{"id":27763,"date":"2024-03-26T10:00:43","date_gmt":"2024-03-26T10:00:43","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=27763"},"modified":"2024-03-26T10:00:43","modified_gmt":"2024-03-26T10:00:43","slug":"%e4%b8%80%e8%af%bb%e5%b0%b1%e6%87%82%e4%b8%80%e5%ad%a6%e5%b0%b1%e4%bc%9a%e7%9a%848-%e5%8d%95%e7%bb%86%e8%83%9e%e7%bb%93%e5%90%88bulk%e5%88%86%e6%9e%90%e6%80%9d%e8%b7%af%e4%bb%8b%e7%bb%8d","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=27763","title":{"rendered":"\u4e00\u8bfb\u5c31\u61c2\u4e00\u5b66\u5c31\u4f1a\u76848 \u5355\u7ec6\u80de\u7ed3\u5408bulk\u5206\u6790\u601d\u8def\u4ecb\u7ecd"},"content":{"rendered":"

May<\/p>\n

\u6982\u666e\u751f\u7269 2023<\/p>\n

NEW TOPIC<\/p>\n

\u661f\u6807\u201c\u751f\u4fe1\u4eba\u201d\u7cbe\u5f69\u4e0d\u9519\u8fc7<\/p>\n

\u5982\u4eca\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u5f00\u59cb\u5c06\u5355\u7ec6\u80de\u4e0e\u7ec4\u7ec7\u6d4b\u5e8f\u6570\u636e\u76f8\u7ed3\u5408\u8fdb\u884c\u5206\u6790\uff0c\u7ed3\u679c\u5f80\u5f80\u8d77\u5230\u4e00\u52a0\u4e00\u5927\u4e8e\u4e8c\u7684\u6548\u679c\u3002\u56e0\u6b64\u751f\u4fe1\u4eba\u4e5f\u4ecb\u7ecd\u4e86\u591a\u4e2a\u5355\u7ec6\u80de\u7ed3\u5408\u7ec4\u7ec7\u7684\u5206\u6790\u601d\u8def\u53ca\u6587\u7ae0\uff0c\u5c0f\u7f16\u4eca\u5929\u518d\u548c\u5927\u5bb6\u5206\u4eab\u4e00\u7bc7\u4eca\u5e742\u6708\u521a\u521a\u53d1\u8868\u5728Front. Immunol(IF\uff1a8.786) \u6742\u5fd7\u4e0a\u6574\u5408\u5355\u7ec6\u80de\u53ca\u7ec4\u7ec7\u6570\u636e\uff0c\u7814\u7a76\u9aa8\u8089\u7624\u5fae\u73af\u5883\u4e2d\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u7684\u6587\u7ae0\u3002\u8fd9\u7bc7\u6587\u7ae0\u65e0\u8bba\u662f\u7ec4\u7ec7\u6570\u636e\u8fd8\u662f\u5355\u7ec6\u80de\u6570\u636e\u7684\u5206\u6790\u65b9\u6cd5\u90fd\u975e\u5e38\u7ecf\u5178\u6613\u61c2\uff0c\u5bf9\u521a\u521a\u63a5\u89e6\u5355\u7ec6\u80de\u6216\u5bf9\u5355\u7ec6\u80de\u7ed3\u5408\u7ec4\u7ec7\u5206\u6790\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6765\u8bf4\u5341\u5206\u5177\u6709\u53c2\u8003\u610f\u4e49\u3002\u957f\u8bdd\u77ed\u8bf4\uff0c\u5c0f\u7f16\u63a5\u4e0b\u6765\u5c31\u5e26\u5927\u5bb6\u4e00\u7779\u4e3a\u5feb\u3002<\/p>\n

\u5355\u7ec6\u80de\u548c\u7ec4\u7ec7RNA\u6570\u636e\u96c6\u5206\u6790\u63ed\u793aC1Q <\/sup>\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u662f\u9aa8\u8089\u7624\u4e2d\u4e3b\u8981\u7684\u6297\u764c\u514d\u75ab\u7ec6\u80de<\/p>\n

