a0\u9020\u53e3\u663e\u8457\u589e\u52a0\u4e25\u91cdLARS\u53d1\u751f\u98ce\u9669\uff08OR 2.84\uff0c95%CI\uff1a1.7~4.75\uff0cP<0.001\uff0c\u88683\uff09\u3002\uff084\uff09\u9884\u9632\u6027\u56de\u80a0\u9020\u53e3\u56de\u7eb3\u65f6\u95f4\u3002\u9884\u9632\u6027\u9020\u53e3\u56de\u7eb3\u65f6\u95f4\u8d85\u8fc712\u4e2a\u6708\uff0c\u4e25\u91cdLARS\u53d1\u751f\u7387\u589e\u52a03.7\u500d\u30026\u4e2a\u6708\u5185\u56de\u7eb3\u9020\u53e3\u662fLARS\u7684\u4e00\u4e2a\u4fdd\u62a4\u6027\u56e0\u7d20\uff08OR 0.2\uff0cP<0.01\uff09\u3002Meta\u5206\u6790\u63d0\u793a\u4e25\u91cdLARS\u60a3\u8005\u9020\u53e3\u56de\u7eb3\u65f6\u95f4\u663e\u8457\u957f\u4e8e\u65e0\u6216\u8f7b\u5ea6LARS\u76f4\u80a0\u764c\u60a3\u8005\uff08\u88684\uff09\u3002\uff085\uff09\u9664\u4e0a\u8ff0\u5f71\u54cd\u56e0\u7d20\u5916\uff0c\u76c6\u5e95\u53ca\u795e\u7ecf\u808c\u8089\u635f\u4f24\uff0c\u6d88\u5316\u9053\u91cd\u5efa\u540e\u987a\u5e94\u6027\u4e0b\u964d\u53ca\u5f02\u7269\u523a\u6fc0\u5982\u543b\u5408\u9489\u3001\u9501\u6263\u5939\u3001\u7f1d\u7ebf\u7b49\u90fd\u53ef\u80fd\u4f1a\u9020\u6210\u4f4e\u4f4d\u76f4\u80a0\u764c\u524d\u5207\u9664\u672f\u540eLARS\u7684\u53d1\u751f\u3002\u88683. \u9884\u9632\u6027\u56de\u80a0\u9020\u53e3\u4e0eLARS\u53d1\u751f\u7387<\/p>\n
\u88684. LARS\u4e0e\u975eLARS\u60a3\u8005\u9884\u9632\u6027\u56de\u80a0\u9020\u53e3\u56de\u7eb3\u65f6\u95f4\u5bf9\u6bd4<\/p>\n<\/p>\n<\/p>\n
\u4e09\u3001LARS\u7684\u8bc4\u4f30\u7cfb\u7edf<\/p>\n
LARS\u4f5c\u4e3a\u4e00\u7cfb\u5217\u4e3b\u89c2\u6027\u75c7\u72b6\u7fa4\uff0c\u7531\u60a3\u8005\u81ea\u8eab\u505a\u51fa\u7684\u8bc4\u4f30\u548c\u5206\u7ea7\u624d\u662f\u201c\u91d1\u6807\u51c6\u201d\u3002\u4e00\u65e6\u4e34\u5e8a\u786e\u8bcaLARS\uff0c\u901a\u5e38\u4f7f\u7528LARS\u8bc4\u5206\u6216MSKCC BFI\u8bc4\u5206\u548c\u81f3\u5c11\u4e00\u4e2a\u6d89\u53ca\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\u7684\u91cf\u8868\uff08EORTC-QLQ-C30\/QLQ-CR38\uff09\u5bf9\u60a3\u8005\u8fdb\u884c\u8bc4\u4f30\uff0c\u5982\u679c\u60a3\u8005\u51fa\u73b0\u6025\u8feb\u5931\u7981\u7c7b\u578b\u7684LARS\uff0c\u5219\u53ef\u4ee5\u4f7f\u7528\u8bc4\u5206\u7cfb\u7edf\u5982Wexner\u5931\u7981\u5206\u7ea7\u91cf\u8868\u548c\u7caa\u4fbf\u5931\u7981\u4e25\u91cd\u7a0b\u5ea6\u6307\u6570\u6765\u8865\u5145\u7279\u5f81\u75c7\u72b6\u7684\u8bc4\u4f30\u3002\u6b64\u5916\uff0c\u8003\u8651\u5230\u76f4\u80a0\u764c\u672f\u540e\u751f\u7406\u5b66\u6539\u53d8\uff0c\u809b\u7ba1\u76f4\u80a0\u6d4b\u538b\u3001\u808c\u7535\u56fe\u3001\u8d85\u58f0\u7b49\u4e5f\u6709\u4e00\u5b9a\u4ef7\u503c\u3002<\/p>\n
