\u75c5\u53f2\u4ecb\u7ecd<\/p>\n
40\u5c81\u5973\u6027\u60a3\u8005\uff0c1\u6708\u524d\u4f53\u68c0\u53d1\u73b0\u5de6\u4fa7\u9644\u4ef6\u5305\u5757\u3002<\/p>\n
\u5927\u4f53\u6240\u89c1<\/p>\n
\u5de6\u9644\u4ef6\u5207\u9664\u6807\u672c\uff0c\u5de6\u8f93\u5375\u7ba1\u4e0a\u9644\u7070\u767d\u5305\u5757\u4e00\u679a\uff0c\u4f53\u68c0\uff1a5cm\u00d72cm\u00d71.5cm\uff0c\u5207\u9762\u5448\u7ed3\u8282\u72b6\uff0c\u7070\u9ec4\u3001\u8d28\u4e2d\uff0c\u5c40\u90e8\u5448\u56ca\u6027\uff0c\u56ca\u5185\u5145\u9ec4\u8272\u6e05\u4eae\u6db2\u4f53\uff0c\u56ca\u5185\u58c1\u5149\u6ed1\uff0c\u56ca\u58c1\u539a\u7ea60.1cm\u3002<\/p>\n
\u56fe1A<\/p>\n
\u80bf\u7269\u5927\u4f53\u5982\u56fe\u6240\u793a\u3002<\/p>\n
\u5149\u955c\u6240\u89c1<\/p>\n
\u56fe2A<\/p>\n
\u5375\u5de2\u95f4\u8d28\u5185\u53ef\u89c1\u4e0a\u76ae\u6837\u7ec6\u80de\u5448\u4e0d\u89c4\u5219\u5de2\u56e2\u72b6\u5206\u5e03\uff0c\u4e0e\u5375\u5de2\u95f4\u8d28\u754c\u9650\u5206\u660e\u3002<\/p>\n
\u56fe2B<\/p>\n
\u90e8\u5206\u5de2\u56e2\u53ef\u89c1\u56ca\u6027\u53d8\uff0c\u56ca\u5185\u542b\u55dc\u9178\u6027\u5206\u6ccc\u7269\u3002<\/p>\n
\u56fe2C<\/p>\n
\u7ea4\u7ef4\u6027\u95f4\u8d28\uff0c\u5c40\u90e8\u4f34\u73bb\u7483\u6837\u53d8\u3002<\/p>\n
\u56fe2D<\/p>\n
\u56ca\u6027\u53d8\u533a\u57df\uff0c\u90e8\u5206\u56ca\u8154\u5185\u886c\u8986\u79fb\u884c\u4e0a\u76ae\uff0c\u90e8\u5206\u4e0a\u76ae\u9ecf\u6db2\u6027\u5316\u751f\u3002<\/p>\n
\u56fe2E<\/p>\n
\u9ad8\u500d\u955c\u4e0b\uff0c\u53ef\u89c1\u7ec6\u80de\u5f62\u6001\u6e29\u548c\uff0c\u80de\u6d46\u8f83\u4e30\u5bcc\uff0c\u6838\u5448\u5375\u5706\u5f62\uff0c\u4e2a\u522b\u7ec6\u80de\u53ef\u89c1\u7eb5\u884c\u6838\u6c9f\uff08\u5706\u5708\u6807\u6ce8\uff09\uff0c\u672a\u89c1\u6838\u5206\u88c2\u8c61\u3002<\/p>\n
\u514d\u75ab\u7ec4\u5316<\/p>\n
CK7\uff08 \uff09\uff0cGATA3\uff08 \uff09\uff0cP63\uff08 \uff09\uff0cS100P\uff08 \uff09\uff0cPAX8\uff08-\uff09\uff0cCK20\uff08-\uff09<\/p>\n
\u56fe3<\/p>\n
\u4e0d\u89c4\u5219\u7ec6\u80de\u5de2CK7\u9633\u6027\u8868\u8fbe<\/p>\n
\u56fe4<\/p>\n
\u4e0d\u89c4\u5219\u7ec6\u80de\u5de2GATA3\u9633\u6027\u8868\u8fbe<\/p>\n