01<\/p>\n

\u7814\u7a76\u80cc\u666f<\/p>\n

Part One<\/p>\n

\u9aa8\u8089\u7624(OS)\u662f\u6700\u5e38\u89c1\u7684\u539f\u53d1\u6027\u9aa8\u80bf\u7624\uff0c\u591a\u53d1\u751f\u5728\u513f\u7ae5\u3001\u9752\u5c11\u5e74\u548c\u5e74\u8f7b\u6210\u4eba\u4e2d\uff0c\u4e14\u60a3\u8005\u5f80\u5f80\u5177\u6709\u6781\u5dee\u7684\u9884\u540e\u3002\u7531\u4e8e\u5148\u524d\u7814\u7a76\u5df2\u7ecf\u53d1\u73b0\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u5bf9OS\u7684\u9884\u540e\u6709\u91cd\u8981\u5f71\u54cd\uff0c\u56e0\u6b64\u8fd9\u7bc7\u6587\u7ae0\u5c31\u6574\u5408\u4e86\u5355\u7ec6\u80de\u548c\u7ec4\u7ec7\u6570\u636e\uff0c\u5bf9OS\u4e2d\u4e3b\u8981\u7684\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u53ca\u5176\u7279\u5f81\u8fdb\u884c\u4e86\u5168\u9762\u8be6\u7ec6\u7684\u5206\u6790\u3002<\/p>\n

02<\/p>\n

\u6587\u7ae0\u6458\u8981<\/p>\n

Part Two<\/p>\n

\u7814\u7a76\u6536\u96c6\u4e86\u6765\u81ea\u516c\u5171\u6570\u636e\u5e93\u7684OS\u5355\u7ec6\u80de\u53ca\u7ec4\u7ec7\u6d4b\u5e8f\u6570\u636e\uff0c\u4f5c\u8005\u9996\u5148\u5728\u7ec4\u7ec7\u6570\u636e\u96c6\u4e2d\u6839\u636e\u514d\u75ab\u6d78\u6da6\u6c34\u5e73\u5bf9\u6837\u672c\u8fdb\u884c\u4e86\u5206\u7ec4\u5e76\u8bc6\u522b\u4e86\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\uff0c\u63a5\u7740\u5728\u5355\u7ec6\u80de\u6570\u636e\u96c6\u4e2d\u5c06\u8fd9\u4e9b\u57fa\u56e0\u5b9a\u4f4d\u5230\u5fae\u73af\u5883\u4e2d\u7684\u7ec6\u80de\u4e9a\u7fa4\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4e5f\u5bf9\u5355\u7ec6\u80de\u6570\u636e\u96c6\u4e2d\u8bc6\u522b\u51fa\u7684\u5404\u7c7b\u9ad3\u7cfb\u7ec6\u80de\u6807\u8bb0\u57fa\u56e0\u8fdb\u884c\u4e86\u529f\u80fd\u5bcc\u96c6\u5206\u6790\uff0c\u5e76\u901a\u8fc7C1Q <\/sup>\u5de8\u566c\u7ec6\u80de\u6807\u5fd7\u7269\u5c06\u9aa8\u8089\u7624\u6837\u672c\u805a\u7c7b\u4e3a\u4e24\u7ec4\uff0c\u5e76\u6bd4\u8f83\u4e86\u4e24\u7ec4\u7684\u751f\u5b58\u5dee\u5f02\u3002\u7ed3\u679c\u7814\u7a76\u53d1\u73b0\u4e0e\u4f4e\u514d\u75ab\u6d78\u6da6\u7ec4\u76f8\u6bd4\uff0c\u9ad8\u514d\u75ab\u6d78\u6da6\u7ec4\u9884\u540e\u8f83\u597d\uff0c\u4e14\u51e0\u4e4e\u6240\u6709\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u90fd\u5728\u9ad3\u7cfb\u7ec6\u80de\u4e2d\u9ad8\u8868\u8fbe\u6216\u4ec5\u5728\u9ad3\u7cfb\u7ec6\u80de\u4e2d\u8868\u8fbe\u3002\u7814\u7a76\u4e5f\u5728\u9ad3\u7cfb\u7ec6\u80de\u4e2d\u8bc6\u522b\u51fa\u4e00\u7c7bC1Q\u9633\u6027\u7684\u5de8\u566c\u7ec6\u80de\uff0c\u4e14\u8be5\u7ec6\u80de\u7684\u6d78\u6da6\u4e0e\u8f83\u957f\u7684\u751f\u5b58\u671f\u76f8\u5173\u3002<\/p>\n