1. LARS\u8bc4\u5206<\/p>\n
LARS\u8bc4\u5206\u5305\u62ec5\u4e2a\u7b80\u5355\u95ee\u9898\uff0c\u5c06\u60a3\u8005\u5206\u4e3a\u201c\u65e0LARS\u201d\u3001\u201c\u8f7b\u5ea6LARS\u201d\u548c\u201c\u91cd\u5ea6LARS\u201d\u4e09\u7c7b\u3002\u5177\u6709\u7b80\u4fbf\u6613\u884c\u7684\u4f18\u52bf\uff0c\u56e0\u6b64\u53ef\u4ee5\u4f5c\u4e3aLARS\u7b5b\u67e5\u7684\u9996\u9009\u5de5\u5177\u3002\u4f46\u9700\u8981\u6307\u51fa\u7684\u662fLARS\u8bc4\u5206\u9ad8\u4e0d\u7b49\u540c\u4e8e\u60a3\u8005\u4e3b\u89c2\u611f\u53d7\u80a0\u9053\u529f\u80fd\u5f02\u5e38\u4e25\u91cd\uff0c\u5982\u6392\u4fbf\u5931\u7981\u88ab\u8ba4\u4e3a\u662fLARS\u6700\u5f71\u54cd\u751f\u6d3b\u8d28\u91cf\u7684\u75c7\u72b6\uff0c\u8fd8\u9700\u7ed3\u5408Wexner\u5931\u7981\u8bc4\u5206\u3002\u6b64\u5916\uff0c\u8be5\u8bc4\u5206\u4e0d\u5305\u62ec\u9488\u5bf9\u4e2a\u4eba\u751f\u6d3b\u8d28\u91cf\u6307\u6807\uff0c\u5e38\u5b58\u5728\u660e\u663e\u5e74\u9f84\u548c\u6027\u522b\u5dee\u5f02\u3002\u5e76\u4e14\u4f4e\u4f4d\u524d\u5207\u8fd8\u4f1a\u6709\u6027\u529f\u80fd\u969c\u788d\u3001\u6392\u5c3f\u529f\u80fd\u969c\u788d\u7b49\uff0c\u56e0\u6b64\u8fd8\u9700\u7ed3\u5408\u76f8\u5173\u751f\u6d3b\u8d28\u91cf\u8bc4\u5206\u3002<\/p>\n
2. MSKCC BFI\u8bc4\u5206<\/p>\n
MSKCC BFI\u8bc4\u5206\u5305\u62ec18\u4e2a\u9879\u76ee\uff0c\u6d89\u53ca\u5404\u79cd\u4e0eLARS\u76f8\u5173\u7684\u95ee\u9898\u3002\u76f8\u5bf9\u7efc\u5408\u8bc4\u5206\u800c\u8a00\uff0c\u8be5\u91cf\u8868\u66f4\u52a0\u5168\u9762\u4e14\u4e25\u8c28\u3002\u4f46\u8be5\u8bc4\u5206\u672a\u5bf9\u4e0d\u540c\u75c7\u72b6\u8bbe\u7f6e\u6743\u91cd\uff0c\u4e14\u8be5\u8bc4\u5206\u7cfb\u7edf\u975e\u5e38\u8017\u65f6\uff0c\u6240\u4ee5\u591a\u7528\u4e8e\u7814\u7a76\u76ee\u7684\u3002<\/p>\n
3. \u5927\u4fbf\u5931\u7981\u7684Wexner\u8bc4\u5206\u7cfb\u7edf<\/p>\n
