\u6587\u732e\u89e3\u8bfb<\/p>\n
731\u4e2a\u514d\u75ab\u7ec6\u80de\u5728\u7cbe\u795e\u5206\u88c2\u75c7<\/p>\n
\u7684\u5b5f\u5fb7\u5c14\u968f\u673a\u5316<\/p>\n
\u8bba\u6587\u9898\u76ee\uff1a<\/p>\n
Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study<\/p>\n
\u53d1\u8868\u6742\u5fd7\uff1aBMC Psychiatry<\/p>\n
\u53d1\u8868\u5e74\u4efd\uff1a2023\u5e74<\/p>\n
\u5f71\u54cd\u56e0\u5b50\uff1a4.4<\/p>\n
\u53d1\u8868\u5355\u4f4d\uff1a\u5f90\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5f90\u5dde\u4e1c\u65b9\u533b\u9662\u7cbe\u795e\u79d1<\/p>\n
\u6458\u8981\uff1a<\/p>\n
\u7814\u7a76\u80cc\u666f \uff1a\u5f71\u54cd\u795e\u7ecf\u53d1\u80b2\u3001\u5b58\u6d3b\u548c\u529f\u80fd\u7684\u590d\u6742\u514d\u75ab-\u5927\u8111\u76f8\u4e92\u4f5c\u7528\u53ef\u80fd\u5bf9\u7cbe\u795e\u75be\u75c5\u5177\u6709\u56e0\u679c\u548c\u6cbb\u7597\u610f\u4e49\u3002\u7136\u800c\uff0c\u5148\u524d\u7814\u7a76\u514d\u75ab\u708e\u75c7\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\uff08SCZ\uff09\u4e4b\u95f4\u7684\u5173\u7cfb\u5f97\u51fa\u4e86\u4e0d\u4e00\u81f4\u7684\u7ed3\u679c\u3002<\/p>\n
\u65b9\u6cd5\uff1a\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u8fdb\u884c\u4e86\u5168\u9762\u7684\u4e24\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08MR\uff09\u5206\u6790\uff0c\u4ee5\u786e\u5b9a\u514d\u75ab\u7ec6\u80de\u7279\u5f81\u4e0eSCZ\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002\u57fa\u4e8e\u516c\u5f00\u7684\u9057\u4f20\u6570\u636e\uff0c\u6211\u4eec\u63a2\u8ba8\u4e86731\u4e2a\u514d\u75ab\u7ec6\u80de\u7279\u5f81\u4e0eSCZ\u98ce\u9669\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002\u5171\u5305\u62ec\u56db\u79cd\u7c7b\u578b\u7684\u514d\u75ab\u7279\u5f81\uff08\u4e2d\u503c\u8367\u5149\u5f3a\u5ea6\uff08MFI\uff09\u3001\u76f8\u5bf9\u7ec6\u80de\uff08RC\uff09\u3001\u7edd\u5bf9\u7ec6\u80de\uff08AC\uff09\u548c\u5f62\u6001\u53c2\u6570\uff08MP\uff09\uff09\u3002\u7efc\u5408\u654f\u611f\u6027\u5206\u6790\u7528\u4e8e\u9a8c\u8bc1\u7ed3\u679c\u7684\u7a33\u5065\u6027\u3001\u5f02\u8d28\u6027\u548c\u6c34\u5e73\u591a\u6548\u6027\u3002<\/p>\n