03<\/p>\n

\u6587\u7ae0\u4e3b\u8981\u5185\u5bb9\u53ca\u7ed3\u679c<\/p>\n

Part Three<\/p>\n

1<\/p>\n

\u9aa8\u8089\u7624\u9ad8\u514d\u75ab\u6d78\u6da6\u7ec4\u9884\u540e\u8f83\u597d<\/p>\n

\u6587\u7ae0\u9996\u5148\u5bf9\u4e0d\u540c\u514d\u75ab\u6d78\u6da6OS\u7684\u9884\u540e\u8fdb\u884c\u4e86\u5206\u6790\u3002\u7814\u7a76\u7684\u603b\u4f53\u6d41\u7a0b\u5982\u56fe1\u6240\u793a\u3002\u7814\u7a76\u9996\u5148\u6839\u636e\u514d\u75ab\u57fa\u56e0\u7684\u8868\u8fbe\u5c06\u6837\u672c\u805a\u7c7b\u5206\u4e3a\u9ad8\u3001\u4f4e\u514d\u75ab\u6d78\u6da6\u7ec4(\u56fe2A)\uff0c\u5e76\u901a\u8fc7ssGSEA\u8ba1\u7b97\u4e24\u7ec4\u4e2d\u514d\u75ab\u7ec6\u80de\u7684\u6d78\u6da6\u8bc4\u5206\uff0c\u7ed3\u679c\u53d1\u73b0\u9ad8\u514d\u75ab\u6d78\u6da6\u7ec4\u8868\u73b0\u51fa\u8f83\u9ad8\u7684\u514d\u75ab\u7ec6\u80de\u8bc4\u5206\uff0c\u4f4e\u514d\u75ab\u6d78\u6da6\u7ec4\u7684\u5404\u79cd\u514d\u75ab\u7ec6\u80de\u8bc4\u5206\u90fd\u8f83\u4f4e(\u56fe2B)\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4e5f\u53d1\u73b0\u9ad8\u514d\u75ab\u6d78\u6da6\u7ec4\u7684\u9884\u540e\u8f83\u597d(\u56fe2C)\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u8bc6\u522b\u4e86\u9ad8\u548c\u4f4e\u514d\u75ab\u6d78\u6da6\u7ec4\u4e4b\u95f4\u7684DEGs\uff0c\u6700\u7ec8\u8bc6\u522b\u51fa\u4e24\u4e2a\u6570\u636e\u96c6\u5171\u6709\u768434\u4e2aDEGs\uff0c\u4e14\u7814\u7a76\u53d1\u73b0\u8fd934\u4e2a\u57fa\u56e0\u51e0\u4e4e\u90fd\u4e0e\u8f83\u597d\u7684\u603b\u751f\u5b58\u671f\u76f8\u5173(\u56fe2F)\u3002\u63a5\u7740\u7814\u7a76\u901a\u8fc7\u529f\u80fd\u5bcc\u96c6\u5206\u6790\u53d1\u73b0\u8fd934\u4e2a\u57fa\u56e0\u4e0e\u767d\u7ec6\u80de\u548cT\u7ec6\u80de\u589e\u6b96\u76f8\u5173(\u56fe2D)\u3002\u7814\u7a76\u8fdb\u4e00\u6b65\u901a\u8fc7GSEA\u5206\u6790\u53d1\u73b0DEGs\u4e0e\u7ec6\u80de\u56e0\u5b50\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u3001\u7834\u9aa8\u7ec6\u80de\u5206\u5316\u3001\u541e\u566c\u4f5c\u7528\u7b49\u76f8\u5173(\u56fe2E)\u3002<\/p>\n