\u56fe5<\/p>\n
\u4e0d\u89c4\u5219\u7ec6\u80de\u5de2P63\u9633\u6027\u8868\u8fbe<\/p>\n
\u56fe6<\/p>\n
\u4e0d\u89c4\u5219\u7ec6\u80de\u5de2S100P\u9633\u6027\u8868\u8fbe<\/p>\n
\u56fe7<\/p>\n
\u4e0d\u89c4\u5219\u4e0a\u76ae\u7ec6\u80de\u5de2\u4e0d\u8868\u8fbePAX8<\/p>\n
\u56fe8<\/p>\n
\u4e0d\u89c4\u5219\u4e0a\u76ae\u7ec6\u80de\u5de2CK20\u9634\u6027\u8868\u8fbe\u75c5\u7406\u8bca\u65ad\uff1a\u5375\u5de2\u826f\u6027Brenner\u7624\u3002<\/p>\n
\u8ba8\u8bba<\/p>\n
\u5375\u5de2Brenner\u7624\u662f\u4f4d\u4e8e\u81f4\u5bc6\u7ea4\u7ef4\u7624\u57fa\u8d28\u5185\uff0c\u7531\u6e29\u548c\u7684\u79fb\u884c\/\u5c3f\u8def\u4e0a\u76ae\u7ec6\u80de\u5de2\u7ec4\u6210\u7684\u80bf\u7624\u3002\u5176\u7ec4\u7ec7\u5b66\u8d77\u6e90\u5c1a\u672a\u660e\u786e\uff0c\u90e8\u5206\u5b66\u8005\u8ba4\u4e3a\u5176\u6765\u6e90\u4e8e\u5375\u5de2\u8868\u9762\u5177\u6709\u591a\u5411\u5206\u5316\u6f5c\u80fd\u7684\u751f\u53d1\u4e0a\u76ae\uff0c\u5927\u90e8\u5206\u5b66\u8005\u8ba4\u4e3a\u5176\u53ef\u80fd\u6765\u6e90\u4e8e\u8f93\u5375\u7ba1\u8179\u819c\u8fde\u63a5\u5904\u7684Walthard\u7ec6\u80de\u5de2\u3002Brenner\u7624\u53ef\u53d1\u751f\u4e8e\u4efb\u4f55\u5e74\u9f84\uff0c\u597d\u53d1\u5e74\u9f84\u4e3a40-60\u5c81\uff0c\u4ee5\u7edd\u7ecf\u540e\u5987\u5973\u5c45\u591a\uff0c\u7ea680%\u7684\u60a3\u8005\u5e74\u9f84\u8d8550\u5c81\u3002\u75c5\u53d8\u5927\u591a\u53d1\u751f\u4e8e\u5355\u4fa7\u5375\u5de2\uff0880%\uff09\uff0c\u4ee5\u5de6\u4fa7\u5375\u5de2\u591a\u89c1\uff0c\u5e74\u9f84\u8d8a\u5927\u6076\u6027\u53ef\u80fd\u8d8a\u5927\u3002\u5375\u5de2Brenner\u7624\u7684\u4e34\u5e8a\u75c7\u72b6\u4e0e\u5176\u4ed6\u4e0a\u76ae\u6027\u5375\u5de2\u80bf\u7624\u76f8\u4f3c\uff0c\u6700\u5e38\u89c1\u7684\u662f\u8179\u90e8\u80bf\u5757\u53ca\u8179\u80c0\uff0c\u5176\u6b21\u662f\u8179\u75db\u548c\u7edd\u7ecf\u540e\u9634\u9053\u51fa\u8840\uff0c\u800c\u90e8\u5206\u60a3\u8005\u65e0\u660e\u663e\u4e34\u5e8a\u75c7\u72b6\u3002\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\uff08World Health Organization\uff0cWHO\uff09\u6839\u636e\u589e\u6b96\u53ca\u4fb5\u88ad\u80fd\u529b\u5c06\u5176\u5206\u4e3a\u826f\u6027\u3001\u4ea4\u754c\u6027\u53ca\u6076\u60273\u79cd\u7c7b\u578b\uff0c\u6700\u5e38\u89c1\u7684\u4e3a\u826f\u6027\uff0c\u6076\u6027\u5360\u6bd4\u4e0d\u8d85\u8fc75%\u3002<\/p>\n