\u7ed3\u679c\uff1a FDR\u6821\u6b63\u540e\uff0cSCZ\u5bf9\u514d\u75ab\u8868\u578b\u6ca1\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u5f71\u54cd\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u4e00\u4e9b\u8868\u578b\u5177\u6709\u672a\u7ecf\u8c03\u6574\u7684\u4f4eP\u503c\uff0c\u5305\u62ecNKT\u4e0a\u7684FSC-A\uff08\u03b2=0.119\uff0c95%CI=0.044\uff5e0.194\uff0cP=0.002\uff09\uff0cDN\uff08CD4-CD8-\uff09NKT%T\u7ec6\u80de\uff08\u03b2=0.131\uff0c95%CI=0.054\uff5e0.208\uff0cP=9.03\u00d710\u22124\uff09\uff0c\u6dcb\u5df4\u7ec6\u80de\u4e0a\u7684SSC-A\uff08\u03b2=0.136\uff0c95%CI=0.059\uff5e0.213\uff0cP=5.43\u00d7104\uff09\u3002SCZ-IgD\u5bf9\u8fc7\u6e21\u671f\u7684\u56e0\u679c\u6548\u5e94\u4f30\u8ba1\u4e3a0.127\uff0895%CI=0.051~0.203\uff0cP=1.09\u00d710\u22123\uff09\u3002SCZ\u5bf9IgD %B\u7ec6\u80de\uff08\u03b2=0.130\uff0c95%CI=0.054~0.207\uff0cP=8.69\u00d710\u22124\uff09\u548cDP\uff08CD4 CD8 \uff09%T\u7ec6\u80de\uff08\u03b2=0.031\uff0c95%CI=0.044~0.07\uff0cP=8.05\u00d710\u22124\u3002\u6b64\u5916\uff0c\u6709\u56db\u79cd\u514d\u75ab\u8868\u578b\u4e0eSCZ\u98ce\u9669\u663e\u8457\u76f8\u5173\uff1a\u521d\u59cbCD4 T\u7ec6\u80de\uff08OR=0.986\uff0c95%CI=0.79~0.992\uff0cP=1.37\u00d710\u22125\uff09\u3001CD14\u2212CD16\u2212\u4e0a\u7684HLA DR\uff08OR=0.738\uff0895%CI=0.642~0.849\uff0cP=2.00\u00d710\u2212\uff09\uff0cCD33dim HLA DR CD11b\u2212AC\uff08OR=0.631\uff0c95%CI=0.529~0.753\uff0cP=3.40\u00d710\u22127\uff09\u548c\u6d3b\u5316\u548c\u9759\u606fTreg%CD4-Treg\uff08OR=0.937\uff0c95%CI0.906~0.970\uff0cP=1.96\u00d710\u22124\uff09\u3002<\/p>\n
\u7ed3\u8bba\uff1a\u6211\u4eec\u7684\u7814\u7a76\u901a\u8fc7\u9057\u4f20\u5b66\u624b\u6bb5\u8bc1\u660e\u4e86\u514d\u75ab\u7ec6\u80de\u4e0eSCZ\u4e4b\u95f4\u7684\u5bc6\u5207\u8054\u7cfb\uff0c\u4ece\u800c\u4e3a\u672a\u6765\u7684\u4e34\u5e8a\u7814\u7a76\u63d0\u4f9b\u4e86\u6307\u5bfc\u3002<\/p>\n
\u5173\u952e\u8bcd\uff1a\u7cbe\u795e\u5206\u88c2\u75c7\uff0c\u514d\u75ab\uff0c\u56e0\u679c\u63a8\u65ad\uff0c\u5927\u8111\uff0cMR\u5206\u6790\uff0c\u654f\u611f\u6027<\/p>\n
\u6ce8\u610f\uff1a\u533b\u5de5\u56e2\u961f\u7684MendelR\u4ee3\u7801\u5305\u53ef\u4ee5\u4e00\u952e\u5b8c\u6210\u4e0a\u8ff0\u5206\u6790\u54e6<\/p>\n
\u8be6\u7ec6\u8bf7\u770b\u516c\u4f17\u53f7\u6b21\u6761\u5185\u5bb9~<\/p>\n
\u524d\u8a00<\/p>\n