\u8be5\u8bc4\u5206\u7cfb\u7edf\uff0c\u603b\u5206\u4e3a0\u8005\u8bf4\u660e\u809b\u95e8\u63a7\u5236\u529f\u80fd\u5b8c\u5168\u6b63\u5e38\uff1b\u603b\u5206\u226410\u5206\u8005\u5b9a\u4e49\u4e3a\u5927\u4fbf\u63a7\u5236\u529f\u80fd\u826f\u597d\uff1b\u603b\u5206>10\u5206\u8005\u5b9a\u4e49\u4e3a\u5b58\u5728\u5927\u4fbf\u63a7\u5236\u529f\u80fd\u5dee\uff1b\u603b\u5206\u4e3a20\u5206\u8005\u4e3a\u5b8c\u5168\u5931\u7981\u3002<\/p>\n<\/p>\n
\u56db\u3001LARS\u7684\u7efc\u5408\u6cbb\u7597<\/p>\n
\u5bf9\u4e8eLARS\u7684\u7efc\u5408\u6cbb\u7597\uff0c\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u56e2\u961f\u63d0\u51faLARS\u4e34\u5e8a\u89c4\u8303\u5316\u7ba1\u7406\u7684\u9010\u6b65\u5206\u7c7b\u6a21\u578b\uff08\u56fe1\uff09\uff0c\u6839\u636eLARS\u7684\u7c7b\u578b\uff0c\u9010\u6b65\u91c7\u7528\u4e00\u3001\u4e8c\u3001\u4e09\u7ebf\u5206\u9636\u6cbb\u7597\u3002<\/p>\n
\u56fe1. LARS\u4e34\u5e8a\u89c4\u8303\u5316\u7ba1\u7406\u7684\u9010\u6b65\u5206\u7c7b\u6a21\u578b\uff08Cancers 2023, 15, 5011\uff09<\/p>\n
1. \u81ea\u6211\u884c\u4e3a\u7ba1\u7406\u548c\u996e\u98df\u8c03\u6574<\/p>\n
\u867d\u7136\u76ee\u524d\u6ca1\u6709\u8bc1\u636e\u660e\u786e\u8fd9\u7c7b\u63aa\u65bd\u5728\u63a7\u5236\u75c7\u72b6\u65b9\u9762\u7684\u6709\u6548\u6027\uff0c\u4f46\u5176\u6ca1\u6709\u526f\u4f5c\u7528\u548c\u5e76\u53d1\u75c7\uff0c\u5e76\u4e14\u5176\u672c\u8eab\u5c31\u662f\u5e94\u8be5\u63d0\u5021\u7684\u5065\u5eb7\u751f\u6d3b\u65b9\u5f0f\u3002\u996e\u98df\u8c03\u6574\u4e3b\u8981\u662f\u589e\u52a0\u81b3\u98df\u7ea4\u7ef4\uff0c\u907f\u514d\u98df\u7528\u53ef\u80fd\u8f6f\u5316\u7caa\u4fbf\u7684\u98df\u7269\uff0c\u5982\u5496\u5561\u56e0\u3001\u67d1\u6a58\u3001\u8f9b\u8fa3\u98df\u7269\u548c\u9152\u7cbe\u3002\u6b64\u5916\u8fd8\u8981\u591a\u6ce8\u610f\u8865\u5145\u6c34\u5206\uff0c\u9002\u91cf\u589e\u52a0\u8fd0\u52a8\uff0c\u5982\u63d0\u809b\u8bad\u7ec3\u7b49\u3002<\/p>\n
2. \u836f\u7269\u6cbb\u7597<\/p>\n
\u836f\u7269\u6cbb\u7597\u662fLARS\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\uff0c\u5e38\u7528\u836f\u7269\u5305\u62ec\u6d1b\u54cc\u4e01\u80fa\u3001\u62c9\u83ab\u53f8\u743c\u3001\u963f\u6258\u54c1\u3001\u6d88\u65cb\u5c71\u83a8\u83ea\u78b1\u7b49\uff0c\u591a\u901a\u8fc7\u6291\u5236\u80a0\u9053\u5f02\u5e38\u9ad8\u9891\u8fd0\u52a8\u5bf9\u75c7\u6cbb\u7597\u6025\u8feb\u5931\u7981\u578bLARS\uff0c\u8fd9\u4e9b\u836f\u7269\u7684\u4e34\u5e8a\u6570\u636e\u5927\u591a\u6765\u6e90\u4e8e\u5176\u4ed