\u826f\u6027Brenner\u7624<\/p>\n
\u955c\u4e0b\uff0c\u5bc6\u96c6\u7684\u7ea4\u7ef4\u6837\u57fa\u8d28\u4e2d\u53ef\u89c1\u692d\u5706\u5f62\u81f3\u4e0d\u89c4\u5219\u7684\u79fb\u884c\/\u5c3f\u8def\u4e0a\u76ae\u7ec6\u80de\u5de2\u72b6\u5206\u5e03\u3002\u5de2\u4e2d\u592e\u5e38\u89c1\u5fae\u56ca\uff0c\u5bcc\u542b\u55dc\u9178\u6027\u6216\u9ecf\u6db2\u6027\u7269\u8d28\uff0c\u56ca\u5185\u58c1\u53ef\u886c\u8986\u79fb\u884c\u3001\u9ecf\u6db2\u6216\u7ea4\u6bdb\u4e0a\u76ae\u3002\u6838\u5206\u88c2\u8c61\u7f55\u89c1\u3002\u5e38\u89c1\u9ecf\u6db2\u6027\u5316\u751f\u3001\u5c40\u7076\u6027\u6216\u5e7f\u6cdb\u6027\u9499\u5316\uff0c\u95f4\u8d28\u53ef\u89c1\u73bb\u7483\u6837\u53d8\u3002\u7ec6\u80de\u5448\u5706\u5f62\u6216\u5375\u5706\u5f62\uff0c\u65e0\u660e\u663e\u5f02\u578b\u6027\uff0c\u5e38\u6709\u7eb5\u884c\u6838\u6c9f\uff0c\u53ef\u89c1\u5c0f\u6838\u4ec1\u3002<\/p>\n
\u4ea4\u754c\u6027Brenner\u7624<\/p>\n
\u955c\u4e0b\uff0c\u80bf\u7624\u7c7b\u4f3c\u4e8e\u4f4e\u7ea7\u522b\u4e73\u5934\u72b6\u5c3f\u8def\u4e0a\u76ae\u764c\uff0c\u4f46\u4e0a\u76ae\u7ec6\u80de\u589e\u6b96\u7a0b\u5ea6\u660e\u663e\u8d85\u8fc7\u826f\u6027Brenner\u7624\u3002\u7ec6\u80de\u5de2\u5927\u5c0f\u4e0d\u4e00\uff0c\u5c42\u6b21\u589e\u591a\uff0c\u7ec6\u80de\u8f7b\u5ea6\u5f02\u578b\u6027\uff0c\u65e0\u95f4\u8d28\u6d78\u6da6\u3002<\/p>\n
\u56fe9A<\/p>\n
\u4f4e\u500d\u955c\u4e0b\uff0c\u4ea4\u754c\u6027Brenner\u7624\u5448\u5185\u751f\u6027\u3001\u5e26\u72b6\u3001\u4e73\u5934\u72b6\u751f\u957f\u6a21\u5f0f\u3002\uff08\u56fe\u6e90\u4e8e\u53c2\u8003\u6587\u732e3\uff09<\/p>\n
\u56fe9B<\/p>\n
\u4e2d\u500d\u955c\u4e0b\uff0c\u4ea4\u754c\u6027Brenner\u7624\u7ec6\u80de\u5c42\u6b21\u589e\u591a\uff0c\u7ec6\u80de\u5448\u8f7b\u5ea6\u5f02\u578b\u6027\u3002\uff08\u56fe\u6e90\u4e8e\u53c2\u8003\u6587\u732e3\uff09<\/p>\n
\u6076\u6027Brenner\u7624<\/p>\n