\u7cbe\u795e\u5206\u88c2\u75c7\uff08SCZ\uff09\u662f\u4e00\u79cd\u4e25\u91cd\u7684\u7cbe\u795e\u969c\u788d\uff0c\u901a\u5e38\u8868\u73b0\u4e3a\u5e7b\u89c9\u3001\u5984\u60f3\u548c\u6781\u5ea6\u65e0\u5e8f\u7684\u601d\u7ef4\u548c\u884c\u4e3a\uff0c\u4f1a\u5f71\u54cd\u65e5\u5e38\u8eab\u4f53\u529f\u80fd\uff0c\u6700\u7ec8\u53ef\u80fd\u5bfc\u81f4\u6b8b\u75be[1\uff0c2]\u3002\u5168\u7403\u75be\u75c5\u8d1f\u62c5\uff08GBD\uff09\u7814\u7a76\u8868\u660e\uff0c\u5168\u7403\u7ea6\u67092090\u4e07\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005[3]\u3002\u76ee\u524d\uff0c\u6297\u7cbe\u795e\u75c5\u836f\u7269\u662f\u6cbb\u7597SCZ\u7684\u4e3b\u8981\u65b9\u6cd5[4]\u3002SCZ\u60a3\u8005\u5f80\u5f80\u9700\u8981\u7ec8\u8eab\u6cbb\u7597\uff0c\u56e0\u6b64\u65e9\u671f\u8bca\u65ad\u548c\u6cbb\u7597\u53ef\u80fd\u6709\u52a9\u4e8e\u5728\u4e25\u91cd\u5e76\u53d1\u75c7\u4e4b\u524d\u63a7\u5236\u75c7\u72b6\uff0c\u6539\u5584\u9884\u540e[5\uff0c6]\u3002<\/p>\n
\u65b9\u6cd5<\/p>\n
1. \u7814\u7a76\u8bbe\u8ba1<\/p>\n
\u57fa\u4e8e\u4e24\u4e2a\u6837\u672c\u7684MR\u5206\u6790\uff0c\u6211\u4eec\u8bc4\u4f30\u4e86731\u4e2a\u514d\u75ab\u7ec6\u80de\u7279\u5f81\uff087\u7ec4\uff09\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002MR\u4f7f\u7528\u9057\u4f20\u53d8\u5f02\u6765\u8868\u793a\u98ce\u9669\u56e0\u7d20\uff0c\u56e0\u6b64\uff0c\u56e0\u679c\u63a8\u65ad\u4e2d\u7684\u6709\u6548\u5de5\u5177\u53d8\u91cf\u5fc5\u987b\u6ee1\u8db3\u4e09\u4e2a\u5173\u952e\u5047\u8bbe\uff1a\uff081\uff09\u9057\u4f20\u53d8\u5f02\u4e0e\u66b4\u9732\u76f4\u63a5\u76f8\u5173\uff1b\uff082\uff09 \u9057\u4f20\u53d8\u5f02\u4e0e\u66b4\u9732\u548c\u7ed3\u679c\u4e4b\u95f4\u53ef\u80fd\u7684\u6df7\u6742\u56e0\u7d20\u65e0\u5173\uff1b\u4ee5\u53ca\uff083\uff09\u9057\u4f20\u53d8\u5f02\u4e0d\u4f1a\u901a\u8fc7\u66b4\u9732\u4ee5\u5916\u7684\u9014\u5f84\u5f71\u54cd\u7ed3\u679c\u3002\u6211\u4eec\u5206\u6790\u4e2d\u7684\u7814\u7a76\u5f97\u5230\u4e86\u76f8\u5173\u673a\u6784\u5ba1\u67e5\u59d4\u5458\u4f1a\u7684\u6279\u51c6\uff0c\u53c2\u4e0e\u8005\u63d0\u4f9b\u4e86\u77e5\u60c5\u540c\u610f\u4e66\u3002<\/p>\n
2. \u5de5\u5177\u53d8\u91cf\u9009\u62e9<\/p>\n