6\u80c3\u80a0\u9053\u75be\u75c5\u5bf9\u6392\u4fbf\u5931\u7981\u7684\u6cbb\u7597\uff0c\u5982IBS\u3002\u6b64\u5916\uff0c\u4e5f\u6709\u5b66\u8005\u6307\u51faLARS\u53ef\u80fd\u662f\u80a0\u8154\u7ec6\u83cc\u73af\u5883\u7684\u6539\u53d8\u5f15\u8d77\u7684\uff0c\u4f46\u662f\u4e00\u9879\u524d\u77bb\u6027\uff0c\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\u63a2\u7d22\u4e86\u76ca\u751f\u5143\u8865\u5145\u5242\u5bf9\u76f4\u80a0\u764c\u524d\u5207\u9664\u672f\u540eARS\u7684\u5f71\u54cd\uff0c\u7ed3\u679c\u8bc1\u660e\u76ca\u751f\u83cc\u7684\u4f7f\u7528\u5e76\u672a\u6539\u53d8\u4e0eARS\u76f8\u5173\u7684\u672f\u540e\u80a0\u529f\u80fd\u3002<\/p>\n
\u6d1b\u54cc\u4e01\u80fa<\/p>\n
\u6d1b\u54cc\u4e01\u80fa\u662f\u4e00\u79cd\u03bc-\u963f\u7247\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u662fLARS\u6700\u5e38\u7528\u7684\u5904\u65b9\u836f\u3002\u901a\u8fc7\u6291\u5236\u80a0\u9053\u5e73\u6ed1\u808c\u7684\u6536\u7f29\uff0c\u51cf\u5c11\u80a0\u8815\u52a8\uff0c\u51cf\u5c11\u80a0\u58c1\u795e\u7ecf\u672b\u68a2\u91ca\u653e\u4e59\u9170\u80c6\u78b1\uff0c\u901a\u8fc7\u80c6\u78b1\u80fd\u548c\u975e\u80c6\u78b1\u80fd\u795e\u7ecf\u5143\u5c40\u90e8\u7684\u76f8\u4e92\u4f5c\u7528\u76f4\u63a5\u6291\u5236\u8815\u52a8\u53cd\u5c04\uff0c\u589e\u52a0\u809b\u95e8\u6269\u7ea6\u808c\u7684\u5f20\u529b\uff0c\u4ece\u800c\u6291\u5236\u5927\u4fbf\u5931\u7981\u548c\u4fbf\u6025\u3002\u5bf9\u6392\u4fbf\u9891\u7387\u589e\u52a0\u548c\u6392\u4fbf\u5931\u7981\u75c7\u72b6\u6700\u6709\u6548\uff0c\u53ef\u6709\u6548\u6539\u5584\u7caa\u4fbf\u9891\u7387\u3001\u51cf\u7f13\u80a0\u9053\u6536\u7f29\u548c\u4f20\u64ad\u3002\u4f46\u56e0\u5176\u4f1a\u5ef6\u957f\u98df\u7269\u5728\u5c0f\u80a0\u7684\u505c\u7559\u65f6\u95f4\uff0c\u4fc3\u8fdb\u6c34\u3001\u7535\u89e3\u8d28\u7b49\u5438\u6536\uff0c\u5bf9\u4e8e\u540c\u65f6\u5177\u6709\u6392\u7a7a\u969c\u788d\u578bLARS\u7684\u60a3\u8005\u5e94\u8c28\u614e\u4f7f\u7528\uff0c\u56e0\u4e3a\u53ef\u80fd\u52a0\u5267\u60a3\u8005\u7684\u4fbf\u79d8\u60c5\u51b5\u3002<\/p>\n
5-HT3\u62ee\u6297\u5242<\/p>\n