\u955c\u4e0b\uff0c\u7ec6\u80de\u5448\u9ad8\u7ea7\u522b\u6838\u7279\u5f81\uff0c\u8868\u73b0\u4e3a\u7ec6\u80de\u6838\u589e\u5927\uff0c\u6709\u660e\u663e\u591a\u5f62\u6027\uff0c\u7ec6\u80de\u6838\u6df1\u67d3\uff0c\u67d3\u8272\u8d28\u5206\u5e03\u4e0d\u5747\uff0c\u51fa\u73b0\u75c5\u7406\u6027\u6838\u5206\u88c2\u8c61\u4e3a\u7279\u5f81\u3002\u8bc6\u522b\u95f4\u8d28\u6d78\u6da6\u662f\u8bca\u65ad\u7684\u5173\u952e\uff0c\u56e0\u4e3aBrenner\u7624\u4e3a\u7ea4\u7ef4\u4e0a\u76ae\u6027\u80bf\u7624\uff0c\u80cc\u666f\u4e3a\u81f4\u5bc6\u7684\u7ea4\u7ef4\u7624\u6837\u80cc\u666f\uff0c\u4e14\u80bf\u7624\u7ec6\u80de\u5de2\u5448\u4e0d\u89c4\u5219\u5f62\uff0c\u6613\u9020\u6210\u5047\u6d78\u6da6\u56fe\u50cf\u3002\u6076\u6027Brenner\u7624\u7684\u95f4\u8d28\u4e3a\u764c\u6027\u95f4\u8d28\uff0c\u6709\u4fc3\u7ed3\u7f14\u7ec4\u7ec7\u589e\u751f\u6027\u95f4\u8d28\u53cd\u5e94\uff0c\u4e0e\u5468\u56f4\u76f8\u5bf9\u6b63\u5e38\u7684\u95f4\u8d28\u6bd4\u8f83\uff0c\u5176\u7ea4\u7ef4\u7ed3\u7f14\u7ec4\u7ec7\u589e\u751f\u66f4\u663e\u8457\uff0c\u6392\u5217\u6742\u4e71\uff0c\u80bf\u7624\u7ec6\u80de\u5de2\u7834\u574f\u5468\u56f4\u95f4\u8d28\uff0c\u4f7f\u5176\u4e0d\u8fde\u7eed\uff0c\u80bf\u7624\u7ec6\u80de\u5de2\u5468\u56f4\u5e38\u6709\u7a7a\u767d\u95f4\u9699\u56f4\u7ed5\u3002\u6076\u6027Brenner\u7624\u90fd\u4f34\u6709\u826f\u6027\u6216\u4ea4\u754c\u6027Brenner\u7624\uff0c\u5982\u679c\u7f3a\u4e4f\u826f\u6027\u6216\u4ea4\u754c\u6027Brenner\u7624\u6210\u5206\uff0c\u5219\u66f4\u53ef\u80fd\u662f\u9ad8\u7ea7\u522b\u6d46\u6db2\u6027\u764c\u6216\u5b50\u5bab\u5185\u819c\u6837\u764c\u4f34\u79fb\u884c\u7ec6\u80de\u6837\u5206\u5316\u3002<\/p>\n
\u56fe10A<\/p>\n
\u4f4e\u500d\u955c\u4e0b\uff0c\u6076\u6027Brenner\u7624\u5448\u5b9e\u6027\u7247\u72b6\u3001\u4e73\u5934\u72b6\u751f\u957f\u3002\uff08\u56fe\u6e90\u4e8e\u53c2\u8003\u6587\u732e3\uff09<\/p>\n
\u56fe10B<\/p>\n