\u56fe1 \u7814\u7a76\u7684\u603b\u4f53\u6d41\u7a0b<\/p>\n

\u56fe2 OS\u7ec4\u7ec7\u6570\u636e\u5206\u6790<\/p>\n

2<\/p>\n

\u5de8\u566c\u7ec6\u80de\u662f\u9aa8\u8089\u7624\u7684\u4e3b\u8981\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4<\/p>\n

\u8fd9\u4e00\u90e8\u5206\u7814\u7a76\u4f7f\u7528\u5355\u7ec6\u80de\u6570\u636e\u96c6\u5bf9OS\u5fae\u73af\u5883\u4e2d\u7684\u7ec6\u80de\u7fa4\u8fdb\u884c\u4e86\u5206\u6790\u3002\u7814\u7a76\u7ecf\u8fc7\u8d28\u63a7\u540e\u4fdd\u7559\u4e8699668\u4e2a\u7ec6\u80de\uff0c\u5e76\u5c06\u5176\u805a\u7c7b\u6ce8\u91ca\u4e3a9\u4e2a\u4e9a\u7fa4\uff0c\u8fdb\u4e00\u6b65\u7814\u7a76\u89c2\u5bdf\u4e86\u7ec4\u7ec7\u6570\u636e\u8bc6\u522b\u7684DEGs\u5728\u8fd9\u4e9b\u7ec6\u80de\u4e9a\u7fa4\u4e2d\u7684\u8868\u8fbe\u60c5\u51b5(\u56fe3A-D)\uff0c\u7ed3\u679c\u53d1\u73b0\u8fd9\u4e9b\u57fa\u56e0\u4e3b\u8981\u5728\u9ad3\u7cfb\u7ec6\u80de\u548cFABP4 <\/sup>\u5de8\u566c\u7ec6\u80de\u4e2d\u8868\u8fbe(\u56fe3E)\u3002\u4f5c\u8005\u63a5\u7740\u5c06\u9ad3\u7cfb\u7ec6\u80de\u91cd\u805a\u7c7b\u4e3a9\u4e2a\u7c07\uff0c\u5e76\u6ce8\u91ca\u4e3a6\u4e2a\u7ec6\u80de\u4e9a\u7fa4(\u56fe4A-D)\uff0c\u5e76\u5206\u6790\u4e86DEGs\u5728\u8fd9\u4e9b\u4e9a\u7fa4\u4e2d\u7684\u8868\u8fbe\u60c5\u51b5\uff0c\u7ed3\u679c\u8bc6\u522b\u51fa\u4e86\u4e00\u7c7bC1Q <\/sup>\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de(TAM)\u3002\u63a5\u4e0b\u6765\u7814\u7a76\u6bd4\u8f83\u4e86\u7ec6\u80de\u4e9a\u7fa4\u7684\u6807\u8bb0\u57fa\u56e0\u548c\u4e4b\u524d\u83b7\u5f97\u768434\u4e2aDEGs\uff0c\u8bc6\u522b\u51fa15\u4e2a\u5171\u6709\u7684DEGs\uff0c\u5176\u4e2dC1QA\u662fC1Q <\/sup> TAM\u7684\u6807\u5fd7\u7269(\u56fe4E)\uff0c\u6b64\u5916\u7814\u7a76\u901a\u8fc7C1Q <\/sup>\u5de8\u566c\u7ec6\u80de\u6807\u5fd7\u57fa\u56e0\u7684\u5bcc\u96c6\u5206\u6790\u53d1\u73b0\u5176\u4e0e\u6297\u539f\u52a0\u5de5\u5448\u9012\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u6d3b\u5316\u6709\u5173(\u56fe4F)\u3002<\/p>\n