5-HT3\u62ee\u6297\u5242\u53ef\u4ee5\u51cf\u5c11\u4f4e\u4f4d\u524d\u5207\u672f\u540e\u4ee3\u76f4\u80a0\u7684\u8fc7\u5ea6\u8fd0\u52a8\uff0c\u5c24\u5176\u662f\u75c9\u631b\u6027\u6536\u7f29\u3002\u8fd9\u7c7b\u836f\u7269\u5728\u6cbb\u7597IBS\u6392\u4fbf\u5931\u7981\u4e2d\u6548\u679c\u8f83\u597d\uff0c\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u8bc1\u5b9e\u6b64\u7c7b\u836f\u7269\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u3002\u7814\u7a76\u8868\u660e\uff0c\u62c9\u83ab\u53f8\u743c\u53ef\u51cf\u5c11\u4e25\u91cdLARS\u60a3\u8005\u6bd4\u4f8b\uff0c\u6cbb\u75974\u5468\u540e\uff085 \u03bcg\/d\uff09\uff0cWexner\u5931\u7981\u8bc4\u5206\u3001\u6392\u4fbf\u6025\u8feb\u7a0b\u5ea6\u548c\u6bcf\u5929\u6392\u4fbf\u6b21\u6570\u5747\u6709\u660e\u663e\u6539\u5584\uff0c\u4e14\u4ec57%\u7684\u60a3\u8005\u62a5\u544a\u4e86\u6f5c\u5728\u526f\u4f5c\u7528\uff0c\u4e3b\u8981\u4e3a\u4fbf\u79d8\u6216\u6392\u4fbf\u56f0\u96be\u3002\u4f46\u76f8\u5173\u7814\u7a76\u591a\u7eb3\u5165\u7537\u6027\u60a3\u8005\uff0c\u62c9\u83ab\u53f8\u743c\u7597\u6cd5\u5bf9\u5973\u6027\u60a3\u8005\u7684\u5b89\u5168\u6027\u4e0e\u53ef\u884c\u6027\u4ecd\u9700\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002<\/p>\n
3. \u704c\u80a0<\/p>\n
\u673a\u68b0\u51b2\u6d17\u8fdc\u7aef\u7ed3\u76f4\u80a0\uff0c\u53ef\u5ef6\u8fdf\u76f4\u80a0\u6392\u7a7a\uff0c\u7528\u4e8e\u6539\u5584\u6392\u4fbf\u5931\u7981\u548c\u76f4\u80a0\u6392\u7a7a\u969c\u788d\u3002\u6b64\u65b9\u6cd5\u60a3\u8005\u7684\u4f9d\u4ece\u6027\u3001\u6ee1\u610f\u5ea6\u3001\u80a0\u529f\u80fd\u548c\u751f\u6d3b\u8d28\u91cf\u65b9\u9762\u5747\u6709\u660e\u663e\u6539\u5584\uff0c\u5b89\u5168\u6027\u9ad8\u3002\u8be5\u7597\u6cd5\u7684\u4f5c\u7528\u65f6\u95f4\u53ef\u957f\u8fbe\u4e00\u5929\u4ee5\u4e0a\u3002\u76ee\u524d\u7814\u7a76\u591a\u91c7\u75286\u4e2a\u6708\u7684\u7597\u7a0b\uff0c\u90e8\u5206LARS\u7ba1\u7406\u534f\u4f5c\u7ec4\u63a8\u8350\u5728\u672f\u540e30\u5929\u5c31\u91c7\u53d6TAI\uff0c\u800c\u53e6\u4e00\u4e9b\u5219\u5efa\u8bae\u7b49\u5f856\u4e2a\u6708\u540e\u518d\u8bc4\u4f30\u3002\u8f83\u591a\u4f7f\u7528TAI\u7684\u60a3\u8005\u4f1a\u57283~12\u4e2a\u6708\u4e4b\u95f4\u505c\u6b62\u6cbb\u7597\u3002\u521d\u59cb\u63a8\u8350500 ml\u6db2\u4f53\u704c\u80a0\uff0c200~300 ml\/min\u901f\u5ea6\uff0c\u540e\u7eed\u53ef\u9010\u6e10\u589e\u52a0\u52301 L\uff0c\u5177\u4f53\u56e0\u4eba\u800c\u5f02\u3002\u76ee\u524d\uff0c\u704c\u80a0\u7684\u5177\u4f53\u9891\u7387\u3001\u836f\u7269\u7528\u91cf\u53ca\u704c\u80a0\u505c\u6b62\u540e\u662f\u5426\u6709\u957f\u671f\u6539\u5584\u4f5c\u7528\u5747\u5c1a\u672a\u660e\u786e\u3002<\/p>\n