\u4e2d\u500d\u955c\u4e0b\uff0c\u7624\u7ec6\u80de\u5448\u5047\u817a\u6837\u6392\u5217\uff0c\u7ec6\u80de\u5f02\u578b\u6027\u663e\u8457\u3002\uff08\u56fe\u6e90\u4e8e\u53c2\u8003\u6587\u732e3\uff09\u6700\u65b0\u7814\u7a76\u8868\u660e\uff0c\u5728\u6076\u6027Brenner\u7624\u53d1\u75c5\u673a\u5236\u7684\u9057\u4f20\u6a21\u578b\u4e2d\uff0cCDKN2A\u7f3a\u5931\u548cPIK3CA\u7a81\u53d8\u53ef\u80fd\u53d1\u751f\u5728\u826f\u6027Brenner\u7624\u5411\u4ea4\u754c\u6027Brenner\u7624\u8f6c\u5316\u7684\u65e9\u671f\uff0c\u4f46\u5728\u4ea4\u754c\u6027Brenner\u7624\u9010\u6b65\u8fdb\u5c55\u4e3a\u6076\u6027Brenner\u7624\u7684\u8fc7\u7a0b\u4e2d\uff0c\u4e0e\u5c3f\u8def\u4e0a\u76ae\u764c\u7c7b\u4f3c\uff0c\u4e0eFGFR3\u6216MDM2\/P53\u57fa\u56e0\u6539\u53d8\u76f8\u5173\uff0c\u8868\u660e\u75be\u75c5\u7684\u665a\u671f\u8fdb\u5c55\u53ef\u6fc0\u6d3b\u4e24\u79cd\u4e0d\u540c\u7684\u4fe1\u53f7\u901a\u8def\uff08\u89c1\u56fe11\uff09\u3002<\/p>\n
\u56fe11<\/p>\n
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\u9274\u522b\u8bca\u65ad<\/p>\n
1\u3001\u6210\u5e74\u578b\u7c92\u5c42\u7ec6\u80de\u7624<\/p>\n
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2\u3001\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c<\/p>\n
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3\u3001\u9ad8\u7ea7\u522b\u6d46\u6db2\u6027\u764c\u548c\u5b50\u5bab\u5185\u819c\u6837\u764c<\/p>\n
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\u53c2\u8003\uff1a<\/p>\n
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1\u3001\u502a\u6d77\u6625,\u674e\u8389,\u8c22\u6c38\u8f89,\u7530\u9752\u9752,\u7ae0\u5b8f\u5cf0.\u5375\u5de2Brenner\u80bf\u7624\u7684\u4e34\u5e8a\u75c5\u7406\u5206\u6790[J].\u4e34\u5e8a\u4e0e\u75c5\u7406\u6742\u5fd7,2022,42(03):526-532.<\/p>\n
2\u3001\u4e07\u6843,\u4fde\u840d\u6e90,\u90a2\u4e49\u6d93,\u738b\u9ece,\u6768\u6c38\u79c0.\u5375\u5de2Brenner\u7624\u7814\u7a76\u8fdb\u5c55[J].\u56fd\u9645\u5987\u4ea7\u79d1\u5b66\u6742\u5fd7,2023,50(01):20-25.<\/p>\n
3\u3001Female Genital Tumours, WHO Classification of Tumours, 5th Edition.<\/p>\n
4\u3001Lin DI, Killian JK, Venstrom JM, Ramkissoon SH, Ross JS, Elvin JA. Recurrent urothelial carcinoma-like FGFR3 genomic alterations in malignant Brenner tumors of the ovary. Mod Pathol. 2021;34(5):983-993.<\/p>\n
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