\u56fe3 \u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793aOS\u5fae\u73af\u5883<\/p>\n

\u56fe4 OS\u9ad3\u7cfb\u7ec6\u80de\u5206\u6790<\/p>\n

3<\/p>\n

C1Q <\/sup> TAM\u6807\u8bb0\u7269\u4e0e\u8f83\u597d\u7684\u9884\u540e\u6709\u5173<\/p>\n

\u8fd9\u4e00\u90e8\u5206\u7814\u7a76\u8fdb\u4e00\u6b65\u5bf9C1Q  <\/sup>TAM\u6807\u8bb0\u7269\u4e0e\u4e34\u5e8a\u7ed3\u5c40\u7684\u5173\u8054\u8fdb\u884c\u4e86\u5206\u6790\u3002\u7814\u7a76\u5728C1Q <\/sup> TAMs\u4e2d\u8bc6\u522b\u4e86219\u4e2a\u663e\u8457\u6807\u8bb0\u57fa\u56e0\uff0c\u4f5c\u8005\u53d1\u73b010\u4e2a\u500d\u6570\u53d8\u5316\u6700\u9ad8\u7684\u6807\u8bb0\u57fa\u56e0\u4e2d\u67095\u4e2a\u4e0e\u8f83\u597d\u7684\u9884\u540e\u76f8\u5173\uff0c\u5206\u522b\u662fC1QA\u3001C1QB\u3001FOLR2\u3001LGMN\u548cAPOE(\u56fe5A)\u3002\u63a5\u7740\u7814\u7a76\u4f7f\u7528C1Q <\/sup> TAMs\u7684\u6807\u8bb0\u57fa\u56e0\uff0c\u57fa\u4e8e\u5c42\u6b21\u805a\u7c7b\u5c06\u7ec4\u7ec7\u6570\u636e\u4e2d\u7684\u6837\u672c\u5206\u4e3a\u4e24\u7ec4(\u56fe5B)\uff0c\u7814\u7a76\u53d1\u73b0C1Q <\/sup>\u5de8\u566c\u7ec6\u80de\u6807\u5fd7\u7269\u9ad8\u8868\u8fbe\u7ec4\u7684\u603b\u751f\u5b58\u671f\u66f4\u597d(\u56fe5C)\uff0c\u8fd9\u8868\u660eC1Q <\/sup> TAM\u6d78\u6da6\u53d1\u6325\u4e86\u6297\u80bf\u7624\u4f5c\u7528\u3002\u63a5\u4e0b\u6765\u7814\u7a76\u8ba1\u7b97\u4e86\u8fd9219\u4e2a\u6807\u8bb0\u57fa\u56e0\u4e4b\u95f4\u7684\u5171\u8868\u8fbe\u7cfb\u6570\uff0c\u5e76\u63d0\u53d6\u4e86\u663e\u8457\u7684\u5171\u8868\u8fbe\u57fa\u56e0\uff0c\u5e76\u7ed8\u5236\u4e86\u5171\u8868\u8fbe\u7f51\u7edc(\u56fe5D)\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4e5f\u5206\u6790\u4e86\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528(\u56fe5E)\uff0c\u7ed3\u679c\u53d1\u73b0C1Q TAMs\u4e3b\u8981\u4f5c\u7528\u4e8e\u5185\u76ae\u7ec6\u80de\u3002<\/p>\n

\u56fe5 C1Q <\/sup> TAM\u7684\u7efc\u5408\u5206\u6790<\/p>\n

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