4. \u591a\u6a21\u5f0f\u76c6\u5e95\u5eb7\u590d\u8bad\u7ec3<\/p>\n
\u76c6\u5e95\u5eb7\u590d\uff08PFR\uff09\u8bad\u7ec3\u901a\u8fc7\u6062\u590d\u808c\u8089\u529b\u91cf\u3001\u9aa8\u76c6\u6536\u7f29\u7684\u534f\u8c03\u3001\u964d\u4f4e\u60a3\u8005\u611f\u77e5\u76f4\u80a0\u6269\u5f20\u7684\u9608\u503c\u7b49\u65b9\u5f0f\u6539\u5584\u4e00\u7ebf\u7ba1\u7406\u5931\u8d25\u60a3\u8005\u7684\u80a0\u529f\u80fd\uff0c\u5305\u62ec\u76c6\u5e95\u808c\u8089\u8bad\u7ec3\u3001\u751f\u7269\u53cd\u9988\u8bad\u7ec3\u548c\u76f4\u80a0\u7403\u56ca\u8bad\u7ec3\u3002\u591a\u9879\u7814\u7a76\u8ba4\u4e3a\u591a\u6a21\u5f0f\u76c6\u5e95\u5eb7\u590d\uff08\u5305\u62ec\u81f3\u5c11\u4e00\u79cd\u4ee5\u4e0aPFR\u6cbb\u7597\uff09\u80fd\u591f\u5bf9\u60a3\u8005\u7684\u5927\u4fbf\u9891\u7387\u3001\u5931\u7981\u53d1\u4f5c\u3001\u4ee5\u53ca\u751f\u6d3b\u8d28\u91cf\u6709\u663e\u8457\u6539\u5584\u3002<\/p>\n
5. \u795e\u7ecf\u7535\u523a\u6fc0<\/p>\n
\u795e\u7ecf\u7535\u523a\u6fc0\u5305\u62ec\u690d\u5165\u795e\u7ecf\u523a\u6fc0\u5982\u9ab6\u795e\u7ecf\u523a\u6fc0\u548c\u65e0\u521b\u795e\u7ecf\u523a\u6fc0\u5982\u80eb\u9aa8\u540e\u795e\u7ecf\u523a\u6fc0\u3001\u7ecf\u76ae\u80eb\u795e\u7ecf\u523a\u6fc0\u3002\u9ab6\u795e\u7ecf\u523a\u6fc0\u7684\u4f5c\u7528\u673a\u5236\u88ab\u8ba4\u4e3a\u53ef\u80fd\u662f\u76f4\u63a5\u4f5c\u7528\u4e8e\u809b\u95e8\u62ec\u7ea6\u808c\u7b49\u6548\u5e94\u5668\uff0c\u6539\u5584\u809b\u95e8\u7684\u81ea\u5236\u529f\u80fd\uff0c\u4f7f\u809b\u95e8\u7684\u5185\u5916\u62ec\u7ea6\u808c\u3001\u76c6\u5e95\u808c\u7684\u6536\u7f29\u8fd0\u52a8\u76f8\u534f\u8c03\u3002<\/p>\n
6. \u5173\u6ce8\u60a3\u8005\u5fc3\u7406\u60c5\u51b5<\/p>\n
\u9664\u4e86\u4e0a\u8ff0\u6cbb\u7597\u65b9\u5f0f\u4ee5\u5916\uff0c\u4e34\u5e8a\u533b\u751f\u8fd8\u5e94\u79ef\u6781\u501f\u52a9\u5404\u9879\u6807\u51c6\u5316\u95ee\u5377\uff0c\u5173\u6ce8\u60a3\u8005\u7684\u5fc3\u7406\u72b6\u51b5\uff0c\u5982\u53ef\u4ee5\u501f\u52a97\u9879\u5e7f\u6cdb\u6027\u7126\u8651\u969c\u788d\u91cf\u8868\uff08GAD-7\uff09\u3001\u60a3\u8005\u5065\u5eb7\u95ee\u5377\u6291\u90c1\u91cf\u8868\uff08PHQ-9\uff09\u3001\u5931\u7720\u4e25\u91cd\u6307\u6570\uff08ISI\uff09\u3001\u8ba4\u77e5\u529f\u80fd\u7f3a\u9677\u81ea\u8bc4\u91cf\u8868\uff08PDQ-5\uff09\u3001\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u751f\u5b58\u8d28\u91cf\u91cf\u8868\uff08EORTC