\u6839\u636e\u6700\u8fd1\u7684\u7814\u7a76[22\uff0c25]\uff0c\u6bcf\u4e2a\u514d\u75ab\u7279\u5f81\u7684IVs\u663e\u8457\u6027\u6c34\u5e73\u8bbe\u7f6e\u4e3a1\u00d710\u22125\u3002PLINK\u8f6f\u4ef6\u4e2d\u7684\u805a\u96c6\u8fc7\u7a0b\uff08\u7248\u672cv1.90\uff09\u7528\u4e8e\u4fee\u526a\u8fd9\u4e9bSNPs\uff08\u5728500kb\u8ddd\u79bb\u5185\u8fde\u9501\u4e0d\u5e73\u8861[LD]r2\u9608\u503c<0.1\uff09[26]\uff0c\u5176\u4e2dLD r2\u662f\u57fa\u4e8e1000\u4e2a\u57fa\u56e0\u7ec4\u9879\u76ee\u4f5c\u4e3a\u53c2\u8003\u9762\u677f\u8ba1\u7b97\u7684\u3002\u5bf9\u4e8eSCZ\uff0c\u6211\u4eec\u5c06\u663e\u8457\u6027\u6c34\u5e73\u8c03\u6574\u4e3a5\u00d710\u22128\u3002\u8ba1\u7b97\u6bcf\u4e2aIV\u7684\u8868\u578b\u53d8\u5f02\u89e3\u91ca\u6bd4\u4f8b\uff08PVE\uff09\u548cF\u7edf\u8ba1\u91cf\uff0c\u4ee5\u8bc4\u4f30IV\u5f3a\u5ea6\u5e76\u907f\u514d\u5f31\u5de5\u5177\u504f\u5dee\u3002\u5171\u786e\u5b9a\u4e867\u81f31786\u4e2a\u72ec\u7acb\u7684\u514d\u75ab\u8868\u578bIVs\uff0c\u8fd9\u4e9b\u751f\u6210\u7684IVs\u53ef\u4ee5\u89e3\u91ca\u5176\u5404\u81ea\u514d\u75ab\u6027\u72b6\u7684\u5e73\u57470.240%\uff08\u8303\u56f40.004\u22123.652%\uff09\u7684\u5dee\u5f02\u3002\u7136\u540e\uff0c\u5728\u53bb\u9664\u5177\u6709\u4f4eF\u7edf\u8ba1\uff08<10\uff09\u7684IVs\u540e\uff0c\u4fdd\u7559108\u4e2aSCZ\u7684IVs\u4ee5\u4f9b\u8fdb\u4e00\u6b65\u5206\u6790\u3002<\/p>\n
3. \u6570\u636e\u6765\u6e90<\/p>\n
SCZ\u7684\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u6570\u636e\u6e90\uff1aSCZ\u7684GWAS\u6c47\u603b\u7edf\u8ba1\u6570\u636e\u6765\u81ea\u7cbe\u795e\u57fa\u56e0\u7ec4\u5b66\u8054\u76df\uff08PGC\uff09[23]\u3002\u8be5\u7814\u7a76\u5bf9150064\u540d\u6b27\u6d32\u4e2a\u4f53\uff08Ncase=36989\uff0cNcontrol=113075\uff09\u8fdb\u884c\u4e86GWAS\uff0c\u5728\u8d28\u91cf\u63a7\u5236\u548c\u63d2\u8865\u540e\u5206\u6790\u4e86\u7ea6950\u4e07\u4e2a\u53d8\u5f02\u3002\u8be5GWAS\u9274\u5b9a\u4e86128\u4e2a\u72ec\u7acb\u7684\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff08SNPs\uff09\uff0883\u4e2a\u4ee5\u524d\u672a\u62a5\u9053\uff09\uff0c\u5305\u62ec\u81f3\u5c11108\u4e2a\u5168\u57fa\u56e0\u7ec4\u663e\u8457\u6027\u6c34\u5e73\u4e0b\u7684\u72ec\u7acb\u57fa\u56e0\u7ec4\u4f4d\u70b9\uff08P\uff1c5\u00d710\u22128\uff09\u3002<\/p>\n