QLQ-CR29\uff09\uff0c\u8bc4\u4f30\u60a3\u8005\u7684\u7126\u8651\u3001\u6291\u90c1\u3001\u7761\u7720\u3001\u8ba4\u77e5\u53ca\u751f\u6d3b\u8d28\u91cf\u3002\u9488\u5bf9LARS\uff0c\u76ee\u524d\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u4e5f\u6b63\u5728\u5f00\u5c55\u4e24\u9879\u524d\u77bb\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u5305\u62ec\u674e\u5fc3\u7fd4\u6559\u6388\u4e3aPI\u7684\u201c\u76ca\u751f\u5143\u8865\u5145\u5242\uff08NZFOS\uff09\u5bf9\u76f4\u80a0\u764c\u524d\u5207\u9664\u672f\u540eARS\u7684\u5f71\u54cd\uff1a\u4e00\u9879\u524d\u77bb\u6027\u3001\u968f\u673a\u3001\u5e73\u884c\u3001\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\u201d\u548c\u674e\u6e05\u56fd\/\u51af\u5a01\u6559\u6388\u5171\u540c\u53d1\u8d77\u7684\u201c\u4f4e\u4f4d\u76f4\u80a0\u5207\u9664\u540e\u7efc\u5408\u5f81\uff08LARS\uff09\u60a3\u8005\u7684\u5fc3\u7406\u72b6\u51b5\u8c03\u67e5\u201d\uff0c\u6211\u4eec\u4e5f\u671f\u5f85\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u80fd\u4e3aLARS\u7684\u4e34\u5e8a\u8bca\u6cbb\u63d0\u4f9b\u9ad8\u7ea7\u522b\u7684\u5faa\u8bc1\u533b\u5b66\u4f9d\u636e\u3002<\/p>\n<\/p>\n
\u4e13\u5bb6\u7b80\u4ecb<\/p>\n
\u674e\u6e05\u56fd<\/p>\n
\u80bf\u7624\u5916\u79d1\u535a\u58eb\uff0c\u526f\u4e3b\u4efb\u533b\u5e08\uff0c\u7855\u58eb\u7814\u7a76\u751f\u5bfc\u5e08<\/p>\n<\/p>\n
\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u5927\u80a0\u5916\u4e8c\u79d1 \u4e3b\u8bca\u7ec4\u957f<\/p>\n<\/li>\n
\u4e0a\u6d77\u5e02\u6297\u764c\u534f\u4f1a\u9752\u5e74\u7406\u4e8b<\/p>\n<\/li>\n
\u4e0a\u6d77\u5e02\u6297\u764c\u534f\u4f1a\u80c3\u80a0\u80bf\u7624\u8179\u8154\u955c\u4e13\u4e1a\u59d4\u5458\u4f1a\u59d4\u5458\u517c\u79d8\u4e66\u957f\u3001\u9752\u59d4\u4e3b\u59d4<\/p>\n<\/li>\n
\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u7ed3\u76f4\u80a0\u80bf\u7624\u4e13\u4e1a\u59d4\u5458\u4f1a\u9752\u5e74\u59d4\u5458<\/p>\n<\/li>\n
\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u809b\u80a0\u533b\u5e08\u5206\u4f1a\u5927\u80a0\u764c\u7efc\u5408\u6cbb\u7597\u4e13\u59d4\u4f1a\u59d4\u5458\u517c\u79d8\u4e66\u957f<\/p>\n<\/li>\n
\u4e2d\u56fd\u4e2d\u897f\u533b\u7ed3\u5408\u5b66\u4f1a\u666e\u901a\u5916\u79d1\u4e13\u4e1a\u59d4\u5458\u4f1a\u76f4\u80a0\u764c\u9632\u6cbb\u4e13\u5bb6\u59d4\u5458\u4f1a\u59d4\u5458\u517c\u79d8\u4e66<\/p>\n<\/li>\n
\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u80bf\u7624\u652f\u6301\u6cbb\u7597\u5916\u79d1\u4e13\u4e1a\u59d4\u5458\u4f1a\u59d4\u5458<\/p>\n<\/li>\n
\u4e2d\u56fd\u7814\u7a76\u578b\u533b\u9662\u534f\u4f1a\u80bf\u7624\u5b66\u4e13\u4e1a\u59d4\u5458\u4f1a\u59d4\u5458<\/p>\n<\/li>\n
\u4e2d\u534e\u6d88\u5316\u5916\u79d1\u83c1\u82f1\u835f\u59d4\u5458<\/p>\n<\/li>\n
\u4e2d\u56fd\u521d\u4fdd\u57fa\u91d1\u4f1a\u7ed3\u76f4\u80a0\u764c\u4e13\u4e1a\u59d4\u5458\u4f1a\u59d4\u5458<\/p>\n<\/li>\n
Annals of Translational Medicine\u7ed3\u76f4\u80a0\u764cSection editor<\/p>\n<\/li>\n
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\uff08\u4e0a\u4e0b\u6ed1\u52a8\u53ef\u67e5\u770b\uff09[1] BMC Surg,2018,18(1):35.[2] Eur J Surg Oncol,2018,44(7):1031-1039 [3] The Lancet Oncology, 2012, 13(9): e403-8.[4] Annals of surgery, 2019, 269(6): 1124-8.[5] Dis Colon Rectum. 2020;63(3):274-284[6] Indian J Surg 83, 1496\u20131501 (2021)[7] Int J Colorectal Dis 33, 787\u2013798 (2018).[8] Br J Surg 94:1278\u20131284[9] Ann Surg Oncol 20:1816\u20131828[10] Br J Surg 93:1519\u20131525?[11] Asian J Surg, 44(10):1260-1265.[12] Tech Coloproctol. 2021;25(7):751-76[13] Int J Colorectal Dis (2017) 32:691\u2013697[14] Colorectal Dis. 2021;23(2):461-475.[15] Curr Gastroenterol Rep. 2020;22(10):48.[16] Int J Colorectal Dis. 2018 Mar;33(3):251-260. [17] Dis Colon Rectum. 2019;62(9):1033-1042. [18] Colorectal Dis. 2001;3(2):95-9.[19] Dis Colon Rectum. 2015;58(10):983-93.[20] Clin Exp Gastroenterol. 2014;7:47-52.[21] Colorectal Dis. 2011;13(10):e335-8.[22] Tech Coloproctol. 2016;20(2):109-15.[23] \u4e2d\u534e\u7ed3\u76f4\u80a0\u75be\u75c5\u7535\u5b50\u6742\u5fd7. 2021, 10(03):250-254.[24] BJS open 2019, 3(4):461-465.[25] Ann Surg. 2021;274(6):e1223-e1229.[26] Techniques in Coloproctology (2020) 24:1247\u20131253[27] Neurourol Urodyn. 2015;34(8):703-12.<\/p>\n
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