\u5168\u514d\u75abGWAS\u6570\u636e\u6e90\uff1a\u6bcf\u4e2a\u514d\u75ab\u7279\u6027\u7684GWAS\u6c47\u603b\u7edf\u8ba1\u6570\u636e\u53ef\u4eceGWAS\u76ee\u5f55\u4e2d\u516c\u5f00\u83b7\u5f97\uff08\u767b\u5f55\u53f7\u4eceGCST0001391\u5230GCST0002121\uff09[22]\u3002\u5171\u5305\u62ec731\u79cd\u514d\u75ab\u8868\u578b\uff0c\u5305\u62ec\u7edd\u5bf9\u7ec6\u80de\uff08AC\uff09\u8ba1\u6570\uff08n=118\uff09\u3001\u53cd\u6620\u8868\u9762\u6297\u539f\u6c34\u5e73\u7684\u4e2d\u503c\u8367\u5149\u5f3a\u5ea6\uff08MFI\uff09\uff08n=389\uff09\u3001\u5f62\u6001\u53c2\u6570[MP]\uff08n=32\uff09\u548c\u76f8\u5bf9\u7ec6\u80de\uff08RC\uff09\u8ba1\u6570\uff08n=192\uff09\u3002\u5177\u4f53\u800c\u8a00\uff0cMFI\u3001AC\u548cRC\u7279\u5f81\u5305\u542bB\u7ec6\u80de\u3001CDCs\u3001T\u7ec6\u80de\u6210\u719f\u671f\u3001\u5355\u6838\u7ec6\u80de\u3001\u9aa8\u9ad3\u7ec6\u80de\u3001TBNK\uff08T\u7ec6\u80de\u3001B\u7ec6\u80de\u3001\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff09\u548cTreg\u9762\u677f\uff0c\u800cMP\u7279\u5f81\u5305\u542bCDC\u548cTBNK\u9762\u677f\u3002\u6700\u521d\u7684\u514d\u75ab\u7279\u5f81GWAS\u662f\u4f7f\u75283757\u540d\u6b27\u6d32\u4e2a\u4f53\u7684\u6570\u636e\u8fdb\u884c\u7684\uff0c\u6ca1\u6709\u91cd\u53e0\u7684\u961f\u5217\u3002\u4f7f\u7528\u57fa\u4e8e\u6492\u4e01\u5c9b\u5e8f\u5217\u7684\u53c2\u8003\u9762\u677f[24]\u4f30\u7b97\u4e86\u7ea62200\u4e07\u4e2a\u4f7f\u7528\u9ad8\u5bc6\u5ea6\u9635\u5217\u8fdb\u884c\u57fa\u56e0\u5206\u578b\u7684SNPs\uff0c\u5e76\u5728\u8c03\u6574\u534f\u53d8\u91cf\uff08\u5373\u6027\u522b\u3001\u5e74\u9f84\u548c\u5e74\u9f842\uff09\u540e\u6d4b\u8bd5\u4e86\u76f8\u5173\u6027\u3002<\/p>\n
4. \u7edf\u8ba1\u5206\u6790<\/p>\n
\u6240\u6709\u5206\u6790\u5747\u5728R 3.5.3\u8f6f\u4ef6\uff08http:\/\/www.Rproject.org\uff09\u4e2d\u8fdb\u884c\u3002\u4e3a\u4e86\u8bc4\u4f30731\u79cd\u514d\u75ab\u8868\u578b\u4e0eSCZ\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u4e3b\u8981\u4f7f\u7528\u201c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u201d\u8f6f\u4ef6\u5305\uff080.4.3\u7248\uff09[30]\u8fdb\u884c\u4e86\u9006\u65b9\u5dee\u52a0\u6743\uff08IVW\uff09[27]\u3001\u57fa\u4e8e\u52a0\u6743\u4e2d\u503c\u7684[28]\u548c\u57fa\u4e8e\u6a21\u5f0f\u7684\u65b9\u6cd5[29]\u3002\u4f7f\u7528Cochran\u7684Q\u7edf\u8ba1\u91cf\u548c\u76f8\u5e94\u7684p\u503c\u6765\u68c0\u9a8c\u6240\u9009IVs\u4e4b\u95f4\u7684\u5f02\u8d28\u6027\u3002\u5982\u679c\u96f6\u5047\u8bbe\u88ab\u62d2\u7edd\uff0c\u5219\u4f7f\u7528\u968f\u673a\u6548\u5e94IVW\u800c\u4e0d\u662f\u56fa\u5b9a\u6548\u5e94IVW[27]\u3002\u4e3a\u4e86\u6392\u9664\u6c34\u5e73\u591a\u6548\u6027\u7684\u5f71\u54cd\uff0c\u4f7f\u7528\u4e86\u4e00\u79cd\u5e38\u89c1\u7684\u65b9\u6cd5\uff08\u5373MR Egger\uff09\uff0c\u8fd9\u610f\u5473\u7740\u5982\u679c\u5176\u622a\u8ddd\u9879\u663e\u8457\uff0c\u5219\u5b58\u5728\u6c34\u5e73\u591a\u91cd\u6027[31]\u3002\u6b64\u5916\uff0c\u4e00\u79cd\u5f3a\u5927\u7684\u65b9\u6cd5\uff0cMR\u591a\u6548\u6027\u6b8b\u5dee\u548c\u548c\u5f02\u5e38\u503c\uff08MR-PRESSO\uff09\u65b9\u6cd5\u88ab\u7528\u6765\u6392\u9664\u53ef\u80fd\u7684\u6c34\u5e73\u591a\u6548\u6027\u5f02\u5e38\u503c\uff0c\u8fd9\u4e9b\u5f02\u5e38\u503c\u53ef\u80fd\u4f1a\u4e25\u91cd\u5f71\u54cdMR-PRESSO\u5305\u4e2d\u7684\u4f30\u8ba1\u7ed3\u679c[32]\u3002\u6b64\u5916\uff0c\u8fd8\u4f7f\u7528\u4e86\u6563\u70b9\u56fe\u548c\u6f0f\u6597\u56fe\u3002\u6563\u70b9\u56fe\u663e\u793a\u7ed3\u679c\u4e0d\u53d7\u5f02\u5e38\u503c\u7684\u5f71\u54cd\u3002\u6f0f\u6597\u56fe\u663e\u793a\u4e86\u76f8\u5173\u6027\u7684\u7a33\u5065\u6027\uff0c\u5e76\u4e14\u6ca1\u6709\u5f02\u8d28\u6027\u3002<\/p>\n
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\u6295\u7a3f\u5efa\u8bae\u3001\u4fee\u7a3f\u5efa\u8bae\uff01<\/p>\n
\u5168\u7f51\u72ec\u5bb6\u9ad8\u6548\u6559\u5b66\u6a21\u5f0f<\/p>\n
\u5b8c\u6574\u7684\u5f55\u5236\u8bfe(\u7406\u8bba\u5b9e\u64cd) \u4e13\u4e1a\u914d\u5957\u4ee3\u7801\u5305 \u6fc0\u6d3b\u7801 \u7406\u8bba\u8001\u5e08 \u6280\u672f\u8001\u5e08 \u4e13\u4eba\u7b54\u7591\u5c0f\u7fa4(2\u8001\u5e081\u5b66\u5458)<\/p>\n
\u9ed1\u9a6c\u9006\u88ad\uff0c\u5feb\u4eba\u4e00\u6b65\uff01<\/p>\n
#artContent h1#artContent p img#artContent table<\/p>\n","protected":false},"excerpt":{"rendered":"
\u6587\u732e\u89e3\u8bfb 731\u4e2a\u514d\u75ab\u7ec6\u80de\u5728\u7cbe\u795e\u5206\u88c2\u75c7 \u7684\u5b5f\u5fb7\u5c14\u968f\u673a\u5316 \u8bba\u6587\u9898\u76ee\uff1a Causal … \u7ee7\u7eed\u9605\u8bfb